DE68921298D1 - Herzschützende tocopherolähnliche Verbindungen. - Google Patents
Herzschützende tocopherolähnliche Verbindungen.Info
- Publication number
- DE68921298D1 DE68921298D1 DE68921298T DE68921298T DE68921298D1 DE 68921298 D1 DE68921298 D1 DE 68921298D1 DE 68921298 T DE68921298 T DE 68921298T DE 68921298 T DE68921298 T DE 68921298T DE 68921298 D1 DE68921298 D1 DE 68921298D1
- Authority
- DE
- Germany
- Prior art keywords
- tocopherol
- heart
- protecting
- compounds
- protecting tocopherol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88402854A EP0369083A1 (de) | 1988-11-14 | 1988-11-14 | Herzschutz-Tocopherolanaloge |
EP88402853A EP0369082A1 (de) | 1988-11-14 | 1988-11-14 | Herzschutz-Tocopherolanaloge |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68921298D1 true DE68921298D1 (de) | 1995-03-30 |
DE68921298T2 DE68921298T2 (de) | 1995-07-06 |
Family
ID=26118102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68921298T Expired - Lifetime DE68921298T2 (de) | 1988-11-14 | 1989-11-14 | Herzschützende tocopherolähnliche Verbindungen. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0369874B1 (de) |
JP (1) | JP3066901B2 (de) |
KR (1) | KR0160112B1 (de) |
CN (1) | CN1033972C (de) |
AR (1) | AR246962A1 (de) |
AT (1) | ATE118771T1 (de) |
AU (1) | AU620660B2 (de) |
CA (1) | CA2002649C (de) |
DE (1) | DE68921298T2 (de) |
DK (1) | DK568189A (de) |
ES (1) | ES2071674T3 (de) |
FI (1) | FI91404C (de) |
HU (2) | HU204807B (de) |
IE (1) | IE65584B1 (de) |
IL (1) | IL92291A (de) |
NO (1) | NO173334C (de) |
NZ (1) | NZ231367A (de) |
PT (1) | PT92299B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2676056B1 (fr) * | 1991-05-03 | 1993-07-16 | Adir | Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5135945A (en) * | 1991-06-05 | 1992-08-04 | Merrell Dow Pharmaceuticals Inc. | Cholesterol-lowering tocopherol analogs |
EP0535283A1 (de) * | 1991-10-02 | 1993-04-07 | Merrell Dow Pharmaceuticals Inc. | Tocopherol Analoge mit kardioprotektiver Wirkung |
DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
CA2082004A1 (en) * | 1991-11-20 | 1993-05-21 | David Laffan | Substituted pentaalkylchromans |
EP0550292A1 (de) * | 1992-01-02 | 1993-07-07 | Merrell Dow Pharmaceuticals Inc. | Tocopherol-Analog zum Gewebeschutz |
US5510373A (en) * | 1992-04-06 | 1996-04-23 | Merrell Pharmaceuticals Inc. | Cardioprotective agents |
US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
DK0635010T3 (da) * | 1992-04-06 | 1996-12-30 | Merrell Pharma Inc | Nye kardioprotektive midler |
US5545660A (en) * | 1992-04-07 | 1996-08-13 | Merrell Pharmaceuticals Inc. | Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans |
IT1256264B (it) * | 1992-12-31 | 1995-11-29 | Lifegroup Spa | N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione |
US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5663194A (en) * | 1995-07-25 | 1997-09-02 | Mewshaw; Richard E. | Chroman-2-ylmethylamino derivatives |
US5670667A (en) * | 1995-07-25 | 1997-09-23 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5684039A (en) * | 1995-07-25 | 1997-11-04 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
CN100334080C (zh) * | 2005-06-01 | 2007-08-29 | 华东理工大学 | 苯并二氢吡喃碳糖苷衍生物 |
CN111269208A (zh) * | 2020-04-09 | 2020-06-12 | 通化师范学院 | 一种Trolox醇酯类衍生物及其制备方法和应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4321270A (en) * | 1981-01-29 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Substituted chromans |
-
1989
- 1989-11-09 CA CA002002649A patent/CA2002649C/en not_active Expired - Lifetime
- 1989-11-10 AR AR89315417A patent/AR246962A1/es active
- 1989-11-13 IE IE364089A patent/IE65584B1/en not_active IP Right Cessation
- 1989-11-13 PT PT92299A patent/PT92299B/pt not_active IP Right Cessation
- 1989-11-13 FI FI895393A patent/FI91404C/fi not_active IP Right Cessation
- 1989-11-13 DK DK568189A patent/DK568189A/da not_active Application Discontinuation
- 1989-11-13 KR KR1019890016464A patent/KR0160112B1/ko not_active IP Right Cessation
- 1989-11-13 NZ NZ231367A patent/NZ231367A/xx unknown
- 1989-11-13 HU HU895879A patent/HU204807B/hu not_active IP Right Cessation
- 1989-11-13 NO NO894521A patent/NO173334C/no not_active IP Right Cessation
- 1989-11-13 IL IL9229189A patent/IL92291A/en not_active IP Right Cessation
- 1989-11-14 ES ES89403125T patent/ES2071674T3/es not_active Expired - Lifetime
- 1989-11-14 AT AT89403125T patent/ATE118771T1/de not_active IP Right Cessation
- 1989-11-14 EP EP89403125A patent/EP0369874B1/de not_active Expired - Lifetime
- 1989-11-14 DE DE68921298T patent/DE68921298T2/de not_active Expired - Lifetime
- 1989-11-14 CN CN89109257A patent/CN1033972C/zh not_active Expired - Fee Related
- 1989-11-14 AU AU44682/89A patent/AU620660B2/en not_active Ceased
- 1989-11-14 JP JP1294094A patent/JP3066901B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-16 HU HU95P/P00237P patent/HU211877A9/hu unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |