JP2000504334A - 医薬製剤を安定化するための緩衝系 - Google Patents

医薬製剤を安定化するための緩衝系

Info

Publication number
JP2000504334A
JP2000504334A JP9527225A JP52722597A JP2000504334A JP 2000504334 A JP2000504334 A JP 2000504334A JP 9527225 A JP9527225 A JP 9527225A JP 52722597 A JP52722597 A JP 52722597A JP 2000504334 A JP2000504334 A JP 2000504334A
Authority
JP
Japan
Prior art keywords
acid
buffer
buffer according
amino
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9527225A
Other languages
English (en)
Japanese (ja)
Inventor
ザクサ，アンドレアス
ハック，ラルフスィグベルト
ロシング，ゲオルグ
ゴリツ，デトレフ
Original Assignee
シェリング アクチェンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シェリング アクチェンゲゼルシャフト filed Critical シェリング アクチェンゲゼルシャフト
Publication of JP2000504334A publication Critical patent/JP2000504334A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP9527225A 1996-01-29 1996-12-20 医薬製剤を安定化するための緩衝系 Pending JP2000504334A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19604230.5 1996-01-29
DE19604230 1996-01-29
PCT/DE1996/002488 WO1997028104A2 (de) 1996-01-29 1996-12-20 Puffersysteme zur stabilisierung pharmazeutischer zubereitungen

Publications (1)

Publication Number Publication Date
JP2000504334A true JP2000504334A (ja) 2000-04-11

Family

ID=7784639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9527225A Pending JP2000504334A (ja) 1996-01-29 1996-12-20 医薬製剤を安定化するための緩衝系

Country Status (7)

Country Link
EP (1) EP0877628A2 (de)
JP (1) JP2000504334A (de)
AU (1) AU1870497A (de)
CA (1) CA2244213A1 (de)
DE (1) DE19648650C2 (de)
NO (1) NO983464D0 (de)
WO (1) WO1997028104A2 (de)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037325A1 (ja) * 2003-10-21 2005-04-28 Konica Minolta Medical & Graphic, Inc. リポソーム含有ｘ線造影剤およびその製造方法
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005220034A (ja) * 2004-02-03 2005-08-18 Konica Minolta Medical & Graphic Inc Ｘ線検査用造影剤の製造方法
JP2005289859A (ja) * 2004-03-31 2005-10-20 Konica Minolta Medical & Graphic Inc Ｘ線ｃｔ用造影組成物およびその製造方法
WO2006009022A1 (ja) * 2004-07-21 2006-01-26 Konica Minolta Medical & Graphic, Inc. リポソーム含有ｘ線造影剤およびその製造方法
JP2013522344A (ja) * 2010-03-23 2013-06-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 安定化ｘ線診断用組成物の製法
JP2018062475A (ja) * 2016-10-11 2018-04-19 学校法人 聖マリアンナ医科大学 非イオン性ヨード造影剤の結合体
JP2021512054A (ja) * 2018-01-31 2021-05-13 サイオクサス セラピューティクス リミテッド グループｂアデノウイルス含有製剤
JP7353453B1 (ja) 2022-10-31 2023-09-29 キユーピー株式会社 エマルジョン、及びその製造方法
JP7372429B1 (ja) 2022-10-31 2023-10-31 キユーピー株式会社 エマルジョン、及びその製造方法
US11938159B2 (en) 2013-10-25 2024-03-26 Akamis Bio Limited Oncolytic adenoviruses armed with heterologous genes
US11970536B2 (en) 2015-12-17 2024-04-30 Akamis Bio Limited Group B adenovirus encoding an anti-TCR-complex antibody or fragment

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7250153B2 (en) * 2002-12-12 2007-07-31 Biophysica Research, Inc. Contrast media formulations having improved biological tolerance
JP6230538B2 (ja) 2012-08-10 2017-11-15 大鵬薬品工業株式会社 安定なオキサリプラチン封入リポソーム水分散液及びその安定化方法
EP4011369A1 (de) 2020-12-14 2022-06-15 G.L. Pharma GmbH Wässrige pharmazeutische zusammensetzung mit tapentadoltartrat

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE445971B (sv) * 1978-07-04 1986-08-04 Nyegaard & Co As Forfarande for framstellning av injicerbart rontgenkontrastmedel samt en losning av nemnda medel
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
DE4121568C2 (de) * 1991-04-22 1997-07-03 Schering Ag Verfahren und Vorrichtung zur Herstellung eines Kontrastmediums aus einem Konzentrat
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037325A1 (ja) * 2003-10-21 2005-04-28 Konica Minolta Medical & Graphic, Inc. リポソーム含有ｘ線造影剤およびその製造方法
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005220034A (ja) * 2004-02-03 2005-08-18 Konica Minolta Medical & Graphic Inc Ｘ線検査用造影剤の製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
JP2005289859A (ja) * 2004-03-31 2005-10-20 Konica Minolta Medical & Graphic Inc Ｘ線ｃｔ用造影組成物およびその製造方法
WO2006009022A1 (ja) * 2004-07-21 2006-01-26 Konica Minolta Medical & Graphic, Inc. リポソーム含有ｘ線造影剤およびその製造方法
JP2013522344A (ja) * 2010-03-23 2013-06-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 安定化ｘ線診断用組成物の製法
US11185598B2 (en) 2010-03-23 2021-11-30 Ge Healthcare As Preparation of stabilised x-ray diagnostic composition
US11938159B2 (en) 2013-10-25 2024-03-26 Akamis Bio Limited Oncolytic adenoviruses armed with heterologous genes
US11970536B2 (en) 2015-12-17 2024-04-30 Akamis Bio Limited Group B adenovirus encoding an anti-TCR-complex antibody or fragment
JP2018062475A (ja) * 2016-10-11 2018-04-19 学校法人 聖マリアンナ医科大学 非イオン性ヨード造影剤の結合体
JP2021512054A (ja) * 2018-01-31 2021-05-13 サイオクサス セラピューティクス リミテッド グループｂアデノウイルス含有製剤
JP7353453B1 (ja) 2022-10-31 2023-09-29 キユーピー株式会社 エマルジョン、及びその製造方法
JP7372429B1 (ja) 2022-10-31 2023-10-31 キユーピー株式会社 エマルジョン、及びその製造方法

Also Published As

Publication number Publication date
WO1997028104A2 (de) 1997-08-07
NO983464L (no) 1998-07-28
WO1997028104A3 (de) 1997-09-12
CA2244213A1 (en) 1997-08-07
WO1997028104A8 (de) 1997-12-18
AU1870497A (en) 1997-08-22
NO983464D0 (no) 1998-07-28
EP0877628A2 (de) 1998-11-18
DE19648650A1 (de) 1997-08-07
DE19648650C2 (de) 1998-07-02

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