MX2015005948A - Polipeptidos para transporte de barrera hematoencefalica. - Google Patents
Polipeptidos para transporte de barrera hematoencefalica.Info
- Publication number
- MX2015005948A MX2015005948A MX2015005948A MX2015005948A MX2015005948A MX 2015005948 A MX2015005948 A MX 2015005948A MX 2015005948 A MX2015005948 A MX 2015005948A MX 2015005948 A MX2015005948 A MX 2015005948A MX 2015005948 A MX2015005948 A MX 2015005948A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptides
- brain barrier
- blood brain
- bbb
- barrier transport
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención provee polipéptidos que cruzan la barrera hematoencefálica (BBB, por sus siglas en inglés). Estos polipéptidos son, por lo tanto, agentes de transporte de BBB. Los polipéptidos son típicamente capaces de cruzar la BBB en un nivel que resulta efectivo y útil desde el punto de vista terapéutico o del diagnóstico o bien, fisiológicamente significativo, ya sea solos o cuando se encuentran acoplados a un agente terapéutico o de diagnóstico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1220474.9A GB201220474D0 (en) | 2012-11-14 | 2012-11-14 | Polypeptides |
PCT/IB2013/060137 WO2014076655A1 (en) | 2012-11-14 | 2013-11-14 | Polypeptides for blood brain barrier transport |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015005948A true MX2015005948A (es) | 2015-12-01 |
Family
ID=47470579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015005948A MX2015005948A (es) | 2012-11-14 | 2013-11-14 | Polipeptidos para transporte de barrera hematoencefalica. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20150376237A1 (es) |
EP (1) | EP2919798A1 (es) |
JP (1) | JP2016539076A (es) |
KR (1) | KR20150100655A (es) |
CN (1) | CN104968359A (es) |
AR (1) | AR093479A1 (es) |
AU (1) | AU2013346420A1 (es) |
CA (1) | CA2890704A1 (es) |
GB (1) | GB201220474D0 (es) |
HK (1) | HK1213789A1 (es) |
MX (1) | MX2015005948A (es) |
RU (1) | RU2015122666A (es) |
TW (1) | TW201427994A (es) |
WO (1) | WO2014076655A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1907009A4 (en) | 2005-07-15 | 2009-09-02 | Angiochem Inc | USE OF APROTININ POLYPEPTIDES AS CARRIER IN PHARMACEUTICAL CONJUGATES |
CN102245642A (zh) | 2008-10-15 | 2011-11-16 | 安吉奥开米公司 | Glp-1激动剂的结合物及其用途 |
EP2885318A4 (en) | 2012-08-14 | 2016-03-30 | Angiochem Inc | PEPTIDE-DENDRIMER CONJUGATES AND USES THEREOF |
US10251935B2 (en) * | 2012-11-28 | 2019-04-09 | Nono Inc. | Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose |
US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
AU2015265487B2 (en) | 2014-05-28 | 2020-08-13 | Nono Inc. | Chloride salt of TAT-NR2B9c |
DK3307326T3 (da) | 2015-06-15 | 2020-10-19 | Angiochem Inc | Fremgangsmåder til behandling af leptomeningeal karcinomatose |
WO2017003668A1 (en) | 2015-07-01 | 2017-01-05 | California Institute Of Technology | Cationic mucic acid polymer-based delivery systems |
EP3465212A4 (en) | 2016-05-23 | 2020-01-08 | California Institute of Technology | REGULAR FLORAL REGULATION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
US10702589B2 (en) | 2016-10-04 | 2020-07-07 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Compositions and methods of treating neurological disorder and stress-induced conditions |
EP3624782A4 (en) | 2017-05-15 | 2021-05-05 | Axial Biotherapeutics, Inc. | INHIBITORS OF MICROBIALLY INDUCED AMYLOID |
CN109422801B (zh) * | 2017-08-31 | 2022-07-08 | 复旦大学 | 多功能靶向多肽rap及其在制备肿瘤靶向递送系统中的用途 |
