IT1193922B - Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione - Google Patents

Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione

Info

Publication number
IT1193922B
IT1193922B IT20021/80A IT2002180A IT1193922B IT 1193922 B IT1193922 B IT 1193922B IT 20021/80 A IT20021/80 A IT 20021/80A IT 2002180 A IT2002180 A IT 2002180A IT 1193922 B IT1193922 B IT 1193922B
Authority
IT
Italy
Prior art keywords
lactamase
preparation
antibacterial agents
beta inhibitors
inhibitors
Prior art date
Application number
IT20021/80A
Other languages
English (en)
Italian (it)
Other versions
IT8020021A0 (it
IT8020021A1 (it
Inventor
Maurizio Foglio
Giovanni Franceschi
Cosimo Scarafile
Federico Arcamone
Aurora Sanfilippo
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of IT8020021A0 publication Critical patent/IT8020021A0/it
Publication of IT8020021A1 publication Critical patent/IT8020021A1/it
Application granted granted Critical
Publication of IT1193922B publication Critical patent/IT1193922B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
IT20021/80A 1979-02-24 1980-02-19 Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione IT1193922B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7906634 1979-02-24
GB7932591 1979-09-20

Publications (3)

Publication Number Publication Date
IT8020021A0 IT8020021A0 (it) 1980-02-19
IT8020021A1 IT8020021A1 (it) 1981-08-19
IT1193922B true IT1193922B (it) 1988-08-31

Family

ID=26270697

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20021/80A IT1193922B (it) 1979-02-24 1980-02-19 Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione

Country Status (24)

Country Link
AT (1) AT368506B (hu)
AU (1) AU535080B2 (hu)
CA (2) CA1154010A (hu)
CH (2) CH654831A5 (hu)
CS (1) CS226010B2 (hu)
DE (1) DE3006273A1 (hu)
DK (1) DK159448C (hu)
ES (2) ES488886A0 (hu)
FI (1) FI75163C (hu)
FR (1) FR2449690B1 (hu)
GB (1) GB2043639B (hu)
GR (1) GR73623B (hu)
HK (1) HK74487A (hu)
HU (1) HU182664B (hu)
IE (1) IE49407B1 (hu)
IT (1) IT1193922B (hu)
LU (1) LU82192A1 (hu)
NL (1) NL192265C (hu)
NO (1) NO161000C (hu)
NZ (1) NZ192949A (hu)
PT (1) PT70849A (hu)
SE (1) SE449489B (hu)
UA (1) UA6041A1 (hu)
YU (1) YU42964B (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
DE3121510A1 (de) * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
EP0180252B1 (en) * 1981-07-15 1989-04-26 Sumitomo Pharmaceuticals Company, Limited Process of preparing azetidinone compounds
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
PH21930A (en) * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0112283B1 (de) * 1982-11-16 1987-08-12 Ciba-Geigy Ag Heterocyclylthioverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
GB8300295D0 (en) * 1983-01-06 1983-02-09 Erba Farmitalia Penem esters
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4711886A (en) * 1984-07-02 1987-12-08 Merck & Co., Inc. β-lactam derivatives as anti-inflammatory and antidegenerative agents
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
DE3882730D1 (de) * 1987-02-11 1993-09-09 Ciba Geigy Ag Bicyclische beta-lactam-carbonsaeuren.
US5364768A (en) * 1987-07-07 1994-11-15 Farmitalia Carlo Erba S.R.L. Process for the preparation of penems
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
IT1286558B1 (it) * 1996-02-27 1998-07-15 Menarini Farma Ind Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
US6156745A (en) 1997-12-29 2000-12-05 Research Corporation Technologies, Inc. 2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6720445B2 (en) * 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same
US6916801B2 (en) 2001-07-24 2005-07-12 Alamx, Llc 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors
JP2005525399A (ja) 2002-04-04 2005-08-25 アラムクス エルエルシー セリンおよびメタロ−β−ラクタマーゼの阻害剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77306A1 (hu) * 1977-05-09 1979-01-18
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
JPS5559193A (en) * 1978-09-20 1980-05-02 Glaxo Group Ltd Bblactam compound
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes

Also Published As

Publication number Publication date
PT70849A (en) 1980-03-01
CH654831A5 (de) 1986-03-14
DK77580A (da) 1980-08-25
FR2449690A1 (fr) 1980-09-19
IT8020021A0 (it) 1980-02-19
FI75163B (fi) 1988-01-29
NO161000C (no) 1989-06-21
IE49407B1 (en) 1985-10-02
IE800338L (en) 1980-08-24
SE8001424L (sv) 1980-08-25
ES8200685A1 (es) 1981-11-16
DE3006273A1 (de) 1980-09-04
FI800493A (fi) 1980-08-25
AU5567080A (en) 1980-09-11
GB2043639A (en) 1980-10-08
CA1154010A (en) 1983-09-20
DK159448B (da) 1990-10-15
ES495977A0 (es) 1981-10-01
SE449489B (sv) 1987-05-04
ATA91980A (de) 1982-02-15
HK74487A (en) 1987-10-23
CA1212665B (en) 1986-10-14
GB2043639B (en) 1983-07-20
ES488886A0 (es) 1981-11-16
LU82192A1 (fr) 1980-06-06
YU42964B (en) 1989-02-28
HU182664B (en) 1984-02-28
AT368506B (de) 1982-10-25
NO800501L (no) 1980-08-25
FR2449690B1 (fr) 1986-06-13
IT8020021A1 (it) 1981-08-19
NO161000B (no) 1989-03-13
ES8107224A1 (es) 1981-10-01
DK159448C (da) 1991-03-04
NZ192949A (en) 1984-03-16
NL192265B (nl) 1996-12-02
FI75163C (fi) 1988-05-09
NL192265C (nl) 1997-04-03
UA6041A1 (uk) 1994-12-29
YU46180A (en) 1983-02-28
CH651570A5 (de) 1985-09-30
AU535080B2 (en) 1984-03-01
NL8001012A (nl) 1980-08-26
CS226010B2 (en) 1984-03-19
GR73623B (hu) 1984-03-26

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970217