ITMI932688A1 - Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di radicali liberi - Google Patents

Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di radicali liberi Download PDF

Info

Publication number
ITMI932688A1
ITMI932688A1 IT002688A ITMI932688A ITMI932688A1 IT MI932688 A1 ITMI932688 A1 IT MI932688A1 IT 002688 A IT002688 A IT 002688A IT MI932688 A ITMI932688 A IT MI932688A IT MI932688 A1 ITMI932688 A1 IT MI932688A1
Authority
IT
Italy
Prior art keywords
antioxidant
compositions according
polyphenols
lipophilic
carotenoids
Prior art date
Application number
IT002688A
Other languages
English (en)
Inventor
Gabriele Fontana
Paolo Morazzoni
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI932688A0 publication Critical patent/ITMI932688A0/it
Priority to IT93MI002688A priority Critical patent/IT1265312B1/it
Priority to AU63132/94A priority patent/AU677048B2/en
Priority to CA002123739A priority patent/CA2123739C/en
Priority to PT94107676T priority patent/PT659402E/pt
Priority to EP94107676A priority patent/EP0659402B1/en
Priority to ES94107676T priority patent/ES2081781T3/es
Priority to DE0659402T priority patent/DE659402T1/de
Priority to AT94107676T priority patent/ATE214264T1/de
Priority to DK94107676T priority patent/DK0659402T3/da
Priority to DE69430109T priority patent/DE69430109T2/de
Priority to KR1019940011104A priority patent/KR100342543B1/ko
Priority to FI942452A priority patent/FI942452A/fi
Priority to CN94106547A priority patent/CN1082369C/zh
Priority to JP12866194A priority patent/JP3604422B2/ja
Priority to US08/463,129 priority patent/US5648377A/en
Publication of ITMI932688A1 publication Critical patent/ITMI932688A1/it
Priority to GR960300007T priority patent/GR960300007T1/el
Application granted granted Critical
Publication of IT1265312B1 publication Critical patent/IT1265312B1/it
Priority to HK98112884A priority patent/HK1011616A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A23L3/3499—Organic compounds containing oxygen with doubly-bound oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3544—Organic compounds containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)

Description

Descrizione dell'invenzione industriale avente per titolo: "FORMULAZIONI CONTENENTI CAROTENOIDI E PROCAROTENOIDI ASSO-CIATI A POLIFENOLI NELLA PREVENZIONE DEI DANNI DA ABNORME PRODUZIONE DI RADICALI LIBERI"
La presente invenzione riguarda nuove formulazioni ed associazioni di antiossidanti lipofili ed idrofili ed il loro uso in campo terapeutico, alimentare e cosmetico. Queste formulazioni hanno comebase l'impiego di carotenoidi, procarotenoidi (e loro derivati) e poliienoli a strutturacatechicao flavanolignanica.
E'ampiamente documentato in letteratura che l'assunzione di vitamina E, ?-carotene, licopene ed ubidecarenone (Coenzima Q 10) attraverso la dieta o in formulazioni farmaceutiche e nutrizionali riduce significativamnete l'incidenza di malattie cardiovascolari e inoltre sembra svolgere un ruolo importante nella prevenzione di alcuni timori. Per quanto concerne l'attivit? antiaterosclerotica dei carotenoidi, studi recenti sembrano identificare nella loro capacit? di prevenire l'ossidazione delle lipoproteine (interferendo quindi con il loro uptake vasaio), uno dei meccanismi pi? inportanti. I carotenoidi vengono infatti incorporati fisiologicamente nelle lipoproteine a bassa densit? (LDL) dove, prevenendo la loro ossidazione, si oppongono efficacemente al "primum movens" del danno aterosclerotico, che avviene soprattutto a carico del tessuto endoteliale [1-4].
I carotenoidi sono anche ritenuti buoni antiossidanti a livello cellulare ed inparticolare la loro funzione si esplica sulle cellule in attiva proliferazione nelle quali la frequenza di errore genico ? pi? elevata. Per quanto concerne la distribuzione tissutale e quindi la biodisponibilit? dei carotenoidi ? bennota la loro attivit?preventiva, dopo assunzione per via orale, nei confronti dei danni cutanei inputabili alle radiazioni ultra violette, noti agenti generatori di radicali dell'ossigeno, o sempre a livello periferico il loro ruolo sulle funzioni visive, ecc..
Le sostanze polifenoliche a struttura catechica di tipo dimerico ed oligomerico sono ampiamenteusate in terapia cardiavascolare ed incampo oftalmico per la loro favorevole azione sui vasi di grande e piccolo calibro. Questi polifenoli naturali, infatti, esplicano un?azione beneficamente modulatrice sulla fragilit? e sulla permeabilit? capillare oltre che sulla protezione degli endoteli. La letteratura recente ? concorde nel ritenere l'attivit? antiossidante un importante meccanismo alla base dell'effettobiologico di questi composti.
I flavanolignani, fra i quali la silimarina ed i suoi tre maggiori componenti silibina, silidianina e silicristina, sono caratterizzati dal possedere uno spiccato potere antiradicalare a livello epatico ed anche periferico, quando incorporati in formulazioni farmaceutiche opportune che ne garantiscano l'assorbimento a livello gastrointestinale. Cane da noi recentemente documentato, le sostanze polifenoliche estratte, per esempio, da Vitis vinifera, Camelia sinensis (Th? verde), Aesculus ippocastanum (Proantoc?anidina A2), Ginkgo biloba o da Cardus marianum, si sono dimostrate, oltre che potenti antiossidanti antiradicalari, anche potenti antimutageni [5].
Quest' ultima propriet? si esplica sia sulla rautagenesi spontanea che sulla metagenesi indotta da radiazioni ultraviolette o da prodotti induttori di mutazioni quali farmaci e inquinanti atmosferici.
I siti di azione delle sostanze polifenoliche sono molto diversi da quelli dei carotenoidi e loro analoghi per cui la contemporanea somministrazione di composti lipof ?li e idrofili porta ad un inaspettato e sorprendente vantaggio dal punto di vista biologico.
Carotenoidi quali la vitamina E, il ?-carotene, il lioopene, il coenzima Q10 e loro isomeri si sono dimostrati ottimi antiradicalari verso forme attivate dell'ossigeno sia nei test classici di perossidazione lipidica, quali per esenpio il sistema xantina-xantina ossidasi, sia in un modello molto selettivo da noi recentemente approntato e che prevede la perossidazione lipidica di un fosfolipide insaturo in mezzo acquoso ad opera di ultrasuoni. Negli stessi testa i polifenoli oggetto dell'invenzione si sono dimostrati parimenti o molto pi? attivi dei precedenti coeposti.
I risultati ottenuti in questi test inpiegando alcune sostanze polifenoliche e la Vitamine E ed il licopene, presi a modello di antiossidanti lipof ili, sono raccolti nelle Tabelle 1 e 2.
Tabella 1 - Attivit? scavenger nei confronti del radicale idrossilioo CH* - Fase induttiva.
Tabella 2 - Attivit? scavenger nei confronti dei radicali lipidici R*, R00*.Fase di propagazione.
Si ? sorprendentemente trovato, ed ? uno degli oggetti della presente invenzione, che l'associazione di un antiossidante idrofilo con uno lipofilo esplica un'azione antiossidante di gran lunga superiore a quella dei singoli cocnpoeti testati ad uguali concentrazioni (Tab. 2).
Questo dato ? stato confermato in un altro modello "in vitro" che prevede l'impiego di fibroblasti umani stimolati con zymosan e valutazione del processo peroesidativo mediante chemiluminescenza. L'associazione licopene e silimarina, per esenpio, ha dimostrato un effetto antiossidante sorprendentemente pi? marcato dei singoli componenti (Fig. 1) .
Gli stessi risultati sono stati ottenuti utilizzando altre associazioni di antiossidanti lipofili ( ubidecarenone , vitamina E) e antiossidanti idrofili (oligomeri estratti da Vitis vinifera) .
I risultati ottenuti nei modelli "in vitro" impiegando licopene puro hanno in seguito trovato conferma in modelli "in vivo" nei quali l' inpiego di associazioni tra antiossidanti lipofili ed antiossidanti idrofili ha portato ad un effettivo e inprevedibile miglioramento di danni sperimentali nei quali i radicali liberi giocano un ruolo importante .
Per un controllo di questo fenomeno, infatti, ? stato da noi scelto un modello di processo infiammatorio nel quale viene mpiegato un agente irritante (estere del forbolo) che innesca la per ossidazione lipidica a livello della membrana biologica e che conseguentemente si propaga attraverso una reazione radicalica a catena.
Nella Tabella 3 vengono riportati i dati dell'attivit? antiedemigena nel topo ottenuti con Bilimarina, silimarina associata ad una frazione lipofila ad elevato contenuto di licopene ( frazione preparata per estrazione esani ca di bucce essiccate di Lioopersicum aesculexitun) e la frazione cesi licopene. I dati sono espressi in percento di riduzione dell'edema misurato alla sesta ora dopo l ' induzione.
Tabella 3 - Attivit? anti-edemigena di silimarina, licopene e loro associazioni sull'edema da estere del forbolo nel topo.
Tutti i dati sopra riportati dimostrano che la combinazione di due antiossidanti di diversa polarit? aumenta di gran lunga l'efficacia dei singoli composti. Verosimilmente questo sinergismo ? dovuto all'intervento simultaneo su pi? specie radicaiiche che si traduce in un blocco quasi completo del processo perossidativo.
Lo stesso fenomeno si verifica quando si vada a controllare l'effetto antimutageno di queste associazioni, effetto per il quale la componente antiossidante gioca un ruolo fondamentale e che per i risvolti sulla prevenzione del cancro e di patologie cardiovascolari ? della massima inportanza.
A titolo di esecpio viene riportato in Tabella 4 l'effetto di polifenoli estratti dal th? verde, del lioopene e di una loro associazione.
Tabella 4 - Attivit? anti-tautagena di oligomeri procianidolici estratti da th? verde, licopene e di una loro associazione sulla frequenza di mutazione spontanea in SalmoneIla typhimrrium.
Con frazione polifenolica di Th? verde si usa un prodotto con titolo in polifenoli espressi come epigallocatechingallato dell' 85% ed a ridotto contenuto in caffeina ( <0.3% ) . Impiegando miscele di frazione licopenica con polifenoli del Th? si ? ottenuta nel test di Anes (Salmonella typhimurium TA-100 e TA-98) un' inibizione del 50% circa della mutazione spontanea.
Tale effetto ? risultato essere indipendente dall 1 attivazione metabolica (-S9 o S9) . Analoghi effetti si sono verificati su ceppi di Saccharomyces cerevisiae dove ? stato controllato l'effetto sulla mutazione spontanea a livello nucleare ed ancora pi? importante a livello di informazione mitocondriale .
I rapporti fra le due frazioni possono variare a partire da una parte di polifenolo fino a 1 parte di antiossidante l ipofilo a seconda dei caitqpi di applicazione delle differenti formulazioni .
Come eccipienti da usare in queste formulazioni rivestono particolare importanza i fosfolipidi, sia quelli naturali che quelli sintetici e le lecitine grezze a diverso contenuto in fosfolipidi. I fosfolipidi rappresentano un carrier particolarmente adatto per facilitare l'assorbimento delle sostanze polifenoli che sia di natura catechica che flavanolignanica. Le forme preferenziali di somministrazione di queste associazioni sono rappresentate dalle capsule di gelatina molle, ma non si esclude in ogni modo l' inpiego di capsule di gelatina dura, di cellulosa od al tre matrici nonch? l'uso di supposte e di forme transdermiche. Gli esempi che seguono illustreranno gli aspetti fondamentali dell'invenzione senza voler essere in alcun modo limitativi.
Esempio I - Formulazione contenente silimarina e licopene in olio di arachide
200 mg di estratto lipofilo di Lioopersioan aesculentum contenente il 5% di licopene sono mescolati con 50 mg di silimarina, 50 mg di fosfatidilcolina naturale di soia e 50 mg di olio di arachide; i prodotti vengono incapsulati in involucri di gelatina molle. La posologia di queste capsule ? di due al giorno.
Ese?>io II - Formulazione contenente oligomeri procianidolici e licopene in olio di arachide
200 mg di estratto lipofilo di Licopersicura aesculentum contenenti il 5% di licopene sono mescolati con 80 mg di silimarina, 50 mg di fosfatidilcolina naturale di soia e 50 mg di olio di arachide; i prodotti vengono incapsulati in involucri di gelatina molle. La posologia di queste capsule ? di una al giorno.
Esempio III - Formulazione contenente Ubidecarenone ed oligooeri procianidolici
20 mg di ubidecarenone sono mescolati con 20 mg di vitamina E ed 80 mg di oligomeri procianidolici; questa miscela viene dispersa in 100 mg di olio di arachide contenente 50 mg di fosfolipidi purificati di soia. La sospensione pu? essere incapsulata in capsule di gelatina molle o fatta assorbire su eccipienti idonei per la preparazione di conpresse. Esempio IV - Formulazione contenente ubichinolo (ubidecarenone ridotto), fosfolipidi insaturi e Proantocianidina A2
20 mg di ubichinolo sono mescolati con 100 mg di fosfatidilcolina di soia e sciolti in 100 mg di olio di arachide. A questa soluzione si aggiungono 80 mg di silibina. La sospensione pu? essere incapsulata in capsule di gelatina molle e cos? somministata .

Claims (7)

1. Composizioni farmaceutiche contenenti orane principio attivo un antiossidante lipofilo in associazione con un antiossidante idrofilo.
2. Composizioni secondo la rivendicazione 1 in cui l'antiossidante lipofilo ? scelto nella classe dei carotene idi, procarotenoidi e loro derivati.
3. Composizioni secondo la rivendicazione 2 in cui l'antiossidante ? scelto fra vitamina E, 0-carotene, licopene, ubidecarenone , ubichinolo.
4. Composizioni secondo una qualunque delle rivendicazioni 1-3 in cui l'antiossidante idrofilo ? scelto nella classe dei polii enoli a struttura catechica o flavanolignanica.
5. Composizioni secondo la rivendicazione 4 in cui l ' antiossidante polifenolioo ? scelto fra silimarina o uno dei suoi componenti, proantocianidina A2, oligomeri procianidolici , sostanze estratte da Vitis vinifera, Camelia sinensis, Aesculus Ginkgo biloba, Cardus marianum.
6. Composizioni secondo una qualunque delle rivendicazioni 1 -5 conprendenti come eccipienti fosfolipidi naturali o sintetici, incluse lecitine grezze a diverso contenuto in fosfolipidi.
7. Composizioni secondo una qualunque delle r ivendicaz ioni precedenti sotto forma di capsule di gelatina molle o dura, supposte o forme transdermiche.
IT93MI002688A 1993-12-21 1993-12-21 Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di IT1265312B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT93MI002688A IT1265312B1 (it) 1993-12-21 1993-12-21 Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di
AU63132/94A AU677048B2 (en) 1993-12-21 1994-05-17 Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
CA002123739A CA2123739C (en) 1993-12-21 1994-05-17 Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
DK94107676T DK0659402T3 (da) 1993-12-21 1994-05-18 Formuleringer indeholdende carotenoider og procarotenoider kombineret med polyphenoler til forebyggelse af beskadigelser som følge af abnorm produktion af frie radikaler
EP94107676A EP0659402B1 (en) 1993-12-21 1994-05-18 Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
ES94107676T ES2081781T3 (es) 1993-12-21 1994-05-18 Formulaciones que contienen carotenoides y procarotenoides combinados con polifenoles en la prevencion de los daños debidos a la produccion anormal de radicales libres.
DE0659402T DE659402T1 (de) 1993-12-21 1994-05-18 Karotenoide und Prokarotenoide enthaltende Zusammensetzungen kombiniert mit Polyphenolen zur Vorbeugung von durch abnormale freie Radikalbildung verursachten Schäden.
AT94107676T ATE214264T1 (de) 1993-12-21 1994-05-18 Karotenoide und prokarotenoide enthaltende zusammensetzungen kombiniert mit polyphenolen zur vorbeugung von durch abnormale freie radikalbildung verursachten schäden
PT94107676T PT659402E (pt) 1993-12-21 1994-05-18 Composicoes contendo carotenoides e procarotenoides combinados com polifenois para a prevencao de danos devidos a uma producao anormal de radicais livres.
DE69430109T DE69430109T2 (de) 1993-12-21 1994-05-18 Karotenoide und Prokarotenoide enthaltende Zusammensetzungen kombiniert mit Polyphenolen zur Vorbeugung von durch abnormale freie Radikalbildung verursachten Schäden
KR1019940011104A KR100342543B1 (ko) 1993-12-21 1994-05-21 유리라디칼의비정상적인생성에기인한손상방지를위한,폴리페놀과결합된리코펜을함유하는조성물
FI942452A FI942452A (fi) 1993-12-21 1994-05-26 Formuloinnit, jotka sisältävät karotenoideja ja prokarotenoideja, jotka on yhdistetty polyfenoleihin vammojen ehkäisyssä, jotka johtuvat epänormaalista vapaaradikaalituotannosta
CN94106547A CN1082369C (zh) 1993-12-21 1994-06-08 类胡萝卜素和类胡萝卜素原与多元酚联合使用的配方
JP12866194A JP3604422B2 (ja) 1993-12-21 1994-06-10 遊離基の異常産生による損傷防止のための、ポリフェノールを組合せた、カロテノイド又はプロカロテノイド含有配合物
US08/463,129 US5648377A (en) 1993-12-21 1995-06-05 Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
GR960300007T GR960300007T1 (en) 1993-12-21 1996-02-29 Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals.
HK98112884A HK1011616A1 (en) 1993-12-21 1998-12-07 Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI002688A IT1265312B1 (it) 1993-12-21 1993-12-21 Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di

