IL98372A - Piperazine Derivatives] 1-Arylpyrrolidine-LV-2 (Ingredients [Piperazine Preparation and Submission Relaxed) - Google Patents

Piperazine Derivatives] 1-Arylpyrrolidine-LV-2 (Ingredients [Piperazine Preparation and Submission Relaxed)

Info

Publication number
IL98372A
IL98372A IL9837291A IL9837291A IL98372A IL 98372 A IL98372 A IL 98372A IL 9837291 A IL9837291 A IL 9837291A IL 9837291 A IL9837291 A IL 9837291A IL 98372 A IL98372 A IL 98372A
Authority
IL
Israel
Prior art keywords
formula
process according
derivatives
solvent
group
Prior art date
Application number
IL9837291A
Other languages
English (en)
Hebrew (he)
Other versions
IL98372A0 (en
Original Assignee
Sythelabo S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sythelabo S A filed Critical Sythelabo S A
Publication of IL98372A0 publication Critical patent/IL98372A0/xx
Publication of IL98372A publication Critical patent/IL98372A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL9837291A 1990-06-07 1991-06-04 Piperazine Derivatives] 1-Arylpyrrolidine-LV-2 (Ingredients [Piperazine Preparation and Submission Relaxed) IL98372A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9007067A FR2663026B1 (fr) 1990-06-07 1990-06-07 Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number Publication Date
IL98372A0 IL98372A0 (en) 1992-07-15
IL98372A true IL98372A (en) 1996-01-31

Family

ID=9397358

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9837291A IL98372A (en) 1990-06-07 1991-06-04 Piperazine Derivatives] 1-Arylpyrrolidine-LV-2 (Ingredients [Piperazine Preparation and Submission Relaxed)

Country Status (21)

Country Link
US (1) US5192763A (fi)
EP (1) EP0461012B1 (fi)
JP (1) JPH04235958A (fi)
KR (1) KR100188902B1 (fi)
AT (1) ATE104662T1 (fi)
AU (1) AU634391B2 (fi)
CA (1) CA2043981A1 (fi)
CS (1) CS173691A3 (fi)
DE (1) DE69101740T2 (fi)
DK (1) DK0461012T3 (fi)
ES (1) ES2054460T3 (fi)
FI (1) FI97055C (fi)
FR (1) FR2663026B1 (fi)
HU (1) HU209620B (fi)
IE (1) IE64688B1 (fi)
IL (1) IL98372A (fi)
NO (1) NO177931C (fi)
NZ (1) NZ238431A (fi)
PL (1) PL165187B1 (fi)
PT (1) PT97885B (fi)
ZA (1) ZA914339B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
FR2684374B1 (fr) * 1991-12-02 1995-05-19 Synthelabo Derives substitues de 1-[(1-arylpyrrolidin-2-yl)methyl]piperazine, leur preparation et leur application en therapeutique.
IT1255704B (it) * 1992-09-30 1995-11-10 Boehringer Mannheim Italia Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3250771A (en) * 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
GB1428493A (en) * 1973-05-02 1976-03-17 Science Union & Cie Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them
US5063242A (en) * 1989-04-21 1991-11-05 Warner-Lambert Company 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino-1-oxaspiro[4,5]decanes as diuretics antiinflammatory, and cerebrovascular agents

Also Published As

Publication number Publication date
DK0461012T3 (da) 1994-09-12
EP0461012A1 (fr) 1991-12-11
US5192763A (en) 1993-03-09
ES2054460T3 (es) 1994-08-01
NO912168D0 (no) 1991-06-06
HUT58070A (en) 1992-01-28
KR100188902B1 (ko) 1999-06-01
PL165187B1 (pl) 1994-11-30
DE69101740D1 (de) 1994-05-26
NO177931B (no) 1995-09-11
JPH04235958A (ja) 1992-08-25
AU7819691A (en) 1991-12-12
IE64688B1 (en) 1995-08-23
EP0461012B1 (fr) 1994-04-20
PL290572A1 (en) 1992-02-10
HU911895D0 (en) 1991-12-30
FR2663026A1 (fr) 1991-12-13
FI97055B (fi) 1996-06-28
NZ238431A (en) 1992-09-25
DE69101740T2 (de) 1994-10-20
FI912733A0 (fi) 1991-06-06
ZA914339B (en) 1992-03-25
FI97055C (fi) 1996-10-10
KR920000751A (ko) 1992-01-29
FI912733A (fi) 1991-12-08
CS173691A3 (en) 1992-02-19
IE911941A1 (en) 1991-12-18
PT97885B (pt) 1998-10-30
NO177931C (no) 1995-12-20
HU209620B (en) 1994-09-28
CA2043981A1 (en) 1991-12-08
NO912168L (no) 1991-12-09
FR2663026B1 (fr) 1992-08-07
AU634391B2 (en) 1993-02-18
ATE104662T1 (de) 1994-05-15
IL98372A0 (en) 1992-07-15
PT97885A (pt) 1992-03-31

Similar Documents

Publication Publication Date Title
KR101432112B1 (ko) 도파민 ｄ3 수용체 리간드로서의 신규 카보닐화된 (아자)사이클로헥산
JP3593037B2 (ja) ピロリジン誘導体ｃｃｒ−３受容体アンタゴニスト
RU2152388C1 (ru) Трициклические производные пиразола
EP1546099B1 (en) 3,6-disubstituted azabicyclo 3.1.0 hexane derivatives useful as muscarinic receptor antagonists
DE19952146A1 (de) Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH11501640A (ja) ５−ｈｔ▲下４▼拮抗作用を有するジ−置換１，４−ピペリジンエステル類及びアミド類
NO329319B1 (no) Kinolinforbindelser, fremgangsmåter for fremstilling derav, farmsøytiske preparater samt anvendelser av forbindelsene
JP2003511377A (ja) 化合物
WO2008054748A2 (en) Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
EA029097B1 (ru) Совместные кристаллы и соли ингибиторов ccr3
AU2008231543B2 (en) Pyrimido [4, 5-D] azepine derivatives as 5-HT2C agonists
EA002352B1 (ru) Производные индазоламида в качестве серотонинергических агентов
JP2009503048A (ja) 尿路機能障害を治療するためのｍｃ４ｒ作動薬
SK132498A3 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
DE60316180T2 (de) Aminoalkoxyindol-derivate als 5-ht6-rezeptorliganden zur bekämpfung von zns-krankheiten
CA2354213C (en) N-triazolylmethyl-piperazine compounds with neurokinin-receptor antagonist activity
CZ294233B6 (cs) Acylaminoalkenylenamidové deriváty, způsob jejich přípravy a farmaceutické prostředky, které je obsahují
CZ342397A3 (cs) Piperazinové deriváty jako antagonisté neurokininu
DE69735811T2 (de) Piperazinoderivate als neurokinin-antagonisten
IE922090A1 (en) 2-(1-piperidyl)ethanol derivatives, their preparation and¹their therapeutic application
WO2011091410A1 (en) Trpv4 antagonists
IL98372A (en) Piperazine Derivatives] 1-Arylpyrrolidine-LV-2 (Ingredients [Piperazine Preparation and Submission Relaxed)
JPS6335573A (ja) 新規置換ピリド〔２，３−ｂ〕〔１，４〕ベンゾジアゼピン−６−オン，その製法及びその化合物を含む医薬
JP2003518108A (ja) ニューロキニン・アンタゴニストとしてのα−アリールエチルピペラジン誘導体
NO170580B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive piperidinderivater

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees