ES2071674T3 - Analogos de tocoferol cardioprotectores. - Google Patents

Analogos de tocoferol cardioprotectores.

Info

Publication number
ES2071674T3
ES2071674T3 ES89403125T ES89403125T ES2071674T3 ES 2071674 T3 ES2071674 T3 ES 2071674T3 ES 89403125 T ES89403125 T ES 89403125T ES 89403125 T ES89403125 T ES 89403125T ES 2071674 T3 ES2071674 T3 ES 2071674T3
Authority
ES
Spain
Prior art keywords
cardioprotectors
tocoferol
analogs
benzopyrans
collect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89403125T
Other languages
English (en)
Inventor
J Martin Grisar
Margaret Petty
Frank Bolkenius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP88402854A external-priority patent/EP0369083A1/en
Priority claimed from EP88402853A external-priority patent/EP0369082A1/en
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2071674T3 publication Critical patent/ES2071674T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

ESTA INVENCION ES RELATIVA A ALQUILAMINO ALQUILENO DERIVADOS DE CIERTOS 2H-1-BENZOPIRANOS, PARA PRODUCTOS INTERMEDIOS Y PROCESOS USADOS PARA SU PREPARACION, PARA RECOGER SU RADICAL LIBRE Y PROPIEDADES DE PROTECCION CELULAR Y SU USO FINAL EN APLICACION COMO AGENTES TERAPEUTICOS.
ES89403125T 1988-11-14 1989-11-14 Analogos de tocoferol cardioprotectores. Expired - Lifetime ES2071674T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88402854A EP0369083A1 (en) 1988-11-14 1988-11-14 Cardioprotective tocopherol analogs
EP88402853A EP0369082A1 (en) 1988-11-14 1988-11-14 Cardioprotective tocopherol analogs

Publications (1)

Publication Number Publication Date
ES2071674T3 true ES2071674T3 (es) 1995-07-01

Family

ID=26118102

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89403125T Expired - Lifetime ES2071674T3 (es) 1988-11-14 1989-11-14 Analogos de tocoferol cardioprotectores.

Country Status (18)

Country Link
EP (1) EP0369874B1 (es)
JP (1) JP3066901B2 (es)
KR (1) KR0160112B1 (es)
CN (1) CN1033972C (es)
AR (1) AR246962A1 (es)
AT (1) ATE118771T1 (es)
AU (1) AU620660B2 (es)
CA (1) CA2002649C (es)
DE (1) DE68921298T2 (es)
DK (1) DK568189A (es)
ES (1) ES2071674T3 (es)
FI (1) FI91404C (es)
HU (2) HU204807B (es)
IE (1) IE65584B1 (es)
IL (1) IL92291A (es)
NO (1) NO173334C (es)
NZ (1) NZ231367A (es)
PT (1) PT92299B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5135945A (en) * 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs
EP0535283A1 (en) * 1991-10-02 1993-04-07 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
EP0550292A1 (en) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tissue protective tocopherol analogs
HU217426B (hu) * 1992-04-06 2000-01-28 Merrell Dow Pharmaceuticals Inc. Eljárás benzopirán-, benzodioxepin- és benzodioxocénszármazékok és ezeket tartalmazó kardioprotektív gyógyszerkészítmények előállítására
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
IT1256264B (it) * 1992-12-31 1995-11-29 Lifegroup Spa N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
CN100334080C (zh) * 2005-06-01 2007-08-29 华东理工大学 苯并二氢吡喃碳糖苷衍生物
CN111269208A (zh) * 2020-04-09 2020-06-12 通化师范学院 一种Trolox醇酯类衍生物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) * 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans

Also Published As

Publication number Publication date
DE68921298D1 (de) 1995-03-30
NO173334B (no) 1993-08-23
DE68921298T2 (de) 1995-07-06
NO894521L (no) 1990-05-15
FI91404C (fi) 1994-06-27
DK568189D0 (da) 1989-11-13
NO894521D0 (no) 1989-11-13
AR246962A1 (es) 1994-10-31
HU204807B (en) 1992-02-28
IE65584B1 (en) 1995-11-01
EP0369874A2 (en) 1990-05-23
IE893640L (en) 1990-05-14
EP0369874A3 (en) 1990-12-27
CN1042911A (zh) 1990-06-13
PT92299A (pt) 1990-05-31
JP3066901B2 (ja) 2000-07-17
AU620660B2 (en) 1992-02-20
CA2002649C (en) 2000-06-06
PT92299B (pt) 1996-07-31
CN1033972C (zh) 1997-02-05
ATE118771T1 (de) 1995-03-15
JPH02178278A (ja) 1990-07-11
FI91404B (fi) 1994-03-15
EP0369874B1 (en) 1995-02-22
NO173334C (no) 1993-12-01
HU895879D0 (en) 1990-02-28
CA2002649A1 (en) 1990-05-14
NZ231367A (en) 1992-12-23
DK568189A (da) 1990-05-15
FI895393A0 (fi) 1989-11-13
IL92291A (en) 1994-10-07
KR900007827A (ko) 1990-06-02
HU211877A9 (en) 1995-12-28
IL92291A0 (en) 1990-07-26
HUT51610A (en) 1990-05-28
AU4468289A (en) 1990-05-17
KR0160112B1 (ko) 1998-12-01

Similar Documents

Publication Publication Date Title
ES2071674T3 (es) Analogos de tocoferol cardioprotectores.
SE8501709D0 (sv) Improvements in or relating to intrleukin therapy
SV1996000114A (es) Nuevos plaguicidas
ES2058185T3 (es) Derivados de camptotecina y procedimiento para su preparacion.
ES2058061T3 (es) Derivado de piperidina, su preparacion y su uso como medicamento.
ES2111092T3 (es) Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
ES2177695T3 (es) Uso de derivados funcionales de la molecual de adhesion intercelular icam-1 en terapia antiviral.
ES2040727T3 (es) Un proceso para preparar una formulacion en aerosol en solucion de un analogo.
BR8807301A (pt) Aparelho para verificar caracteristicas de pecas de trabalho
UY24986A1 (es) Compuestos
ES2044849T3 (es) Un procedimiento para preparar un glicosido de flavona.
BR8700699A (pt) Composicao de protecao de madeira
ES2039198T3 (es) Procedimiento para preparar 5-amino y 5-hidroxi-6,8-difluorquinolonas como agentes antibacteriales.
DE3777756D1 (de) Schutz fuer den ausgangsschalter eines schrittmachers.
ES2084101T3 (es) Fenoxialcanol como un estabilizante para isotiazolonas.
MX5821E (es) El nuevo uso de caracter industrial de los 1,3-dioxolanos como agentes odorantes
CO4230021A1 (es) Glicosidos esteroideos, procedimientos de uso de los mismos como agentes hipocolesterolemicos y agentes antiateroscle- roticos en mamiferos.
ES2057004T3 (es) N-alcoxialquilamidas de hidroxiacidos y composiciones a base de las mismas para el tratamiento de la piel.
ES2169420T3 (es) Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para tratar enfermedades proliferativas.
ES2054881T3 (es) Pantetina como agente inhibidor de la fibrosis hepatica.
FI892222A0 (fi) Peptidalkoholer med antikoagulantverkan.
ES2175246T3 (es) Reticulante pobre en reversion.
DE3560313D1 (en) Improvements in or relating to anticonvulsant agents
ES2147453T3 (es) Antagonistas de adenosina, procedimiento para su preparacion y su uso como medicamentos.
ES2166838T3 (es) 6-(triazolil(3-(trifluorometil)fenil)metil)-2-quinolinonas y -quinolinationas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 369874

Country of ref document: ES