IN2012DN02358A - - Google Patents

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Publication number
IN2012DN02358A
IN2012DN02358A IN2358DEN2012A IN2012DN02358A IN 2012DN02358 A IN2012DN02358 A IN 2012DN02358A IN 2358DEN2012 A IN2358DEN2012 A IN 2358DEN2012A IN 2012DN02358 A IN2012DN02358 A IN 2012DN02358A
Authority
IN
India
Prior art keywords
silk
active agents
microparticles
present
compositions
Prior art date
Application number
Other languages
English (en)
Inventor
Xiaoqin Wang
David L Kaplan
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Publication of IN2012DN02358A publication Critical patent/IN2012DN02358A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5052Proteins, e.g. albumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
IN2358DEN2012 2009-09-29 2010-09-29 IN2012DN02358A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24667609P 2009-09-29 2009-09-29
PCT/US2010/050698 WO2011041395A2 (fr) 2009-09-29 2010-09-29 Nanosphères et microsphères de soie et leurs procédés de fabrication

Publications (1)

Publication Number Publication Date
IN2012DN02358A true IN2012DN02358A (fr) 2015-08-21

Family

ID=43826861

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2358DEN2012 IN2012DN02358A (fr) 2009-09-29 2010-09-29

Country Status (7)

Country Link
US (2) US8715740B2 (fr)
EP (1) EP2483199B1 (fr)
JP (1) JP5730317B2 (fr)
CA (1) CA2774643A1 (fr)
IL (1) IL218654A (fr)
IN (1) IN2012DN02358A (fr)
WO (1) WO2011041395A2 (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6092337A (ja) * 1983-10-26 1985-05-23 Sekisui Plastics Co Ltd 発泡フエノ−ル樹脂成形物の製造方法
EP2650907A3 (fr) 2004-06-04 2014-10-08 The Board of Trustees of the University of Illinois Procédés et dispositifs permettant de fabriquer et d'assembler des éléments à semiconducteur imprimables
JP2010509645A (ja) 2006-11-03 2010-03-25 トラスティーズ オブ タフツ カレッジ ナノパターンが形成されたバイオポリマー光学デバイスおよびその製造方法
WO2008127402A2 (fr) 2006-11-03 2008-10-23 Trustees Of Tufts College Capteur de biopolymère et procédé de fabrication de celui-ci
WO2008140562A2 (fr) * 2006-11-03 2008-11-20 Trustees Of Tufts College Dispositifs optiques et électro-optiques à biopolymère électroactif et leur procédé de fabrication
WO2010042653A1 (fr) 2008-10-07 2010-04-15 Mc10, Inc. Ballonnet de cathéter comportant un circuit intégré étirable et un réseau de détecteurs
US8389862B2 (en) 2008-10-07 2013-03-05 Mc10, Inc. Extremely stretchable electronics
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
JP2013506058A (ja) 2009-09-28 2013-02-21 タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ 延伸したシルクegel繊維およびその製造方法
CA2774643A1 (fr) * 2009-09-29 2011-04-07 Trustees Of Tufts College Nanospheres et microspheres de soie et leurs procedes de fabrication
WO2011041727A1 (fr) 2009-10-01 2011-04-07 Mc10, Inc. Boîtiers protecteurs avec des circuits électroniques intégrés
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
JP6046491B2 (ja) 2009-12-16 2016-12-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ コンフォーマル電子機器を使用した生体内での電気生理学
US8666471B2 (en) 2010-03-17 2014-03-04 The Board Of Trustees Of The University Of Illinois Implantable biomedical devices on bioresorbable substrates
JP2013542181A (ja) 2010-09-03 2013-11-21 タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ プラズモンナノ粒子ドープ絹材料
CA2833879C (fr) * 2011-04-21 2023-03-14 David L. Kaplan Compositions et procedes de stabilisation de principes actifs
US9765934B2 (en) 2011-05-16 2017-09-19 The Board Of Trustees Of The University Of Illinois Thermally managed LED arrays assembled by printing
WO2012166686A2 (fr) 2011-05-27 2012-12-06 Mc10, Inc. Appareil électronique, optique et/ou mécanique et systèmes et procédés pour le fabriquer
WO2012167096A2 (fr) 2011-06-03 2012-12-06 The Board Of Trustees Of The University Of Illinois Réseau d'électrodes de surface conformables, multiplexées de manière active et à haute densité, pour un interfaçage avec le cerveau
CN102344686A (zh) * 2011-08-02 2012-02-08 北京汇亨创管理咨询有限公司 一种以聚乙烯醇为稳定剂的丝素蛋白纳米颗粒的制备方法
KR101979354B1 (ko) 2011-12-01 2019-08-29 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 프로그램 변형을 실행하도록 설계된 과도 장치
EP3884931A3 (fr) 2012-02-06 2021-12-01 Children's Medical Center, Corp. Biomatériau multicouche pour la régénération tissulaire et la cicatrisation de plaies
CA2867464A1 (fr) 2012-03-20 2013-09-26 Trustees Of Tufts College Reservoirs de soie pour l'administration de medicaments
US9554484B2 (en) 2012-03-30 2017-01-24 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces
WO2013152265A1 (fr) 2012-04-06 2013-10-10 Trustees Of Tufts College Procédés de production et d'utilisation de microfibres de soie
WO2014021954A2 (fr) * 2012-04-13 2014-02-06 Trustees Of Tufts College Matières à base de fibroïne de soie magnéto-sensible
WO2013155404A1 (fr) * 2012-04-13 2013-10-17 Trustees Of Tufts College Procédés et compositions destinés à la préparation d'une microsphère en soie
EP2841108A4 (fr) * 2012-04-25 2015-11-25 Tufts College Microsphères de soie et procédés de lubrification de surface
EP2872115A4 (fr) * 2012-07-13 2016-04-06 Univ Tufts Encapsulation de phases non miscibles dans des biomatières de fibroïne de soie
WO2014012101A1 (fr) 2012-07-13 2014-01-16 Trustees Of Tufts College Compactage de poudre de soie pour fabrication de constructions à résistance mécanique et rigidité élevées
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
ES2935659T3 (es) 2013-03-15 2023-03-09 Tufts College Composiciones de seda de bajo peso molecular y composiciones de seda estabilizadoras
WO2014176458A2 (fr) 2013-04-24 2014-10-30 Trustees Of Tufts College Dispositifs pour anastomose en biopolymère biorésorbable
EP3016634A2 (fr) * 2013-07-05 2016-05-11 Therakine Biodelivery GmbH Composition d'administration de médicament pour applications topiques et injections et formulations ophtalmiques, procédés de fabrication associés et procédés d'administration d'une composition d'administration de médicament
WO2015009246A1 (fr) * 2013-07-19 2015-01-22 National University Of Singapore Dispositif d'augmentation d'interface tissulaire pour reconstruction ligamentaire/tendineuse
WO2015048527A1 (fr) * 2013-09-27 2015-04-02 Tufts University Hydrogels de soie optiquement transparents
WO2015048433A1 (fr) * 2013-09-27 2015-04-02 Tufts University Synthèse de sphères de taille micronique et submicronique de fibroïne de soie au moyen d'un procédé à écoulement descendant
MX2016003961A (es) 2013-09-30 2018-02-19 Silk Therapeutics Inc Composiciones de fragmentos de proteinas de seda y articulos fabricados a partir de las mismas.
JP6135486B2 (ja) * 2013-12-06 2017-05-31 豊田合成株式会社 樹脂成形体
CN107405277B (zh) 2014-12-02 2021-08-10 丝绸医疗公司 丝性能服装和产品及其制备方法
WO2016115159A1 (fr) * 2015-01-12 2016-07-21 Silk Therapeutics, Inc. Compositions de fragment de protéine de soie conservées et articles
WO2016196673A1 (fr) 2015-06-01 2016-12-08 The Board Of Trustees Of The University Of Illinois Approche alternative de détection d'uv
KR20180033468A (ko) 2015-06-01 2018-04-03 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 무선 전력 및 근거리 통신기능을 갖는 소형화된 전자 시스템
US11512425B2 (en) 2015-07-14 2022-11-29 Evolved By Nature, Inc. Silk performance apparel and products and methods of preparing the same
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
CN105297289B (zh) * 2015-12-07 2017-10-31 清华大学深圳研究生院 一种丝素蛋白储能调温纤维膜制备方法
CN105963275B (zh) * 2016-05-31 2019-05-17 中国医学科学院生物医学工程研究所 壳层可控的丝素蛋白微囊及制备方法
US11413319B2 (en) 2016-06-23 2022-08-16 Phagelux (Canada) Inc. Microencapsulation of bacteriophages and related products
EP3474898A4 (fr) 2016-06-23 2020-04-15 Phagelux (Canada) Inc. Micro-encapsulation de bactériophages et de produits associés
US11248313B2 (en) 2016-08-01 2022-02-15 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
US11617815B2 (en) 2016-10-31 2023-04-04 Sofregen Medical, Inc. Compositions comprising silk fibroin particles and uses thereof
KR101957013B1 (ko) * 2017-04-04 2019-03-11 서울대학교산학협력단 골 형성 단백질을 포함하는 약물 전달체 및 그 제조 방법
US11390988B2 (en) 2017-09-27 2022-07-19 Evolved By Nature, Inc. Silk coated fabrics and products and methods of preparing the same
US11794161B1 (en) 2018-11-21 2023-10-24 Trucapsol, Llc Reduced permeability microcapsules
US11571674B1 (en) 2019-03-28 2023-02-07 Trucapsol Llc Environmentally biodegradable microcapsules
US11542392B1 (en) 2019-04-18 2023-01-03 Trucapsol Llc Multifunctional particle additive for enhancement of toughness and degradation in biodegradable polymers
CN110327307B (zh) * 2019-06-26 2020-06-23 浙江大学 一种丝素载药纳米微囊的制备方法及产品
CN110483830B (zh) * 2019-07-31 2021-08-17 武汉纺织大学 超轻高弹丝素微纳米纤维气凝胶及其制备方法与应用
WO2021076798A1 (fr) 2019-10-15 2021-04-22 Sofregen Medical, Inc. Dispositifs de distribution pour l'administration et procédés de distribution de compositions
US11484857B2 (en) 2020-01-30 2022-11-01 Trucapsol Llc Environmentally biodegradable microcapsules
CN111454468B (zh) * 2020-03-27 2021-04-20 西安交通大学 一种形状可控的智能响应微球及其制备方法
EP4188417A1 (fr) * 2020-07-28 2023-06-07 University of Georgia Research Foundation, Inc. Nanoparticules de soie antimicrobiennes et leurs procédés de fabrication et méthodes d'utilisation
US11878280B2 (en) 2022-04-19 2024-01-23 Trucapsol Llc Microcapsules comprising natural materials
CN115414533B (zh) * 2022-09-20 2024-02-23 中国人民解放军总医院第一医学中心 一种模拟膀胱壁生理结构的组织工程支架及其制备方法
US11904288B1 (en) 2023-02-13 2024-02-20 Trucapsol Llc Environmentally biodegradable microcapsules

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE380083A (fr) 1929-12-23
US3424164A (en) 1966-05-20 1969-01-28 Ethicon Inc Silk suture
JPS5838449B2 (ja) 1979-04-17 1983-08-23 カネボウ株式会社 微粉末状絹フィプロインの製造法
JPS56166235A (en) 1980-05-24 1981-12-21 Kanebo Ltd Hydrophilic porous body and its preparation
JPS5838449A (ja) 1981-08-31 1983-03-05 Matsushita Electronics Corp 高圧ナトリウムランプ装置
JPS60142259A (ja) 1983-12-29 1985-07-27 Kanebo Ltd 固定化抗体
JPS60259677A (ja) 1984-05-31 1985-12-21 水島 繁三郎 動物蛋白吸着再生繊維からなる原糸、織物、編物及びその製造方法
CA1340581C (fr) 1986-11-20 1999-06-08 Joseph P. Vacanti Neomorphogenese chimerique d'organes par implatation cellulaire controlee, utilisant des matrices artificielles
JPS63190604A (ja) 1987-02-03 1988-08-08 Agency Of Ind Science & Technol 新規の水−アルコ−ル分離膜
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
JPH0694518B2 (ja) 1987-11-02 1994-11-24 工業技術院長 絹フィブロイン多孔質体の製造方法
GB8800078D0 (en) 1988-01-05 1988-02-10 Ciba Geigy Ag Novel antibodies
JPH0669485B2 (ja) * 1988-10-19 1994-09-07 住江織物株式会社 シルクフィブロイン含有成形物
US5290494A (en) 1990-03-05 1994-03-01 Board Of Regents, The University Of Texas System Process of making a resorbable implantation device
US5989894A (en) 1990-04-20 1999-11-23 University Of Wyoming Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA
JPH04263611A (ja) 1991-02-16 1992-09-18 Pola Chem Ind Inc 水不溶性固形フィブロイン成形物及びその製造法
JPH06346314A (ja) 1993-06-02 1994-12-20 Toyobo Co Ltd 再生絹フィブロイン繊維およびその製造方法
JPH08295697A (ja) 1995-04-26 1996-11-12 Kanebo Ltd 高濃度絹フィブロイン水溶液の製造方法
JPH1036676A (ja) 1996-07-26 1998-02-10 Kanebo Ltd タンパク質水溶液の濃縮方法
JP2990239B2 (ja) 1997-06-18 1999-12-13 農林水産省蚕糸・昆虫農業技術研究所長 絹フィブロインおよび絹セリシンを主成分とする創傷被覆材並びにその製造方法
WO1999001089A1 (fr) 1997-07-01 1999-01-14 Brown University Research Foundation Dispositifs prothetiques implantables enrobes de molecules bioactives
US6123819A (en) 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
US5994099A (en) 1997-12-31 1999-11-30 The University Of Wyoming Extremely elastic spider silk protein and DNA coding therefor
US6110590A (en) 1998-04-15 2000-08-29 The University Of Akron Synthetically spun silk nanofibers and a process for making the same
US6196358B1 (en) 1998-07-08 2001-03-06 Shimano Inc. Detachable fluid cooling system for bicycle disc brake
US20030007991A1 (en) 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US6592623B1 (en) 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
JP3151665B2 (ja) 1999-03-23 2001-04-03 農林水産省蚕糸・昆虫農業技術研究所長 生体高分子/ポリアリルアミン複合体およびその製造方法
WO2001036531A1 (fr) 1999-11-15 2001-05-25 Zaidan-Houjin Ueda Sen-I Kagaku Shinkoukai Materiau polymere moleculairement composite en fibroine/cellulose et procede de production de ce materiau
JP2003521350A (ja) 2000-02-03 2003-07-15 ネクシア バイオテクノロジーズ, インコーポレイテッド クモの糸を含む外科用縫合糸
IT1316885B1 (it) 2000-10-02 2003-05-13 Consorzio Per Gli Studi Uni Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta.
JP2002128691A (ja) 2000-10-24 2002-05-09 National Institute Of Agrobiological Sciences セリシン含有素材、その製造方法およびその使用方法
JPWO2002072931A1 (ja) 2001-03-14 2004-07-02 東京農工大学長 絹及び絹様材料の繊維及びフィルムの製造方法
ITVR20010098A1 (it) 2001-09-11 2003-03-11 Consorzio Per Gli Studi Uni Procedimento per l'ottenimento di idrogeli di fibroina di seta.
EP1461605A4 (fr) 2001-10-02 2009-10-21 Univ Northwestern Nanoreseaux de proteines et de peptides
GB0126118D0 (en) 2001-10-31 2002-01-02 Vollrath Friedrich W L Precursor feedstock for forming filaments
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
AU2002365734A1 (en) 2001-12-07 2003-06-17 Lumileds Lighting U.S., Llc Compact lighting system and display device
JP3803962B2 (ja) 2001-12-28 2006-08-02 独立行政法人科学技術振興機構 絹タンパク質フィルムとその製造方法
US7057023B2 (en) 2002-01-11 2006-06-06 Nexia Biotechnologies Inc. Methods and apparatus for spinning spider silk protein
JP3772207B2 (ja) 2002-06-19 2006-05-10 独立行政法人農業生物資源研究所 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材
JP4638735B2 (ja) 2002-06-24 2011-02-23 タフツ ユニバーシティー 絹糸生体材料およびその使用方法
JP4800622B2 (ja) 2002-11-01 2011-10-26 トラスティーズ オブ タフツ カレッジ テンプレート化した天然絹スメクティックゲル
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
EP1613796B1 (fr) 2003-04-10 2017-03-22 Tufts University Solution aqueuse concentree de fibroine et utilisation
WO2005000483A1 (fr) 2003-06-06 2005-01-06 Tufts University Procede de formation d'enrobages inorganiques
WO2005123114A2 (fr) 2004-06-11 2005-12-29 Trustees Of Tufts College Systeme d'administration de medicament a base de soie
WO2006076711A2 (fr) 2005-01-14 2006-07-20 Trustees Of Tufts College Proteines hybrides fibreuses et leur utilisation dans la formation de matieres composites organiques/anorganiques de pointe
US9290579B2 (en) 2005-04-20 2016-03-22 Trustees Of Tufts College Covalently immobilized protein gradients in three-dimensional porous scaffolds
CA2645934C (fr) 2005-08-02 2014-04-29 Trustees Of Tufts College Procedes de depot progressif de revetements de fibroine
GB0516846D0 (en) 2005-08-17 2005-09-21 Knight David P Meniscal repair device
DE102005043609A1 (de) 2005-09-13 2007-03-22 Technische Universität München Verfahren und Vorrichtung zur Herstellung eines Fadens aus Seidenproteinen
US20100028451A1 (en) 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
US20110121485A1 (en) 2006-10-30 2011-05-26 Spintec Engineering Gmbh Method and apparatus for the manufacture of a fiber
US20100046902A1 (en) 2006-11-03 2010-02-25 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
WO2008127402A2 (fr) 2006-11-03 2008-10-23 Trustees Of Tufts College Capteur de biopolymère et procédé de fabrication de celui-ci
JP2010509645A (ja) 2006-11-03 2010-03-25 トラスティーズ オブ タフツ カレッジ ナノパターンが形成されたバイオポリマー光学デバイスおよびその製造方法
US20100068740A1 (en) 2006-11-03 2010-03-18 Trustees Of Tufts College Microfluidic device with a cylindrical microchannel and a method for fabricating same
WO2008140562A2 (fr) 2006-11-03 2008-11-20 Trustees Of Tufts College Dispositifs optiques et électro-optiques à biopolymère électroactif et leur procédé de fabrication
JP2010522583A (ja) 2007-02-27 2010-07-08 トラスティーズ オブ タフツ カレッジ 組織工学的に作製された絹製臓器
EP2211876B1 (fr) 2007-05-29 2014-10-01 Trustees Of Tufts College Procédé de gélification de la fibroïne de soie à l'aide de la sonication
US9808557B2 (en) 2007-08-10 2017-11-07 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
WO2009061823A1 (fr) 2007-11-05 2009-05-14 Trustees Of Tufts College Fabrication de structures photoniques de fibroïne de soie par impression par nanocontact
WO2009100280A2 (fr) 2008-02-07 2009-08-13 Trustees Of Tufts College Compositions d'hydroxyapatite et de soie en trois dimensions
US8206774B2 (en) 2008-03-13 2012-06-26 Trustees Of Tufts College Diazonium salt modification of silk polymer
WO2009126689A2 (fr) 2008-04-08 2009-10-15 Trustees Of Tufts College Système et procédé pour fabriquer des structures de biomatériau
US9040073B2 (en) 2008-05-15 2015-05-26 Trustees Of Tufts College Silk polymer-based adenosine release: therapeutic potential for epilepsy
US20090297588A1 (en) 2008-05-28 2009-12-03 Spin'tec Engineering Gmbh Antibiotic dressing for the treatment of infected wounds
US20110135697A1 (en) 2008-06-18 2011-06-09 Trustees Of Tufts College Edible holographic silk products
GB2461125A (en) 2008-06-25 2009-12-30 Spintec Engineering Gmbh A silk membrane for bone graft material
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
GB2464348A (en) 2008-10-17 2010-04-21 Spintec Engineering Gmbh Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties
EP2253336A1 (fr) 2009-05-15 2010-11-24 Spintec Engineering GmbH Dispositif médical en soie avec des propriétés antimicrobiennes et son procédé de préparation
CA2805403A1 (fr) 2009-07-10 2011-01-13 Trustees Of Tufts College Systeme d'administration d'acide nucleique a base de proteine de soie biologiquement modifiee
CA2774643A1 (fr) 2009-09-29 2011-04-07 Trustees Of Tufts College Nanospheres et microspheres de soie et leurs procedes de fabrication

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US20120187591A1 (en) 2012-07-26
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US20150056293A1 (en) 2015-02-26
JP2013506007A (ja) 2013-02-21
IL218654A0 (en) 2012-05-31
EP2483199B1 (fr) 2017-04-26
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