IL88313A - Derivatives of 3-substituted- 5-isopropylimidazo (1,5-a) quinoxalin-4(5h)-one and the isosteric pyridine analog, their preparation and pharmaceutical compositions containing them - Google Patents
Derivatives of 3-substituted- 5-isopropylimidazo (1,5-a) quinoxalin-4(5h)-one and the isosteric pyridine analog, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL88313A IL88313A IL88313A IL8831388A IL88313A IL 88313 A IL88313 A IL 88313A IL 88313 A IL88313 A IL 88313A IL 8831388 A IL8831388 A IL 8831388A IL 88313 A IL88313 A IL 88313A
- Authority
- IL
- Israel
- Prior art keywords
- isopropylimidazo
- isosteric
- quinoxalin
- derivatives
- substituted
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 3-substituted- 5-isopropylimidazo (1,5-a) quinoxalin-4(5h)-one Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- YELMWJNXDALKFE-UHFFFAOYSA-N 3h-imidazo[4,5-f]quinoxaline Chemical class N1=CC=NC2=C(NC=N3)C3=CC=C21 YELMWJNXDALKFE-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940005530 anxiolytics Drugs 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000003920 cognitive function Effects 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK642287A DK160876C (da) | 1987-12-08 | 1987-12-08 | Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL88313A0 IL88313A0 (en) | 1989-06-30 |
| IL88313A true IL88313A (en) | 1993-06-10 |
Family
ID=8148726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL88313A IL88313A (en) | 1987-12-08 | 1988-11-07 | Derivatives of 3-substituted- 5-isopropylimidazo (1,5-a) quinoxalin-4(5h)-one and the isosteric pyridine analog, their preparation and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4968682A (pt) |
| EP (1) | EP0320136B1 (pt) |
| JP (1) | JPH01190684A (pt) |
| KR (1) | KR0133079B1 (pt) |
| AT (1) | ATE109147T1 (pt) |
| AU (1) | AU613125B2 (pt) |
| CA (1) | CA1327797C (pt) |
| DE (1) | DE3850861T2 (pt) |
| DK (1) | DK160876C (pt) |
| ES (1) | ES2056941T3 (pt) |
| FI (2) | FI90548C (pt) |
| IE (1) | IE66336B1 (pt) |
| IL (1) | IL88313A (pt) |
| NO (1) | NO169540C (pt) |
| NZ (1) | NZ227212A (pt) |
| PH (1) | PH24818A (pt) |
| PT (1) | PT89170B (pt) |
| ZA (1) | ZA888558B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK155524C (da) * | 1987-03-18 | 1989-09-11 | Ferrosan As | Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse |
| IL90315A0 (en) * | 1988-06-01 | 1989-12-15 | Ferrosan As | Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them |
| DK626288D0 (da) * | 1988-11-10 | 1988-11-10 | Ferrosan As | Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen |
| US5602252A (en) * | 1989-11-17 | 1997-02-11 | Berlex Laboratories, Inc. | Tricyclic pteridinones and a process for their preparation |
| US5854419A (en) * | 1989-11-17 | 1998-12-29 | Schering Aktiengesellschaft | Tricyclic pteridinones and a process for their preparation |
| DK588489D0 (da) * | 1989-11-22 | 1989-11-22 | Ferrosan As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| DK588389D0 (da) * | 1989-11-22 | 1989-11-22 | Ferrosan As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| US5371080A (en) * | 1990-06-22 | 1994-12-06 | Novo Nordisk A/S | Imidazoquinazoline compounds and their use |
| DK151890D0 (da) * | 1990-06-22 | 1990-06-22 | Ferrosan As | Heterocykliske forbindelser deres fremstilling og brug |
| US5276028A (en) * | 1990-06-22 | 1994-01-04 | Nordisk A/S | Imidazoquinoxaline compounds |
| AU657986B2 (en) * | 1991-06-14 | 1995-03-30 | Pharmacia & Upjohn Company | Imidazo(1,5-a)quinoxalines |
| JPH0525037A (ja) * | 1991-07-01 | 1993-02-02 | Upjohn Co:The | 経口投与酵素感受性腸溶製剤 |
| JP3512110B2 (ja) * | 1992-02-13 | 2004-03-29 | ファルマシア・アンド・アップジョン・カンパニー | ベンゾジアゼピン受容体結合剤として有用な４−オキソ−および４Ｈ−イミダゾ（５，１−ｃ）（１，４）ベンゾオキサジン類 |
| TW274550B (pt) * | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
| US5620978A (en) * | 1994-01-03 | 1997-04-15 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor |
| US5792766A (en) | 1996-03-13 | 1998-08-11 | Neurogen Corporation | Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands |
| JP2009523820A (ja) * | 2006-01-23 | 2009-06-25 | アミラ ファーマシューティカルス，インコーポレーテッド | ５−リポキシゲナーゼの三環系抑制剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5823693A (ja) * | 1981-07-16 | 1983-02-12 | ユ−エスヴイ−・フア−マシユ−テイカル・コ−ポレ−シヨン | イミダゾキノキザリン化合物類 |
| US4440929A (en) * | 1981-07-16 | 1984-04-03 | Usv Pharmaceutical Corporation | Imidazoquinoxaline compounds |
| DK476885D0 (da) * | 1985-10-17 | 1985-10-17 | Ferrosan As | Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf |
| DK155524C (da) * | 1987-03-18 | 1989-09-11 | Ferrosan As | Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse |
| DK161148C (da) * | 1988-06-14 | 1991-11-18 | Novo Nordisk As | Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne |
-
1987
- 1987-12-08 DK DK642287A patent/DK160876C/da not_active IP Right Cessation
-
1988
- 1988-11-07 IL IL88313A patent/IL88313A/xx not_active IP Right Cessation
- 1988-11-07 IE IE334788A patent/IE66336B1/en not_active IP Right Cessation
- 1988-11-11 PH PH37802A patent/PH24818A/en unknown
- 1988-11-16 ZA ZA888558A patent/ZA888558B/xx unknown
- 1988-11-21 ES ES88310982T patent/ES2056941T3/es not_active Expired - Lifetime
- 1988-11-21 AT AT88310982T patent/ATE109147T1/de not_active IP Right Cessation
- 1988-11-21 DE DE3850861T patent/DE3850861T2/de not_active Expired - Fee Related
- 1988-11-21 EP EP88310982A patent/EP0320136B1/en not_active Expired - Lifetime
- 1988-11-28 FI FI885518A patent/FI90548C/fi not_active IP Right Cessation
- 1988-11-30 CA CA000584610A patent/CA1327797C/en not_active Expired - Fee Related
- 1988-12-06 NZ NZ227212A patent/NZ227212A/xx unknown
- 1988-12-06 AU AU26602/88A patent/AU613125B2/en not_active Ceased
- 1988-12-06 PT PT89170A patent/PT89170B/pt not_active IP Right Cessation
- 1988-12-06 KR KR1019880016202A patent/KR0133079B1/ko not_active Expired - Fee Related
- 1988-12-07 US US07/281,090 patent/US4968682A/en not_active Expired - Fee Related
- 1988-12-07 NO NO885442A patent/NO169540C/no unknown
- 1988-12-08 JP JP63308994A patent/JPH01190684A/ja active Pending
-
1990
- 1990-01-03 US US07/460,310 patent/US4999354A/en not_active Expired - Fee Related
-
1992
- 1992-11-23 FI FI925309A patent/FI93836C/fi not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL88313A (en) | Derivatives of 3-substituted- 5-isopropylimidazo (1,5-a) quinoxalin-4(5h)-one and the isosteric pyridine analog, their preparation and pharmaceutical compositions containing them | |
| IL90543A0 (en) | Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them | |
| PH25034A (en) | Process for the preparation of imidazoquinazoline compounds and intermediate for use in said process | |
| IL71887A0 (en) | Beta-carbolin-3-carboxilyc acid derivatives and methods for the preparation thereof | |
| NZ226461A (en) | S-oxo-imidazo-(1,5-a)-thienopyrimidine derivatives; pharmaceutical compositions and processes for preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |