TW363955B - Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof - Google Patents
Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereofInfo
- Publication number
- TW363955B TW363955B TW080107103A TW80107103A TW363955B TW 363955 B TW363955 B TW 363955B TW 080107103 A TW080107103 A TW 080107103A TW 80107103 A TW80107103 A TW 80107103A TW 363955 B TW363955 B TW 363955B
- Authority
- TW
- Taiwan
- Prior art keywords
- acetal
- hemi
- intermediates
- arylglyoxal
- hydrates
- Prior art date
Links
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002052 salbutamol Drugs 0.000 title abstract 3
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001241 acetals Chemical class 0.000 title abstract 2
- 150000002373 hemiacetals Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 150000004677 hydrates Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
- 229910052796 boron Inorganic materials 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58070590A | 1990-09-11 | 1990-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW363955B true TW363955B (en) | 1999-07-11 |
Family
ID=24322195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW080107103A TW363955B (en) | 1990-09-11 | 1991-09-09 | Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5283359A (zh) |
| EP (1) | EP0548224B1 (zh) |
| JP (2) | JPH07113006B2 (zh) |
| KR (1) | KR960006670B1 (zh) |
| CN (1) | CN1051759C (zh) |
| AT (1) | ATE114300T1 (zh) |
| AU (2) | AU648114B2 (zh) |
| CA (2) | CA2091352C (zh) |
| DE (2) | DE69105277T2 (zh) |
| DK (1) | DK0548224T3 (zh) |
| ES (1) | ES2059288T3 (zh) |
| GR (1) | GR930300087T1 (zh) |
| HR (1) | HRP920384B1 (zh) |
| HU (1) | HUT65809A (zh) |
| IE (1) | IE66041B1 (zh) |
| IL (6) | IL119477A (zh) |
| MX (1) | MX9101019A (zh) |
| NZ (2) | NZ248939A (zh) |
| PT (1) | PT98906B (zh) |
| SI (1) | SI9111498A (zh) |
| TW (1) | TW363955B (zh) |
| WO (1) | WO1992004314A2 (zh) |
| YU (1) | YU48672B (zh) |
| ZA (1) | ZA917150B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11530852B2 (en) | 2014-11-25 | 2022-12-20 | B. Medical Systems S.a.r.l. | Cooling device |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5442118A (en) * | 1994-04-22 | 1995-08-15 | Sepracor, Inc. | Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones |
| US5399765A (en) * | 1994-05-23 | 1995-03-21 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| US5545745A (en) * | 1994-05-23 | 1996-08-13 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| US7488758B2 (en) | 2004-05-20 | 2009-02-10 | Teva Pharmaceutical Fine Chemicals, S.R.L. | Levalbuterol hydrochloride polymorph B |
| US8070044B1 (en) * | 2010-12-02 | 2011-12-06 | Rohm And Haas Electronic Materials Llc | Polyamine flux composition and method of soldering |
| US8070045B1 (en) * | 2010-12-02 | 2011-12-06 | Rohm And Haas Electronic Materials Llc | Curable amine flux composition and method of soldering |
| CN105001100A (zh) * | 2015-06-11 | 2015-10-28 | 山西云鹏制药有限公司 | 一种精制硫酸沙丁胺醇的方法 |
| KR102330633B1 (ko) | 2016-05-12 | 2021-11-24 | 산토리 홀딩스 가부시키가이샤 | L-하이드록시프롤린을 함유하는 효모 야로위아 리폴리티카의 균체 혹은 균체 배양물 또는 이들의 추출물 및 그 용도 그리고 l-하이드록시프롤린의 제조 방법 |
| CN106748824A (zh) * | 2016-11-21 | 2017-05-31 | 河南工业大学 | 一种新的沙丁胺醇药物盐‑沙丁胺醇富马酸盐及其制备方法 |
| CN108863819B (zh) * | 2018-06-26 | 2021-01-15 | 南京逐陆医药科技有限公司 | 一种游离的消旋沙丁胺醇的制备方法 |
| CN110734382B (zh) * | 2019-10-09 | 2024-02-20 | 苏州弘森药业股份有限公司 | 一种合成特布他林的方法 |
| CN112341373B (zh) * | 2020-11-30 | 2022-04-08 | 山东嘉成医药科技有限公司 | 一种酞丁安的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
| GB1214012A (en) * | 1967-12-21 | 1970-11-25 | Allen & Hanburys Ltd | Phenylethanolamines |
| GB1247370A (en) * | 1968-12-31 | 1971-09-22 | Allen & Hanburys Ltd | Glyoxals and production thereof |
| GB1266058A (zh) * | 1969-07-08 | 1972-03-08 | ||
| US3928293A (en) * | 1974-04-01 | 1975-12-23 | Dynapol Corp | Polymeric reagent |
| US4029706A (en) * | 1974-04-01 | 1977-06-14 | Dynapol | Reduction with polymeric reagent |
| DE2730462A1 (de) * | 1976-07-15 | 1978-01-19 | Ciba Geigy Ag | Photoinitiatoren fuer uv-haertbare massen |
| EP0114389A3 (en) * | 1983-01-20 | 1985-12-18 | American Cyanamid Company | Substituted arylglyoxal derivatives |
| EP0329719A1 (en) * | 1987-06-24 | 1989-08-30 | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. | Process for the preparation of quinoline carboxylic acid derivatives |
-
1991
- 1991-09-06 IL IL11947791A patent/IL119477A/xx not_active IP Right Cessation
- 1991-09-06 CA CA002091352A patent/CA2091352C/en not_active Expired - Fee Related
- 1991-09-06 EP EP91916922A patent/EP0548224B1/en not_active Expired - Lifetime
- 1991-09-06 AT AT91916922T patent/ATE114300T1/de not_active IP Right Cessation
- 1991-09-06 AU AU86170/91A patent/AU648114B2/en not_active Ceased
- 1991-09-06 DE DE69105277T patent/DE69105277T2/de not_active Expired - Fee Related
- 1991-09-06 KR KR1019930700720A patent/KR960006670B1/ko not_active IP Right Cessation
- 1991-09-06 ES ES91916922T patent/ES2059288T3/es not_active Expired - Lifetime
- 1991-09-06 JP JP3515879A patent/JPH07113006B2/ja not_active Expired - Lifetime
- 1991-09-06 US US08/030,185 patent/US5283359A/en not_active Expired - Fee Related
- 1991-09-06 JP JP6303806A patent/JP3055757B2/ja not_active Expired - Lifetime
- 1991-09-06 IL IL9943691A patent/IL99436A/en not_active IP Right Cessation
- 1991-09-06 DK DK91916922.7T patent/DK0548224T3/da active
- 1991-09-06 CA CA002121914A patent/CA2121914C/en not_active Expired - Fee Related
- 1991-09-06 IL IL11947691A patent/IL119476A/xx not_active IP Right Cessation
- 1991-09-06 HU HU9300684A patent/HUT65809A/hu unknown
- 1991-09-06 DE DE91916922T patent/DE548224T1/de active Pending
- 1991-09-06 WO PCT/US1991/006248 patent/WO1992004314A2/en active IP Right Grant
- 1991-09-09 ZA ZA917150A patent/ZA917150B/xx unknown
- 1991-09-09 TW TW080107103A patent/TW363955B/zh active
- 1991-09-09 YU YU149891A patent/YU48672B/sh unknown
- 1991-09-09 SI SI9111498A patent/SI9111498A/sl unknown
- 1991-09-09 PT PT98906A patent/PT98906B/pt not_active IP Right Cessation
- 1991-09-10 MX MX9101019A patent/MX9101019A/es not_active IP Right Cessation
- 1991-09-10 NZ NZ248939A patent/NZ248939A/en unknown
- 1991-09-10 IE IE317491A patent/IE66041B1/en not_active IP Right Cessation
- 1991-09-10 CN CN91108911A patent/CN1051759C/zh not_active Expired - Fee Related
- 1991-09-10 NZ NZ239732A patent/NZ239732A/en unknown
-
1992
- 1992-09-21 HR HRP-1498/91A patent/HRP920384B1/xx not_active IP Right Cessation
-
1993
- 1993-09-30 GR GR930300087T patent/GR930300087T1/el unknown
-
1994
- 1994-02-10 AU AU55086/94A patent/AU656287B2/en not_active Ceased
-
1995
- 1995-10-19 IL IL115678A patent/IL115678A/en not_active IP Right Cessation
-
1996
- 1996-10-23 IL IL11947696A patent/IL119476A0/xx unknown
- 1996-10-23 IL IL11947796A patent/IL119477A0/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11530852B2 (en) | 2014-11-25 | 2022-12-20 | B. Medical Systems S.a.r.l. | Cooling device |
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