IN2014CN02163A - - Google Patents

Info

Publication number
IN2014CN02163A
IN2014CN02163A IN2163CHN2014A IN2014CN02163A IN 2014CN02163 A IN2014CN02163 A IN 2014CN02163A IN 2163CHN2014 A IN2163CHN2014 A IN 2163CHN2014A IN 2014CN02163 A IN2014CN02163 A IN 2014CN02163A
Authority
IN
India
Prior art keywords
endos49
igg
mutant
endos
seq
Prior art date
Application number
Other languages
English (en)
Inventor
Mattias Collin
Maria Allhorn
Jonathan Sjögren
Original Assignee
Genovis Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genovis Ab filed Critical Genovis Ab
Publication of IN2014CN02163A publication Critical patent/IN2014CN02163A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56944Streptococcus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN2163CHN2014 2011-09-13 2012-09-12 IN2014CN02163A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201115841A GB201115841D0 (en) 2011-09-13 2011-09-13 Protein and method
PCT/EP2012/067841 WO2013037824A1 (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it

Publications (1)

Publication Number Publication Date
IN2014CN02163A true IN2014CN02163A (zh) 2015-05-29

Family

ID=44908522

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2163CHN2014 IN2014CN02163A (zh) 2011-09-13 2012-09-12

Country Status (20)

Country Link
US (1) US9493752B2 (zh)
EP (1) EP2756077B1 (zh)
JP (1) JP6076349B2 (zh)
KR (1) KR102001427B1 (zh)
CN (1) CN103946377B (zh)
AU (1) AU2012307461B2 (zh)
BR (1) BR112014005816A2 (zh)
CA (1) CA2848230C (zh)
DK (1) DK2756077T3 (zh)
EA (1) EA028490B8 (zh)
ES (1) ES2627334T3 (zh)
GB (2) GB201115841D0 (zh)
IL (1) IL231410A0 (zh)
IN (1) IN2014CN02163A (zh)
MX (1) MX347727B (zh)
PL (1) PL2756077T3 (zh)
PT (1) PT2756077T (zh)
SG (1) SG11201400505YA (zh)
WO (1) WO2013037824A1 (zh)
ZA (1) ZA201401840B (zh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002216863B8 (en) * 2000-12-21 2008-03-20 Id Biomedical Corporation Streptococcus pyogenes antigens and corresponding DNA fragments
HUE038285T2 (hu) 2012-10-23 2018-10-29 Synaffix Bv Módosított antitest, antitest-konjugátum és eljárás ezek elõállítására
EP3613468A1 (en) 2013-05-02 2020-02-26 Glykos Finland Oy Glycoprotein-toxic payload conjugates
WO2015057064A1 (en) 2013-10-14 2015-04-23 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
US20160235861A1 (en) 2013-10-14 2016-08-18 SynAffix. B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
CN105829543B (zh) 2013-10-14 2021-06-01 西纳福克斯股份有限公司 糖基改造的抗体、抗体-缀合物及其制备方法
EP2935608A1 (en) 2013-10-14 2015-10-28 SynAffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
GB201318490D0 (en) * 2013-10-18 2013-12-04 Genovis Ab Method
EP3925951A1 (en) 2014-01-24 2021-12-22 SynAffix B.V. Process for the cycloaddition of a(hetero)aryl 1,3-dipole compound with a (hetero)cycloalkyne
ES2785551T3 (es) 2014-06-30 2020-10-07 Glykos Finland Oy Derivado de sacárido de una carga útil tóxica y sus conjugados con anticuerpos
GB201413240D0 (en) * 2014-07-25 2014-09-10 Hansa Medical Ab Method
JP2017528124A (ja) 2014-08-04 2017-09-28 シンアフィックス ビー.ブイ. ベータ−(1,4)−n−アセチルガラクトサミニルトランスフェラーゼ又はその突然変異体を用いる糖タンパク質の改変方法
GB201502305D0 (en) 2015-02-12 2015-04-01 Hansa Medical Ab Protein
GB201502306D0 (en) * 2015-02-12 2015-04-01 Hansa Medical Ab Protein
WO2016170186A1 (en) 2015-04-23 2016-10-27 Synaffix B.V. PROCESS FOR THE MODIFICATION OF A GLYCOPROTEIN USING A GLYCOSYLTRANSFERASE THAT IS OR IS DERIVED FROM A β(1,4)-N-ACETYLGALACTOSAMINYLTRANSFERASE
CN109071630B (zh) * 2016-01-15 2022-05-31 马里兰大学帕克分校 作为糖苷合酶的Endo-S2突变体、制备方法以及用于糖蛋白的糖工程化的用途
CN109311951B (zh) 2016-02-04 2022-10-11 杰诺维斯公司 新型链球菌蛋白酶
AU2017315677B2 (en) * 2016-08-24 2021-03-11 Academia Sinica Endoglycosidase mutants for glycoprotein remodeling and methods of using it
AU2018272984B2 (en) 2017-05-26 2024-05-23 Genovis Ab Enzymes for glycan analysis
US20210228738A1 (en) 2017-07-17 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
CN112672764A (zh) 2018-06-19 2021-04-16 格莱科斯生物医药公司 结合物
CA3102155A1 (en) 2018-06-29 2020-01-02 Glykos Biomedical Oy Conjugates
US20230038373A1 (en) 2019-12-18 2023-02-09 Glykos Biomedical Oy Stabile conjugate
CN111044731B (zh) * 2019-12-19 2021-05-07 北京科技大学 脉冲温育免疫反应分离富集多肽药物中肽类杂质的方法
WO2021142199A1 (en) 2020-01-09 2021-07-15 Mersana Therapeutics, Inc. Site specific antibody-drug conjugates with peptide-containing linkers
WO2022057942A1 (zh) * 2020-09-21 2022-03-24 上海宝济药业有限公司 一种药物组合及其应用
BR112023013263A2 (pt) 2021-01-04 2023-12-12 Mersana Therapeutics Inc Conjugados anticorpo-fármaco alvejados a b7h4 e métodos de uso dos mesmos
EP4079848A1 (en) 2021-04-22 2022-10-26 Genovis Ab Immunoglobulin cleaving enzyme
CN115873833A (zh) * 2022-11-08 2023-03-31 上海泰昶生物技术有限公司 生产免疫球蛋白g降解酶的工程菌株和工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130228D0 (en) 2001-12-18 2002-02-06 Hansa Medica Ab Protein
GB0624874D0 (en) * 2006-12-13 2007-01-24 Hansa Medical Ab Treatment
WO2009033670A2 (en) * 2007-09-14 2009-03-19 Genovis Ab Method and kits for dissociating fcgamma-receptor-igg complexes and for igg purification and detection
GB0821100D0 (en) 2008-11-18 2008-12-24 Hansa Medical Ab Antibodies
US20120196310A1 (en) * 2009-10-02 2012-08-02 Christiane Jaeger A-fucosylation detection in antibodies

Also Published As

Publication number Publication date
KR20140081813A (ko) 2014-07-01
US9493752B2 (en) 2016-11-15
MX347727B (es) 2017-05-10
SG11201400505YA (en) 2014-04-28
EP2756077B1 (en) 2017-03-29
US20140302519A1 (en) 2014-10-09
PL2756077T3 (pl) 2017-09-29
DK2756077T3 (en) 2017-07-03
ZA201401840B (en) 2018-05-30
EA028490B8 (ru) 2018-01-31
MX2014002906A (es) 2014-10-17
GB201406321D0 (en) 2014-05-21
JP2014531205A (ja) 2014-11-27
ES2627334T3 (es) 2017-07-27
CN103946377B (zh) 2016-10-05
WO2013037824A1 (en) 2013-03-21
AU2012307461B2 (en) 2016-08-18
PT2756077T (pt) 2017-06-21
EP2756077A1 (en) 2014-07-23
NZ622172A (en) 2016-04-29
KR102001427B1 (ko) 2019-07-18
IL231410A0 (en) 2014-04-30
EA028490B1 (ru) 2017-11-30
CA2848230C (en) 2020-03-24
CA2848230A1 (en) 2013-03-21
BR112014005816A2 (pt) 2020-12-29
JP6076349B2 (ja) 2017-02-08
GB201115841D0 (en) 2011-10-26
EA201490447A1 (ru) 2014-09-30
CN103946377A (zh) 2014-07-23
GB2509284A (en) 2014-06-25
AU2012307461A1 (en) 2014-03-27

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