IT1271677B - Procedimento per la preparazione di buspirone ad alta purezza e del suo idrocoloruro - Google Patents

Procedimento per la preparazione di buspirone ad alta purezza e del suo idrocoloruro

Info

Publication number
IT1271677B
IT1271677B ITMI941492A ITMI941492A IT1271677B IT 1271677 B IT1271677 B IT 1271677B IT MI941492 A ITMI941492 A IT MI941492A IT MI941492 A ITMI941492 A IT MI941492A IT 1271677 B IT1271677 B IT 1271677B
Authority
IT
Italy
Prior art keywords
azaspiro
piperazin
pyrimidin
dione
ecan
Prior art date
Application number
ITMI941492A
Other languages
English (en)
Inventor
Tibor Mezei
Gabor Blasko
Zoltan Budai
Margit Csorgo
Eva Furdyga
Imre Klebovitch
Laszlo Koncz
Ilona Sztruhar
Attilia Mandi
Kalman Nagy
Klara Reiter
Gyula Simig
Judit Szegi
Gyongyi Vereczkey
Original Assignee
Egis Gyogyszergyar Rt &
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt & filed Critical Egis Gyogyszergyar Rt &
Publication of ITMI941492A0 publication Critical patent/ITMI941492A0/it
Publication of ITMI941492A1 publication Critical patent/ITMI941492A1/it
Application granted granted Critical
Publication of IT1271677B publication Critical patent/IT1271677B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ITMI941492A 1993-07-16 1994-07-18 Procedimento per la preparazione di buspirone ad alta purezza e del suo idrocoloruro IT1271677B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9302040A HU217129B (hu) 1993-07-16 1993-07-16 Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására

Publications (3)

Publication Number Publication Date
ITMI941492A0 ITMI941492A0 (it) 1994-07-18
ITMI941492A1 ITMI941492A1 (it) 1996-01-18
IT1271677B true IT1271677B (it) 1997-06-04

Family

ID=10983790

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941492A IT1271677B (it) 1993-07-16 1994-07-18 Procedimento per la preparazione di buspirone ad alta purezza e del suo idrocoloruro

Country Status (20)

Country Link
US (1) US5473072A (it)
EP (1) EP0634411B1 (it)
JP (1) JPH07165755A (it)
KR (1) KR950003287A (it)
AT (1) ATE180480T1 (it)
BG (1) BG98904A (it)
CA (1) CA2128164A1 (it)
CZ (1) CZ287531B6 (it)
DE (1) DE59408299D1 (it)
ES (1) ES2082722B1 (it)
FR (1) FR2709128B1 (it)
GB (1) GB2280185B (it)
HR (1) HRP940408B1 (it)
HU (1) HU217129B (it)
IT (1) IT1271677B (it)
PL (1) PL176708B1 (it)
RU (1) RU2131875C1 (it)
SK (1) SK281622B6 (it)
UA (1) UA44687C2 (it)
ZA (1) ZA945210B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2146593A1 (en) * 1994-05-05 1995-11-06 Jack Melton Large-scale process for azapirone synthesis
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1943024B2 (de) * 1969-08-23 1972-12-21 Metallgesellschaft Ag, 6000 Frankfurt Vorrichtung zur abdichtung von end-windkaesten von wanderrosten
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
JPS6310786A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd 新規イミド誘導体およびその製造法
JPS6310760A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd イミド誘導体の新規製造法
PL152958B1 (en) * 1987-02-25 1991-02-28 Egyt Gyogyszervegyeszeti Gyar Method for manufacturing piperazine derivatives
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes

Also Published As

Publication number Publication date
CZ170994A3 (en) 1995-04-12
PL176708B1 (pl) 1999-07-30
GB2280185B (en) 1997-04-16
HU217129B (hu) 1999-11-29
PL304313A1 (en) 1995-01-23
UA44687C2 (uk) 2002-03-15
SK281622B6 (sk) 2001-05-10
CA2128164A1 (en) 1995-01-17
ZA945210B (en) 1996-01-15
GB9414325D0 (en) 1994-09-07
GB2280185A (en) 1995-01-25
ITMI941492A0 (it) 1994-07-18
CZ287531B6 (en) 2000-12-13
BG98904A (bg) 1995-05-31
ATE180480T1 (de) 1999-06-15
ES2082722B1 (es) 1996-10-01
JPH07165755A (ja) 1995-06-27
ES2082722A1 (es) 1996-03-16
EP0634411B1 (de) 1999-05-26
DE59408299D1 (de) 1999-07-01
HUT69720A (en) 1995-09-28
ITMI941492A1 (it) 1996-01-18
EP0634411A1 (de) 1995-01-18
HRP940408B1 (en) 2000-02-29
RU94026281A (ru) 1996-05-27
HRP940408A2 (en) 1996-10-31
KR950003287A (ko) 1995-02-16
SK86194A3 (en) 1995-03-08
HU9302040D0 (en) 1993-10-28
FR2709128A1 (fr) 1995-02-24
RU2131875C1 (ru) 1999-06-20
FR2709128B1 (fr) 1996-02-23
US5473072A (en) 1995-12-05

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970730