IN2012DN00248A - - Google Patents

Info

Publication number
IN2012DN00248A
IN2012DN00248A IN248DEN2012A IN2012DN00248A IN 2012DN00248 A IN2012DN00248 A IN 2012DN00248A IN 248DEN2012 A IN248DEN2012 A IN 248DEN2012A IN 2012DN00248 A IN2012DN00248 A IN 2012DN00248A
Authority
IN
India
Prior art keywords
agents
bbb
cell types
multimeric
particular cell
Prior art date
Application number
Other languages
English (en)
Inventor
Michel Demeule
Christian Che
Carine Thiot
Original Assignee
Angiochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiochem Inc filed Critical Angiochem Inc
Publication of IN2012DN00248A publication Critical patent/IN2012DN00248A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
IN248DEN2012 2009-07-02 2010-06-30 IN2012DN00248A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22278509P 2009-07-02 2009-07-02
US25202409P 2009-10-15 2009-10-15
PCT/CA2010/001014 WO2011000095A1 (fr) 2009-07-02 2010-06-30 Conjugués peptidiques multimères et leurs utilisations

Publications (1)

Publication Number Publication Date
IN2012DN00248A true IN2012DN00248A (fr) 2015-05-01

Family

ID=43410407

Family Applications (1)

Application Number Title Priority Date Filing Date
IN248DEN2012 IN2012DN00248A (fr) 2009-07-02 2010-06-30

Country Status (12)

Country Link
US (1) US9161988B2 (fr)
EP (1) EP2448965A4 (fr)
JP (1) JP5932642B2 (fr)
CN (1) CN102596993A (fr)
AU (1) AU2010268726A1 (fr)
BR (1) BRPI1015918A2 (fr)
CA (1) CA2766537A1 (fr)
IN (1) IN2012DN00248A (fr)
MX (1) MX2012000016A (fr)
RU (1) RU2012103240A (fr)
WO (1) WO2011000095A1 (fr)
ZA (1) ZA201109324B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102775472A (zh) 2003-01-06 2012-11-14 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
PL2233156T3 (pl) 2005-07-15 2013-09-30 Angiochem Inc Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych
CA2666841A1 (fr) 2006-10-19 2008-04-24 Angiochem, Inc. Composes destines a stimuler le fonctionnement de la p-glycoproteine et leurs utilisations
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
EP2346906A4 (fr) 2008-10-15 2013-04-24 Angiochem Inc Conjugués d'agonistes de glp-1 et leurs utilisations
BRPI0922689A2 (pt) 2008-12-05 2018-11-06 Angiochem Inc. conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos
JP2012512185A (ja) 2008-12-17 2012-05-31 アンジオケム インコーポレーテッド 膜1型マトリックス金属タンパク質阻害剤およびその使用
JP2012524030A (ja) 2009-04-20 2012-10-11 アンジオケム インコーポレーテッド Angiopep−2アナログにコンジュゲート化した抗癌剤を用いた卵巣癌の治療
BRPI1015918A2 (pt) 2009-07-02 2019-09-24 Angiochem Inc conjugados de peptídeo multiméricos e usos dos mesmos
EP2885318A4 (fr) 2012-08-14 2016-03-30 Angiochem Inc Conjugués peptides-dendrimères et leurs utilisations
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
SG11201503526UA (en) 2012-12-21 2015-06-29 Sanofi Sa Dual glp1/gip or trigonal glp1/gip/glucagon agonists
JP6412676B2 (ja) * 2013-03-12 2018-10-24 セファロン、インク. ナノ粒子及びナノ粒子製剤
US20160367691A1 (en) * 2013-06-06 2016-12-22 Angiochem Inc. Targeted enzyme compounds and uses thereof
WO2015086728A1 (fr) 2013-12-13 2015-06-18 Sanofi Analogues peptidiques de l'exendine 4 en tant qu'agonistes mixtes des récepteurs glp-1/gip
WO2015086733A1 (fr) 2013-12-13 2015-06-18 Sanofi Agonistes mixtes des récepteurs du glp-1/glucagon
WO2015086730A1 (fr) 2013-12-13 2015-06-18 Sanofi Analogues peptidiques de l'exendine 4 non acylés
WO2015086729A1 (fr) 2013-12-13 2015-06-18 Sanofi Agonistes mixtes des récepteurs glp-1/gip
SG11201606824VA (en) * 2014-02-19 2016-09-29 Hoffmann La Roche Blood brain barrier shuttle
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
CN107592865B (zh) * 2015-05-11 2022-01-25 扬森疫苗与预防公司 中和流感病毒的拟肽化合物
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
AR105284A1 (es) * 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
CA3006313C (fr) 2015-11-24 2020-02-11 Transfert Plus, S.E.C. Composes peptidiques et conjugues peptidiques destines au traitement du cancer par chimiotherapie a mediation par un recepteur
DK3393496T3 (en) 2015-12-23 2023-11-13 Univ Johns Hopkins Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions
CN105481975A (zh) * 2015-12-31 2016-04-13 南京工业大学 治疗II型糖尿病的α-螺旋多肽及其制备方法与应用
JP7317706B2 (ja) * 2016-12-14 2023-07-31 リガンダル インコーポレイテッド 核酸およびタンパク質ペイロード送達のための方法および組成物
US10040831B2 (en) 2016-12-19 2018-08-07 Morehouse School Of Medicine Compositions and methods for treating diseases by inhibiting exosome release
CA3109702A1 (fr) 2018-08-13 2020-02-20 Signablok, Inc. Peptides et compositions pour traitement et imagerie cibles
BR112023001061A2 (pt) 2020-07-23 2023-04-04 Othair Prothena Ltd Anticorpos antiabeta
WO2023147053A2 (fr) * 2022-01-28 2023-08-03 Sigilon Therapeutics, Inc. Thérapies pour la mucopolysaccharidose de type 6
WO2023150552A1 (fr) 2022-02-04 2023-08-10 Dana-Farber Cancer Institute, Inc. Compositions et méthodes de traitement de troubles neurologiques
CN115353551B (zh) * 2022-06-27 2024-01-26 上海理工大学 一种燕麦源促glp-1分泌寡肽及其制备方法和应用

Family Cites Families (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
AU599373B2 (en) 1986-03-13 1990-07-19 Biotechnology Australia Proprietary Limited Method of assay of inhibin
US4801575A (en) 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4904768A (en) 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
GB2208511A (en) 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US4942184A (en) 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
US5632990A (en) 1988-04-22 1997-05-27 Cancer Research Campaign Tech. Ltd. Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
US5258499A (en) 1988-05-16 1993-11-02 Vestar, Inc. Liposome targeting using receptor specific ligands
US5028697A (en) 1988-08-08 1991-07-02 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
US5169933A (en) 1988-08-15 1992-12-08 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5948634A (en) 1988-12-21 1999-09-07 The General Hospital Coporation Neural thread protein gene expression and detection of alzheimer's disease
DE3912638A1 (de) 1989-04-18 1990-10-31 Bayer Ag Gentechnologisch hergestellte homologe des alzheimer protease inhibitors, wirtstaemme sowie expressionsvektoren fuer ihre herstellung und ihre verwendung als arzneimittel
US5126249A (en) 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
US6020145A (en) 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
US6475781B1 (en) 1990-05-17 2002-11-05 Dana-Farber Cancer Institute, Inc. Trans-dominant suppressor genes for oligomeric proteins
GB9017008D0 (en) 1990-08-02 1990-09-19 Erba Carlo Spa Process for the enzymatic preparation of basic fibroblast growth factor
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5955444A (en) 1991-08-09 1999-09-21 Massachusetts Institute Of Technology Method of inhibiting abnormal tau hyper phosphorylation in a cell
US5627270A (en) 1991-12-13 1997-05-06 Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
US5204354A (en) 1992-02-14 1993-04-20 Merck & Co., Inc. Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders
GB9213077D0 (en) 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
CA2145517A1 (fr) 1992-09-25 1994-04-14 Ignace Lasters Inhibiteurs du complexe facteur viia-facteur tissulaire derives de l'inhibiteur de la trypsine pancreatique bovine
JPH06228199A (ja) * 1992-11-27 1994-08-16 Takeda Chem Ind Ltd 血液脳関門通過可能なペプチド結合体
EP0599303A3 (fr) * 1992-11-27 1998-07-29 Takeda Chemical Industries, Ltd. Conjugués peptidiques
WO1994019692A1 (fr) 1993-02-18 1994-09-01 The General Hospital Corporation Substance therapeutique destinee a la maladie d'alzheimer
EP0820466A2 (fr) 1995-04-04 1998-01-28 Advanced Bioconcept Inc. Peptides fluorescent
WO1996035788A2 (fr) 1995-05-08 1996-11-14 Scios, Inc. Peptides inhibiteurs de proteases de type kunitz
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
AU5908296A (en) 1995-05-31 1996-12-24 Fred Hutchinson Cancer Research Center Compositions and methods for targeted delivery of effector m olecules
US5780265A (en) 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5665702A (en) 1995-06-06 1997-09-09 Biomeasure Incorporated Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
EP0831880A4 (fr) 1995-06-07 2004-12-01 Imclone Systems Inc Anticorps et fragments d'anticorps inhibant la croissance des tumeurs
DE69735996T2 (de) 1996-03-11 2007-02-15 Bayer Corp. Menschlicher bikunin
CA2252706A1 (fr) 1996-05-01 1997-11-06 Antivirals Inc. Conjugues polypeptidiques destines au transport de substances a travers des membranes cellulaires
DE19636889A1 (de) 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
WO1998016201A1 (fr) 1996-10-11 1998-04-23 Sequus Pharmaceuticals, Inc. Composition de liposomes therapeutiques et procede
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US5948750A (en) 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
EP0975792B1 (fr) 1997-03-04 2007-10-10 Savient Pharmaceuticals, Inc. Isolement de ligands peptidiques a specificite tissulaire et utilisation de ces derniers pour cibler des substances pharmaceutiques sur des organes
GB9705903D0 (en) 1997-03-21 1997-05-07 Elliott Gillian D VP22 Proteins and uses thereof
US6126965A (en) 1997-03-21 2000-10-03 Georgetown University School Of Medicine Liposomes containing oligonucleotides
PL337033A1 (en) 1997-05-21 2000-07-31 Univ Leland Stanford Junior Composition for and methods of enhancing transport through permeable biological membranes
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6093692A (en) 1997-09-25 2000-07-25 The University Of Southern California Method and compositions for lipidization of hydrophilic molecules
US6475481B2 (en) 1997-11-18 2002-11-05 Canji Inc Purging of stem cell products
WO1999026657A1 (fr) 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibiteurs de la monoxyde d'azote-synthase
US5981564A (en) 1998-07-01 1999-11-09 Universite Laval Water-soluble derivatives of paclitaxel, method for producing same and uses thereof
GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US5922754A (en) 1998-10-02 1999-07-13 Abbott Laboratories Pharmaceutical compositions containing paclitaxel
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
AU768027B2 (en) 1999-02-24 2003-11-27 Uab Research Foundation, The Taxane derivatives for targeted therapy of cancer
US6329336B1 (en) * 1999-05-17 2001-12-11 Conjuchem, Inc. Long lasting insulinotropic peptides
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
US6180607B1 (en) 1999-08-05 2001-01-30 Christopher Davies Protein having proteinase inhibitor activity
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
WO2001021584A1 (fr) 1999-09-24 2001-03-29 Genentech, Inc. Derives de tyrosine
US6136846A (en) 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel
DE19953696A1 (de) 1999-11-09 2001-05-10 Alexander Cherkasky Selektive proteolytische Synzyme (SPS)
CA2355334A1 (fr) 2000-10-16 2002-04-16 Procyon Biopharma Inc. Preparations pharmaceutiques et methodes visant a inhiber la croissance de tumeurs
WO2002043765A2 (fr) 2000-11-28 2002-06-06 Transform Pharmaceuticals, Inc. Formulations pharmaceutiques contenant du paclitaxel, ses derives et ses sels pharmaceutiquement acceptables
PL393178A1 (pl) 2000-12-07 2011-02-14 Eli Lilly And Company Heterogenne białko fuzyjne, kompozycja farmaceutyczna do leczenia pacjentów z cukrzycą insulino-niezależną i kompozycja farmaceutyczna do leczenia pacjentów z otyłością
EP1383492A4 (fr) 2001-03-23 2008-12-24 Napro Biotherapeutics Inc Conjugues moleculaires destines a etre utilises dans le traitement du cancer
EP2322631B1 (fr) 2001-04-19 2014-11-12 The Scripps Research Institute Procédés et composition pour la production de paires d'aminoacyl-ARN-T synthétase orthogonales
WO2003102583A1 (fr) 2002-05-29 2003-12-11 Symbiontics, Inc. Proteines therapeutiques ciblees
US20030170891A1 (en) 2001-06-06 2003-09-11 Mcswiggen James A. RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)
WO2003009815A2 (fr) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique
US20040161776A1 (en) 2001-10-23 2004-08-19 Maddon Paul J. PSMA formulations and uses thereof
US7192921B2 (en) 2001-11-08 2007-03-20 The Burnham Institute Peptides that home to tumor lymphatic vasculature and methods of using same
US20040058865A1 (en) * 2001-11-26 2004-03-25 Danishefsky Samuel J Homing peptide multimers, their preparation and uses
EP1472351B1 (fr) 2002-02-07 2007-06-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sequences d'acides amines facilitant la penetration a travers une barriere biologique
US7101844B2 (en) 2002-03-29 2006-09-05 Creagene, Inc. Cytoplasmic transduction peptides and uses thereof
US6881829B2 (en) 2002-04-26 2005-04-19 Chimeracom, L.L.C. Chimeric hybrid analgesics
WO2004003145A2 (fr) 2002-06-28 2004-01-08 Nastech Pharmaceutical Company Inc. Compositions et methodes permettant de moduler la physiologie de molecules d'adhesion jonctionnelle epitheliale en vue d'ameliorer l'administration de composes therapeutiques par voie muqueuse
EP2305812A3 (fr) 2002-11-14 2012-06-06 Dharmacon, Inc. SIRNA fonctionnel et hyperfonctionnel
US7829694B2 (en) 2002-11-26 2010-11-09 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of siRNA
US20040102369A1 (en) 2002-11-27 2004-05-27 The Regents Of The University Of California Transport of basic fibroblast growth factor across the blood brain barrier
US7388079B2 (en) 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
US7319090B2 (en) 2002-11-27 2008-01-15 University Of North Carolina At Chapel Hill Methods of treating cerebral ischemia
CN102775472A (zh) 2003-01-06 2012-11-14 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
US20040162284A1 (en) 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
DK2368553T3 (en) 2003-04-08 2015-02-09 Progenics Pharm Inc Pharmaceutical preparation comprising methylnaltrexone
JP4848267B2 (ja) 2003-04-08 2011-12-28 バイオテンプト、ビー.ヴイ. Hcg断片を含む粘膜及び経口投与のための組成物
EP1620544B1 (fr) 2003-04-17 2018-09-19 Alnylam Pharmaceuticals Inc. Agents modifies d'arni
WO2004108071A2 (fr) 2003-06-05 2004-12-16 Salk Institute For Biological Studies Compositions et methodes destinees a cibler un polypeptide sur le systeme nerveux central
US20050026823A1 (en) 2003-06-20 2005-02-03 Biomarin Pharmaceutical Inc. Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
JP5624256B2 (ja) 2003-06-20 2014-11-12 ラプター・ファーマシューティカル・インコーポレイテッド 脳および他の組織への治療化合物の送達
CN100457775C (zh) 2003-08-08 2009-02-04 普洛图斯科学株式会社 具有脑定位活性的多肽及其用途
US20070275871A1 (en) 2003-08-28 2007-11-29 Biorexis Technology, Inc. Epo Mimetic Peptides and Fusion Proteins
US20050058702A1 (en) 2003-09-17 2005-03-17 Ben-Sasson Shmuel A. Compositions capable of facilitating penetration across a biological barrier
US20050208095A1 (en) 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US7208174B2 (en) 2003-12-18 2007-04-24 Hoffmann-La Roche Inc. Liposome compositions
AU2005327906B2 (en) 2004-07-21 2010-05-13 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
KR100891509B1 (ko) 2004-07-26 2009-04-06 아스테리온 리미티드 연결체들
ATE439440T1 (de) 2004-09-29 2009-08-15 Childrens Memorial Hospital Sirna-vermitteltes gen-silencing von alpha- synuklein
US9002652B1 (en) 2005-01-27 2015-04-07 Institute For Systems Biology Methods for identifying and using organ-specific proteins in blood
ES2383901T5 (es) 2005-02-18 2015-02-25 Angiochem Inc. Polipéptidos de aprotinina para transportar un compuesto a través de la barrera sangre-cerebro
ATE531365T1 (de) 2005-02-18 2011-11-15 Abraxis Bioscience Llc Kombinationen und modi zur verabreichung therapeutischer mittel und kombinationstherapie
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
WO2006108052A2 (fr) 2005-04-06 2006-10-12 Genzyme Corporation Ciblage de glycoproteines therapeutiques
AU2006247471A1 (en) 2005-05-12 2006-11-23 Tapestry Pharmaceuticals, Inc. Molecular constructs suitable for targeted conjugates
WO2006138343A2 (fr) 2005-06-14 2006-12-28 Raptor Pharmaceutical Inc. Compositions comprenant des variants de proteine associee au recepteur (rap) specifiques a lrp2, et utilisations correspondantes
PL2233156T3 (pl) 2005-07-15 2013-09-30 Angiochem Inc Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych
BRPI0615562A2 (pt) 2005-07-19 2010-01-26 Univ Illinois agentes de transporte para atravessamento da barreira sangue-cérebro e entrada nas células cancerìgenas do cérebro e métodos para o seu uso
GB0517092D0 (en) 2005-08-19 2005-09-28 Novartis Ag New compositions containing taxane derivatives
CA2621694A1 (fr) 2005-09-08 2007-03-15 Nastech Pharmaceutical Company Inc. Compositions pharmaceutiques pour acheminer de l'acide ribonucleique dans une cellule
WO2007035716A2 (fr) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions de proteines rap specifiques des proteines contenant du cr, et leurs utilisations
US8142781B2 (en) 2005-10-07 2012-03-27 Armagen Technologies, Inc. Fusion proteins for blood-brain barrier delivery
US20070197460A1 (en) 2005-11-01 2007-08-23 Alnylam Pharmaceuticals, Inc. Rnai inhibition of influenza virus replication
WO2007053946A1 (fr) 2005-11-09 2007-05-18 Conjuchem Biotechnologies Inc. Procede de traitement du diabete et/ou de l'obesite en reduisant les effets secondaires nauseeux au moyen d'un peptide insulinotrope conjugue a de l'albumine
US8290433B2 (en) 2007-11-14 2012-10-16 Blaze Mobile, Inc. Method and system for securing transactions made through a mobile communication device
AR054215A1 (es) 2006-01-20 2007-06-13 Eriochem Sa Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
EP2863222A1 (fr) * 2006-03-06 2015-04-22 Amunix Operating Inc. Polymères recombinants non structurés et leurs utilisations
US7477504B1 (en) 2006-03-13 2009-01-13 C.P.D. Technologies, Inc. Versatile stun glove
ES2484967T3 (es) * 2006-03-30 2014-08-12 Glaxo Group Limited Anticuerpos contra el péptido beta-amiloide
CA2657649A1 (fr) 2006-07-13 2008-08-21 Burnham Institute For Medical Research Procedes et compositions de ciblage de la proteine gc1qr/p32
AU2007278994B2 (en) 2006-07-24 2013-08-15 Biorexis Pharmaceutical Corporation Exendin fusion proteins
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白(rap)-缀合物对肝病症的治疗
CA2666841A1 (fr) 2006-10-19 2008-04-24 Angiochem, Inc. Composes destines a stimuler le fonctionnement de la p-glycoproteine et leurs utilisations
WO2008069876A2 (fr) 2006-10-27 2008-06-12 University Of Kentucky Research Foundation Peptides amides stimulant les neurones dopaminergiques pour la régulation dopaminergique à la hausse du système nerveux central
US9399675B2 (en) 2007-02-28 2016-07-26 The Board Of Regents Of The University Of Oklahoma Methods and compositions for diagnosing Alzheimer's disease and age-related macular degeneration
BRPI0809234A2 (pt) 2007-03-21 2014-09-02 Raptor Pharmaceutical Inc Peptídeos de proteína associada a receptor (rap) cíclico
CA2688344C (fr) 2007-05-29 2019-09-03 Angiochem, Inc. Polypeptides de type aprotinine pour administrer a des tissus des agents conjugues a ceux-ci
US8802631B2 (en) 2007-09-17 2014-08-12 Ludwig Institute For Cancer Research Ltd. Peptides and methods for the treatment of gliomas and other cancers
CN101939027B (zh) 2007-10-02 2014-07-30 玛瑞纳生物技术有限公司 用于递送核酸的脂肽
WO2009070597A2 (fr) 2007-11-26 2009-06-04 Armagen Technologies, Inc. Protéines de fusion assurant le transport du gdnf jusqu'au système nerveux central
MX2010006925A (es) * 2007-12-20 2011-05-02 Angiochem Inc Conjugados de polipeptido-acido nucleico y sus usos.
