|
US5514646A
(en)
|
1989-02-09 |
1996-05-07 |
Chance; Ronald E. |
Insulin analogs modified at position 29 of the B chain
|
|
US5424286A
(en)
|
1993-05-24 |
1995-06-13 |
Eng; John |
Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
|
|
DE19616486C5
(de)
|
1996-04-25 |
2016-06-30 |
Royalty Pharma Collection Trust |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
|
ES2283025T3
(es)
|
1996-08-30 |
2007-10-16 |
Novo Nordisk A/S |
Derivados de glp-1.1.
|
|
JP4339402B2
(ja)
|
1996-12-31 |
2009-10-07 |
ドクター・レディーズ・ラボラトリーズ・リミテッド |
新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物、並びに糖尿病及び関連疾患の治療におけるこれらの使用
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US6803357B1
(en)
|
1998-02-02 |
2004-10-12 |
New England Medical Center Hospitals, Inc. |
Method of regulating glucose metabolism, and reagents related thereto
|
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
|
US6566131B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad6 expression
|
|
CN1308828A
(zh)
|
1998-06-30 |
2001-08-15 |
松下电器产业株式会社 |
网络控制系统及其方法
|
|
US20030219427A1
(en)
|
1998-08-18 |
2003-11-27 |
Allen Hamish J. |
TPL-2/COT kinase and methods of use
|
|
US6410323B1
(en)
|
1999-08-31 |
2002-06-25 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of human Rho family gene expression
|
|
US6107091A
(en)
|
1998-12-03 |
2000-08-22 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of G-alpha-16 expression
|
|
US5981732A
(en)
|
1998-12-04 |
1999-11-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-13 expression
|
|
SG125915A1
(en)
|
1998-12-07 |
2006-10-30 |
Sod Conseils Rech Applic |
Analogues of glp-1
|
|
US6046321A
(en)
|
1999-04-09 |
2000-04-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-i1 expression
|
|
EP1076066A1
(en)
|
1999-07-12 |
2001-02-14 |
Zealand Pharmaceuticals A/S |
Peptides for lowering blood glucose levels
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
AU2001245793A1
(en)
|
2000-03-16 |
2001-09-24 |
Cold Spring Harbor Laboratory |
Methods and compositions for rna interference
|
|
US6365354B1
(en)
|
2000-07-31 |
2002-04-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of lysophospholipase I expression
|
|
US6566135B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of caspase 6 expression
|
|
HUP0200849A2
(hu)
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
|
HUP0202001A2
(hu)
|
2002-06-14 |
2005-08-29 |
Sanofi-Aventis |
DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
|
|
RU2301803C2
(ru)
|
2002-10-18 |
2007-06-27 |
Мерк Энд Ко., Инк. |
Производные гексагидродиазепинона, фармацевтическая композиция, их содержащая, и применение для получения лекарственного средства для лечения инсулиннезависимого диабета
|
|
UY28103A1
(es)
|
2002-12-03 |
2004-06-30 |
Boehringer Ingelheim Pharma |
Nuevas imidazo-piridinonas sustituidas, su preparación y su empleo como medicacmentos
|
|
DE10333935A1
(de)
|
2003-07-25 |
2005-02-24 |
Aventis Pharma Deutschland Gmbh |
Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
PE20050249A1
(es)
|
2003-07-25 |
2005-06-01 |
Aventis Pharma Gmbh |
Nuevas cianopirrolididas y procedimiento para su preparacion como medicamentos
|
|
TW200526254A
(en)
|
2003-09-19 |
2005-08-16 |
Novo Nordisk As |
Novel GLP-1 derivatives
|
|
TW200519105A
(en)
|
2003-10-20 |
2005-06-16 |
Lg Life Science Ltd |
Novel inhibitors of DPP-IV, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent
|
|
DE10359098A1
(de)
|
2003-12-17 |
2005-07-28 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-(Piperazin-1-yl)- und 2-([1,4]Diazepan-1-yl)-imidazo[4,5-d]pyridazin-4-one, deren Herstellung und deren Verwendung als Arzneimittel
|
|
US20060074102A1
(en)
|
2004-05-14 |
2006-04-06 |
Kevin Cusack |
Kinase inhibitors as therapeutic agents
|
|
DE102004037554A1
(de)
|
2004-08-03 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte 8-Aminoalkylthio-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE102004038268A1
(de)
|
2004-08-06 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte, bizyklische 8-Pyrrolidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE102004038269A1
(de)
|
2004-08-06 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte, bizyklische 8-Piperidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE102004038270A1
(de)
|
2004-08-06 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte, bizyklische 8-Amino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE102004039507A1
(de)
|
2004-08-14 |
2006-03-02 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte 8-Aminoalkoxi-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
CA2582447C
(en)
|
2004-10-01 |
2012-04-17 |
Merck & Co., Inc. |
Aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
|
US7893017B2
(en)
|
2004-10-07 |
2011-02-22 |
Novo Nordisk A/S |
Protracted GLP-1 compounds
|
|
WO2006037811A2
(en)
|
2004-10-07 |
2006-04-13 |
Novo Nordisk A/S |
Protracted exendin-4 compounds
|
|
JP2006160733A
(ja)
|
2004-11-15 |
2006-06-22 |
Taisho Pharmaceut Co Ltd |
シアノフルオロピロリジン誘導体を有効成分として含有する医薬
|
|
ATE527259T1
(de)
|
2004-11-29 |
2011-10-15 |
Merck Sharp & Dohme |
Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
|
|
WO2006065826A2
(en)
|
2004-12-15 |
2006-06-22 |
Merck & Co., Inc. |
Process to chiral beta amino acid derivatives by asymmetric hydrogenation
|
|
US20080318922A1
(en)
|
2004-12-24 |
2008-12-25 |
Dainippon Sumitomo Pharma Co., Ltd. |
Bicyclic Pyrrole Derivatives
|
|
US7635699B2
(en)
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
WO2006073167A1
(ja)
|
2005-01-07 |
2006-07-13 |
Ono Pharmaceutical Co., Ltd. |
ピロリジン誘導体
|
|
CN101107251A
(zh)
|
2005-01-19 |
2008-01-16 |
默克公司 |
用于治疗或预防糖尿病的作为二肽基肽酶-ⅳ抑制剂的双环嘧啶类
|
|
WO2006085685A1
(ja)
|
2005-02-09 |
2006-08-17 |
Takeda Pharmaceutical Company Limited |
ピラゾール化合物
|
|
ZA200708144B
(en)
|
2005-02-25 |
2008-11-26 |
Takeda Pharmaceutical |
Pyridyl acetic acid compounds
|
|
DE102005012874A1
(de)
|
2005-03-19 |
2006-09-21 |
Sanofi-Aventis Deutschland Gmbh |
Amid substituierte 8-N-Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE102005012873B4
(de)
|
2005-03-19 |
2007-05-03 |
Sanofi-Aventis Deutschland Gmbh |
Aminocarbonyl substituierte 8-N-Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
TWI357902B
(en)
|
2005-04-01 |
2012-02-11 |
Lg Life Science Ltd |
Dipeptidyl peptidase-iv inhibiting compounds, meth
|
|
DE102005017605B4
(de)
|
2005-04-16 |
2007-03-15 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte 2-Aminoalkylthio-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
EA012442B1
(ru)
|
2005-05-13 |
2009-10-30 |
Эли Лилли Энд Компани |
Пегилированные соединения glp-1
|
|
EP1888529A2
(en)
|
2005-05-18 |
2008-02-20 |
Wyeth |
3-cyanoquinoline inhibitors of tpl2 kinase and methods of making and using the same
|
|
BRPI0611521A2
(pt)
|
2005-05-18 |
2010-09-14 |
Wyeth Corp |
inibidores de 4,6-diamino-[1,7]naftiridina-3-carbonitrila de quìnase tpl2 e métodos de fabricação e uso dos mesmos
|
|
CN103275083A
(zh)
|
2005-05-25 |
2013-09-04 |
默沙东公司 |
用于糖尿病治疗或者预防的作为二肽基肽酶-iv抑制剂的氨基环己烷
|
|
ATE432259T1
(de)
|
2005-07-20 |
2009-06-15 |
Lilly Co Eli |
Pyridinderivate als dipeptedyl-peptidase-hemmer
|
|
US8153694B2
(en)
|
2005-07-29 |
2012-04-10 |
Takeda Pharmaceutical Company Limited |
Cyclopropanecarboxylic acid compound
|
|
ATE549926T1
(de)
|
2005-08-26 |
2012-04-15 |
Merck Sharp & Dohme |
Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
|
|
US20080300251A1
(en)
|
2005-09-05 |
2008-12-04 |
Sattigeri Jitendra A |
Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors
|
|
AU2006291234A1
(en)
|
2005-09-14 |
2007-03-22 |
Amgen Inc. |
Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
|
|
WO2007063928A1
(ja)
|
2005-11-30 |
2007-06-07 |
Toray Industries, Inc. |
新規な非環状アミンカルボキシアミド誘導体及びその塩
|
|
EP1962601B1
(en)
|
2005-12-14 |
2014-10-15 |
Merck Sharp & Dohme Corp. |
Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes
|
|
CA2633803A1
(en)
|
2005-12-19 |
2007-09-07 |
Trustees Of Tufts College |
Soft protease inhibitors and pro-soft forms thereof
|
|
EP1966193B1
(en)
|
2005-12-21 |
2010-09-29 |
F. Hoffmann-La Roche AG |
New salt and polymorph of dpp-iv inhibitor
|
|
BRPI0620643A2
(pt)
|
2005-12-23 |
2011-12-20 |
Novartis Ag |
compostos de heterocìclicos condensados úteis como inibidores de dpp-iv, formulações farmacêuticas, produtos e usos dos compostos
|
|
PL1969004T3
(pl)
|
2005-12-28 |
2012-01-31 |
Novo Nordisk As |
Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
|
|
US20090156465A1
(en)
|
2005-12-30 |
2009-06-18 |
Sattigeri Jitendra A |
Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
|
|
CA2636757A1
(en)
|
2006-01-25 |
2007-08-02 |
Tesfaye Biftu |
Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
|
US7910596B2
(en)
|
2006-02-15 |
2011-03-22 |
Merck Sharp & Dohme Corp. |
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
|
WO2007099385A1
(en)
|
2006-03-01 |
2007-09-07 |
Glenmark Pharmaceuticals S.A. |
Dipeptidyl peptidase iv inhibitor compounds and compositions
|
|
US20070270492A1
(en)
|
2006-03-06 |
2007-11-22 |
Avestha Gengraine Technologies Pvt. Ltd. |
Nananoic acid derivatives as dipeptidyl peptidase inhibitors
|
|
US20080051452A1
(en)
|
2006-03-06 |
2008-02-28 |
Avestha Gengraine Technologies Pvt. Ltd. |
Hexanoic acid derivatives as dipeptidyl peptidase inhibitors
|
|
WO2007106469A2
(en)
|
2006-03-14 |
2007-09-20 |
Amgen Inc. |
Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
|
|
JP5252435B2
(ja)
|
2006-03-15 |
2013-07-31 |
ノボ・ノルデイスク・エー/エス |
アミリン誘導体
|
|
WO2007112347A1
(en)
|
2006-03-28 |
2007-10-04 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
TW200806669A
(en)
|
2006-03-28 |
2008-02-01 |
Merck & Co Inc |
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
|
WO2007113226A1
(en)
|
2006-03-31 |
2007-10-11 |
Novartis Ag |
Organic compounds
|
|
EP2004601B1
(en)
|
2006-04-03 |
2011-03-02 |
Matrix Laboratories Limited |
Novel dipeptidyl peptidase iv inhibitors and processes for their preparation and pharmaceutical compositions containing them
|
|
CN101050194B
(zh)
|
2006-04-05 |
2013-08-21 |
上海恒瑞医药有限公司 |
双环辛烷类衍生物、其制备方法及其在医药上的用途
|
|
JP2009533368A
(ja)
|
2006-04-11 |
2009-09-17 |
ノバルティス アクチエンゲゼルシャフト |
有機化合物
|
|
AU2007235876A1
(en)
|
2006-04-12 |
2007-10-18 |
Probiodrug Ag |
Enzyme inhibitors
|
|
CN101466394A
(zh)
|
2006-04-13 |
2009-06-24 |
科学研究和应用咨询股份公司 |
hGLP-1、胰高血糖素样肽的抑制剂-4及其类似物的药物组合物
|
|
AU2007240313B2
(en)
|
2006-04-20 |
2012-02-02 |
Amgen Inc. |
GLP-1 compounds
|
|
TW200815377A
(en)
|
2006-04-24 |
2008-04-01 |
Astellas Pharma Inc |
Oxadiazolidinedione compound
|
|
BRPI0711558A2
(pt)
|
2006-05-04 |
2011-11-08 |
Boeringer Ingelheim Internat Gmbh |
polimorfos
|
|
EP1852108A1
(en)
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
|
DE102006021874B4
(de)
|
2006-05-11 |
2008-03-27 |
Sanofi-Aventis |
4,5-Diphenyl-pyrimidinyl-amino substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
WO2007131621A1
(de)
|
2006-05-11 |
2007-11-22 |
Sanofi-Aventis |
4,5-diphenyl-pyrimidinyl substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
|
|
DE102006021878A1
(de)
|
2006-05-11 |
2007-11-15 |
Sanofi-Aventis |
Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
DE102006021872B4
(de)
|
2006-05-11 |
2008-04-17 |
Sanofi-Aventis |
4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
ATE552245T1
(de)
|
2006-05-15 |
2012-04-15 |
Merck Sharp & Dohme |
Antidiabetische bicyclische verbindungen
|
|
AU2007254357B2
(en)
|
2006-05-16 |
2011-07-21 |
Merck Sharp & Dohme Corp. |
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
|
JP2009190971A
(ja)
|
2006-06-06 |
2009-08-27 |
Mitsubishi Tanabe Pharma Corp |
2−シアノピロリジン誘導体
|
|
WO2007148185A2
(en)
|
2006-06-21 |
2007-12-27 |
Pfizer Products Inc. |
Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
|
|
CA2838448A1
(en)
|
2006-06-27 |
2008-01-03 |
Takeda Pharmaceutical Company Limited |
Fused cyclic compounds
|
|
JP2008031064A
(ja)
|
2006-07-27 |
2008-02-14 |
Astellas Pharma Inc |
ジアシルピペラジン誘導体
|
|
WO2008017670A1
(en)
|
2006-08-08 |
2008-02-14 |
Boehringer Ingelheim International Gmbh |
Pyrrolo [3, 2 -d] pyrimidines as dpp-iv inhibitors for the treatment of diabetes mellitus
|
|
WO2008022015A2
(en)
|
2006-08-11 |
2008-02-21 |
Trustees Of Tufts College |
Retro-inverso incretin analogues, and methods of use thereof
|
|
WO2008029217A2
(en)
|
2006-08-29 |
2008-03-13 |
Orchid Research Laboratories Limited |
Dipeptidyl peptidase iv inhibitors
|
|
CL2007002499A1
(es)
|
2006-08-30 |
2008-03-14 |
Phenomix Corp |
Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes.
|
|
JP2008063256A
(ja)
|
2006-09-06 |
2008-03-21 |
Astellas Pharma Inc |
β‐アミノ酸誘導体
|
|
US7687526B2
(en)
|
2006-09-07 |
2010-03-30 |
Amgen Inc. |
Benzo-fused compounds for use in treating metabolic disorders
|
|
WO2008028662A1
(en)
|
2006-09-07 |
2008-03-13 |
Santhera Pharmaceuticals (Schweiz) Ag |
N-[1-(3-amino-4-phenyl-butyryl)-4-hydroxy-pyrrolidin-2-ylmethyl}-propionamide and related compounds as dpp-iv inhibitors for the treatment of type 2 diabetes mellitus
|
|
WO2008030520A1
(en)
|
2006-09-07 |
2008-03-13 |
Amgen Inc. |
Heterocyclic gpr40 modulators
|
|
RS51965B
(sr)
|
2006-09-13 |
2012-02-29 |
Takeda Pharmaceutical Company Limited |
Upotreba 2-6-(3-amino-piperidin-1-il)-3-metil-2,4-diokso-3,4-dihidro-2h-pirimidin-1-ilmetil-4-fluoro-benzonitrila za lečenje dijabetesa, kancera, autoimunih poremećaja i hiv infekcije
|
|
MX2009003400A
(es)
|
2006-10-03 |
2009-04-28 |
Cadila Healthcare Ltd |
Compuestos antidiabeticos.
|
|
WO2008040995A1
(en)
|
2006-10-07 |
2008-04-10 |
Peakdale Molecular Limited |
Indazoles for use as dpp-iv inhibitors
|
|
CA2667249A1
(en)
|
2006-10-31 |
2008-05-08 |
Merck & Co., Inc. |
Antidiabetic bicyclic compounds
|
|
WO2008054674A2
(en)
|
2006-10-31 |
2008-05-08 |
Merck & Co., Inc. |
Antidiabetic bicyclic compounds
|
|
JP2010043001A
(ja)
|
2006-11-09 |
2010-02-25 |
Sanwa Kagaku Kenkyusho Co Ltd |
Glp−1誘導体とその用途
|
|
JP5232160B2
(ja)
|
2006-11-14 |
2013-07-10 |
メルク・シャープ・アンド・ドーム・コーポレーション |
糖尿病の治療又は予防のためのジペプチジルペプチダーゼivインヒビターとしての三環式芳香族複素環化合物
|
|
US7750048B2
(en)
|
2006-11-15 |
2010-07-06 |
Janssen Pharmaceutica Nv |
GPR40 agonists
|
|
ATE549334T1
(de)
|
2006-11-20 |
2012-03-15 |
Bristol Myers Squibb Co |
7,8-dihydro-1,6-naphthyridin-5(6h)-one und verwandte bicyclische verbindungen als hemmer der dipeptidyl-peptidase iv sowie verfahren
|
|
WO2008061355A1
(en)
|
2006-11-24 |
2008-05-29 |
Matregen Corp. |
Glp-1 depot systems, and methods of manufacture and uses thereof
|
|
JP5176964B2
(ja)
|
2006-11-29 |
2013-04-03 |
ユーハ味覚糖株式会社 |
ジペプチジルペプチダーゼiv阻害剤
|
|
TW200838526A
(en)
|
2006-12-01 |
2008-10-01 |
Astellas Pharma Inc |
Carboxylic acid derivatives
|
|
CN101610761A
(zh)
|
2006-12-22 |
2009-12-23 |
诺瓦提斯公司 |
作为ddp-iv抑制剂的1-氨基甲基-l-苯基-环己烷衍生物
|
|
JP2008156318A
(ja)
|
2006-12-26 |
2008-07-10 |
Dainippon Sumitomo Pharma Co Ltd |
1,3,4−オキサジアゾール−2−オン誘導体
|
|
JP2008169195A
(ja)
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
キャリア物質を用いたインスリン分泌ペプチド薬物結合体
|
|
US20090098130A1
(en)
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
|
KR100848491B1
(ko)
|
2007-01-16 |
2008-07-28 |
영진약품공업주식회사 |
베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
|
|
CN101230058A
(zh)
|
2007-01-23 |
2008-07-30 |
上海恒瑞医药有限公司 |
双环氮杂烷类衍生物、其制备方法及其在医药上的用途
|
|
KR20080071476A
(ko)
|
2007-01-30 |
2008-08-04 |
주식회사 엘지생명과학 |
신규한 디펩티딜 펩티데이즈 iv(dpp-iv) 저해제
|
|
JP2010120851A
(ja)
|
2007-02-09 |
2010-06-03 |
Kyorin Pharmaceut Co Ltd |
二量化シクロ誘導体
|
|
EA017849B1
(ru)
|
2007-02-15 |
2013-03-29 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Соагонисты глюкагоновых/glp-1-рецепторов
|
|
EP1961742A1
(en)
|
2007-02-22 |
2008-08-27 |
Novartis AG |
compounds of formula (I) as serine protease inhibitors
|
|
WO2008112938A2
(en)
|
2007-03-13 |
2008-09-18 |
New England Medical Center Hospitals, Inc. |
Composition and method for the treatment of diseases affected by a peptide receptor
|
|
EP1972349A1
(en)
|
2007-03-21 |
2008-09-24 |
Biocompatibles UK Limited |
GLP-1 fusion peptides conjugated to polymer(s), their production and use
|
|
WO2008116294A1
(en)
|
2007-03-23 |
2008-10-02 |
Matregen Corp. |
Exendin analogs
|
|
WO2008118848A1
(en)
|
2007-03-23 |
2008-10-02 |
Trustees Of Tufts College |
N-substituted peptidomimetic inhibitors of dipeptidylpeptidase iv
|
|
WO2008119005A1
(en)
|
2007-03-27 |
2008-10-02 |
Trustees Of Tufts College |
3,4-dehydro-proline-containing inhibitors of dipeptidylpeptidase iv
|
|
EP1975176A1
(en)
|
2007-03-27 |
2008-10-01 |
Biocompatibles UK Limited |
Novel glp-1 fusion peptides, their production and use
|
|
WO2008121506A2
(en)
|
2007-03-30 |
2008-10-09 |
Takeda Pharmaceutical Company Limited |
Renin inhibitors
|
|
CN101274918A
(zh)
|
2007-03-30 |
2008-10-01 |
中国科学院上海药物研究所 |
一类取代五元杂环化合物,其制备方法和医学用途
|
|
CN101279955B
(zh)
|
2007-04-03 |
2012-11-28 |
北京摩力克科技有限公司 |
作为二肽肽激酶-iv抑制剂的n-取代硫吗啉衍生物及其医药用途
|
|
ES2529149T3
(es)
|
2007-04-03 |
2015-02-17 |
Mitsubishi Tanabe Pharma Corporation |
Una combinación de inhibidor de dipeptidil peptidasa IV y edulcorante para uso en el tratamiento de la obesidad
|
|
WO2008130514A1
(en)
|
2007-04-16 |
2008-10-30 |
Amgen Inc. |
Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
|
|
AU2008241692B2
(en)
|
2007-04-19 |
2011-02-10 |
Dong-A Pharm. Co., Ltd. |
DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating a diabetes or an obesity
|
|
PE20090696A1
(es)
|
2007-04-20 |
2009-06-20 |
Bristol Myers Squibb Co |
Formas cristalinas de saxagliptina y procesos para preparar las mismas
|
|
US7829664B2
(en)
|
2007-06-01 |
2010-11-09 |
Boehringer Ingelheim International Gmbh |
Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof
|
|
WO2008148839A2
(en)
|
2007-06-08 |
2008-12-11 |
Ascendis Pharma As |
Long-acting polymeric prodrugs of exendin
|
|
WO2008152403A1
(en)
|
2007-06-15 |
2008-12-18 |
Zealand Pharma A/S |
Glucagon analogues
|
|
WO2009003681A1
(en)
|
2007-07-02 |
2009-01-08 |
Santhera Pharmaceuticals (Schweiz) Ag |
Dpp-iv inhibitors
|
|
WO2009014676A1
(en)
|
2007-07-23 |
2009-01-29 |
Merck & Co., Inc. |
Novel crystalline form of a dihydrochloride salt of a dipeptidyl peptidase-iv inhibitor
|
|
US8653059B2
(en)
|
2007-08-21 |
2014-02-18 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
|
US20090105480A1
(en)
|
2007-08-30 |
2009-04-23 |
Ulrike Bromberger |
Process for the preparation of a dpp-iv inhibitor
|
|
ES2550363T3
(es)
|
2007-09-05 |
2015-11-06 |
Novo Nordisk A/S |
Derivados truncados de GLP-1 y su uso terapéutico
|
|
WO2009030738A1
(en)
|
2007-09-05 |
2009-03-12 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
|
WO2009030771A1
(en)
|
2007-09-05 |
2009-03-12 |
Novo Nordisk A/S |
Peptides derivatized with a-b-c-d- and their therapeutical use
|
|
EP2650006A1
(en)
|
2007-09-07 |
2013-10-16 |
Ipsen Pharma S.A.S. |
Analogues of exendin-4 and exendin-3
|
|
EP2036923A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Improved derivates of amylin
|
|
WO2009038204A1
(ja)
|
2007-09-17 |
2009-03-26 |
Pharma Frontier Co., Ltd. |
新規長鎖脂肪酸誘導体化合物及びそれら化合物を有効成分とするgタンパク質共役型レセプター作動剤
|
|
AU2008303975B2
(en)
|
2007-09-21 |
2013-05-16 |
Sanofi |
(Cyclopropyl-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
|
|
GB2465132B
(en)
|
2007-09-21 |
2012-06-06 |
Lupin Ltd |
Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
|
|
WO2009039943A1
(de)
|
2007-09-21 |
2009-04-02 |
Sanofi-Aventis |
(carboxylalkylen-phenyl)-phenyl-oxalamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
|
|
BRPI0818253A2
(pt)
|
2007-10-10 |
2015-04-07 |
Amgen Inc |
Moduladores de gpr40 bifenil substituídos
|
|
CN101417999A
(zh)
|
2007-10-25 |
2009-04-29 |
上海恒瑞医药有限公司 |
哌嗪类衍生物,其制备方法及其在医药上的应用
|
|
EP2684861A3
(en)
|
2007-10-26 |
2014-05-07 |
Japan Tobacco Inc. |
Spiro compounds and pharmaceutical use thereof
|
|
JP5542058B2
(ja)
|
2007-10-29 |
2014-07-09 |
メルク・シャープ・アンド・ドーム・コーポレーション |
抗糖尿病性三環式化合物
|
|
WO2009058734A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
|
WO2009070314A2
(en)
|
2007-11-26 |
2009-06-04 |
Teva Pharmaceutical Industries Ltd. |
Crystalline form of sitagliptin
|
|
CA2704493A1
(en)
|
2007-11-30 |
2009-06-04 |
Novartis Ag |
Organic compounds
|
|
CA2707448C
(en)
|
2007-12-11 |
2014-10-14 |
Cadila Healthcare Limited |
Peptidomimetics with glucagon antagonistic and glp-1 agonistic activities
|
|
WO2009080024A1
(en)
|
2007-12-20 |
2009-07-02 |
Fertin Pharma A/S |
Compressed chewing gum comprising an incretin mimetic
|
|
WO2009080032A1
(en)
|
2007-12-20 |
2009-07-02 |
Fertin Pharma A/S |
Compressed chewing gum comprising a systemically active small peptide
|
|
UA103181C2
(ru)
|
2007-12-21 |
2013-09-25 |
Ел Джи Лайф Сайєнсіз, Лтд. |
Соединения, которые ингибируют дипептидилпептидазу-iv и фармацевтическая композиция, которая содержит их как активный агент
|
|
CN101468988A
(zh)
|
2007-12-26 |
2009-07-01 |
上海恒瑞医药有限公司 |
哌嗪类衍生物,其制备方法及其在医药上的应用
|
|
TW200938200A
(en)
|
2007-12-28 |
2009-09-16 |
Dainippon Sumitomo Pharma Co |
Methyl-substituted piperidine derivative
|
|
MX2010007593A
(es)
|
2008-01-10 |
2010-10-13 |
Sun Pharma Advanced Res Co Ltd |
Derivados novedosos de acil cianopirrolidinas.
|
|
US20090238879A1
(en)
|
2008-01-24 |
2009-09-24 |
Northwestern University |
Delivery scaffolds and related methods of use
|
|
BRPI0906705A2
(pt)
|
2008-01-24 |
2015-06-30 |
Panacea Biotec Ltd |
Composto heterocíclicos
|
|
WO2009099171A1
(ja)
|
2008-02-07 |
2009-08-13 |
Takeda Pharmaceutical Company Limited |
医薬
|
|
WO2009099172A1
(ja)
|
2008-02-07 |
2009-08-13 |
Takeda Pharmaceutical Company Limited |
医薬
|
|
KR100864584B1
(ko)
|
2008-02-25 |
2008-10-24 |
성균관대학교산학협력단 |
비오틴으로 수식된 엑센딘 유도체, 이의 제조방법 및 이의용도
|
|
EP2252582B1
(en)
|
2008-03-05 |
2014-07-23 |
National Health Research Institutes |
Pyrrolidine derivatives
|
|
EP2260017A1
(en)
|
2008-03-06 |
2010-12-15 |
Amgen, Inc |
Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
|
|
WO2009111700A2
(en)
|
2008-03-07 |
2009-09-11 |
Transtech Pharma, Inc. |
Oxadiazoanthracene compounds for the treatment of diabetes
|
|
EP2264034A1
(en)
|
2008-03-10 |
2010-12-22 |
Dainippon Sumitomo Pharma Co., Ltd. |
Bicyclic pyrrole compound
|
|
US20090247532A1
(en)
|
2008-03-28 |
2009-10-01 |
Mae De Ltd. |
Crystalline polymorph of sitagliptin phosphate and its preparation
|
|
CN101565408A
(zh)
|
2008-04-25 |
2009-10-28 |
国家新药筛选中心 |
一类受体信号转导增效剂,其制备方法和用途
|
|
CA2726903A1
(en)
|
2008-06-03 |
2009-12-10 |
Trustees Of Tufts College |
Long-acting glp-1 derivatives, and methods of treating cardiac dysfunction
|
|
PA8830501A1
(es)
|
2008-06-17 |
2010-07-27 |
Univ Indiana Res & Tech Corp |
Co-agonistas del receptor de glucagon/glp-1
|
|
US8450270B2
(en)
|
2008-06-17 |
2013-05-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
|
|
JP5604297B2
(ja)
|
2008-06-17 |
2014-10-08 |
株式会社糖鎖工学研究所 |
糖鎖付加glp−1ペプチド
|
|
EP2318411A2
(en)
|
2008-07-03 |
2011-05-11 |
Ratiopharm GmbH |
Crystalline salts of sitagliptin
|
|
CN102137836B
(zh)
|
2008-07-28 |
2015-08-26 |
赛丹思科大学 |
用于治疗代谢疾病的化合物
|
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
|
TW201221505A
(en)
|
2010-07-05 |
2012-06-01 |
Sanofi Sa |
Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
|