ATE118771T1 - Herzschützende tocopherolähnliche verbindungen. - Google Patents

Herzschützende tocopherolähnliche verbindungen.

Info

Publication number
ATE118771T1
ATE118771T1 AT89403125T AT89403125T ATE118771T1 AT E118771 T1 ATE118771 T1 AT E118771T1 AT 89403125 T AT89403125 T AT 89403125T AT 89403125 T AT89403125 T AT 89403125T AT E118771 T1 ATE118771 T1 AT E118771T1
Authority
AT
Austria
Prior art keywords
tocopherol
heart
protective
compounds
protective tocopherol
Prior art date
Application number
AT89403125T
Other languages
English (en)
Inventor
J Martin Grisar
Margaret Petty
Frank Bolkenius
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP88402854A external-priority patent/EP0369083A1/de
Priority claimed from EP88402853A external-priority patent/EP0369082A1/de
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE118771T1 publication Critical patent/ATE118771T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AT89403125T 1988-11-14 1989-11-14 Herzschützende tocopherolähnliche verbindungen. ATE118771T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88402854A EP0369083A1 (de) 1988-11-14 1988-11-14 Herzschutz-Tocopherolanaloge
EP88402853A EP0369082A1 (de) 1988-11-14 1988-11-14 Herzschutz-Tocopherolanaloge

Publications (1)

Publication Number Publication Date
ATE118771T1 true ATE118771T1 (de) 1995-03-15

Family

ID=26118102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89403125T ATE118771T1 (de) 1988-11-14 1989-11-14 Herzschützende tocopherolähnliche verbindungen.

Country Status (18)

Country Link
EP (1) EP0369874B1 (de)
JP (1) JP3066901B2 (de)
KR (1) KR0160112B1 (de)
CN (1) CN1033972C (de)
AR (1) AR246962A1 (de)
AT (1) ATE118771T1 (de)
AU (1) AU620660B2 (de)
CA (1) CA2002649C (de)
DE (1) DE68921298T2 (de)
DK (1) DK568189A (de)
ES (1) ES2071674T3 (de)
FI (1) FI91404C (de)
HU (2) HU204807B (de)
IE (1) IE65584B1 (de)
IL (1) IL92291A (de)
NO (1) NO173334C (de)
NZ (1) NZ231367A (de)
PT (1) PT92299B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5135945A (en) * 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs
EP0535283A1 (de) * 1991-10-02 1993-04-07 Merrell Dow Pharmaceuticals Inc. Tocopherol Analoge mit kardioprotektiver Wirkung
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
EP0550292A1 (de) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tocopherol-Analog zum Gewebeschutz
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
DK0635010T3 (da) * 1992-04-06 1996-12-30 Merrell Pharma Inc Nye kardioprotektive midler
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
IT1256264B (it) * 1992-12-31 1995-11-29 Lifegroup Spa N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
CN100334080C (zh) * 2005-06-01 2007-08-29 华东理工大学 苯并二氢吡喃碳糖苷衍生物
CN111269208A (zh) * 2020-04-09 2020-06-12 通化师范学院 一种Trolox醇酯类衍生物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) * 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans

Also Published As

Publication number Publication date
CA2002649A1 (en) 1990-05-14
HU211877A9 (en) 1995-12-28
JPH02178278A (ja) 1990-07-11
PT92299A (pt) 1990-05-31
NO894521D0 (no) 1989-11-13
DK568189D0 (da) 1989-11-13
DE68921298D1 (de) 1995-03-30
AU620660B2 (en) 1992-02-20
EP0369874A3 (en) 1990-12-27
CN1042911A (zh) 1990-06-13
NO173334B (no) 1993-08-23
KR900007827A (ko) 1990-06-02
IE893640L (en) 1990-05-14
NO173334C (no) 1993-12-01
CA2002649C (en) 2000-06-06
ES2071674T3 (es) 1995-07-01
IL92291A0 (en) 1990-07-26
FI91404B (fi) 1994-03-15
JP3066901B2 (ja) 2000-07-17
AU4468289A (en) 1990-05-17
HU895879D0 (en) 1990-02-28
EP0369874B1 (de) 1995-02-22
IL92291A (en) 1994-10-07
DE68921298T2 (de) 1995-07-06
NO894521L (no) 1990-05-15
FI895393A0 (fi) 1989-11-13
HUT51610A (en) 1990-05-28
PT92299B (pt) 1996-07-31
NZ231367A (en) 1992-12-23
FI91404C (fi) 1994-06-27
EP0369874A2 (de) 1990-05-23
KR0160112B1 (ko) 1998-12-01
DK568189A (da) 1990-05-15
AR246962A1 (es) 1994-10-31
IE65584B1 (en) 1995-11-01
CN1033972C (zh) 1997-02-05
HU204807B (en) 1992-02-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee