DE69214358T2 - Verbesserungen von oder in Bezug auf exzitatorische Aminosäurenrezeptorantagonisten - Google Patents
Verbesserungen von oder in Bezug auf exzitatorische AminosäurenrezeptorantagonistenInfo
- Publication number
- DE69214358T2 DE69214358T2 DE69214358T DE69214358T DE69214358T2 DE 69214358 T2 DE69214358 T2 DE 69214358T2 DE 69214358 T DE69214358 T DE 69214358T DE 69214358 T DE69214358 T DE 69214358T DE 69214358 T2 DE69214358 T2 DE 69214358T2
- Authority
- DE
- Germany
- Prior art keywords
- eaa
- amino acid
- acid receptor
- receptor antagonists
- excitatory amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/710,649 US5153196A (en) | 1991-06-05 | 1991-06-05 | Excitatory amino acid receptor antagonists and methods for the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69214358D1 DE69214358D1 (de) | 1996-11-14 |
DE69214358T2 true DE69214358T2 (de) | 1997-03-06 |
Family
ID=24854947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69214358T Expired - Fee Related DE69214358T2 (de) | 1991-06-05 | 1992-05-29 | Verbesserungen von oder in Bezug auf exzitatorische Aminosäurenrezeptorantagonisten |
Country Status (9)
Country | Link |
---|---|
US (1) | US5153196A (de) |
EP (1) | EP0518530B1 (de) |
JP (1) | JPH05163147A (de) |
AT (1) | ATE143806T1 (de) |
CA (1) | CA2070055A1 (de) |
DE (1) | DE69214358T2 (de) |
DK (1) | DK0518530T3 (de) |
ES (1) | ES2092639T3 (de) |
GR (1) | GR3021874T3 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4241564A1 (de) * | 1992-12-10 | 1994-06-16 | Basf Ag | Triazolochinazoline zur Behandlung zentralnervöser Erkrankungen |
DE4241562A1 (de) * | 1992-12-10 | 1994-06-16 | Basf Ag | Neue Triazolopyrimidone, ihre Herstellung und Verwendung |
DE4241563A1 (de) * | 1992-12-10 | 1994-06-16 | Basf Ag | Neue Triazolochinazoline, ihre Herstellung und Verwendung |
DK31093D0 (de) * | 1993-03-19 | 1993-03-19 | Novo Nordisk As | |
DE4310523A1 (de) * | 1993-03-31 | 1994-10-06 | Basf Ag | Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen |
JPH08508271A (ja) * | 1993-03-31 | 1996-09-03 | ビーエーエスエフ アクチエンゲゼルシャフト | Eaa拮抗体としてのイミダゾロキノキサリノン誘導体 |
IL110309A0 (en) * | 1993-07-15 | 1994-10-21 | Univ Kentucky Res Found | A method of protecting against neuron loss |
FR2707643B1 (fr) * | 1993-07-16 | 1995-08-11 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant. |
JPH09508632A (ja) * | 1994-02-11 | 1997-09-02 | ノボ ノルディスク アクティーゼルスカブ | 複素環式化合物並びにそれらの製造及び使用 |
FR2717811B1 (fr) * | 1994-03-28 | 1996-04-26 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant. |
FR2717813B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant . |
FR2717814B1 (fr) * | 1994-03-28 | 1996-04-26 | Rhone Poulenc Rorer Sa | Dérivés de 1,2,4-triazolo(4,3-a)pyrazine-4-one, leur préparation et les médicaments les contenant. |
FR2717805B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant . |
FR2717812B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
DK0783504T3 (da) * | 1994-09-16 | 2000-08-14 | Novo Nordisk As | (1,2,4)triazolo (4,3-a)guinoxalinon-derivater, deres fremstilling og anvendelse som antagonister af ampa-receptorer |
CZ284930B6 (cs) * | 1994-09-16 | 1999-04-14 | Novo Nordisk A/S | [1,2,4]triazolo[4,3-a]chinoxalinonové deriváty, jejich příprava a použití |
WO1996010572A1 (de) * | 1994-09-30 | 1996-04-11 | Basf Aktiengesellschaft | Neue heterocyclische substituierte imidazolo-chinoxalinone, ihre herstellung und verwendung |
DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
FR2743363A1 (fr) * | 1996-01-10 | 1997-07-11 | Rhone Poulenc Rorer Sa | 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-a-ones substituees en position 2, leur preparation et les medicaments les contenant |
US6869956B2 (en) * | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
CA2424303A1 (en) * | 2000-10-03 | 2002-04-11 | Bristol-Myers Squibb Company | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same |
EP1836807A2 (de) * | 2005-01-06 | 2007-09-26 | Merck & Co., Inc. | Inhibitoren von prüfpunktkinasen |
WO2006074281A2 (en) * | 2005-01-06 | 2006-07-13 | Merck & Co., Inc. | Inhibitors of checkpoint kinases |
CA2671980C (en) * | 2006-12-13 | 2015-05-05 | Aska Pharmaceutical Co., Ltd. | Quinoxaline derivatives |
KR101168235B1 (ko) | 2010-06-16 | 2012-07-30 | 건국대학교 산학협력단 | 4?클로로테트라졸로[1,5?a]퀴녹살린 및 그 유도체를 유효성분으로 함유하는 알레르기성 질환의 예방 및 치료용 조성물 |
US9540379B2 (en) * | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
US9617031B1 (en) * | 2015-02-13 | 2017-04-11 | Carol Jean Piechocinski | Foldable liquid retaining bowl |
US9701435B2 (en) | 2015-02-13 | 2017-07-11 | Carol Jean Piechocinski | Foldable liquid retaining bowl |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3764681A (en) * | 1970-07-08 | 1973-10-09 | Lilly Co Eli | Certain tetrazolo-(1,5-a) quinoline compounds as fungus control agents |
US3953457A (en) * | 1972-07-28 | 1976-04-27 | Eli Lilly And Company | Agent for the control of plant-pathogenic organisms |
US3987196A (en) * | 1975-06-10 | 1976-10-19 | Eli Lilly And Company | Tetrazolo(1,5-a)quinoxalines for control of phytopathogens |
US3979387A (en) * | 1975-06-10 | 1976-09-07 | Eli Lilly And Company | 4,5-Dihydrotetrazolo(1,5-A)quinoxalines |
US4008322A (en) * | 1975-06-10 | 1977-02-15 | Eli Lilly And Company | Triazolo(4,3-a)quinoxalines for control of rice |
US4128644A (en) * | 1977-07-29 | 1978-12-05 | E. R. Squibb & Sons, Inc. | Pyrazolo(1,5-c)quinazoline derivatives and related compounds |
US4354027A (en) * | 1980-05-19 | 1982-10-12 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-4-ones |
US4623725A (en) * | 1982-10-18 | 1986-11-18 | Pfizer Inc. | [1,2,4]Triazolo[4,3-a]quinoxaline-4-amine derivatives |
US4495187A (en) * | 1982-10-18 | 1985-01-22 | Pfizer Inc. | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents |
US4713383A (en) * | 1984-10-01 | 1987-12-15 | Ciba-Geigy Corporation | Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses |
NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
US4968678A (en) * | 1988-02-19 | 1990-11-06 | Eli Lilly And Company | Tetrazole excitatory amino acid receptor antagonists |
DK161148C (da) * | 1988-06-14 | 1991-11-18 | Novo Nordisk As | Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne |
DK160941C (da) * | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
US4902687A (en) * | 1989-03-27 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
-
1991
- 1991-06-05 US US07/710,649 patent/US5153196A/en not_active Expired - Fee Related
-
1992
- 1992-05-29 CA CA002070055A patent/CA2070055A1/en not_active Abandoned
- 1992-05-29 DK DK92304887.0T patent/DK0518530T3/da active
- 1992-05-29 JP JP4138986A patent/JPH05163147A/ja active Pending
- 1992-05-29 EP EP92304887A patent/EP0518530B1/de not_active Expired - Lifetime
- 1992-05-29 DE DE69214358T patent/DE69214358T2/de not_active Expired - Fee Related
- 1992-05-29 AT AT92304887T patent/ATE143806T1/de not_active IP Right Cessation
- 1992-05-29 ES ES92304887T patent/ES2092639T3/es not_active Expired - Lifetime
-
1996
- 1996-12-04 GR GR960403285T patent/GR3021874T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0518530B1 (de) | 1996-10-09 |
DE69214358D1 (de) | 1996-11-14 |
JPH05163147A (ja) | 1993-06-29 |
EP0518530A3 (en) | 1993-01-20 |
ES2092639T3 (es) | 1996-12-01 |
US5153196A (en) | 1992-10-06 |
GR3021874T3 (en) | 1997-03-31 |
EP0518530A2 (de) | 1992-12-16 |
CA2070055A1 (en) | 1992-12-06 |
DK0518530T3 (da) | 1997-03-17 |
ATE143806T1 (de) | 1996-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |