IL97892A - 3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1- ylalkyl]-9-substituted-4h- pyrido [1,2-a] pyrimidin-4- ones, their preparation and pharmaceutical compositions containing them - Google Patents

3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1- ylalkyl]-9-substituted-4h- pyrido [1,2-a] pyrimidin-4- ones, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL97892A
IL97892A IL9789291A IL9789291A IL97892A IL 97892 A IL97892 A IL 97892A IL 9789291 A IL9789291 A IL 9789291A IL 9789291 A IL9789291 A IL 9789291A IL 97892 A IL97892 A IL 97892A
Authority
IL
Israel
Prior art keywords
formula
compound
compounds
methyl
alk
Prior art date
Application number
IL9789291A
Other languages
English (en)
Other versions
IL97892A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL97892A0 publication Critical patent/IL97892A0/xx
Publication of IL97892A publication Critical patent/IL97892A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
IL9789291A 1990-04-19 1991-04-17 3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1- ylalkyl]-9-substituted-4h- pyrido [1,2-a] pyrimidin-4- ones, their preparation and pharmaceutical compositions containing them IL97892A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909008850A GB9008850D0 (en) 1990-04-19 1990-04-19 Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Publications (2)

Publication Number Publication Date
IL97892A0 IL97892A0 (en) 1992-06-21
IL97892A true IL97892A (en) 1995-03-30

Family

ID=10674694

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9789291A IL97892A (en) 1990-04-19 1991-04-17 3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1- ylalkyl]-9-substituted-4h- pyrido [1,2-a] pyrimidin-4- ones, their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US5482943A (cs)
EP (1) EP0453042B1 (cs)
JP (1) JP3216889B2 (cs)
KR (1) KR100190297B1 (cs)
CN (1) CN1027506C (cs)
AT (1) ATE186301T1 (cs)
AU (1) AU636969B2 (cs)
BG (2) BG60394B1 (cs)
CA (1) CA2040086C (cs)
CZ (1) CZ281135B6 (cs)
DE (1) DE69131759T2 (cs)
DK (1) DK0453042T3 (cs)
ES (1) ES2140381T3 (cs)
FI (1) FI96206C (cs)
GB (1) GB9008850D0 (cs)
GR (1) GR3032122T3 (cs)
HU (1) HUT57763A (cs)
IE (1) IE911301A1 (cs)
IL (1) IL97892A (cs)
NO (1) NO176840C (cs)
NZ (1) NZ237713A (cs)
PL (2) PL169740B1 (cs)
PT (1) PT97395B (cs)
RU (1) RU2037495C1 (cs)
SK (1) SK279005B6 (cs)
ZA (1) ZA912913B (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
ES2159526T3 (es) * 1992-07-13 2001-10-16 Janssen Pharmaceutica Nv Nuevos derivados de 4-(3-benzofuranil)piperidinilo y 4-(3-benzotienil)piperidinilo y composiciones farmaceuticas que los contienen.
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
JP3553951B2 (ja) * 1993-11-23 2004-08-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規な９−ヒドロキシ−ピリド［１，２−ａ］ピリミジン−４−オンエーテル誘導体
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
HU227118B1 (en) * 2001-11-13 2010-07-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
ES2197801B1 (es) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
WO2004009591A1 (en) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. A process for the preparation of antipsychotic risperidone
BR0306204A (pt) * 2002-08-30 2004-09-08 Torrent Pharmaceuticals Ltd Processo melhorado para a preparação de risperidona
KR20040025224A (ko) * 2002-09-18 2004-03-24 주식회사 대웅 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
HRP20050424A2 (en) 2002-11-13 2006-08-31 Synthon B.V. Process for making risperidone and intermediates thereof
EP1615923A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Risperidone monohydrochloride
HUP0401379A3 (en) * 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
EP1690540A1 (en) * 2005-02-15 2006-08-16 Neuro3D Composition comprising ocaperidone
EP1695973A1 (en) * 2005-02-24 2006-08-30 Neuro3D Ocaperidone salt and pharmaceutical compositions containing the same
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2009077551A1 (en) * 2007-12-18 2009-06-25 Janssen Pharmaceutica Nv Process for preparing risperidone
MX2024007815A (es) 2022-01-11 2024-07-04 Suven Life Sciences Ltd Derivados heteroaliciclicos y su uso en el tratamiento de trastornos del snc.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4777252A (en) * 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives

Also Published As

Publication number Publication date
PL169744B1 (pl) 1996-08-30
BG60394B1 (bg) 1995-02-28
PT97395A (pt) 1992-01-31
PT97395B (pt) 1998-08-31
EP0453042B1 (en) 1999-11-03
NZ237713A (en) 1992-09-25
CS9101099A2 (en) 1991-11-12
JP3216889B2 (ja) 2001-10-09
JPH04234882A (ja) 1992-08-24
NO911525L (no) 1991-10-21
IL97892A0 (en) 1992-06-21
CN1055929A (zh) 1991-11-06
BG94282A (bg) 1993-12-24
KR910018380A (ko) 1991-11-30
CA2040086C (en) 2003-12-30
DE69131759T2 (de) 2000-06-21
PL289935A1 (en) 1992-04-06
RU2037495C1 (ru) 1995-06-19
ES2140381T3 (es) 2000-03-01
ATE186301T1 (de) 1999-11-15
CN1027506C (zh) 1995-01-25
FI96206B (fi) 1996-02-15
SK279005B6 (sk) 1998-05-06
CZ281135B6 (cs) 1996-06-12
FI911885A0 (fi) 1991-04-18
KR100190297B1 (ko) 1999-06-01
NO176840C (no) 1995-06-07
US5482943A (en) 1996-01-09
CA2040086A1 (en) 1991-10-20
GB9008850D0 (en) 1990-06-13
EP0453042A1 (en) 1991-10-23
DE69131759D1 (de) 1999-12-09
AU7436691A (en) 1991-10-24
DK0453042T3 (da) 2000-04-25
IE911301A1 (en) 1991-10-23
HU911301D0 (en) 1991-10-28
FI911885A7 (fi) 1991-10-20
NO176840B (no) 1995-02-27
BG95241A (bg) 1993-12-24
HUT57763A (en) 1991-12-30
FI96206C (fi) 1996-05-27
PL169740B1 (pl) 1996-08-30
ZA912913B (en) 1992-12-30
GR3032122T3 (en) 2000-04-27
AU636969B2 (en) 1993-05-13
NO911525D0 (no) 1991-04-18

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