ITMI20130794A1 - Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle vaginosi batteriche. - Google Patents
Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle vaginosi batteriche.Info
- Publication number
- ITMI20130794A1 ITMI20130794A1 IT000794A ITMI20130794A ITMI20130794A1 IT MI20130794 A1 ITMI20130794 A1 IT MI20130794A1 IT 000794 A IT000794 A IT 000794A IT MI20130794 A ITMI20130794 A IT MI20130794A IT MI20130794 A1 ITMI20130794 A1 IT MI20130794A1
- Authority
- IT
- Italy
- Prior art keywords
- bacteria
- strain
- lactobacillus
- dsm
- composition
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000794A ITMI20130794A1 (it) | 2013-05-14 | 2013-05-14 | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle vaginosi batteriche. |
| RU2015148752A RU2015148752A (ru) | 2013-05-14 | 2014-05-14 | Композиция, содержащая лактобактерии, для применения в превентивном и/или куративном лечении бактериального вагиноза |
| CA2912015A CA2912015A1 (en) | 2013-05-14 | 2014-05-14 | Composition comprising lactic acid bacteria for use in the preventive and/or curative treatment of bacterial vaginosis |
| DK14733289.4T DK2996701T3 (da) | 2013-05-14 | 2014-05-14 | Sammensætning omfattende mælkesyrebakterier til anvendelse i den forebyggende og/eller helbredende behandling af bakteriel vaginose |
| US14/891,321 US20160184372A1 (en) | 2013-05-14 | 2014-05-14 | Composition comprising lactic acid bacteria for use in the preventive and/or curative treatment of bacterial vaginosis |
| EP14733289.4A EP2996701B1 (en) | 2013-05-14 | 2014-05-14 | Composition comprising lactic acid bacteria for use in the preventive and/or curative treatment of bacterial vaginosis |
| KR1020157035132A KR102434323B1 (ko) | 2013-05-14 | 2014-05-14 | 세균질증의 예방적 및/또는 치료적 치료에서 사용하기 위한 락트산 박테리아를 포함하는 조성물 |
| PCT/IB2014/000739 WO2014184643A1 (en) | 2013-05-14 | 2014-05-14 | Composition comprising lactic acid bacteria for use in the preventive and/or curative treatment of bacterial vaginosis |
| CN201480027964.3A CN105263504A (zh) | 2013-05-14 | 2014-05-14 | 用于预防和/或治愈细菌性阴道病的包含乳酸菌的组合物 |
| BR112015028385A BR112015028385A2 (pt) | 2013-05-14 | 2014-05-14 | composição compreendendo bactérias de ácido láctico para uso no tratamento preventivo e/ou curativo da vaginose bacteriana |
| JP2016513455A JP6509822B2 (ja) | 2013-05-14 | 2014-05-14 | 細菌性腟症の予防的および／または治療的処置に使用するための乳酸菌含有組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000794A ITMI20130794A1 (it) | 2013-05-14 | 2013-05-14 | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle vaginosi batteriche. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20130794A1 true ITMI20130794A1 (it) | 2014-11-15 |
Family
ID=48748369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT000794A ITMI20130794A1 (it) | 2013-05-14 | 2013-05-14 | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle vaginosi batteriche. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160184372A1 (ja) |
| EP (1) | EP2996701B1 (ja) |
| JP (1) | JP6509822B2 (ja) |
| KR (1) | KR102434323B1 (ja) |
| CN (1) | CN105263504A (ja) |
| BR (1) | BR112015028385A2 (ja) |
| CA (1) | CA2912015A1 (ja) |
| DK (1) | DK2996701T3 (ja) |
| IT (1) | ITMI20130794A1 (ja) |
| RU (1) | RU2015148752A (ja) |
| WO (1) | WO2014184643A1 (ja) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20110791A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri in grado di metabolizzare gli ossalati. |
| ITMI20110792A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia. |
| ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
| ITMI20111718A1 (it) | 2011-09-23 | 2013-03-24 | Probiotical Spa | Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali. |
| ITMI20130793A1 (it) | 2013-05-14 | 2014-11-15 | Probiotical Spa | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti. |
| EP3064072A1 (en) * | 2015-02-11 | 2016-09-07 | AB-Biotics S.A. | Probiotic lactobacillus strains for use in treating urinary tract infections |
| MA45334A (fr) * | 2016-03-24 | 2019-01-30 | Probiotical Spa | Composition bactérienne d'acide lactique pour le traitement d'infections vaginales bactériennes par gardnerella vaginalis et, éventuellement, d'infections fongiques concurrentes |
| WO2017163216A1 (en) * | 2016-03-24 | 2017-09-28 | Probiotical S.P.A. | Lactic acid bacterial composition for the treatment of bacterial vaginal infections by gardnerella vaginalis and, if present, of concurrent fungal infections |
| CA3030408A1 (en) * | 2016-07-11 | 2018-01-18 | Hennepin Life Sciences, Llc | Compositions for sexually transmitted diseases |
| IT201600084470A1 (it) * | 2016-08-10 | 2018-02-10 | Probiotical Spa | Composizione per uso nel trattamento del disturbo depressivo maggiore |
| CN106265864A (zh) * | 2016-08-30 | 2017-01-04 | 王守亮 | 一种用于生殖系统的复合益生菌及其制备方法和用途 |
| EP3522879A4 (en) * | 2016-10-04 | 2020-06-03 | Evofem, Inc. | METHOD OF TREATING AND PREVENTING BACTERIAL VAGINOSIS |
| EP3427745A1 (en) | 2017-07-12 | 2019-01-16 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | New probiotic composition for prevention of bacterial vaginosis |
| JP6964191B2 (ja) * | 2017-11-02 | 2021-11-10 | ユニバーシティ−インダストリー コーオペレイション グループ オブ キョンヒ ユニバーシティUniversity−Industry Cooperation Group Of Kyung Hee University | 新規な乳酸菌およびその使用 |
| CA3085855A1 (en) | 2017-12-19 | 2019-06-27 | Probiotical S.P.A. | Composition for use in the treatment and/or improvement of sleep and mood disorders |
| EP3727407A1 (en) * | 2017-12-19 | 2020-10-28 | Probiotical S.p.A. | Composition for use in the treatment and/or improvement of sleep and mood disorders |
| CN108295096B (zh) * | 2017-12-21 | 2020-12-25 | 天津科睿恒生物科技有限公司 | 菌株在预防和治疗霉菌性、细菌性阴道炎制剂中的应用 |
| US10456430B1 (en) | 2018-05-25 | 2019-10-29 | Genmont Biotech Incorporation | Lactobacillus composition for prevention and treatment of bacterial vaginosis |
| WO2020084589A1 (en) * | 2018-10-26 | 2020-04-30 | Sofar S.P.A. | Bacterial strains of the lactobacillus paracasei species for use, oral or topical, in the treatment of disorders of the female urogenital tract |
| CN109439592A (zh) * | 2018-12-06 | 2019-03-08 | 青岛东海药业有限公司 | 植物乳杆菌制剂及其应用 |
| CN111632073A (zh) * | 2019-03-01 | 2020-09-08 | 王飞 | 一种抗菌消炎的女性私密益生菌组合物及其制备 |
| CN110664731A (zh) * | 2019-11-25 | 2020-01-10 | 哈尔滨欧替药业有限公司 | 一种含有乳酸杆菌和低聚糖的阴道膨胀栓及其制备方法 |
| IT202000004663A1 (it) * | 2020-03-05 | 2021-09-05 | Marca Antonio La | Nuovo uso di probiotici |
| CN115361963A (zh) | 2020-03-16 | 2022-11-18 | 生物探索有限公司 | 包含益生菌、胶原和细菌胞外多糖的生物复合材料及其用途 |
| AU2021417032A1 (en) * | 2021-01-05 | 2023-07-27 | Lactobio A/S | Strains, compositions and methods of use |
| IT202100015398A1 (it) * | 2021-06-11 | 2022-12-11 | Probiotical Spa | Ceppi di batteri probiotici per uso in un metodo di trattamento preventivo o in un metodo di trattamento coadiuvante per le infezioni respiratorie virali |
| WO2023220318A2 (en) * | 2022-05-12 | 2023-11-16 | Bcd Bioscience, Inc. | Methods for treating urogenital health conditions |
| CN115418338B (zh) * | 2022-11-03 | 2023-02-24 | 山东锦鲤生物工程有限公司 | 副干酪乳杆菌及其应用 |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006013588A1 (en) * | 2004-08-05 | 2006-02-09 | Anidral S.R.L. | Folic acid producing bifidobacterium bacterial strains, formulations and use thereof |
| WO2008038075A2 (en) * | 2006-09-27 | 2008-04-03 | Mofin S.R.L. | Microbial liquid cultures having high stability and fermentative activity |
| EP2000530A1 (en) * | 2007-06-04 | 2008-12-10 | Instytut Biotechnologii Surowic i Szczepionek BIOMED S.A. | Composition of lactobacillus strains and the application of the composition of lactobacillus strains |
| US20100092440A1 (en) * | 2006-11-28 | 2010-04-15 | Probiotical S.P.A. | composition for the administration of biologically active principles in gynaecologic and rectal field and uses thereof |
| WO2010099824A1 (en) * | 2009-03-05 | 2010-09-10 | Probiotical S.P.A. | Bacteria strains having a high anti-inflammatory activity |
| WO2010133761A1 (en) * | 2009-05-19 | 2010-11-25 | Bayer Schering Pharma Oy | Intravaginal delivery system comprising one or more therapeutically active substances capable of preventing and/or treating vaginal infections |
| WO2010136891A1 (en) * | 2009-05-27 | 2010-12-02 | Probiotical S.P.A. | Bacteriocin-producing lactobacillus pentosus and the use thereof in food and pharmaceutical compositions |
| EP2269465A1 (en) * | 2006-05-03 | 2011-01-05 | Probiotical S.p.a. | Compositions comprising Bifidobacterium adolescentis |
| WO2012101500A1 (en) * | 2011-01-28 | 2012-08-02 | Probiotical S.P.A. | Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections |
| WO2013034974A1 (en) * | 2011-09-09 | 2013-03-14 | Giovanni Mogna | Composition comprising n-acetylcysteine and/or microencapsulated gastroprotected lysozyme in association with probiotic bacteria capable of restoring the stomach's own barrier effect which is lost during the pharmacological treatment of gastric hyperacidity |
| WO2013034975A1 (en) * | 2011-09-09 | 2013-03-14 | Probiotical S.P.A. | Strains of lactic acid bacteria and/or bifidobacteria inhibiting/reducing the growth of different biotypes of e. coli and different biotypes of clostridia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE290391T1 (de) * | 1998-12-11 | 2005-03-15 | Urex Biotech Inc | Orale verabreichung von laktobacillus zur behandlung und prävention von urogenitalen infektionen |
| IT1306716B1 (it) * | 1999-06-21 | 2001-10-02 | Mendes S U R L | Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori. |
| EP2081607B1 (en) * | 2006-11-17 | 2015-03-18 | SCA Hygiene Products AB | Hygiene tissue comprising a microbe-inhibiting composition |
| AU2010281534B2 (en) * | 2009-07-27 | 2014-10-16 | Société des Produits Nestlé S.A. | Nutritional compositions comprising fiber and probiotics |
-
2013
- 2013-05-14 IT IT000794A patent/ITMI20130794A1/it unknown
-
2014
- 2014-05-14 CN CN201480027964.3A patent/CN105263504A/zh active Pending
- 2014-05-14 US US14/891,321 patent/US20160184372A1/en not_active Abandoned
- 2014-05-14 BR BR112015028385A patent/BR112015028385A2/pt not_active IP Right Cessation
- 2014-05-14 JP JP2016513455A patent/JP6509822B2/ja not_active Expired - Fee Related
- 2014-05-14 WO PCT/IB2014/000739 patent/WO2014184643A1/en active Application Filing
- 2014-05-14 DK DK14733289.4T patent/DK2996701T3/da active
- 2014-05-14 EP EP14733289.4A patent/EP2996701B1/en active Active
- 2014-05-14 CA CA2912015A patent/CA2912015A1/en not_active Abandoned
- 2014-05-14 RU RU2015148752A patent/RU2015148752A/ru not_active Application Discontinuation
- 2014-05-14 KR KR1020157035132A patent/KR102434323B1/ko active IP Right Grant
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006013588A1 (en) * | 2004-08-05 | 2006-02-09 | Anidral S.R.L. | Folic acid producing bifidobacterium bacterial strains, formulations and use thereof |
| EP2269465A1 (en) * | 2006-05-03 | 2011-01-05 | Probiotical S.p.a. | Compositions comprising Bifidobacterium adolescentis |
| WO2008038075A2 (en) * | 2006-09-27 | 2008-04-03 | Mofin S.R.L. | Microbial liquid cultures having high stability and fermentative activity |
| US20100092440A1 (en) * | 2006-11-28 | 2010-04-15 | Probiotical S.P.A. | composition for the administration of biologically active principles in gynaecologic and rectal field and uses thereof |
| EP2000530A1 (en) * | 2007-06-04 | 2008-12-10 | Instytut Biotechnologii Surowic i Szczepionek BIOMED S.A. | Composition of lactobacillus strains and the application of the composition of lactobacillus strains |
| WO2010099824A1 (en) * | 2009-03-05 | 2010-09-10 | Probiotical S.P.A. | Bacteria strains having a high anti-inflammatory activity |
