IS2138B - Hýdroxýltenging kompaktíns við pravastatín með Micromonospora - Google Patents
Hýdroxýltenging kompaktíns við pravastatín með MicromonosporaInfo
- Publication number
- IS2138B IS2138B IS6227A IS6227A IS2138B IS 2138 B IS2138 B IS 2138B IS 6227 A IS6227 A IS 6227A IS 6227 A IS6227 A IS 6227A IS 2138 B IS2138 B IS 2138B
- Authority
- IS
- Iceland
- Prior art keywords
- compactin
- micromonospora
- pravastatin
- hydroxylation
- Prior art date
Links
- VGMFHMLQOYWYHN-UHFFFAOYSA-N Compactin Natural products OCC1OC(OC2C(O)C(O)C(CO)OC2Oc3cc(O)c4C(=O)C(=COc4c3)c5ccc(O)c(O)c5)C(O)C(O)C1O VGMFHMLQOYWYHN-UHFFFAOYSA-N 0.000 title 1
- 241000187708 Micromonospora Species 0.000 title 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title 1
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 title 1
- 230000033444 hydroxylation Effects 0.000 title 1
- 238000005805 hydroxylation reaction Methods 0.000 title 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 title 1
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 title 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
- 229960002965 pravastatin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/29—Micromonospora
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902352A HUP9902352A1 (hu) | 1999-07-12 | 1999-07-12 | Eljárás pravasztatin mikrobiológiai előállítására |
| PCT/HU2000/000066 WO2001004340A1 (en) | 1999-07-12 | 2000-06-29 | Hydroxylation of compactin to pravastatin by micromonospora |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IS6227A IS6227A (is) | 2002-01-11 |
| IS2138B true IS2138B (is) | 2006-08-15 |
Family
ID=89998701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS6227A IS2138B (is) | 1999-07-12 | 2002-01-11 | Hýdroxýltenging kompaktíns við pravastatín með Micromonospora |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6905851B1 (de) |
| EP (3) | EP1190087B1 (de) |
| JP (2) | JP4531315B2 (de) |
| KR (2) | KR100479837B1 (de) |
| CN (2) | CN1590555A (de) |
| AP (1) | AP1405A (de) |
| AT (1) | ATE243262T1 (de) |
| AU (2) | AU773633B2 (de) |
| BG (1) | BG65109B1 (de) |
| BR (1) | BR0013156A (de) |
| CA (2) | CA2379015A1 (de) |
| CZ (2) | CZ297009B6 (de) |
| DE (1) | DE60003424T2 (de) |
| DK (1) | DK1190087T3 (de) |
| ES (1) | ES2200891T3 (de) |
| HR (1) | HRP20020028B1 (de) |
| HU (1) | HUP9902352A1 (de) |
| IL (2) | IL147583A0 (de) |
| IS (1) | IS2138B (de) |
| MX (1) | MXPA02000356A (de) |
| NO (1) | NO20020119L (de) |
| NZ (1) | NZ516563A (de) |
| OA (1) | OA12150A (de) |
| PL (2) | PL353493A1 (de) |
| PT (1) | PT1190087E (de) |
| RU (2) | RU2235780C2 (de) |
| SK (2) | SK285726B6 (de) |
| TR (1) | TR200200726T2 (de) |
| UA (1) | UA67854C2 (de) |
| WO (2) | WO2001004340A1 (de) |
| YU (1) | YU2002A (de) |
| ZA (1) | ZA200200273B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI9800046A (sl) | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| EP1265604B1 (de) | 1999-11-30 | 2006-10-18 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe |
| CA2394200C (en) | 1999-12-14 | 2006-10-03 | Biogal Gyogyszergyar Rt. | Novel forms of pravastatin sodium |
| JP3737801B2 (ja) * | 2000-10-05 | 2006-01-25 | テバ ジョジセルジャール レースベニュタールシャシャーグ | プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物 |
| JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| AU2002235885A1 (en) * | 2001-02-09 | 2002-08-28 | Unilever N.V. | Process for the preparation of one or more statins by fermentation |
| JP2003026634A (ja) * | 2001-07-17 | 2003-01-29 | Mercian Corp | プラバスタチンナトリウム塩の製造方法 |
| US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
| EP1452602A1 (de) * | 2003-02-25 | 2004-09-01 | Antibiotic Co., | Fermentatives Verfahren zur Herstellung von Pravastatin |
| CN1244688C (zh) * | 2003-07-09 | 2006-03-08 | 上海天伟生物制药有限公司 | 生产普伐他汀钠的微生物和方法 |
| WO2005051372A2 (en) | 2003-11-24 | 2005-06-09 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Method of purifying pravastatin |
| JP5587795B2 (ja) * | 2008-02-06 | 2014-09-10 | バイオコン・リミテッド | 発酵培地、及びそのプロセス |
| RU2522806C1 (ru) * | 2012-11-27 | 2014-07-20 | Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук | Усовершенствованный способ очистки правастатина |
| JP6441599B2 (ja) * | 2014-07-14 | 2018-12-19 | 合同酒精株式会社 | プラバスタチンの製造法 |
| CN114031496B (zh) * | 2021-11-30 | 2024-09-27 | 广东蓝宝制药有限公司 | 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法 |
| CN114133331A (zh) * | 2021-12-10 | 2022-03-04 | 广东蓝宝制药有限公司 | 一种回收获得高纯度普伐他汀酯的方法 |
| CN116694497B (zh) * | 2022-12-25 | 2024-10-18 | 塔里木大学 | 一株转化甘油和甘氨酸的放线菌 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| JPS5810572A (ja) | 1981-07-07 | 1983-01-21 | Sankyo Co Ltd | Ｍｌ−２３６ｂ誘導体およびその製造法 |
| JPS5889191A (ja) | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| JPS59175450A (ja) * | 1983-03-24 | 1984-10-04 | Sankyo Co Ltd | Ｍｌ−２３６ｂ誘導体 |
| US5179013A (en) | 1987-02-02 | 1993-01-12 | Sankyo Company, Limited | Cytochrome P-450 enzymes |
| JPH06253853A (ja) * | 1993-03-09 | 1994-09-13 | Asahi Chem Ind Co Ltd | マクロライド抗生物質生合成遺伝子を含有するｄｎａ |
| US6043064A (en) * | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| JPH0889277A (ja) * | 1994-09-28 | 1996-04-09 | Taisho Pharmaceut Co Ltd | １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法 |
| JPH08149986A (ja) * | 1994-09-28 | 1996-06-11 | Taisho Pharmaceut Co Ltd | １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法 |
| US5942423A (en) * | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
| HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| IN191580B (de) * | 1999-12-17 | 2003-12-06 | Ranbaxy Lab Ltd |
-
1999
- 1999-07-12 HU HU9902352A patent/HUP9902352A1/hu unknown
-
2000
- 2000-06-29 OA OA1200200015A patent/OA12150A/en unknown
- 2000-06-29 IL IL14758300A patent/IL147583A0/xx not_active IP Right Cessation
- 2000-06-29 JP JP2001509543A patent/JP4531315B2/ja not_active Expired - Fee Related
- 2000-06-29 WO PCT/HU2000/000066 patent/WO2001004340A1/en active IP Right Grant
- 2000-06-29 TR TR2002/00726T patent/TR200200726T2/xx unknown
- 2000-06-29 DK DK00944121T patent/DK1190087T3/da active
- 2000-06-29 CN CNA2004100493556A patent/CN1590555A/zh active Pending
- 2000-06-29 ES ES00944121T patent/ES2200891T3/es not_active Expired - Lifetime
- 2000-06-29 UA UA2002010326A patent/UA67854C2/uk unknown
- 2000-06-29 YU YU2002A patent/YU2002A/sh unknown
- 2000-06-29 KR KR10-2002-7000475A patent/KR100479837B1/ko not_active IP Right Cessation
- 2000-06-29 CZ CZ20020119A patent/CZ297009B6/cs not_active IP Right Cessation
- 2000-06-29 MX MXPA02000356A patent/MXPA02000356A/es active IP Right Grant
- 2000-06-29 CN CN00811127A patent/CN1399686A/zh active Pending
- 2000-06-29 DE DE60003424T patent/DE60003424T2/de not_active Expired - Fee Related
- 2000-06-29 RU RU2002103376/13A patent/RU2235780C2/ru not_active IP Right Cessation
- 2000-06-29 AT AT00944121T patent/ATE243262T1/de not_active IP Right Cessation
- 2000-06-29 EP EP00944121A patent/EP1190087B1/de not_active Expired - Lifetime
- 2000-06-29 NZ NZ516563A patent/NZ516563A/xx unknown
- 2000-06-29 PL PL00353493A patent/PL353493A1/xx not_active Application Discontinuation
- 2000-06-29 AU AU58355/00A patent/AU773633B2/en not_active Ceased
- 2000-06-29 BR BR0013156-3A patent/BR0013156A/pt not_active Application Discontinuation
- 2000-06-29 EP EP03075550A patent/EP1327689A1/de not_active Withdrawn
- 2000-06-29 US US10/030,726 patent/US6905851B1/en not_active Expired - Fee Related
- 2000-06-29 SK SK49-2002A patent/SK285726B6/sk unknown
- 2000-06-29 CA CA002379015A patent/CA2379015A1/en not_active Abandoned
- 2000-06-29 AP APAP/P/2002/002404A patent/AP1405A/en active
- 2000-06-29 PT PT00944121T patent/PT1190087E/pt unknown
- 2000-07-11 IL IL14758800A patent/IL147588A0/xx unknown
- 2000-07-11 KR KR1020027000486A patent/KR20020060150A/ko not_active Application Discontinuation
- 2000-07-11 PL PL00364872A patent/PL364872A1/xx unknown
- 2000-07-11 AU AU63492/00A patent/AU6349200A/en not_active Abandoned
- 2000-07-11 WO PCT/US2000/019384 patent/WO2001003647A2/en not_active Application Discontinuation
- 2000-07-11 CA CA002373544A patent/CA2373544A1/en not_active Abandoned
- 2000-07-11 CZ CZ2002127A patent/CZ2002127A3/cs unknown
- 2000-07-11 EP EP00950379A patent/EP1198448A4/de not_active Withdrawn
- 2000-07-11 JP JP2001508931A patent/JP2003528576A/ja active Pending
- 2000-07-11 SK SK61-2002A patent/SK612002A3/sk unknown
-
2002
- 2002-01-10 NO NO20020119A patent/NO20020119L/no not_active Application Discontinuation
- 2002-01-10 HR HR20020028A patent/HRP20020028B1/xx not_active IP Right Cessation
- 2002-01-11 ZA ZA200200273A patent/ZA200200273B/xx unknown
- 2002-01-11 IS IS6227A patent/IS2138B/xx unknown
- 2002-01-14 BG BG106302A patent/BG65109B1/bg unknown
-
2004
- 2004-05-13 RU RU2004114667/13A patent/RU2004114667A/ru not_active Application Discontinuation
- 2004-12-16 US US11/014,658 patent/US20050124051A1/en not_active Abandoned
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