Publications (3)

Publication Number Publication Date
ITMI932688A0 ITMI932688A0 (it) 1993-12-21
ITMI932688A1 true ITMI932688A1 (it) 1995-06-21
IT1265312B1 IT1265312B1 (it) 1996-10-31

Family

ID=11367371

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI002688A IT1265312B1 (it) 1993-12-21 1993-12-21 Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di

Country Status (15)

Country Link
EP (1) EP0659402B1 (it)
JP (1) JP3604422B2 (it)
KR (1) KR100342543B1 (it)
CN (1) CN1082369C (it)
AT (1) ATE214264T1 (it)
AU (1) AU677048B2 (it)
CA (1) CA2123739C (it)
DE (2) DE69430109T2 (it)
DK (1) DK0659402T3 (it)
ES (1) ES2081781T3 (it)
FI (1) FI942452A (it)
GR (1) GR960300007T1 (it)
HK (1) HK1011616A1 (it)
IT (1) IT1265312B1 (it)
PT (1) PT659402E (it)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4401902C2 (de) * 1994-01-24 2000-02-03 Madaus Ag Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
JPH09175982A (ja) * 1995-12-28 1997-07-08 Nikka Uisukii Kk 化粧品
US6261565B1 (en) * 1996-03-13 2001-07-17 Archer Daniels Midland Company Method of preparing and using isoflavones
IT1283143B1 (it) * 1996-07-12 1998-04-07 Indena Spa Metodo di estrazione del licopene ed estratti che lo contengono
JP3926888B2 (ja) * 1997-05-27 2007-06-06 株式会社カネカ コレステロール低下剤
FR2763850B1 (fr) * 1997-06-02 2000-02-18 Slow Age Creations Utilisation d'une ubiquinone en association avec un tocopherol et un polyphenol pour le traitement du vieillissement de la peau
US6066327A (en) * 1997-12-17 2000-05-23 Color Access, Inc. Antioxidant mixture
US6068848A (en) * 1997-12-17 2000-05-30 Color Access, Inc. Antioxidant mixture comprising tocopherol
JP3763075B2 (ja) * 1998-04-24 2006-04-05 サンスター株式会社 歯周病の予防又は治療用の食品組成物、口腔用組成物及び医薬組成物
ES2141687B1 (es) * 1998-09-07 2000-11-01 Provital S A Complejo vegetal antipolucion, procedimiento para su obtencion y uso del mismo en la preparacion de composiciones farmaceuticas y/o cosmeticas.
WO2000018374A1 (en) * 1998-10-01 2000-04-06 Elan Pharma International, Ltd. Controlled release nanoparticulate compositions
IT1304183B1 (it) * 1998-12-18 2001-03-08 Indena Spa Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici.
US7153503B1 (en) * 1998-12-19 2006-12-26 Janeel Henderson Comprehensive dietary supplement
DE19903716A1 (de) * 1999-01-30 2000-08-03 Henkel Kgaa Antioxidative Hautpflegemittel
FR2792831B1 (fr) * 1999-04-28 2001-08-03 Bionatec Sarl Composition a destination cosmetique et/ou dietetique comprenant un melange de lycopene et d'extrait de feuille d'olivier
IL130556A0 (en) * 1999-06-20 2000-06-01 Lycored Natural Prod Ind Ltd Synergistic compositions for treatment of liver diseases
FR2799368A1 (fr) * 1999-10-07 2001-04-13 Oreal Utilisation du lycopene dans des compositions destinees a traiter les signes cutanes du vieillissement
FR2799370B1 (fr) 1999-10-07 2005-08-19 Oreal Utilisation du lycopene dans des compositions destinees a traiter les signes cutanes du vieillissement
JP3233624B2 (ja) * 2000-04-20 2001-11-26 中島水産株式会社 養殖魚の体色調・身光沢を改良したカロチノイド・ポリフェノール添加養殖魚用飼料
PT1283713E (pt) * 2000-05-12 2006-08-31 Olson Bengt Krister Composicoes de extractos marinhos e de plantas combinados
CA2409688A1 (en) * 2000-05-25 2001-11-29 Pharmaton S.A. Method for improving the cell protection
US6511675B2 (en) * 2000-06-12 2003-01-28 Access Business Group International, Llc Composition and method for correcting a dietary phytochemical deficiency
US7122212B2 (en) 2000-06-14 2006-10-17 Pure Green Co., Ltd. Process for producing oily cosmetics
FR2810242B1 (fr) * 2000-06-16 2003-01-17 Nuxe Lab Composition cosmetique et/ou dermatologique a base d'extraits de cacao
FR2816839B1 (fr) * 2000-11-20 2003-09-26 Schwartz Laboratoires Robert Produit preparant et protegeant la peau contre les rayons uv, agissant a l'encontre du vieillissement cellulaire et excercant une action immunostimulante
JP2002220333A (ja) * 2001-01-25 2002-08-09 Kanebo Ltd 経口美白剤
US6524599B2 (en) * 2001-02-21 2003-02-25 Skinceuticals, Inc. Use of milk thistle extract in skin care compositions
EP1256335A1 (de) * 2001-05-10 2002-11-13 Cognis France S.A. Verwendung von oligomeren Procyanolidinen
KR20010079021A (ko) * 2001-06-05 2001-08-22 강성종 산화억제제의 안정제와 안정제를 첨가한 제품.
EP1314438A1 (en) * 2001-11-23 2003-05-28 Nutricia N.V. Anti-proliferative composition
TW200302055A (en) 2002-01-18 2003-08-01 Kaneka Corp Ubiquinol-enriched fat-containing foods
TW200302056A (en) * 2002-01-18 2003-08-01 Kaneka Corp Method for stabilizing reduced coenzyme Q10 and composition therefor
KR20030087566A (ko) * 2002-05-07 2003-11-14 액세스 비지니스 그룹 인터내셔날 엘엘씨 식물생리활성 영양 보조물
DE10225772A1 (de) * 2002-06-10 2003-12-24 Beiersdorf Ag Kosmetische oder dermatologische Formulierungen zur Pflege der Haut nach einem Sonnenbad oder einer Rasur
ES2292882T3 (es) * 2003-06-24 2008-03-16 Cognis Ip Management Gmbh Extracto de litchi sinensis que contiene proantocianidinas oligomericas.
ITMI20031313A1 (it) * 2003-06-27 2004-12-28 Indena Spa Associazioni di agenti vasoprotettori e formulazioni che li contengono.
ITMI20031388A1 (it) * 2003-07-08 2005-01-09 Indena Spa Formulazioni per il trattamento e la prevenzione di patologie della prostata.
US7999003B2 (en) * 2003-08-26 2011-08-16 Mannatech, Incorporated Antioxidant compositions and methods thereto
RU2006132336A (ru) * 2004-02-10 2008-03-20 Нестек С.А. (Ch) Композиции, содержащие цис-изомеры каротиноидного соединения, и способ их получения
US9265808B2 (en) 2004-03-23 2016-02-23 Lifeline Nutraceuticals Corporation Compositions for alleviating inflammation and oxidative stress in a mammal
CA2560826C (en) * 2004-03-23 2014-05-13 Lifeline Nutraceuticals Corporation Antioxidant-promoting herbal extract compositions for alleviating oxidative stress in a mammal
JP2006070016A (ja) * 2004-08-02 2006-03-16 Kaneka Corp 還元型補酵素ｑを含有する美白用組成物
JP4033877B2 (ja) 2005-09-29 2008-01-16 株式会社ファンケル Ｉ型コラーゲン産生促進用組成物
DE102005048779A1 (de) * 2005-10-10 2007-04-12 Beiersdorf Ag Kosmetische Formulierungen zur Verbesserung der Hautbarrierefunktion
EP2123266B1 (en) * 2006-12-06 2014-01-15 Kaneka Corporation Cancer therapeutic agent and anti-carcinogenic agent
EP1958611A1 (en) * 2006-12-20 2008-08-20 DSMIP Assets B.V. Oral composition containing EGCG and lycopene
US20100226994A1 (en) * 2007-10-03 2010-09-09 Nobuaki Hirai Granule, tablet and methods for producing the same
ATE533364T1 (de) * 2008-09-25 2011-12-15 Nestec Sa Reduktion der astringenz in zusammensetzungen mit phenolverbindungen
EP2355793B1 (en) * 2008-11-12 2018-09-05 June Jacobs Laboratories, Llc Antioxidant compositions for the cleansing and conditioning of skin
IT1398624B1 (it) * 2009-02-02 2013-03-08 Dermogyn S R L Uso cosmetico della proantocianidina a2
ES2606546T3 (es) * 2009-02-11 2017-03-24 Heglund, A.S. Compuesto destinado a la absorción bucal de nicotina con el objetivo de dejar de fumar
JP5459699B2 (ja) * 2009-03-27 2014-04-02 キッコーマン株式会社 クランベリー抽出物及びその製造方法
KR101558184B1 (ko) 2009-04-15 2015-10-08 (주)아모레퍼시픽 적포도잎 추출물, 베리 혼합물 및 셀레늄을 함유하는 항산화용 조성물
JP5783699B2 (ja) * 2009-09-30 2015-09-24 小林製薬株式会社 経口組成物
JP2011079786A (ja) * 2009-10-08 2011-04-21 Sankyo:Kk 崩壊遅延を防止または抑制したポリフェノール類、レシチン、ビタミンｅ含有ソフトカプセル
CN106616987A (zh) * 2016-12-21 2017-05-10 中山大学 营养乳剂及其制备方法和应用
KR102591301B1 (ko) 2023-04-27 2023-10-20 피엠원 주식회사 지하철 역사 공기여과장치용 필터 및 이를 이용한 세정식 공기여과장치
KR102686248B1 (ko) 2023-10-13 2024-07-19 김혜신 분리 세척용 필터 및 공간 활용도가 향상된 공기여과장치

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5097M (it) * 1965-12-23 1967-05-22
CH662505A5 (it) * 1985-04-30 1987-10-15 Seuref Ag Composizioni farmaceutiche ad azione protettiva vascolare.
CH670763A5 (it) * 1985-08-02 1989-07-14 Seuref Ag
DE4101122A1 (de) * 1991-01-16 1992-07-23 Betrix Cosmetic Gmbh & Co Kosmetisches oder pharmazeutisches mittel
FR2675996B1 (fr) * 1991-04-30 1993-10-15 Georges Baritiu Compositions sanogenes dietetiques complexes.
JPH07112979B2 (ja) * 1991-11-13 1995-12-06 株式会社スカイ・フード 活性酸素フリーラジカル消去剤
JPH05328947A (ja) * 1992-03-31 1993-12-14 Sankaino Chinmi:Kk 茶類錠剤
RU2002438C1 (ru) * 1992-08-14 1993-11-15 Pilipenko Lyudmila N Способ стабилизации пищевых продуктов
JPH07112980B2 (ja) * 1992-11-04 1995-12-06 株式会社スカイ・フード 活性酸素フリーラジカル消去剤

Also Published As

Publication number Publication date
AU677048B2 (en) 1997-04-10
ITMI932688A0 (it) 1993-12-21
GR960300007T1 (en) 1996-02-29
JPH07196534A (ja) 1995-08-01
CA2123739A1 (en) 1995-06-22
DE69430109T2 (de) 2002-10-02
CN1082369C (zh) 2002-04-10
DK0659402T3 (da) 2002-06-17
ATE214264T1 (de) 2002-03-15
DE69430109D1 (de) 2002-04-18
KR100342543B1 (ko) 2002-12-11
EP0659402A3 (en) 1996-12-18
FI942452A (fi) 1995-06-22
PT659402E (pt) 2002-06-28
ES2081781T1 (es) 1996-03-16
EP0659402A2 (en) 1995-06-28
CA2123739C (en) 2004-01-27
KR950016704A (ko) 1995-07-20
CN1111506A (zh) 1995-11-15
FI942452A0 (fi) 1994-05-26
JP3604422B2 (ja) 2004-12-22
AU6313294A (en) 1995-07-13
EP0659402B1 (en) 2002-03-13
DE659402T1 (de) 1996-10-10
ES2081781T3 (es) 2002-09-16
HK1011616A1 (en) 1999-07-16
IT1265312B1 (it) 1996-10-31

Similar Documents

Publication Publication Date Title
ITMI932688A1 (it) Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di radicali liberi
US5648377A (en) Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
Watson et al. Nutraceutical and antioxidant effects of a delphinidin-rich maqui berry extract Delphinol®: a review
Povichit et al. Phenolic content and in vitro inhibitory effects on oxidation and protein glycation of some Thai medicinal plants
DE60122196T2 (de) Synergistische antioxidans-kombination von delta tocols und polyphenolen
Wang et al. Structure–activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells
US20030105031A1 (en) Methods for the treatment of skin disorders
CA2470603A1 (en) Methods for the treatment of peripheral neural and vascular ailments
KR20090040344A (ko) 국소 피부 조성물, 이들의 제조 및 이들의 용도
KR20080026663A (ko) 경구 투여용 조성물
KR20090038460A (ko) 국소 피부 조성물, 이들의 제조 및 이들의 용도
CA2431079C (en) Method and composition for the treatment of diabetic neuropathy
Lee et al. Cytoprotective effects and mechanisms of quercetin, quercitrin and avicularin isolated from Lespedeza cuneata G. Don against ROS-induced cellular damage
JP2006193512A (ja) 外用剤
WO2006076387A2 (en) Cyanidin-3-glucoside as an anti-neoplastic agent
US9034399B2 (en) Dietary compositions for promoting brain health
KR101467627B1 (ko) 다실미역 추출물을 유효성분으로 함유하는 자외선에 의한 인간 피부세포의 세포사멸 억제용 조성물
US5972357A (en) Healthy foods and cosmetics
Tosato et al. Nanomaterials and natural products for UV-photoprotection
JP2006298887A (ja) 活性酸素除去剤、肌の弾力保持剤、抗酸化作用補助剤
ES2274163T3 (es) Preparacion para su aplicacion (i) oral y/o topica.
US20050053560A1 (en) Use of a composition containing extracts of Vitis vinifera and lycopersicum for protecting the skin
Motohashi et al. Functionality of anthocyanins as alternative medicine
BRPI0612828A2 (pt) extratos de ginkgo biloba
KR20180060607A (ko) 피부 개선용 조성물

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971223