IN2014DN04226A - - Google Patents
Info
- Publication number
- IN2014DN04226A IN2014DN04226A IN4226DEN2014A IN2014DN04226A IN 2014DN04226 A IN2014DN04226 A IN 2014DN04226A IN 4226DEN2014 A IN4226DEN2014 A IN 4226DEN2014A IN 2014DN04226 A IN2014DN04226 A IN 2014DN04226A
- Authority
- IN
- India
- Prior art keywords
- subject
- depression
- effectiveness
- treating
- resistant
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 abstract 3
- 239000000935 antidepressant agent Substances 0.000 abstract 2
- 238000011269 treatment regimen Methods 0.000 abstract 2
- JVJFIQYAHPMBBX-FNORWQNLSA-N (E)-4-hydroxynon-2-enal Chemical compound CCCCCC(O)\C=C\C=O JVJFIQYAHPMBBX-FNORWQNLSA-N 0.000 abstract 1
- JVJFIQYAHPMBBX-UHFFFAOYSA-N HNE Natural products CCCCCC(O)C=CC=O JVJFIQYAHPMBBX-UHFFFAOYSA-N 0.000 abstract 1
- 101001013648 Homo sapiens Methionine synthase Proteins 0.000 abstract 1
- 101001116314 Homo sapiens Methionine synthase reductase Proteins 0.000 abstract 1
- 101000587058 Homo sapiens Methylenetetrahydrofolate reductase Proteins 0.000 abstract 1
- 102100031551 Methionine synthase Human genes 0.000 abstract 1
- 102100024614 Methionine synthase reductase Human genes 0.000 abstract 1
- 102100029684 Methylenetetrahydrofolate reductase Human genes 0.000 abstract 1
- 101001030849 Rhinella marina Mesotocin receptor Proteins 0.000 abstract 1
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559541P | 2011-11-14 | 2011-11-14 | |
| PCT/US2012/065084 WO2013074676A2 (en) | 2011-11-14 | 2012-11-14 | Assays and methods for selecting a treatment regimen for a subject with depression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN04226A true IN2014DN04226A (https=) | 2015-05-22 |
Family
ID=47279072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN4226DEN2014 IN2014DN04226A (https=) | 2011-11-14 | 2012-11-14 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9540691B2 (https=) |
| EP (1) | EP2780467B1 (https=) |
| JP (1) | JP6285865B2 (https=) |
| KR (1) | KR102035877B1 (https=) |
| CN (1) | CN104053785A (https=) |
| AU (1) | AU2012340015B2 (https=) |
| BR (1) | BR112014011491A2 (https=) |
| CA (1) | CA2855640C (https=) |
| IL (1) | IL232407B (https=) |
| IN (1) | IN2014DN04226A (https=) |
| MX (1) | MX354547B (https=) |
| RU (1) | RU2622082C2 (https=) |
| WO (1) | WO2013074676A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102035877B1 (ko) * | 2011-11-14 | 2019-10-23 | 알파시그마 에스.피.에이. | 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법 |
| RU2015143177A (ru) * | 2013-03-12 | 2017-04-18 | Нестек С.А. | Анализы и способы выбора схемы лечения для субъекта с депрессией |
| PE20200404A1 (es) | 2013-03-15 | 2020-02-26 | Janssen Pharmaceutica Nv | Composicion farmaceutica de clorhidrato de s-ketamina |
| US9549937B2 (en) * | 2013-12-05 | 2017-01-24 | Burvia, LLC. | Composition containing phospholipid-DHA and folate |
| US9610302B2 (en) * | 2013-12-05 | 2017-04-04 | Buriva, LLC. | Composition containing phospholipid-DHA and B vitamins |
| US20150250813A1 (en) * | 2013-12-05 | 2015-09-10 | Buriva, LLC | Dietary supplement containing phospholipid-dha, folate, and n-acetyl-l-cysteine |
| JP2017512204A (ja) * | 2014-03-05 | 2017-05-18 | 武田薬品工業株式会社 | うつ病および大うつ病性障害を治療するための方法 |
| WO2015136446A1 (en) * | 2014-03-11 | 2015-09-17 | Nestec S.A. | Methods for selecting antidepressant drug therapy to treat depression |
| KR101588119B1 (ko) * | 2014-05-16 | 2016-01-25 | 동아대학교 산학협력단 | Ｓｌｃ6ａ3 유전자의 다형성 소위성과 이를 이용한 ｄｎａ 타이핑 키트 및 상기 유전자 관련 질병의 진단키트 |
| CN106714789A (zh) | 2014-08-13 | 2017-05-24 | 詹森药业有限公司 | 用于治疗抑郁症的方法 |
| CN107208133A (zh) | 2014-09-15 | 2017-09-26 | 詹森药业有限公司 | 用于治疗抑郁症的Val66Met (SNPrs6265)基因型特异性给药方案和方法 |
| CN105671130A (zh) * | 2014-11-18 | 2016-06-15 | 武汉白原科技有限公司 | 一种心理性格检测试剂盒和方法 |
| US20160203591A1 (en) * | 2015-01-09 | 2016-07-14 | Umm Al-Qura University | System and process for monitoring the quality of food in a refrigerator |
| CN104655705B (zh) * | 2015-02-12 | 2017-03-08 | 江苏省原子医学研究所 | 一种用毛细管电泳快速检测生物样本中儿茶酚氧甲基转移酶comt活性的方法 |
| CN104789668A (zh) * | 2015-04-10 | 2015-07-22 | 浙江博惠生物科技有限公司 | 一种叶酸代谢能力评估的检测位点rs1801394的检测PCR扩增引物和单碱基延伸引物 |
| US11122997B2 (en) | 2015-04-17 | 2021-09-21 | Mayo Foundation For Medical Education And Research | Modulating the aryl hydrocarbon receptor system to treat major depressive disorder |
| WO2016176458A1 (en) * | 2015-04-28 | 2016-11-03 | Proove Biosciences, Inc. | System and method for processing genotype information relating to opiod risk |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| AU2016267091B2 (en) * | 2015-05-25 | 2020-01-16 | Xiujuan Hao | Use of fluorescence for the quick and easy determination of S-Adenosylmethionine, S-Adenosylhomocysteine and Homocysteine |
| US11313868B2 (en) | 2016-06-14 | 2022-04-26 | Board Of Regents, The University Of Texas System | Methods of detecting anti-folic acid antibodies and uses thereof |
| WO2018053605A1 (en) * | 2016-09-26 | 2018-03-29 | Precision Medicine Holdings Pty Ltd | Diagnosis, prognosis and treatment for schizophrenia and schizoaffective psychosis |
| CN107245527A (zh) * | 2017-07-25 | 2017-10-13 | 重庆京因生物科技有限责任公司 | Mtrr基因多态性快速检测的引物、分子信标、试剂盒及其检测方法 |
| US11399575B2 (en) * | 2017-08-02 | 2022-08-02 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Wearable device and application for behavioral support |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| MX2020006650A (es) | 2017-12-22 | 2020-11-06 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
| CN108251522B (zh) * | 2018-04-09 | 2020-11-27 | 江苏硕世生物科技股份有限公司 | 人类mthfr和mtrr基因检测试剂盒及其用途 |
| CN108642138B (zh) * | 2018-05-02 | 2021-11-30 | 广东药科大学 | 一种检测叶酸代谢相关基因遗传信息的方法及试剂盒 |
| EP3788644A4 (en) | 2018-05-03 | 2023-03-01 | L. Pierre De Rochemont | HIGH-FAST/LOW-PERFORMANCE SERVER SYSTEMS AND SERVER NETWORKS |
| JP7426103B2 (ja) | 2018-06-05 | 2024-02-01 | デ，ロシェモント，エル．，ピエール | 高ピーク帯域幅ｉ／ｏチャネルを備えたモジュール |
| CN108823299A (zh) * | 2018-06-11 | 2018-11-16 | 苏州艾达康医疗科技有限公司 | 一种抑郁症用药相关基因的检测方法及试剂盒 |
| KR20210081335A (ko) * | 2018-09-03 | 2021-07-01 | 비스비 메디컬, 인코포레이티드 | 항생제 감수성 시험을 위한 장치 및 방법 |
| MX2021010683A (es) | 2019-03-05 | 2021-12-10 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
| JP2022533956A (ja) | 2019-05-14 | 2022-07-27 | プロメテウス バイオサイエンシーズ，インク． | Ｔｌ１ａ患者を選択する方法、システム、およびデバイス |
| CN110148461B (zh) * | 2019-06-26 | 2021-09-21 | 周建勋 | 用于多参数测量的模块切换系统 |
| CN110693507A (zh) * | 2019-08-30 | 2020-01-17 | 中国民用航空飞行学院 | 一种民航飞行学员心理健康测试和心理援助系统 |
| CN111351945B (zh) * | 2020-03-18 | 2021-04-23 | 东南大学 | 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用 |
| WO2022115277A1 (en) * | 2020-11-24 | 2022-06-02 | Genomind, Inc. | Methods and systems for reporting patient-and drug-specific medical data |
| CN116103385B (zh) * | 2021-11-11 | 2024-11-15 | 深圳理工大学 | 一种预测抑郁障碍患者对治疗反应的基因诊断试剂盒和系统 |
| KR102925724B1 (ko) * | 2022-01-17 | 2026-02-10 | 서울대학교산학협력단 | 게놈-대사체 통합 분석 기반의 만성신장질환 분석 장치 및 방법 |
| KR102925722B1 (ko) * | 2022-01-17 | 2026-02-10 | 서울대학교산학협력단 | 멀티오믹스 기반의 신경계 질환 분석 장치 및 방법 |
| CN116298233A (zh) * | 2022-03-16 | 2023-06-23 | 昱言科技(北京)有限公司 | 用于诊断双相障碍的生物标记物 |
| WO2023220213A1 (en) * | 2022-05-11 | 2023-11-16 | Higgins Evelyn | Methods for providing a personalized therapeutic treatment regime for addictions |
| CN120847438B (zh) * | 2025-07-16 | 2026-02-03 | 江西众康中药饮片有限公司 | 药材辨识系统及方法 |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US548257A (en) | 1895-10-22 | Hay rake and loader | ||
| US3837376A (en) | 1971-06-01 | 1974-09-24 | Metropolitan Pathology Labor I | Blood serum collection tube and method |
| US4336185A (en) | 1976-03-02 | 1982-06-22 | Rohm And Haas Company | Folic acid derivatives |
| US4120448A (en) | 1977-06-08 | 1978-10-17 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing apparatus with automatically positioned collection port |
| US4656035A (en) | 1984-12-21 | 1987-04-07 | University Of Tennessee Research Corporation | Method of separating blood platelets |
| US4946773A (en) | 1985-12-23 | 1990-08-07 | President And Fellows Of Harvard College | Detection of base pair mismatches using RNAase A |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| WO1989006700A1 (en) | 1988-01-21 | 1989-07-27 | Genentech, Inc. | Amplification and detection of nucleic acid sequences |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| WO1989010414A1 (en) | 1988-04-28 | 1989-11-02 | Robert Bruce Wallace | AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs) |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5925525A (en) | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| US5118937A (en) | 1989-08-22 | 1992-06-02 | Finnigan Mat Gmbh | Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules |
| US5045694A (en) | 1989-09-27 | 1991-09-03 | The Rockefeller University | Instrument and method for the laser desorption of ions in mass spectrometry |
| US6013431A (en) | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
| US5846710A (en) | 1990-11-02 | 1998-12-08 | St. Louis University | Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension |
| DE69132905T2 (de) | 1990-12-06 | 2002-08-01 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Detektion von Nukleinsäuresequenzen |
| US5169766A (en) | 1991-06-14 | 1992-12-08 | Life Technologies, Inc. | Amplification of nucleic acid molecules |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| ATE242485T1 (de) | 1993-05-28 | 2003-06-15 | Baylor College Medicine | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US6136540A (en) | 1994-10-03 | 2000-10-24 | Ikonisys Inc. | Automated fluorescence in situ hybridization detection of genetic abnormalities |
| US5952172A (en) | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| US6566065B1 (en) | 1994-05-26 | 2003-05-20 | Mcgill University | Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene |
| GB9410620D0 (en) | 1994-05-26 | 1994-07-13 | Univ Mcgill | cDNA for human mehylenetetrahydrofolate reductase |
| US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
| US5849483A (en) | 1994-07-28 | 1998-12-15 | Ig Laboratories, Inc. | High throughput screening method for sequences or genetic alterations in nucleic acids |
| US5866337A (en) | 1995-03-24 | 1999-02-02 | The Trustees Of Columbia University In The City Of New York | Method to detect mutations in a nucleic acid using a hybridization-ligation procedure |
| US5704888A (en) | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Intermittent collection of mononuclear cells in a centrifuge apparatus |
| US5968740A (en) | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
| US6264970B1 (en) | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6465611B1 (en) | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| WO1999013108A1 (en) | 1997-09-10 | 1999-03-18 | University Of Maryland, Baltimore | Method of amplifying dna and rna mismatch cleavage products |
| ATE369135T1 (de) * | 1998-04-24 | 2007-08-15 | Scarista Ltd | Behandlung von depression und zusammensetzungen dazu |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| BR9914251A (pt) | 1998-10-01 | 2001-06-19 | Novartis Ag | Formulações orais de liberação sustentada |