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
BRPI0907363A2 (pt) 2008-02-21 2015-08-18 Burnham Inst Medical Research Métodos e composições relativos a peptídeos e proteínas com elementos de c-terminal
ES2721148T3 (es) 2008-04-18 2019-07-29 Angiochem Inc Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso
US20110117627A1 (en) 2008-07-10 2011-05-19 The Board Of Trustees Of The University Of Illinois Regulation of apoptosis by neural specific splice variants of ig20
EP2346896A4 (fr) 2008-10-15 2014-06-25 Angiochem Inc Conjugués de l'étoposide et de la doxorubicine pour l'administration de médicaments
EP2346906A4 (fr) 2008-10-15 2013-04-24 Angiochem Inc Conjugués d'agonistes de glp-1 et leurs utilisations
BRPI0922689A2 (pt) 2008-12-05 2018-11-06 Angiochem Inc. conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos
JP2012510797A (ja) 2008-12-05 2012-05-17 アンジオケム インコーポレーテッド レプチンおよびレプチン類似体コンジュゲートならびにそれらの使用
MX2011005964A (es) * 2008-12-05 2011-09-01 Angiochem Inc Conjugados terapeuticos de peptidos y sus usos.
JP2012512185A (ja) 2008-12-17 2012-05-31 アンジオケム インコーポレーテッド 膜1型マトリックス金属タンパク質阻害剤およびその使用
JP2012524030A (ja) 2009-04-20 2012-10-11 アンジオケム インコーポレーテッド Angiopep−2アナログにコンジュゲート化した抗癌剤を用いた卵巣癌の治療
US20100284921A1 (en) 2009-05-08 2010-11-11 Temple University - Of The Commonwealth System Of Higher Education Targeted nanoparticles for intracellular cancer therapy
CN102753187A (zh) 2009-06-03 2012-10-24 戴瑟纳制药公司 肽-dicer底物试剂及其特异性抑制基因表达的方法
AU2010258052A1 (en) 2009-06-11 2012-01-12 Angiochem Inc. Fusion proteins for delivery of GDNF and BDNF to the central nervous system
BRPI1015918A2 (pt) 2009-07-02 2019-09-24 Angiochem Inc conjugados de peptídeo multiméricos e usos dos mesmos
HUE026708T2 (en) 2009-07-14 2016-07-28 Mayo Foundation Peptide-mediated, non-covalent delivery of active substances in blood glucose
US20120277158A1 (en) 2009-10-06 2012-11-01 Angiochem Inc. Compositions and methods for the transport of therapeutic agents
US9095541B2 (en) 2009-11-24 2015-08-04 Arch Cancer Therapeutics, Inc. Brain tumor targeting peptides and methods
US8530429B2 (en) 2009-11-24 2013-09-10 Arch Cancer Therapeutics, Inc. Brain tumor targeting peptides and methods
EP2333074A1 (fr) 2009-12-14 2011-06-15 Robert Steinfeld Substances et procédés pour le traitement de maladies liées au stockage lysosomal
EA025443B1 (ru) 2010-03-08 2016-12-30 Слоан-Кеттеринг Институт Фор Кэнсер ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРА КИНАЗЫ Cdc7 ГРАНАТИЦИНА B
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
WO2011119608A1 (fr) 2010-03-26 2011-09-29 University Of Tennessee Research Foundation Peptides qui ciblent spécifiquement les dépôts d'amyloïde
WO2011127580A1 (fr) 2010-04-14 2011-10-20 National Research Council Of Canada Compositions et méthodes utilisées pour l'administration en direction du cerveau de peptides analgésiques
WO2011153642A1 (fr) 2010-06-10 2011-12-15 Angiochem Inc. Conjugués et protéines de fusion de la leptine et d'analogues de la leptine et leur utilisation
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
US8218280B2 (en) 2010-07-08 2012-07-10 Schneider Electric USA, Inc. Secondary thermal sensor for primary conductors
US20120156130A1 (en) 2010-08-06 2012-06-21 Thore Hettmann Use of her3 binding agents in prostate treatment
CN102406949B (zh) 2010-09-21 2013-05-29 复旦大学 一种靶向示踪的多模式诊断纳米影像药物
WO2012037687A1 (fr) 2010-09-23 2012-03-29 Angiochem Inc. Polypeptides thérapeutiques et leurs utilisations
US8901133B2 (en) 2010-11-10 2014-12-02 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
RU2018102375A (ru) 2010-11-18 2019-02-21 Зе Дженерал Хоспитал Корпорейшен Новые композиции и применения антигипертензивных средств для терапии рака
CN102552928A (zh) 2010-12-19 2012-07-11 复旦大学 一种治疗脑部肿瘤的双级靶向递药系统及其制备方法
PE20141303A1 (es) 2011-01-10 2014-10-01 Infinity Pharmaceuticals Inc Procedimiento para preparar isoquinolinonas y formas solidas de isoquinolinonas
CN102614105A (zh) 2011-01-28 2012-08-01 复旦大学 一种脑靶向载两性霉素b聚合物胶束给药系统
EP2680820B1 (fr) 2011-03-01 2022-11-02 2-BBB Medicines B.V. Chargement liposomal actif avancé de substances médiocrement solubles dans l'eau
WO2012135025A2 (fr) 2011-03-28 2012-10-04 Massachusetts Institute Of Technology Lipomères conjugués et utilisations associées
US20140010886A1 (en) 2011-04-07 2014-01-09 Georgia Tech Research Corporation Compositions comprising saccharide binding moieties and methods for targeted therapy
JP2014518862A (ja) 2011-05-09 2014-08-07 インスティトゥト・キミク・デ・サリア 薬物送達用ポリマーナノ粒子
WO2013004716A1 (fr) 2011-07-04 2013-01-10 Universität Basel Billes à base de peptides
JP6027610B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ, インコーポレイテッド 複素環式化合物及びその使用
CA2842190A1 (fr) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Composes heterocycliques et leurs utilisations
CN103957918A (zh) 2011-08-11 2014-07-30 因特利凯有限责任公司 激酶抑制剂多晶型物
US8785470B2 (en) 2011-08-29 2014-07-22 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2013049332A1 (fr) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibiteurs de monoacylglycérol lipase et procédés de leur utilisation
WO2013056096A1 (fr) 2011-10-13 2013-04-18 Angiochem Inc. Conjugués polypeptides opioïdes et utilisations associées
MX363734B (es) 2011-10-27 2019-03-29 Massachusetts Inst Technology Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco.
WO2013071272A1 (fr) 2011-11-11 2013-05-16 Intellikine, Llc Polymorphes d'inhibiteur de kinase
US20140335163A1 (en) 2011-12-01 2014-11-13 Angiochem Inc. Targeted iduronate-2-sulfatase compounds
MX2014006594A (es) 2011-12-01 2015-09-16 Angiochem Inc Compuestos de enzimas lisosomales apuntados.
MX359410B (es) 2011-12-13 2018-09-27 Engeneic Molecular Delivery Pty Ltd Minicélulas intactas derivadas bacterialmente para suministro de agentes terapéuticos a tumores cerebrales.
AU2012351967A1 (en) 2011-12-16 2014-07-17 Massachusetts Institute Of Technology Alpha-aminoamidine polymers and uses thereof
WO2013120107A1 (fr) 2012-02-09 2013-08-15 University Of Rochester Procédés et compositions pour traiter un sujet pour inhiber la perte auditive
EP2819686A4 (fr) 2012-03-02 2016-05-25 Icahn School Med Mount Sinai Variants de prothymosine alpha et leurs procédés d'utilisation
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
WO2013162757A1 (fr) 2012-04-26 2013-10-31 Yale University Molécule de délivrance de médicament sous forme cytotoxique ciblant le vih (cdm-h), activité cytotoxique contre le virus de l'immunodéficience humaine et leurs méthodes d'utilisation
JP2015521463A (ja) 2012-06-15 2015-07-30 アンジオケム インコーポレーテッド 標的化イズロニダーゼ化合物

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AU2010268726A1 (en) 2012-01-19
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