| WO2010133761A1 (en) * | 2009-05-19 | 2010-11-25 | Bayer Schering Pharma Oy | Intravaginal delivery system comprising one or more therapeutically active substances capable of preventing and/or treating vaginal infections |
| WO2010136891A1 (en) * | 2009-05-27 | 2010-12-02 | Probiotical S.P.A. | Bacteriocin-producing lactobacillus pentosus and the use thereof in food and pharmaceutical compositions |
| WO2012101500A1 (en) * | 2011-01-28 | 2012-08-02 | Probiotical S.P.A. | Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections |
| WO2013034974A1 (en) * | 2011-09-09 | 2013-03-14 | Giovanni Mogna | Composition comprising n-acetylcysteine and/or microencapsulated gastroprotected lysozyme in association with probiotic bacteria capable of restoring the stomach's own barrier effect which is lost during the pharmacological treatment of gastric hyperacidity |
| WO2013034975A1 (en) * | 2011-09-09 | 2013-03-14 | Probiotical S.P.A. | Strains of lactic acid bacteria and/or bifidobacteria inhibiting/reducing the growth of different biotypes of e. coli and different biotypes of clostridia |
Non-Patent Citations (7)
| Title |
|---|
| HOESL C E ET AL: "The Probiotic Approach: An Alternative Treatment Option in Urology", EUROPEAN UROLOGY, ELSEVIER BV, NL, vol. 47, no. 3, 1 March 2005 (2005-03-01), pages 288 - 296, XP027606331, ISSN: 0302-2838, [retrieved on 20050301] * |
| ISMAIL AL-WAHSH ET AL: "Acute probiotic ingestion reduces gastrointestinal oxalate absorption in healthy subjects", UROLOGICAL RESEARCH ; A JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION IN UROLITHIASIS AND RELATED AREAS, SPRINGER, BERLIN, DE, vol. 40, no. 3, 28 August 2011 (2011-08-28), pages 191 - 196, XP035058023, ISSN: 1434-0879, DOI: 10.1007/S00240-011-0421-7 * |
| L. PASCUAL ET AL: "Vaginal colonization and activity of the probiotic bacterium Lactobacillus fermentum L23 in a murine model of vaginal tract infection", JOURNAL OF MEDICAL MICROBIOLOGY, vol. 59, no. 3, 19 November 2009 (2009-11-19), pages 360 - 364, XP055077489, ISSN: 0022-2615, DOI: 10.1099/jmm.0.012583-0 * |
| MOGNA LUCA ET AL: "Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains", JOURNAL OF CLINICAL GASTROENTEROLOGY UNITED STATES, USA, vol. 46, no. Suppl, 1 October 2012 (2012-10-01), pages S29 - S32, XP009167929, ISSN: 1539-2031, DOI: 10.1097/MCG.0B013E31826852B7 * |
| SAGGIORO ALFREDO: "Probiotics in the treatment of irritable bowel syndrome.", JOURNAL OF CLINICAL GASTROENTEROLOGY JUL 2004, vol. 38, no. 6 Suppl, July 2004 (2004-07-01), pages S104 - S106, XP009172163, ISSN: 0192-0790 * |
| STRUS M ET AL: "Studies on the effects of probiotic Lactobacillus mixture given orally on vaginal and rectal colonization and on parameters of vaginal health in women with intermediate vaginal flora", EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY 2012 ELSEVIER IRELAND LTD IRL, vol. 163, no. 2, August 2012 (2012-08-01), pages 210 - 215, XP002712127, ISSN: 0301-2115 * |
| VIOLETA CASTRO-LEYVA ET AL: "Preserved Ex Vivo Inflammatory Status in Decidual Cells from Women with Preterm Labor and Subclinical Intrauterine Infection", PLOS ONE, vol. 7, no. 8, 22 August 2012 (2012-08-22), pages e43605, XP055077158, DOI: 10.1371/journal.pone.0043605 * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015148752A (ru) | 2017-06-20 |
| BR112015028385A2 (pt) | 2017-07-25 |
| EP2996701B1 (en) | 2020-06-24 |
| CN105263504A (zh) | 2016-01-20 |
| JP6509822B2 (ja) | 2019-05-08 |
| EP2996701A1 (en) | 2016-03-23 |
| KR20160007608A (ko) | 2016-01-20 |
| KR102434323B1 (ko) | 2022-08-18 |
| DK2996701T3 (da) | 2020-09-21 |
| US20160184372A1 (en) | 2016-06-30 |
| CA2912015A1 (en) | 2014-11-20 |
| WO2014184643A1 (en) | 2014-11-20 |
| JP2016520076A (ja) | 2016-07-11 |
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