IL99436A - Process for the preparation of albuterol, and hydrates of the intermediates arylglyoxal and their boron complex ariethanolamine - Google Patents

Process for the preparation of albuterol, and hydrates of the intermediates arylglyoxal and their boron complex ariethanolamine

Info

Publication number
IL99436A
IL99436A IL9943691A IL9943691A IL99436A IL 99436 A IL99436 A IL 99436A IL 9943691 A IL9943691 A IL 9943691A IL 9943691 A IL9943691 A IL 9943691A IL 99436 A IL99436 A IL 99436A
Authority
IL
Israel
Prior art keywords
alkyl
aryl
boron
formula
arylethanolamine
Prior art date
Application number
IL9943691A
Other languages
English (en)
Hebrew (he)
Other versions
IL99436A0 (en
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to IL11947791A priority Critical patent/IL119477A/xx
Priority to IL11947691A priority patent/IL119476A/xx
Publication of IL99436A0 publication Critical patent/IL99436A0/xx
Priority to IL11947696A priority patent/IL119476A0/xx
Priority to IL11947796A priority patent/IL119477A0/xx
Publication of IL99436A publication Critical patent/IL99436A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
IL9943691A 1990-09-11 1991-09-06 Process for the preparation of albuterol, and hydrates of the intermediates arylglyoxal and their boron complex ariethanolamine IL99436A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL11947791A IL119477A (en) 1990-09-11 1991-09-06 Process for preparing glyoxal hydrates
IL11947691A IL119476A (en) 1990-09-11 1991-09-06 Process for preparing acetals and hemi-acetals
IL11947696A IL119476A0 (en) 1990-09-11 1996-10-23 A process for preparing acetals and hemi-acetals
IL11947796A IL119477A0 (en) 1990-09-11 1996-10-23 A process for preparing glyoxal hydrates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58070590A 1990-09-11 1990-09-11

Publications (2)

Publication Number Publication Date
IL99436A0 IL99436A0 (en) 1992-08-18
IL99436A true IL99436A (en) 1999-03-12

Family

ID=24322195

Family Applications (6)

Application Number Title Priority Date Filing Date
IL9943691A IL99436A (en) 1990-09-11 1991-09-06 Process for the preparation of albuterol, and hydrates of the intermediates arylglyoxal and their boron complex ariethanolamine
IL11947691A IL119476A (en) 1990-09-11 1991-09-06 Process for preparing acetals and hemi-acetals
IL11947791A IL119477A (en) 1990-09-11 1991-09-06 Process for preparing glyoxal hydrates
IL115678A IL115678A (en) 1990-09-11 1995-10-19 Acetyl and Arimglioxal Acyl Acetal
IL11947696A IL119476A0 (en) 1990-09-11 1996-10-23 A process for preparing acetals and hemi-acetals
IL11947796A IL119477A0 (en) 1990-09-11 1996-10-23 A process for preparing glyoxal hydrates

Family Applications After (5)

Application Number Title Priority Date Filing Date
IL11947691A IL119476A (en) 1990-09-11 1991-09-06 Process for preparing acetals and hemi-acetals
IL11947791A IL119477A (en) 1990-09-11 1991-09-06 Process for preparing glyoxal hydrates
IL115678A IL115678A (en) 1990-09-11 1995-10-19 Acetyl and Arimglioxal Acyl Acetal
IL11947696A IL119476A0 (en) 1990-09-11 1996-10-23 A process for preparing acetals and hemi-acetals
IL11947796A IL119477A0 (en) 1990-09-11 1996-10-23 A process for preparing glyoxal hydrates

Country Status (24)

Country Link
US (1) US5283359A (pt)
EP (1) EP0548224B1 (pt)
JP (2) JP3055757B2 (pt)
KR (1) KR960006670B1 (pt)
CN (1) CN1051759C (pt)
AT (1) ATE114300T1 (pt)
AU (2) AU648114B2 (pt)
CA (2) CA2091352C (pt)
DE (2) DE69105277T2 (pt)
DK (1) DK0548224T3 (pt)
ES (1) ES2059288T3 (pt)
GR (1) GR930300087T1 (pt)
HR (1) HRP920384B1 (pt)
HU (1) HUT65809A (pt)
IE (1) IE66041B1 (pt)
IL (6) IL99436A (pt)
MX (1) MX9101019A (pt)
NZ (2) NZ248939A (pt)
PT (1) PT98906B (pt)
SI (1) SI9111498A (pt)
TW (1) TW363955B (pt)
WO (1) WO1992004314A2 (pt)
YU (1) YU48672B (pt)
ZA (1) ZA917150B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442118A (en) * 1994-04-22 1995-08-15 Sepracor, Inc. Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones
US5545745A (en) * 1994-05-23 1996-08-13 Sepracor, Inc. Enantioselective preparation of optically pure albuterol
US5399765A (en) * 1994-05-23 1995-03-21 Sepracor, Inc. Enantioselective preparation of optically pure albuterol
EP1648855A2 (en) 2004-05-20 2006-04-26 Teva Pharmaceutical Fine Chemicals S.R.L. Levalbuterol hydrochloride polymorph a
US8070045B1 (en) * 2010-12-02 2011-12-06 Rohm And Haas Electronic Materials Llc Curable amine flux composition and method of soldering
US8070044B1 (en) * 2010-12-02 2011-12-06 Rohm And Haas Electronic Materials Llc Polyamine flux composition and method of soldering
WO2016082862A1 (de) 2014-11-25 2016-06-02 Dometic S.A.R.L. Kühlvorrichtung
CN105001100A (zh) * 2015-06-11 2015-10-28 山西云鹏制药有限公司 一种精制硫酸沙丁胺醇的方法
CN109072171A (zh) 2016-05-12 2018-12-21 三得利控股株式会社 含有l-羟脯氨酸的解脂耶氏酵母的菌体或菌体培养物或者它们的提取物及其用途以及l-羟脯氨酸的制造方法
CN106748824A (zh) * 2016-11-21 2017-05-31 河南工业大学 一种新的沙丁胺醇药物盐‑沙丁胺醇富马酸盐及其制备方法
CN108863819B (zh) * 2018-06-26 2021-01-15 南京逐陆医药科技有限公司 一种游离的消旋沙丁胺醇的制备方法
CN110734382B (zh) * 2019-10-09 2024-02-20 苏州弘森药业股份有限公司 一种合成特布他林的方法
CN112341373B (zh) * 2020-11-30 2022-04-08 山东嘉成医药科技有限公司 一种酞丁安的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1200886A (en) * 1966-09-23 1970-08-05 Allen & Hanburys Ltd Phenylaminoethanol derivatives
GB1214012A (en) * 1967-12-21 1970-11-25 Allen & Hanburys Ltd Phenylethanolamines
GB1247370A (en) * 1968-12-31 1971-09-22 Allen & Hanburys Ltd Glyoxals and production thereof
GB1266058A (pt) * 1969-07-08 1972-03-08
US4029706A (en) * 1974-04-01 1977-06-14 Dynapol Reduction with polymeric reagent
US3928293A (en) * 1974-04-01 1975-12-23 Dynapol Corp Polymeric reagent
DE2730462A1 (de) * 1976-07-15 1978-01-19 Ciba Geigy Ag Photoinitiatoren fuer uv-haertbare massen
EP0114389A3 (en) * 1983-01-20 1985-12-18 American Cyanamid Company Substituted arylglyoxal derivatives
WO1988010253A1 (en) * 1987-06-24 1988-12-29 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acid derivatives

Also Published As

Publication number Publication date
IL119476A0 (en) 1997-01-10
EP0548224A1 (en) 1993-06-30
NZ248939A (en) 1995-03-28
DE69105277D1 (de) 1995-01-05
IL115678A0 (en) 1996-01-19
IE66041B1 (en) 1995-12-13
CA2091352A1 (en) 1992-03-12
HRP920384B1 (en) 1998-10-31
US5283359A (en) 1994-02-01
PT98906A (pt) 1992-09-30
MX9101019A (es) 1992-05-04
JPH05506668A (ja) 1993-09-30
HRP920384A2 (en) 1995-10-31
CN1051759C (zh) 2000-04-26
ES2059288T3 (es) 1995-01-16
HUT65809A (en) 1994-07-28
HU9300684D0 (en) 1993-06-28
NZ239732A (en) 1995-03-28
CN1059904A (zh) 1992-04-01
AU648114B2 (en) 1994-04-14
YU48672B (sh) 1999-06-15
DK0548224T3 (da) 1995-01-09
IL119476A (en) 1999-10-28
AU8617091A (en) 1992-03-30
CA2121914A1 (en) 1992-03-12
ES2059288T1 (es) 1994-11-16
ATE114300T1 (de) 1994-12-15
IL99436A0 (en) 1992-08-18
CA2121914C (en) 1998-09-29
KR960006670B1 (ko) 1996-05-22
IL119477A0 (en) 1997-01-10
JPH07233115A (ja) 1995-09-05
CA2091352C (en) 1996-12-03
YU149891A (sh) 1994-01-20
AU5508694A (en) 1994-04-28
PT98906B (pt) 1999-02-26
JP3055757B2 (ja) 2000-06-26
IE913174A1 (en) 1992-03-11
WO1992004314A2 (en) 1992-03-19
EP0548224B1 (en) 1994-11-23
SI9111498A (en) 1997-12-31
DE548224T1 (de) 1993-10-14
DE69105277T2 (de) 1995-04-06
JPH07113006B2 (ja) 1995-12-06
ZA917150B (en) 1992-05-27
GR930300087T1 (en) 1993-09-30
WO1992004314A3 (en) 1992-05-29
IL119477A (en) 1999-10-28
TW363955B (en) 1999-07-11
IL115678A (en) 1998-01-04
AU656287B2 (en) 1995-01-27

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees