HUE038285T2 - Módosított antitest, antitest-konjugátum és eljárás ezek elõállítására - Google Patents

Módosított antitest, antitest-konjugátum és eljárás ezek elõállítására

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Publication number
HUE038285T2
HUE038285T2 HUE13786322A HUE13786322A HUE038285T2 HU E038285 T2 HUE038285 T2 HU E038285T2 HU E13786322 A HUE13786322 A HU E13786322A HU E13786322 A HUE13786322 A HU E13786322A HU E038285 T2 HUE038285 T2 HU E038285T2
Authority
HU
Hungary
Prior art keywords
antibody
conjugate
preparation
modified
modified antibody
Prior art date
Application number
HUE13786322A
Other languages
English (en)
Inventor
Delft Floris Louis Van
Geel Remon Van
Maria Antonia Wijdeven
Original Assignee
Synaffix Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50544942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE038285(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synaffix Bv filed Critical Synaffix Bv
Publication of HUE038285T2 publication Critical patent/HUE038285T2/hu

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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2911699T1 (en) * 2012-10-23 2018-04-30 Synaffix B.V. MODIFIED AGAINST, PROTITELO-KONJUGAT AND PROCESS FOR THEIR PREPARATION
CN105188766B (zh) 2013-03-15 2019-07-12 瑞泽恩制药公司 生物活性分子、其偶联物及治疗用途
US20160106860A1 (en) * 2013-05-02 2016-04-21 Glykos Finland Oy Conjugates of a glycoprotein or a glycan with a toxic payload
BR112016004023A2 (pt) 2013-08-26 2022-11-16 Regeneron Pharma Composição, métodos para preparar uma composição e para tratar uma doença, e, composto
CN105829543B (zh) * 2013-10-14 2021-06-01 西纳福克斯股份有限公司 糖基改造的抗体、抗体-缀合物及其制备方法
US10072096B2 (en) 2013-10-14 2018-09-11 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
US9987373B2 (en) 2013-10-14 2018-06-05 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
EP3097080A1 (en) 2014-01-24 2016-11-30 SynAffix B.V. Process for the cycloaddition of a halogenated 1,3-dipole compound with a (hetero)cycloalkyne
EP3925951A1 (en) 2014-01-24 2021-12-22 SynAffix B.V. Process for the cycloaddition of a(hetero)aryl 1,3-dipole compound with a (hetero)cycloalkyne
EP3129402A4 (en) 2014-04-08 2017-12-13 University Of Georgia Research Foundation, Inc. Site-specific antibody-drug glycoconjugates and methods
CA2954934C (en) 2014-06-30 2023-09-26 Glykos Finland Oy Drug derivative and conjugates
EP2974744A1 (en) 2014-07-16 2016-01-20 Stichting Katholieke Universiteit Strain-promoted oxidation controlled cycloaddition with high reaction rate
WO2016022027A1 (en) 2014-08-04 2016-02-11 Synaffix B.V. Process for the modification of a glycoprotein using a βeta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof
EP3598983A1 (en) * 2014-10-03 2020-01-29 Synaffix B.V. Sulfamide linker, conjugates thereof, and methods of preparation
EP4289483A3 (en) * 2014-12-04 2024-02-28 Celgene Corporation Biomolecule conjugates
JP6595600B2 (ja) * 2014-12-31 2019-10-23 ディヴェロップメント センター フォー バイオテクノロジー 糖タンパク質連鎖による部位特異的な複合体形成およびその方法
US11559581B2 (en) * 2015-01-09 2023-01-24 Oxford University Innovation Limited Antibody conjugates and methods of making the antibody conjugates
EP3273998B1 (en) 2015-03-27 2019-09-04 Regeneron Pharmaceuticals, Inc. Maytansinoid derivatives, conjugates thereof, and methods of use
NO3134520T3 (hu) 2015-04-23 2018-05-19
US10988508B2 (en) * 2015-04-24 2021-04-27 University Of Delaware Synthetic N-acetyl-muramic acid derivatives and uses thereof
MX2017017117A (es) 2015-07-06 2018-03-06 Regeneron Pharma Moleculas multiespecificas de union a antigenos y usos de estas.
CA2995145C (en) * 2015-08-26 2023-08-01 Vib Vzw Means and methods for monitoring inflammation
US11014953B2 (en) 2015-10-07 2021-05-25 The Board Of Trustees Of The University Of Illinois Trigger-activatable metabolic sugar precursors for cancer-selective labeling and targeting
TWI618697B (zh) 2015-11-03 2018-03-21 財團法人工業技術研究院 化合物、連接子-藥物、及配體-藥物耦合體
CA3007644A1 (en) 2015-12-11 2017-06-15 Regeneron Pharmaceuticals, Inc. Methods for reducing or preventing growth of tumors resistant to egfr and/or erbb3 blockade
MA43094B1 (fr) 2016-01-25 2020-10-28 Regeneron Pharma Dérivés de maytansinoïde, leurs conjugués, et procédés d'utilisation
AU2017212484C1 (en) * 2016-01-27 2020-11-05 Medimmune, Llc Methods for preparing antibodies with a defined glycosylation pattern
JP2017197512A (ja) * 2016-02-08 2017-11-02 シンアフィックス ビー.ブイ. Cd30腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法
US10874746B2 (en) 2016-02-08 2020-12-29 Synaffix B.V. Sulfamide linkers for use in bioconjugates
JP2017200902A (ja) * 2016-02-08 2017-11-09 シンアフィックス ビー.ブイ. Her2腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法
EP3414328B1 (en) 2016-02-08 2024-01-10 Synaffix B.V. Enzymes for trimming of glycoproteins
WO2017137457A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
JP2019507741A (ja) 2016-02-08 2019-03-22 シンアフィックス ビー.ブイ. 治療において使用するためのスルファミドリンカーを含むバイオコンジュゲート
EP3413915A1 (en) 2016-02-08 2018-12-19 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting her2 tumours and method for improving therapeutic index of antibody-conjugates
EP3413916A1 (en) 2016-02-08 2018-12-19 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
PE20231050A1 (es) 2016-03-02 2023-07-11 Eisai Randd Man Co Ltd Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso
EP3448891A1 (en) 2016-04-28 2019-03-06 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
JP7020403B2 (ja) * 2016-05-02 2022-02-16 味の素株式会社 アジド基含有Fcタンパク質
WO2017218891A1 (en) * 2016-06-17 2017-12-21 Life Technologies Corporation Site-specific crosslinking of antibodies
CN109641922A (zh) * 2016-06-28 2019-04-16 文塔纳医疗系统公司 点击化学用于ihc和ish测定中的信号扩增的应用
EP3480211A4 (en) * 2016-07-01 2019-12-25 Daiichi Sankyo Company, Limited HANP FC CONTAINING MOLECULAR CONJUGATE
WO2018002902A1 (en) 2016-07-01 2018-01-04 Glaxosmithkline Intellectual Property (No.2) Limited Antibody-drug conjugates and therapeutic methods using the same
CA3037732A1 (en) * 2016-09-23 2018-03-29 Regeneron Pharmaceuticals, Inc. Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US10711032B2 (en) 2016-11-08 2020-07-14 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
WO2018090045A1 (en) * 2016-11-14 2018-05-17 Cho Pharma Inc Antibody-drug conjugates
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
CA3048452C (en) * 2016-12-29 2021-06-15 Development Center For Biotechnology Processes for preparing glycoprotein-drug conjugates
WO2018141959A1 (en) 2017-02-06 2018-08-09 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
EP3595729A4 (en) 2017-02-10 2022-01-12 The Board of Trustees of the University of Illinois TRIGGER-ACTIVATED SUGAR CONJUGATES FOR CANCER SELECTIVE LABELING AND TARGETING
WO2018206734A1 (en) 2017-05-11 2018-11-15 Vib Vzw Glycosylation of variable immunoglobulin domains
MA47392B1 (fr) 2017-05-18 2021-09-30 Regeneron Pharma Bis-octahydrophénanthrène carboxamides et leurs conjugués protéiques
AU2018270784B2 (en) 2017-05-18 2024-05-16 Regeneron Pharmaceuticals, Inc. Cyclodextrin protein drug conjugates
JP7218351B2 (ja) 2017-08-09 2023-02-06 ヘルムホルツ-ツェントルン フュル インフェクティオンスフォルシュング ゲゼルシャフト ミット ベシュレンクテル ハフツング 新たな標的化された細胞傷害性ラトジャドン誘導体及びそのコンジュゲート
ES2803350T3 (es) * 2017-08-11 2021-01-26 Life Science Inkubator Sachsen Gmbh & Co Kg Novedosos conjugados de anticuerpos adecuados para su uso en inmunoensayos aislados de desplazamiento de la inactivación de la fluorescencia
KR20200061376A (ko) 2017-09-29 2020-06-02 다이이찌 산쿄 가부시키가이샤 항체-피롤로벤조디아제핀 유도체 콘쥬게이트
CA3080857A1 (en) 2017-11-07 2019-05-16 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
JP7165193B2 (ja) 2017-11-27 2022-11-02 パーデュー、ファーマ、リミテッド、パートナーシップ ヒト組織因子を標的とするヒト化抗体
EP3720504A1 (en) 2017-12-06 2020-10-14 Synaffix B.V. Enediyne conjugates
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
SG11202006510XA (en) 2018-01-08 2020-08-28 Regeneron Pharma Steroids and antibody-conjugates thereof
JP7328990B2 (ja) 2018-04-30 2023-08-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Her2及び/またはaplp2に結合する抗体及び二重特異性抗原結合分子、ならびにそれらのコンジュゲート及び使用
KR20210008008A (ko) 2018-05-09 2021-01-20 리제너론 파마슈티칼스 인코포레이티드 항-msr1 항체 및 이의 사용 방법
US20210079109A1 (en) 2018-05-17 2021-03-18 Regeneron Pharmaceuticals, Inc. Anti-cd63 antibodies, conjugates, and uses thereof
JP2019206491A (ja) * 2018-05-29 2019-12-05 国立研究開発法人理化学研究所 乳がんまたは胃がんの治療のための抗体−薬物複合体
EP3806905B1 (en) 2018-06-15 2024-08-07 Shanghai Miracogen Inc. Methods and materials for treating cancer
US11911484B2 (en) * 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
EP3830259A4 (en) 2018-08-02 2022-05-04 Dyne Therapeutics, Inc. MUSCLE TARGETING COMPLEXES AND THEIR USES FOR THE TREATMENT OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
SG11202100931QA (en) * 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle-targeting complexes and uses thereof
US12097263B2 (en) 2018-08-02 2024-09-24 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
EP3829595A4 (en) 2018-08-02 2022-08-24 Dyne Therapeutics, Inc. MUSCLE TARGETING COMPLEXES AND THEIR USES FOR THE TREATMENT OF DYSTROPHINOPATHIES
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
EP3876998A1 (en) 2018-11-05 2021-09-15 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing trop-2
EA202191430A1 (ru) 2018-11-20 2021-11-29 Регенерон Фармасьютикалз, Инк. Производные бис-октагидрофенантренкарбоксамида и их белковые конъюгаты
WO2020132483A1 (en) 2018-12-21 2020-06-25 Regeneron Pharmaceuticals, Inc. Rifamycin analogs and antibody-drug conjugates thereof
CN118027137A (zh) 2018-12-21 2024-05-14 里珍纳龙药品有限公司 微管溶素及蛋白质-微管溶素偶联物
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
CA3122321A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Galectin-3 inhibiting c-glycosides
SG11202107212QA (en) 2019-01-08 2021-07-29 Regeneron Pharma Traceless linkers and protein-conjugates thereof
GB201901608D0 (en) 2019-02-06 2019-03-27 Vib Vzw Vaccine adjuvant conjugates
US20220040319A1 (en) 2019-02-21 2022-02-10 Regeneron Pharmaceuticals, Inc. Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met
CA3134403A1 (en) * 2019-03-25 2020-10-01 Daiichi Sankyo Company, Limited Anti-her2 antibody-pyrrolobenzodiazepine derivative conjugate
EP3950061A4 (en) * 2019-03-25 2022-11-16 Daiichi Sankyo Company, Limited ANTIBODY PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE
EP3949988A4 (en) 2019-03-27 2022-11-16 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DERIVATIVE CONJUGATE OF PYRROLOBENZODIAZEPINE AND A PARP INHIBITOR
WO2020245229A1 (en) 2019-06-03 2020-12-10 Synaffix B.V. Acetal-based cleavable linkers
MX2022002886A (es) 2019-09-16 2022-04-06 Regeneron Pharma Proteinas de union met radiomarcadas para la obtencion de imagenes por inmuno-pet.
US11814428B2 (en) 2019-09-19 2023-11-14 Regeneron Pharmaceuticals, Inc. Anti-PTCRA antibody-drug conjugates and uses thereof
WO2021056754A1 (zh) * 2019-09-29 2021-04-01 烟台迈百瑞国际生物医药股份有限公司 一种酸法制备抗体药物偶联物中间体的方法及其应用
GB201918279D0 (en) 2019-12-12 2020-01-29 Vib Vzw Glycosylated single chain immunoglobulin domains
US11786605B2 (en) * 2020-01-09 2023-10-17 Mersana Therapeutics, Inc. Site specific antibody-drug conjugates with peptide-containing linkers
EP4090376A1 (en) 2020-01-13 2022-11-23 Synaffix B.V. Via cycloaddition bilaterally functionalized antibodies
CN115768483A (zh) 2020-01-13 2023-03-07 西纳福克斯股份有限公司 抗体与免疫细胞衔接器的缀合物
EP4090379A1 (en) 2020-01-13 2022-11-23 Synaffix B.V. Via cycloaddition bilaterally functionalized antibodies
CN115348874A (zh) 2020-01-24 2022-11-15 里珍纳龙药品有限公司 蛋白质-抗病毒化合物偶联物
IL295312A (en) 2020-02-28 2022-10-01 Regeneron Pharma Bispecific antigen binding molecules that bind her2 and methods of using them
WO2021211984A1 (en) 2020-04-16 2021-10-21 Regeneron Pharmaceuticals, Inc. Diels-alder conjugation methods
US20230183347A1 (en) 2020-05-25 2023-06-15 Foundation For Biomedical Research And Innovation At Kobe PD-1 Agonist-Containing Pharmaceutical Composition for Treating or PReventing TH2-Mediated Disease
CN111560078A (zh) * 2020-06-19 2020-08-21 联宁(苏州)生物制药有限公司 具有马来酰亚胺接头的双臂中间体及其合成方法
CN115867563A (zh) 2020-06-24 2023-03-28 里珍纳龙药品有限公司 微管溶素及蛋白质-微管溶素偶联物
EP4172141A1 (en) 2020-06-26 2023-05-03 Synaffix B.V. Methods for the preparation of linker payload constructs
WO2022015656A1 (en) 2020-07-13 2022-01-20 Regeneron Pharmaceuticals, Inc. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use
NL2026400B1 (en) 2020-09-02 2022-05-04 Synaffix Bv Methods for the preparation of bioconjugates
MX2023002974A (es) 2020-09-14 2023-05-25 Regeneron Pharma Conjugados de anticuerpo-farmaco que comprenden peptidomimeticos glp1 y usos de los mismos.
EP4213885A1 (en) 2020-09-15 2023-07-26 Synaffix B.V. Antibody-exatecan conjugates
MX2023004395A (es) 2020-10-16 2023-05-22 Univ Georgia Glicoconjugados.
US20230372528A1 (en) 2020-10-16 2023-11-23 University Of Georgia Research Foundation, Inc. Glycoconjugates
CA3190569A1 (en) 2020-10-22 2022-04-28 Christopher Daly Anti-fgfr2 antibodies and methods of use thereof
NL2026947B1 (en) 2020-11-20 2022-07-01 Synaffix Bv Tyrosine-based antibody conjugates
EP4267195A1 (en) 2020-12-24 2023-11-01 Synaffix B.V. Glycan-conjugated antibodies binding to fc-gamma receptor
EP4288108A1 (en) 2021-02-08 2023-12-13 Synaffix B.V. Multifunctional antibodies
TW202304524A (zh) 2021-04-10 2023-02-01 美商普方生物製藥美國公司 Folr1結合劑、其結合物及使用方法
CA3216459A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
US11648318B2 (en) 2021-07-09 2023-05-16 Dyne Therapeutics, Inc. Anti-transferrin receptor (TFR) antibody and uses thereof
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
EP4376895A2 (en) 2021-07-28 2024-06-05 Regeneron Pharmaceuticals, Inc. Protein-antiviral compound conjugates
CN118119633A (zh) * 2021-10-20 2024-05-31 岩唐生物科技(杭州)有限责任公司 位点特异性糖蛋白偶联物及其制备方法
CA3235096A1 (en) 2021-11-17 2023-05-25 Disc Medicine, Inc. Methods for treating anemia of kidney disease
US20230414775A1 (en) 2021-12-29 2023-12-28 Regeneron Pharmaceuticals, Inc. Tubulysins and protein-tubulysin conjugates
US20230287138A1 (en) 2022-01-12 2023-09-14 Regneron Pharmaceuticals, Inc. Protein-drug conjugates comprising camptothecin analogs and methods of use thereof
US20230277682A1 (en) 2022-01-14 2023-09-07 Regeneron Pharmaceuticals, Inc. Verrucarin a derivatives and antibody drug conjugates thereof
CN118541380A (zh) * 2022-01-27 2024-08-23 岩唐生物科技(杭州)有限责任公司 具有多种载荷的蛋白偶联物及其制备方法
WO2023161296A1 (en) * 2022-02-22 2023-08-31 Adc Therapeutics Sa Conjugation method involving a transglutaminase at the fc region comprising a trimmed n-glycan
US20230330254A1 (en) 2022-03-11 2023-10-19 Regeneron Pharmaceuticals, Inc. Anti-glp1r antibody-tethered drug conjugates comprising glp1 peptidomimetics and uses thereof
IL315207A (en) 2022-03-23 2024-10-01 Synaffix B V Antibody pairs for targeting TROP-2 expressing tumors
AU2023237620A1 (en) 2022-03-23 2024-08-29 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen
WO2023180490A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing nectin-4
WO2023180484A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing ptk7
AU2023254846A1 (en) 2022-04-15 2024-10-10 Dyne Therapeutics, Inc. Muscle targeting complexes and formulations for treating myotonic dystrophy
EP4285934A1 (en) 2022-05-30 2023-12-06 CER Groupe Modified trimannose-oligosacharides, bisected n-glycans comprising said trimannose core and method for obtaining them
US20240218011A1 (en) 2022-07-21 2024-07-04 Firefly Bio, Inc. Glucocorticoid receptor agonists and conjugates thereof
WO2024038065A1 (en) 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof
EP4344707A1 (en) 2022-09-29 2024-04-03 Emergence Therapeutics AG New anti-nectin-4 antibody drug conjugates
WO2024118785A2 (en) 2022-11-30 2024-06-06 Regeneron Pharmaceuticals, Inc. Tlr7 agonists and antibody-drug-conjugates thereof
WO2024121123A1 (en) 2022-12-06 2024-06-13 Synaffix B.V. Synthesis of endo-bicyclononene
US20240269308A1 (en) 2022-12-21 2024-08-15 Regeneron Pharmaceuticals, Inc. Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof
WO2024134403A1 (en) * 2022-12-22 2024-06-27 Janssen Research & Development, Llc Methods of preparing antibody-polynucleotide conjugates
EP4389152A1 (en) 2022-12-23 2024-06-26 Synaffix B.V. Conjugates of pbd prodrugs
WO2024150074A2 (en) 2023-01-13 2024-07-18 Takeda Pharmaceutical Company Limited Coronavirus antibodies and therapeutic uses thereof
EP4410313A1 (en) 2023-01-31 2024-08-07 Synaffix B.V. Homogeneous antibody-conjugates with high payload loading
WO2024168199A1 (en) 2023-02-09 2024-08-15 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates via inverse electron demand diels-alder reactions
WO2024182714A1 (en) 2023-03-02 2024-09-06 Alloy Therapeutics, Inc. Anti-cd22 antibodies and uses thereof
WO2024199432A1 (en) * 2023-03-30 2024-10-03 Genequantum Healthcare (Suzhou) Co., Ltd. Site-speicfic orthogonal bioconjugate modality and application thereof
EP4450093A1 (en) 2023-04-17 2024-10-23 Synaffix B.V. Cleavable immune cell engagers
EP4450489A1 (en) 2023-04-18 2024-10-23 Synaffix B.V. Stable 4-isoxazoline conjugates

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20011671A (fi) 2001-08-20 2003-02-21 Carbion Oy Tuumorispesifiset oligosakkaridisekvenssit ja niiden käyttö
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
EP1587919A4 (en) * 2003-01-10 2006-10-11 Us Gov Health & Human Serv CATALYTIC DOMAINS OF BETA / 1,4) -GALACTOSYLTRANSFERASE I WITH CHANGED DONOR AND ACCEPTOR SPECIFICATIONS, THE IN-VITRO-PROTEIN FILLING PROMOTING DOMAINS, AND METHODS FOR THEIR USE
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
JP2007521047A (ja) 2003-10-29 2007-08-02 ビーエスエヌ メディカル,インク. 医療用包帯製品
US7332355B2 (en) * 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
US20070258986A1 (en) * 2003-11-19 2007-11-08 Govt of the US as represented by the secretary, Targeted Delivery System for Bioactive Agents
JP4521490B2 (ja) * 2003-11-21 2010-08-11 国立大学法人高知大学 類似パターン検索装置、類似パターン検索方法、類似パターン検索プログラム、および分画分離装置
WO2005056783A1 (en) * 2003-12-05 2005-06-23 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Catalytic domains of beta(1,4)-galactosyltransferase i having altered metal ion specificity
JP5064037B2 (ja) * 2004-02-23 2012-10-31 ジェネンテック, インコーポレイテッド 複素環式自壊的リンカーおよび結合体
US8431558B2 (en) 2004-11-01 2013-04-30 The Regents Of The University Of California Compositions and methods for modification of biomolecules
US20070249014A1 (en) 2006-02-10 2007-10-25 Invitrogen Corporation Labeling and detection of post translationally modified proteins
JP2009531289A (ja) * 2006-02-10 2009-09-03 ライフ テクノロジーズ コーポレーション オリゴ糖によるタンパク質の修飾及び標識方法
WO2007133855A2 (en) * 2006-03-27 2007-11-22 University Of Maryland Biotechnology Institute Glycoprotein synthesis and remodeling by enzymatic transglycosylation
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
WO2008143944A2 (en) 2007-05-14 2008-11-27 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Methods of glycosylation and bioconjugation
WO2009025646A1 (en) 2007-08-22 2009-02-26 Government Of The U.S.A, As Represented By The Secretary, Department Of Health & Human Services Alpha 1-3 n-galactosyltransferase with altered donor specificities
WO2009025645A1 (en) * 2007-08-22 2009-02-26 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
DK2907525T3 (en) 2007-11-21 2018-08-06 Univ Georgia DIBENZOCYCLOOCTEN COMPOUNDS FOR BIOORTHOGONAL TRANSMISSIONS
WO2009102820A2 (en) * 2008-02-11 2009-08-20 Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services Modified sugar substrates and methods of use
US7914904B2 (en) * 2008-03-25 2011-03-29 General Electric Company Component in a combustion system, and process for preventing slag, ash, and char buildup
US8519122B2 (en) 2010-02-12 2013-08-27 The Regents Of The University Of California Compositions and methods for modification of biomolecules
WO2011136645A1 (en) 2010-04-27 2011-11-03 Stichting Katholieke Universiteit, More Particularly Radboud University Nijmegen Fused cyclooctyne compounds and their use in metal-free click reactions
WO2012121973A1 (en) 2011-03-04 2012-09-13 Life Technologies Corporation Compounds and methods for conjugation of biomolecules
US9145361B2 (en) 2011-03-25 2015-09-29 Life Technologies Corporation SDP-containing heterobifunctional agents
SI2694111T1 (sl) * 2011-04-01 2016-10-28 Wyeth Llc Konjugati protitelo-zdravilo
GB201115841D0 (en) 2011-09-13 2011-10-26 Genovis Ab Protein and method
SI2911699T1 (en) * 2012-10-23 2018-04-30 Synaffix B.V. MODIFIED AGAINST, PROTITELO-KONJUGAT AND PROCESS FOR THEIR PREPARATION

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