IL96324A - History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents - Google Patents

History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents

Info

Publication number
IL96324A
IL96324A IL9632490A IL9632490A IL96324A IL 96324 A IL96324 A IL 96324A IL 9632490 A IL9632490 A IL 9632490A IL 9632490 A IL9632490 A IL 9632490A IL 96324 A IL96324 A IL 96324A
Authority
IL
Israel
Prior art keywords
bis
triiodo
oxo
benzenedicarboxamide
compound according
Prior art date
Application number
IL9632490A
Other languages
English (en)
Hebrew (he)
Other versions
IL96324A0 (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IL96324A0 publication Critical patent/IL96324A0/xx
Publication of IL96324A publication Critical patent/IL96324A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL9632490A 1989-11-29 1990-11-13 History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents IL96324A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44286989A 1989-11-29 1989-11-29

Publications (2)

Publication Number Publication Date
IL96324A0 IL96324A0 (en) 1991-08-16
IL96324A true IL96324A (en) 1995-01-24

Family

ID=23758470

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9632490A IL96324A (en) 1989-11-29 1990-11-13 History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents

Country Status (24)

Country Link
EP (1) EP0431838B1 (ru)
JP (1) JP2931089B2 (ru)
KR (1) KR0160981B1 (ru)
CN (2) CN1052114A (ru)
AT (1) ATE129493T1 (ru)
AU (1) AU623293B2 (ru)
CA (1) CA2029830A1 (ru)
CZ (1) CZ280698B6 (ru)
DE (1) DE69023210T2 (ru)
DK (1) DK0431838T3 (ru)
EG (1) EG19359A (ru)
ES (1) ES2078321T3 (ru)
FI (1) FI97130C (ru)
GR (1) GR3018215T3 (ru)
HU (1) HUT56075A (ru)
IE (1) IE73448B1 (ru)
IL (1) IL96324A (ru)
MX (1) MX23489A (ru)
NO (1) NO174925C (ru)
NZ (1) NZ236143A (ru)
PL (1) PL164291B1 (ru)
PT (1) PT96020B (ru)
RU (1) RU2046795C1 (ru)
ZA (1) ZA909140B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
CA2068089C (en) * 1991-05-31 2003-09-16 Ramachandran S. Ranganathan Method and compositions for using non-ionic contrast agents to reduce the risk of clot formulation in diagnostic procedures
US5359077A (en) * 1992-06-05 1994-10-25 Bristol-Myers Squibb Company Process for preparation of 2-oxo-1 piperidinyl derivatives
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
US5686061A (en) * 1994-04-11 1997-11-11 The Board Of Regents Of The University Of Texas System Particulate contrast media derived from non-ionic water soluble contrast agents for CT enhancement of hepatic tumors
KR100513900B1 (ko) * 1999-07-12 2005-09-07 주식회사 효성 폴리에스터 인조 스웨드의 제조방법
TW200304374A (en) 2001-11-30 2003-10-01 Smithkline Beecham Plc Novel compounds
CN101891696A (zh) * 2009-05-22 2010-11-24 史命锋 一种多碘苯环化合物及其制备方法和应用
WO2016004563A1 (en) * 2014-07-07 2016-01-14 Chih-Yung Lin Aqueous tissue clearing solution and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH512247A (de) * 1968-05-02 1971-09-15 Bracco Ind Chimica Spa Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4066743A (en) * 1976-06-21 1978-01-03 Mallinckrodt, Inc. X-ray contrast agents
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
JP2568166B2 (ja) * 1982-10-01 1996-12-25 ニユコメド・イメージング・アクシェセルカペト Ｘ線造影剤
DE3429949A1 (de) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel

Also Published As

Publication number Publication date
DE69023210D1 (de) 1995-11-30
DE69023210T2 (de) 1996-03-28
FI97130C (fi) 1996-10-25
IE904181A1 (en) 1991-06-05
GR3018215T3 (en) 1996-02-29
KR0160981B1 (ko) 1998-12-01
FI97130B (fi) 1996-07-15
NO174925B (no) 1994-04-25
ZA909140B (en) 1991-09-25
FI905883A (fi) 1991-05-30
IE73448B1 (en) 1997-06-04
DK0431838T3 (da) 1995-12-04
NO905107D0 (no) 1990-11-26
EP0431838B1 (en) 1995-10-25
MX23489A (es) 1993-10-01
NO905107L (no) 1991-05-30
HU907680D0 (en) 1991-06-28
KR910009655A (ko) 1991-06-28
NO174925C (no) 1994-08-03
PL164291B1 (pl) 1994-07-29
CZ280698B6 (cs) 1996-04-17
PL288021A1 (en) 1991-12-02
CN1107468A (zh) 1995-08-30
RU2046795C1 (ru) 1995-10-27
CN1052114A (zh) 1991-06-12
EG19359A (en) 1994-12-30
PT96020A (pt) 1991-09-13
ATE129493T1 (de) 1995-11-15
ES2078321T3 (es) 1995-12-16
HUT56075A (en) 1991-07-29
IL96324A0 (en) 1991-08-16
JPH03176470A (ja) 1991-07-31
CA2029830A1 (en) 1991-05-30
AU623293B2 (en) 1992-05-07
EP0431838A1 (en) 1991-06-12
PT96020B (pt) 1998-02-27
AU6663790A (en) 1991-06-06
NZ236143A (en) 1993-08-26
CZ595490A3 (en) 1995-12-13
JP2931089B2 (ja) 1999-08-09
FI905883A0 (fi) 1990-11-29

Similar Documents

Publication Publication Date Title
EP0074304B1 (fr) Ethers tricycliques, leur préparation et les compositions pharmaceutiques les contenant
CS228119B2 (en) Production of n2-arylsulphonyl-l-argininamides
US5075502A (en) Nonionic x-ray contrast agents, compositions and methods
US5993780A (en) Contrast media
IL96324A (en) History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents
JPH0568468B2 (ru)
US5158970A (en) Proline derivatives
EP0558395A1 (fr) Composés utilisables dans des produits de contraste pour la radiographie
US5628980A (en) Nonionic radiographic contrast agents
US5192797A (en) Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their preparation and their therapeutic application
US5191120A (en) Process for preparing nonionic X-ray contrast agents
US4162325A (en) N-substituted lactams
US5278311A (en) Nonionic radiographic contrast agents
CH661271A5 (fr) Derives de piperazine et d'homopiperazine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant.
CH632999A5 (fr) (2-thio)urees 1,3-disubstituees.
EP0260605B1 (en) Dihydropyridine-5-phosphonic acid cyclic ester
EP0647618B1 (en) New non ionic iodine-containing dimers useful as x-ray contrast agents, method for the preparation thereof, and galenical compositions containing them
GB1565021A (en) Pharmaceutical compositions containing alkylamine deratives
FR2566410A1 (fr) Nouveaux derives de l'acide diaminopimelique, leur procede de preparation et leur application en therapeutique
CA1305149C (en) Dihydropyridine-5-phosphonic acid cyclic ester
FI78696C (fi) Foerfarande foer framstaellning av smaertstillande 11-/ -(karboximetyl)tio/halogendibenso/b,f/oxepin.
US5053424A (en) 2-(n-acyl)amino-6,7-dimethoxy tetralines, and pharmaceutical compositions having antihypertensive activity containing same
HU197319B (en) Process for producing optically active 2-methyl-1-/4-trifluoromethylphenyl/-3-pyrrolidino-1-propanone
CN101998956A (zh) 氟化二氢丁苯那嗪醚成像剂和探针
MXPA98004536A (en) Derivatives of 5-naftalen-1-il-1,3-dioxan, preparation and therapeutic use of mis

Legal Events

Date Code Title Description
RH Patent void