ZA945210B - Process for the preparation of high purity buspiron and the hydrochloride thereof - Google Patents

Process for the preparation of high purity buspiron and the hydrochloride thereof

Info

Publication number
ZA945210B
ZA945210B ZA945210A ZA945210A ZA945210B ZA 945210 B ZA945210 B ZA 945210B ZA 945210 A ZA945210 A ZA 945210A ZA 945210 A ZA945210 A ZA 945210A ZA 945210 B ZA945210 B ZA 945210B
Authority
ZA
South Africa
Prior art keywords
azaspiro
piperazin
pyrimidin
dione
ecan
Prior art date
Application number
ZA945210A
Other languages
English (en)
Inventor
Tibor Mezei
Zoltan Budai
Eva Furdyga
Laszlo Koncz
Attila Mandi
Klara Reiter
Judit Szego
Gabor Blasko
Margit Csorgo
Imre Klebovich
Ilona Sztruhar
Kalman Nagy
Gyula Simig
Gyongyi Vereczkey
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ZA945210B publication Critical patent/ZA945210B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA945210A 1993-07-16 1994-07-15 Process for the preparation of high purity buspiron and the hydrochloride thereof ZA945210B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9302040A HU217129B (hu) 1993-07-16 1993-07-16 Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására

Publications (1)

Publication Number Publication Date
ZA945210B true ZA945210B (en) 1996-01-15

Family

ID=10983790

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA945210A ZA945210B (en) 1993-07-16 1994-07-15 Process for the preparation of high purity buspiron and the hydrochloride thereof

Country Status (20)

Country Link
US (1) US5473072A (xx)
EP (1) EP0634411B1 (xx)
JP (1) JPH07165755A (xx)
KR (1) KR950003287A (xx)
AT (1) ATE180480T1 (xx)
BG (1) BG98904A (xx)
CA (1) CA2128164A1 (xx)
CZ (1) CZ287531B6 (xx)
DE (1) DE59408299D1 (xx)
ES (1) ES2082722B1 (xx)
FR (1) FR2709128B1 (xx)
GB (1) GB2280185B (xx)
HR (1) HRP940408B1 (xx)
HU (1) HU217129B (xx)
IT (1) IT1271677B (xx)
PL (1) PL176708B1 (xx)
RU (1) RU2131875C1 (xx)
SK (1) SK281622B6 (xx)
UA (1) UA44687C2 (xx)
ZA (1) ZA945210B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2146593A1 (en) * 1994-05-05 1995-11-06 Jack Melton Large-scale process for azapirone synthesis
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1943024B2 (de) * 1969-08-23 1972-12-21 Metallgesellschaft Ag, 6000 Frankfurt Vorrichtung zur abdichtung von end-windkaesten von wanderrosten
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
JPS6310760A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd イミド誘導体の新規製造法
JPS6310786A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd 新規イミド誘導体およびその製造法
CH677924A5 (xx) * 1987-02-25 1991-07-15 Egyt Gyogyszervegyeszeti Gyar
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes

Also Published As

Publication number Publication date
ES2082722A1 (es) 1996-03-16
RU94026281A (ru) 1996-05-27
IT1271677B (it) 1997-06-04
HU9302040D0 (en) 1993-10-28
GB9414325D0 (en) 1994-09-07
GB2280185B (en) 1997-04-16
US5473072A (en) 1995-12-05
FR2709128B1 (fr) 1996-02-23
HRP940408A2 (en) 1996-10-31
ITMI941492A1 (it) 1996-01-18
SK281622B6 (sk) 2001-05-10
BG98904A (bg) 1995-05-31
EP0634411B1 (de) 1999-05-26
ITMI941492A0 (it) 1994-07-18
RU2131875C1 (ru) 1999-06-20
HU217129B (hu) 1999-11-29
HRP940408B1 (en) 2000-02-29
CA2128164A1 (en) 1995-01-17
SK86194A3 (en) 1995-03-08
JPH07165755A (ja) 1995-06-27
CZ287531B6 (en) 2000-12-13
PL176708B1 (pl) 1999-07-30
UA44687C2 (uk) 2002-03-15
HUT69720A (en) 1995-09-28
PL304313A1 (en) 1995-01-23
CZ170994A3 (en) 1995-04-12
KR950003287A (ko) 1995-02-16
GB2280185A (en) 1995-01-25
FR2709128A1 (fr) 1995-02-24
DE59408299D1 (de) 1999-07-01
EP0634411A1 (de) 1995-01-18
ES2082722B1 (es) 1996-10-01
ATE180480T1 (de) 1999-06-15

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