IT1142170B - Composti eterosiclici dotati di attivita' farmacologica e procedimento per la loro preparazione - Google Patents

Composti eterosiclici dotati di attivita' farmacologica e procedimento per la loro preparazione

Info

Publication number
IT1142170B
IT1142170B IT50537/79A IT5053779A IT1142170B IT 1142170 B IT1142170 B IT 1142170B IT 50537/79 A IT50537/79 A IT 50537/79A IT 5053779 A IT5053779 A IT 5053779A IT 1142170 B IT1142170 B IT 1142170B
Authority
IT
Italy
Prior art keywords
heterosyclic
procedure
preparation
pharmacological activity
compounds equipped
Prior art date
Application number
IT50537/79A
Other languages
English (en)
Italian (it)
Other versions
IT7950537A0 (it
Inventor
Colin Frederick Webb
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IT7950537A0 publication Critical patent/IT7950537A0/it
Application granted granted Critical
Publication of IT1142170B publication Critical patent/IT1142170B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT50537/79A 1978-10-12 1979-10-11 Composti eterosiclici dotati di attivita' farmacologica e procedimento per la loro preparazione IT1142170B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7840279 1978-10-12

Publications (2)

Publication Number Publication Date
IT7950537A0 IT7950537A0 (it) 1979-10-11
IT1142170B true IT1142170B (it) 1986-10-08

Family

ID=10500283

Family Applications (1)

Application Number Title Priority Date Filing Date
IT50537/79A IT1142170B (it) 1978-10-12 1979-10-11 Composti eterosiclici dotati di attivita' farmacologica e procedimento per la loro preparazione

Country Status (18)

Country Link
US (1) US4252803A (enExample)
JP (1) JPS5562063A (enExample)
AU (1) AU531783B2 (enExample)
BE (1) BE879381A (enExample)
CA (1) CA1146550A (enExample)
CH (1) CH646151A5 (enExample)
DE (1) DE2940687A1 (enExample)
DK (1) DK425579A (enExample)
ES (2) ES8100261A1 (enExample)
FI (1) FI793071A7 (enExample)
FR (1) FR2438651A1 (enExample)
GB (1) GB2035310B (enExample)
IE (1) IE49304B1 (enExample)
IT (1) IT1142170B (enExample)
NL (1) NL7907583A (enExample)
NZ (1) NZ191802A (enExample)
SE (1) SE448628B (enExample)
ZA (1) ZA795239B (enExample)

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AT381491B (de) * 1980-08-12 1986-10-27 Glaxo Group Ltd Verfahren zur herstellung von neuen indolverbindungen und ihren salzen
IT1171449B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici procedimento per produrli e composizioni farmaceutiche che li contengono
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
US4428962A (en) 1981-10-30 1984-01-31 Schering Corporation Indoles in treatment of peptic ulcers
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
US4582848A (en) * 1982-06-10 1986-04-15 Sandoz, Inc. 2-substituted-3-indolamines and use thereof as anti-diabetics
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4521606A (en) * 1983-06-30 1985-06-04 American Home Products Corp. 5-Indolyl substituted aminoethanols
US4622399A (en) * 1983-06-30 1986-11-11 American Home Products Corporation Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
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GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
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DE3537289A1 (de) * 1985-10-19 1987-04-23 Hoechst Ag 2-(3-brompropyl)-5,5-dimethyl-1,3-dioxan, sowie verfahren zur herstellung desselben und des 2-(4-brombutyl)-5,5-dimethyl-1,3-dioxans
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GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
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GB8614287D0 (en) * 1986-06-12 1986-07-16 Glaxo Group Ltd Chemical compounds
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US5276045A (en) * 1989-06-16 1994-01-04 Rhone-Poulenc Sante Thioformamide derivative, process for its preparation, pharmaceutical composition thereof and treatment method
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
PT97888B (pt) * 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
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CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
HUT69705A (en) * 1991-11-25 1995-09-28 Pfizer Indole derivatives
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US5747501A (en) 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
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GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
KR100191973B1 (ko) * 1993-08-31 1999-06-15 디. 제이. 우드, 스피겔 알렌 제이 5-아릴인돌 유도체
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
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JP3092946B2 (ja) 1995-12-14 2000-09-25 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモン拮抗剤
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JP4559230B2 (ja) 2002-11-28 2010-10-06 スベン ライフ サイエンシズ リミティド セロトニン受容体に対する親和性を有する新規ｎ−アリールスルホニル−３−置換されたインドール、その調製方法、それを含有する医薬組成物
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US7645886B2 (en) * 2002-12-20 2010-01-12 Ciba Specialty Corporation Synthesis of amines and intermediates for the synthesis thereof
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US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
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WO2022104475A1 (en) * 2020-11-19 2022-05-27 Magicmed Industries Inc. Nitrilated psilocybin derivatives and methods of using
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US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
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DE2314489A1 (de) * 1973-03-23 1974-10-03 Thomae Gmbh Dr K (+)-3-(2-dimethylamino-1-propyl)-2methyl-3-phenyl-3h-indol, dessen saeureadditionssalze und verfahren zu deren herstellung
US3997539A (en) * 1974-05-31 1976-12-14 American Hoechst Corporation 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof

Also Published As

Publication number Publication date
SE7908443L (sv) 1980-04-13
AU531783B2 (en) 1983-09-08
IT7950537A0 (it) 1979-10-11
US4252803A (en) 1981-02-24
NZ191802A (en) 1983-02-15
CH646151A5 (de) 1984-11-15
FI793071A7 (fi) 1981-01-01
IE49304B1 (en) 1985-09-18
ZA795239B (en) 1980-11-26
DE2940687C2 (enExample) 1991-08-01
FR2438651B1 (enExample) 1983-03-04
JPS6358817B2 (enExample) 1988-11-17
CA1146550A (en) 1983-05-17
NL7907583A (nl) 1980-04-15
ES484980A0 (es) 1980-11-01
DE2940687A1 (de) 1980-04-30
AU5165779A (en) 1980-04-17
JPS5562063A (en) 1980-05-10
ES8106142A1 (es) 1981-07-16
ES492114A0 (es) 1981-07-16
ES8100261A1 (es) 1980-11-01
IE791945L (en) 1980-04-12
BE879381A (fr) 1980-02-01
FR2438651A1 (fr) 1980-05-09
GB2035310A (en) 1980-06-18
DK425579A (da) 1980-04-13
SE448628B (sv) 1987-03-09
GB2035310B (en) 1982-12-22

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