IL92291A - מלחי אמוניום רבעוניים ותולדות אלקיל אמינו של h 2 1- בנזופיראנים, הכנתם ותכשירי רוקחות המגינים על הלבהמכילים אותם - Google Patents

מלחי אמוניום רבעוניים ותולדות אלקיל אמינו של h 2 1- בנזופיראנים, הכנתם ותכשירי רוקחות המגינים על הלבהמכילים אותם

Info

Publication number
IL92291A
IL92291A IL9229189A IL9229189A IL92291A IL 92291 A IL92291 A IL 92291A IL 9229189 A IL9229189 A IL 9229189A IL 9229189 A IL9229189 A IL 9229189A IL 92291 A IL92291 A IL 92291A
Authority
IL
Israel
Prior art keywords
compound
alkyl
methyl
dihydro
benzopyran
Prior art date
Application number
IL9229189A
Other languages
English (en)
Other versions
IL92291A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP88402854A external-priority patent/EP0369083A1/en
Priority claimed from EP88402853A external-priority patent/EP0369082A1/en
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL92291A0 publication Critical patent/IL92291A0/xx
Publication of IL92291A publication Critical patent/IL92291A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
IL9229189A 1988-11-14 1989-11-13 מלחי אמוניום רבעוניים ותולדות אלקיל אמינו של h 2 1- בנזופיראנים, הכנתם ותכשירי רוקחות המגינים על הלבהמכילים אותם IL92291A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88402854A EP0369083A1 (en) 1988-11-14 1988-11-14 Cardioprotective tocopherol analogs
EP88402853A EP0369082A1 (en) 1988-11-14 1988-11-14 Cardioprotective tocopherol analogs

Publications (2)

Publication Number Publication Date
IL92291A0 IL92291A0 (en) 1990-07-26
IL92291A true IL92291A (he) 1994-10-07

Family

ID=26118102

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9229189A IL92291A (he) 1988-11-14 1989-11-13 מלחי אמוניום רבעוניים ותולדות אלקיל אמינו של h 2 1- בנזופיראנים, הכנתם ותכשירי רוקחות המגינים על הלבהמכילים אותם

Country Status (18)

Country Link
EP (1) EP0369874B1 (he)
JP (1) JP3066901B2 (he)
KR (1) KR0160112B1 (he)
CN (1) CN1033972C (he)
AR (1) AR246962A1 (he)
AT (1) ATE118771T1 (he)
AU (1) AU620660B2 (he)
CA (1) CA2002649C (he)
DE (1) DE68921298T2 (he)
DK (1) DK568189A (he)
ES (1) ES2071674T3 (he)
FI (1) FI91404C (he)
HU (2) HU204807B (he)
IE (1) IE65584B1 (he)
IL (1) IL92291A (he)
NO (1) NO173334C (he)
NZ (1) NZ231367A (he)
PT (1) PT92299B (he)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5135945A (en) * 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs
EP0535283A1 (en) * 1991-10-02 1993-04-07 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
EP0550292A1 (en) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tissue protective tocopherol analogs
HU217426B (hu) * 1992-04-06 2000-01-28 Merrell Dow Pharmaceuticals Inc. Eljárás benzopirán-, benzodioxepin- és benzodioxocénszármazékok és ezeket tartalmazó kardioprotektív gyógyszerkészítmények előállítására
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
IT1256264B (it) * 1992-12-31 1995-11-29 Lifegroup Spa N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
CN100334080C (zh) * 2005-06-01 2007-08-29 华东理工大学 苯并二氢吡喃碳糖苷衍生物
CN111269208A (zh) * 2020-04-09 2020-06-12 通化师范学院 一种Trolox醇酯类衍生物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) * 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans

Also Published As

Publication number Publication date
DE68921298D1 (de) 1995-03-30
NO173334B (no) 1993-08-23
DE68921298T2 (de) 1995-07-06
NO894521L (no) 1990-05-15
FI91404C (fi) 1994-06-27
DK568189D0 (da) 1989-11-13
NO894521D0 (no) 1989-11-13
AR246962A1 (es) 1994-10-31
HU204807B (en) 1992-02-28
IE65584B1 (en) 1995-11-01
EP0369874A2 (en) 1990-05-23
IE893640L (en) 1990-05-14
EP0369874A3 (en) 1990-12-27
CN1042911A (zh) 1990-06-13
PT92299A (pt) 1990-05-31
JP3066901B2 (ja) 2000-07-17
AU620660B2 (en) 1992-02-20
CA2002649C (en) 2000-06-06
PT92299B (pt) 1996-07-31
CN1033972C (zh) 1997-02-05
ES2071674T3 (es) 1995-07-01
ATE118771T1 (de) 1995-03-15
JPH02178278A (ja) 1990-07-11
FI91404B (fi) 1994-03-15
EP0369874B1 (en) 1995-02-22
NO173334C (no) 1993-12-01
HU895879D0 (en) 1990-02-28
CA2002649A1 (en) 1990-05-14
NZ231367A (en) 1992-12-23
DK568189A (da) 1990-05-15
FI895393A0 (fi) 1989-11-13
KR900007827A (ko) 1990-06-02
HU211877A9 (en) 1995-12-28
IL92291A0 (en) 1990-07-26
HUT51610A (en) 1990-05-28
AU4468289A (en) 1990-05-17
KR0160112B1 (ko) 1998-12-01

Similar Documents

Publication Publication Date Title
CA2002649C (en) Cardioprotective tocopherol analogs
EP0536036B1 (en) Cardioprotective tocopherol analogs
US5135945A (en) Cholesterol-lowering tocopherol analogs
EP0550337B1 (en) Tissue protective tocopherol analogs
EP0369083A1 (en) Cardioprotective tocopherol analogs
US5500444A (en) Cardioprotective tocopherol analogs
EP0369082A1 (en) Cardioprotective tocopherol analogs
US5175188A (en) Ascorbic acid derivatives
US5270336A (en) Ascorbic acid derivatives
IL105319A (he) תולדות הידראזיד של 3,4-דיהידרו- h2-1-בנזופיראנים ותכשירי רוקחות המכילים אותן

Legal Events

Date Code Title Description
RH Patent void
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
RH1 Patent not in force
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.