| US6395481B1 (en) | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
| US7429466B2 (en) | 2000-01-24 | 2008-09-30 | Hypromatrix, Inc | Methods and arrays for detecting biological molecules |
| US6618679B2 (en) | 2000-01-28 | 2003-09-09 | Althea Technologies, Inc. | Methods for analysis of gene expression |
| WO2001066172A2 (en) | 2000-03-09 | 2001-09-13 | Gambro, Inc. | Extracorporeal blood processing method and apparatus |
| WO2001080896A2 (en) | 2000-04-21 | 2001-11-01 | Arch Development Corporation | Flavopiridol drug combinations and methods with reduced side effects |
| DE10022510A1 (de) | 2000-05-10 | 2001-11-15 | Basf Ag | Zusammensetzungen enthaltend Folsäure und reduziertes Folat |
| US6355433B1 (en) | 2000-06-02 | 2002-03-12 | Dna Sciences, Inc. | Determination of nucleotide sequence variations through limited primer extension |
| ES2291329T3 (es) | 2000-07-18 | 2008-03-01 | Dainippon Sumitomo Pharma Co., Ltd. | Inhibidores de la recaptacion de serotonina. |
| WO2002059375A2 (en) | 2001-01-26 | 2002-08-01 | University Of Chicago | Determination of ugt2b7 gene polymorphisms for predicting ugt2b7 substrate toxicity and for optimising drug dosage |
| US6720003B2 (en) | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
| KR20030031911A (ko) | 2001-04-19 | 2003-04-23 | 싸이퍼젠 바이오시스템즈, 인코포레이티드 | 질량 분석법과 친화성 태그를 이용한 생물분자 특성화 |
| US20030100476A1 (en) | 2001-05-11 | 2003-05-29 | Weinberger Daniel R. | Effect of COMT genotype on frontal lobe function |
| EP1390497A2 (en) | 2001-05-25 | 2004-02-25 | Genset | Human cdnas and proteins and uses thereof |
| US7112408B2 (en) | 2001-06-08 | 2006-09-26 | The Brigham And Women's Hospital, Inc. | Detection of ovarian cancer based upon alpha-haptoglobin levels |
| US20030013208A1 (en) | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
| WO2003017177A2 (en) | 2001-08-13 | 2003-02-27 | Beyong Genomics, Inc. | Method and system for profiling biological systems |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| IL163645A0 (en) | 2002-02-21 | 2005-12-18 | Idgene Pharmaceuticals Ltd | Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer |
| US20030215858A1 (en) | 2002-04-08 | 2003-11-20 | Baylor College Of Medicine | Enhanced gene expression system |
| US7241281B2 (en) | 2002-04-08 | 2007-07-10 | Thermogenesis Corporation | Blood component separation method and apparatus |
| US20030194711A1 (en) | 2002-04-10 | 2003-10-16 | Matthew Zapala | System and method for analyzing gene expression data |
| WO2003091735A1 (en) | 2002-04-23 | 2003-11-06 | Millipore Corporation | Sample preparation of biological fluids for proteomic applications |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| CA2415154C (en) | 2002-12-24 | 2009-06-16 | Biovail Laboratories Inc. | Modified release formulations of selective serotonin re-uptake inhibitors |
| US20040203034A1 (en) | 2003-01-03 | 2004-10-14 | The University Of Chicago | Optimization of cancer treatment with irinotecan |
| SI1610791T1 (sl) | 2003-03-31 | 2011-05-31 | Titan Pharmaceuticals Inc | Implantibilna polimerna naprava za zadržano sproščanje dopaminskega agonista |
| US20050054688A1 (en) | 2003-08-08 | 2005-03-10 | Pfizer Inc | Selective serotonin reuptake inhibitors in the treatment of disease |
| US20050069936A1 (en) | 2003-09-26 | 2005-03-31 | Cornelius Diamond | Diagnostic markers of depression treatment and methods of use thereof |
| US7893261B2 (en) | 2004-03-26 | 2011-02-22 | Baylor University | Serotonin reuptake inhibitors |
| JP2005312435A (ja) | 2004-03-29 | 2005-11-10 | Kazuhito Rokutan | うつ病の評価方法 |
| WO2006099164A2 (en) | 2005-03-10 | 2006-09-21 | Applera Corporation | Methods for multiplex amplification |
| US7972770B2 (en) | 2005-08-16 | 2011-07-05 | Memorial Sloan-Kettering Cancer Center | Methods of detection of cancer using peptide profiles |
| EP1954832A4 (en) | 2005-12-06 | 2009-10-28 | Gen Hospital Corp | DIAGNOSTIC METHODS FOR PAIN SENSITIVITY AND PAIN CHRONICITY AND METHODS FOR TETRAHYDROBIOPTERIN RELATED DISORDERS |
| US20080064702A1 (en) | 2006-09-08 | 2008-03-13 | Charalambos Antoniades | Use of folates for the prevention and treatment of vascular diseases |
| US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US20100273153A1 (en) | 2006-11-29 | 2010-10-28 | Boris Tabakoff | Genetic diagnosis of depression |
| US20090075827A1 (en) | 2007-01-19 | 2009-03-19 | Queensland University Of Technology | Diagnostic methods and agents |
| US7947662B2 (en) | 2008-02-20 | 2011-05-24 | Gnosis S.P.A. | Folates, compositions and uses thereof |
| US20090307179A1 (en) | 2008-03-19 | 2009-12-10 | Brandon Colby | Genetic analysis |
| US8344115B2 (en) | 2008-04-21 | 2013-01-01 | Chan-Sui Pang, legal representative | Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples |
| EP2485747A4 (en) | 2008-06-21 | 2013-10-23 | Kenneth Blum | CUSTOMIZATION DIRECTED BY THE DNA OF ANALGESIC COMPOUNDS AS A THERAPEUTIC MODALITY |
| WO2010060189A1 (en) | 2008-11-03 | 2010-06-03 | Newlab Clinical Research Inc. | Allele-allele interactions of mthfr gene variants, and uses thereof in predicting disease risk |
| WO2010138796A2 (en) | 2009-05-29 | 2010-12-02 | Genomind, Llc | Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis |
| CA2776173A1 (en) | 2009-09-30 | 2011-04-07 | Nicholas Marini | Cofactors and methods of use for individuals |
| WO2012128799A2 (en) * | 2010-12-03 | 2012-09-27 | General Hospital Corporation, The | Treating schizophrenia |
| KR20120092993A (ko) | 2011-02-14 | 2012-08-22 | 지엘팜텍 주식회사 | 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제 |
| BR112013024863A2 (pt) | 2011-03-28 | 2016-12-20 | Yissum Res Dev Co | formulação injetável de liberação sustentada |
| US20120329749A1 (en) | 2011-06-21 | 2012-12-27 | Stephen Albert Lonnie Smith | Methods Of Preventing Or Treating Disease States Related To Certain Metabolic Abnormalities |
| US20160058766A1 (en) * | 2011-11-14 | 2016-03-03 | Nestec S.A. | Assays and methods for selecting a treatment regimen for a subject with depression |
| KR102035877B1 (ko) | 2011-11-14 | 2019-10-23 | 알파시그마 에스.피.에이. | 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법 |
-
2012
- 2012-11-14 KR KR1020147016192A patent/KR102035877B1/ko not_active Expired - Fee Related
- 2012-11-14 MX MX2014005786A patent/MX354547B/es active IP Right Grant
- 2012-11-14 WO PCT/US2012/065084 patent/WO2013074676A2/en not_active Ceased
- 2012-11-14 BR BR112014011491A patent/BR112014011491A2/pt active Search and Examination
- 2012-11-14 RU RU2014124121A patent/RU2622082C2/ru active
- 2012-11-14 CA CA2855640A patent/CA2855640C/en active Active
- 2012-11-14 IN IN4226DEN2014 patent/IN2014DN04226A/en unknown
- 2012-11-14 AU AU2012340015A patent/AU2012340015B2/en not_active Ceased
- 2012-11-14 JP JP2014541420A patent/JP6285865B2/ja not_active Expired - Fee Related
- 2012-11-14 CN CN201280065415.6A patent/CN104053785A/zh active Pending
- 2012-11-14 EP EP12795214.1A patent/EP2780467B1/en active Active
-
2013
- 2013-03-07 US US13/789,075 patent/US9540691B2/en active Active
- 2013-03-12 US US13/796,362 patent/US9546401B2/en active Active
-
2014
- 2014-05-01 IL IL232407A patent/IL232407B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN104053785A (zh) | 2014-09-17 |
| IL232407A0 (en) | 2014-06-30 |
| HK1202590A1 (en) | 2015-10-02 |
| EP2780467B1 (en) | 2018-10-17 |
| KR20140100524A (ko) | 2014-08-14 |
| CA2855640C (en) | 2020-03-10 |
| IL232407B (en) | 2019-03-31 |
| RU2622082C2 (ru) | 2017-06-09 |
| US20130172361A1 (en) | 2013-07-04 |
| WO2013074676A3 (en) | 2013-08-15 |
| JP6285865B2 (ja) | 2018-02-28 |
| US20130267523A1 (en) | 2013-10-10 |
| JP2015508281A (ja) | 2015-03-19 |
| NZ624231A (en) | 2016-10-28 |
| US9540691B2 (en) | 2017-01-10 |
| MX354547B (es) | 2018-03-09 |
| AU2012340015A1 (en) | 2014-05-22 |
| BR112014011491A2 (pt) | 2017-05-09 |
| MX2014005786A (es) | 2014-08-27 |
| CA2855640A1 (en) | 2013-05-23 |
| US9546401B2 (en) | 2017-01-17 |
| KR102035877B1 (ko) | 2019-10-23 |
| EP2780467A2 (en) | 2014-09-24 |
| WO2013074676A2 (en) | 2013-05-23 |
| RU2014124121A (ru) | 2015-12-27 |
| AU2012340015B2 (en) | 2017-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014DN04226A (https=) | ||
| GB201317477D0 (en) | Methods, compositions and kits for determing the presence/absnece of a variant nucleic acid sequence | |
| MX350533B (es) | Biomarcadores de cancer pancreatico y usos de los mismos. | |
| MX373248B (es) | Prediccion de riesgo de evento cardiovascular y usos del mismo. | |
| MX364410B (es) | Metodo para detectar nucleosomas que contienen nucleotidos. | |
| BR112012011230A2 (pt) | fatores de risco e previsão de infarto do miocárdio | |
| MX2018007826A (es) | Tecnicas para predecir, detectar, y reducir la interferencia de proteinas no especificas en ensayos que implican dominios variables individuales de inmonoglobulina. | |
| WO2013009655A3 (en) | Uses of labeled hsp90 inhibitors | |
| PH12018550037A1 (en) | Quencher containing water-soluble polymer-conjugated nanomaterial and use thereof | |
| BRPI0919882A8 (pt) | Métodos para avaliar padrões de rna | |
| BRPI0816393A2 (pt) | Método para determinar o número de cópias relativo de uma sequência de polinucleotídeo alvo em um genoma de um indivíduo | |
| EP4249605A3 (en) | Methods for analyte detection | |
| WO2013177245A3 (en) | Nano46 genes and methods to predict breast cancer outcome | |
| EA201590630A1 (ru) | Способы лечения и диагностики, связанные с лизилоксидазоподобным белком 2 (loxl2) | |
| EA030186B9 (ru) | Способ проведения количественных анализов | |
| ATE504002T1 (de) | Erkennung und vorhersage von frühgeburten | |
| BR112014020213A2 (pt) | biomarcadores para o diagnóstico, o prognóstico, a avaliação e a estratificação de terapia de síncope | |
| MX360236B (es) | Uso de marcadores en el diagnostico y tratamiento de cancer de prostata. | |
| BRPI0519570A2 (pt) | mÉtodo de determinaÇço de faixa de dose de uma warfarina para um indivÍduo, kit para determinaÇço da faixa de dose de uma warfarina, oligonucleotÍdeo ou complemento do mesmo, e, arranjo de oligonucleotÍdeos | |
| WO2013106844A3 (en) | Methods and compositions for the treatment and diaginosis of pancreatic cancer | |
| BR122020012978A8 (pt) | Método de quantificação de um produto específico em uma reação de amplificação por corte e extensão (near) | |
| BR112012021411A2 (pt) | mutações braf que conferem resistência a inibidores braf. | |
| BR112012018545A2 (pt) | método de determinação e confirmação da presença de um hpv em uma amostra | |
| BR112017016752A2 (pt) | métodos para determinar o risco de recidiva de câncer de endométrio em um indivíduo, para predizer a recidiva em um indivíduo com câncer de endométrio, para orientar o tratamento em um indivíduo com câncer de endométrio, para detectar a instabilidade de microssatélites, e, para determinar subtipos de câncer | |
| EP2668288A2 (en) | Complex mirna sets as novel biomarkers for lung diseases |