EP3806887A4 (en) * | 2018-06-13 | 2022-04-06 | California Institute of Technology | NANOPARTICLES FOR CROSSING THE BLOOD-BRAIN BARRIER AND METHODS OF TREATMENT USING IT |
KR102320650B1 (ko) * | 2019-10-16 | 2021-11-04 | 주식회사 시선테라퓨틱스 | 혈뇌장벽 투과능을 가지는 펩티드 핵산 복합체 및 이를 포함하는 조성물 |
JP2023506703A (ja) | 2019-12-04 | 2023-02-20 | ダンタリ インコーポレイテッド | 治療用ナノ粒子を合成するための方法及び組成物 |
EP4142737A4 (en) * | 2020-04-27 | 2024-06-05 | Aruna Bio Inc | BINDING AGENTS AND USES THEREOF FOR CENTRAL NERVOUS SYSTEM DEPRESSION |
WO2023128122A1 (ko) * | 2021-12-29 | 2023-07-06 | 주식회사 펩스젠 | 혈액뇌장벽 투과능을 가지는 펩타이드 및 이의 용도 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5707829A (en) | 1995-08-11 | 1998-01-13 | Genetics Institute, Inc. | DNA sequences and secreted proteins encoded thereby |
DE69625575T2 (de) * | 1995-10-25 | 2003-09-25 | Senju Pharma Co | Angiogense-Inhibitor |
JP3996659B2 (ja) * | 1995-10-25 | 2007-10-24 | 千寿製薬株式会社 | 血管新生抑制剤 |
EP0928786B1 (en) * | 1995-10-25 | 2003-01-02 | Senju Pharmaceutical Co., Ltd. | Angiogenesis inhibitor |
US7361821B2 (en) * | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
WO2008036682A2 (en) * | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
EP2132224B1 (en) * | 2007-03-21 | 2011-12-28 | Raptor Pharmaceutical Inc | Cyclic receptor-associated protein (rap) peptides |
WO2009075836A2 (en) * | 2007-12-10 | 2009-06-18 | The Brigham And Women's Hospital, Inc. | Rap variants for drug delivery |
WO2010088729A1 (en) * | 2009-02-04 | 2010-08-12 | University Of Tasmania Through The Menzies Research Institute | Compositions and uses therefor |
WO2011119608A1 (en) * | 2010-03-26 | 2011-09-29 | University Of Tennessee Research Foundation | Peptides that specifically target amyloid deposits |
JP2014518862A (ja) * | 2011-05-09 | 2014-08-07 | インスティトゥト・キミク・デ・サリア | 薬物送達用ポリマーナノ粒子 |
-
2012
- 2012-11-14 GB GBGB1220474.9A patent/GB201220474D0/en not_active Ceased
-
2013
- 2013-11-14 MX MX2015005948A patent/MX2015005948A/es unknown
- 2013-11-14 KR KR1020157015370A patent/KR20150100655A/ko not_active Application Discontinuation
- 2013-11-14 JP JP2015542397A patent/JP2016539076A/ja active Pending
- 2013-11-14 EP EP13802717.2A patent/EP2919798A1/en not_active Withdrawn
- 2013-11-14 WO PCT/IB2013/060137 patent/WO2014076655A1/en active Application Filing
- 2013-11-14 AU AU2013346420A patent/AU2013346420A1/en not_active Abandoned
- 2013-11-14 TW TW102141590A patent/TW201427994A/zh unknown
- 2013-11-14 CA CA2890704A patent/CA2890704A1/en not_active Abandoned
- 2013-11-14 CN CN201380069981.9A patent/CN104968359A/zh active Pending
- 2013-11-14 RU RU2015122666A patent/RU2015122666A/ru not_active Application Discontinuation
- 2013-11-14 AR ARP130104184A patent/AR093479A1/es unknown
- 2013-11-14 US US14/442,908 patent/US20150376237A1/en not_active Abandoned
-
2016
- 2016-02-18 HK HK16101812.6A patent/HK1213789A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2014076655A1 (en) | 2014-05-22 |
KR20150100655A (ko) | 2015-09-02 |
RU2015122666A (ru) | 2017-01-10 |
AU2013346420A1 (en) | 2015-05-28 |
CN104968359A (zh) | 2015-10-07 |
EP2919798A1 (en) | 2015-09-23 |
JP2016539076A (ja) | 2016-12-15 |
US20150376237A1 (en) | 2015-12-31 |
AR093479A1 (es) | 2015-06-10 |
TW201427994A (zh) | 2014-07-16 |
HK1213789A1 (zh) | 2016-07-15 |
GB201220474D0 (en) | 2012-12-26 |
CA2890704A1 (en) | 2014-05-22 |
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