IL86751A - תכשירי רוקחות המכילים ציקלוספורינים וציקלוספורינים למיניהם - Google Patents
תכשירי רוקחות המכילים ציקלוספורינים וציקלוספורינים למיניהםInfo
- Publication number
- IL86751A IL86751A IL8675188A IL8675188A IL86751A IL 86751 A IL86751 A IL 86751A IL 8675188 A IL8675188 A IL 8675188A IL 8675188 A IL8675188 A IL 8675188A IL 86751 A IL86751 A IL 86751A
- Authority
- IL
- Israel
- Prior art keywords
- residue
- cyclosporin
- cyclosporins
- mebmt
- ciclosporin
- Prior art date
Links
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878714115A GB8714115D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
| GB878714093A GB8714093D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
| GB878714125A GB8714125D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
| GB878714098A GB8714098D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
| GB878714100A GB8714100D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
| GB878714119A GB8714119D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
| GB878714118A GB8714118D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
| GB878714090A GB8714090D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL86751A0 IL86751A0 (en) | 1988-11-30 |
| IL86751A true IL86751A (he) | 1994-02-27 |
Family
ID=27571252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8675188A IL86751A (he) | 1987-06-17 | 1988-06-15 | תכשירי רוקחות המכילים ציקלוספורינים וציקלוספורינים למיניהם |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5525590A (he) |
| EP (1) | EP0296122B1 (he) |
| JP (2) | JPH0832724B2 (he) |
| KR (1) | KR970010927B1 (he) |
| AT (1) | ATE95193T1 (he) |
| AU (1) | AU614086B2 (he) |
| CA (1) | CA1338728C (he) |
| CY (1) | CY1939A (he) |
| CZ (1) | CZ411791A3 (he) |
| DE (1) | DE3884470T2 (he) |
| DK (1) | DK173873B1 (he) |
| ES (1) | ES2059558T3 (he) |
| HK (1) | HK152796A (he) |
| HU (1) | HU211678A9 (he) |
| IE (1) | IE62482B1 (he) |
| IL (1) | IL86751A (he) |
| MY (1) | MY103582A (he) |
| NZ (1) | NZ225041A (he) |
| PT (1) | PT87745B (he) |
| SA (1) | SA97170746A (he) |
| SK (1) | SK411791A3 (he) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
| US5236899A (en) * | 1987-11-16 | 1993-08-17 | Merck & Co., Inc. | 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance |
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| GB2230440B (en) * | 1989-02-09 | 1993-05-19 | Sandoz Ltd | Novel cyclosporin galenic forms |
| US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| GB8916901D0 (en) * | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| GB9204466D0 (en) * | 1992-03-02 | 1992-04-15 | Sandoz Ltd | Improvements in or relating to organic compounds |
| GB9208712D0 (en) * | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
| EP0642332B1 (en) | 1992-05-13 | 1997-01-15 | Sandoz Ltd. | Ophthalmic compositions containing a cyclosporin |
| SK278290B6 (en) * | 1992-09-07 | 1996-08-07 | Milan Stuchlik | Medicaments with n-methylated cyclic undecapeptides |
| ES2168271T3 (es) | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
| US20020099067A1 (en) * | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
| GB9318612D0 (en) * | 1993-09-08 | 1993-10-27 | Sandoz Ltd | An assay |
| US6187547B1 (en) | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
| ES2293638T3 (es) * | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| PT789580E (pt) | 1994-11-03 | 2002-09-30 | Novartis Ag | Formulacoes de ciclosporina para administracao oral com composicao simples e alta biodisponibilidade e processo para a sua producao |
| GR1002687B (el) * | 1995-04-17 | 1997-05-06 | Novartis Ag (Novartis Sa) (Novartis Inc.) | Διαδικασια παραγωγης. |
| US6395770B1 (en) * | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| DE19549852B4 (de) | 1995-11-29 | 2009-06-04 | Novartis Ag | Cyclosporin enthaltende Präparate |
| GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| EP0988046B1 (en) | 1997-01-30 | 2004-09-15 | Novartis AG | Oil-free pharmaceutical compositions containing cyclosporin a |
| NZ502362A (en) * | 1997-10-08 | 2001-05-25 | Isotechnika Inc | Deuterated cyclosporine A derivatives and their use as immunomodulating agents |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| US6201165B1 (en) | 1997-10-16 | 2001-03-13 | Board Of Regents, University Of Texas System | Transgenic animal models for cardiac hypertrophy and methods of use thereof |
| EP1091975B1 (fr) | 1998-07-01 | 2005-12-14 | Debiopharm S.A. | Nouvelle cyclosporine ayant un profil d'activite ameliore |
| WO2000040219A1 (en) | 1998-12-30 | 2000-07-13 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosporin |
| US6255280B1 (en) * | 1999-04-08 | 2001-07-03 | University Of Kentucky Research Foundation | Protection against traumatic brain injury |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| US6784156B2 (en) | 2001-03-05 | 2004-08-31 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of respiratory diseases |
| GB0113663D0 (en) * | 2001-06-05 | 2001-07-25 | Novartis Ag | Use of organic compounds |
| US20030087813A1 (en) | 2001-10-12 | 2003-05-08 | Or Yat Sun | Cyclosporin analogs for the treatment of lung diseases |
| US6809077B2 (en) | 2001-10-12 | 2004-10-26 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogs for the treatment of autoimmune diseases |
| PT1436322E (pt) * | 2001-10-19 | 2008-10-23 | Isotechnika Inc | Misturas de análogos da ciclosporina e sua utilização como agentes imunomodulantes |
| AU2007221839B2 (en) * | 2001-10-19 | 2011-05-12 | Aurinia Pharmaceuticals Inc. | Synthesis of cyclosporin analogs |
| DE60233150D1 (de) | 2001-10-19 | 2009-09-10 | Isotechnika Inc | Neue cyclosporin-analoge mikroemulsionsvorkonzentrate |
| CN100334106C (zh) * | 2001-10-19 | 2007-08-29 | 伊索泰克尼卡股份有限公司 | 环孢菌素类似物的合成 |
| US7012065B2 (en) | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
| US7538084B2 (en) * | 2003-03-17 | 2009-05-26 | Amr Technology, Inc. | Cyclosporins |
| TW200505946A (en) * | 2003-04-08 | 2005-02-16 | Hoffmann La Roche | Process for preparation of cyclosporin a analog |
| BRPI0509755A (pt) * | 2004-04-08 | 2007-10-16 | Applied Research Systems | composição compreendendo um inibidor de jnk e ciclosporina |
| US20060014677A1 (en) * | 2004-07-19 | 2006-01-19 | Isotechnika International Inc. | Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds |
| WO2006039164A2 (en) * | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
| EP1809656A4 (en) * | 2004-09-29 | 2009-03-25 | Amr Technology Inc | CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS |
| EP1812037A4 (en) * | 2004-10-06 | 2009-11-11 | Amr Technology Inc | ALKYNES OF CYCLOSPORINE AND THEIR USEFUL AS PHARMACEUTICAL AGENTS |
| TW200635954A (en) * | 2004-12-17 | 2006-10-16 | Isotechnika Inc | Metabolites of cyclosporin analogs |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US20080206287A1 (en) * | 2006-09-18 | 2008-08-28 | Reed John C | Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands |
| BRPI0806265A2 (pt) * | 2007-01-04 | 2011-09-06 | Debiopharm Sa | ciclosporina não-imunossupressora para tratamento de distrofia muscular congênita de ullrich |
| TW200932240A (en) | 2007-10-25 | 2009-08-01 | Astellas Pharma Inc | Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production |
| CN102164948A (zh) * | 2008-07-30 | 2011-08-24 | 伊索技术制药公司 | 非免疫抑制的环孢菌素类似分子 |
| AU2009303389B2 (en) | 2008-10-17 | 2014-10-16 | Wisconsin Alumni Research Foundation | Method of making biologically active alpha-beta peptides |
| EP2376524B1 (en) * | 2008-12-31 | 2017-03-15 | Cypralis Limited | Derivatives of cyclosporin a |
| MX2011008000A (es) * | 2009-01-30 | 2011-09-15 | Enanta Pharm Inc | Analogos de ciclosporina para la prevención o tratamiento de la infeccion de hepatitis c. |
| US8481483B2 (en) * | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8349312B2 (en) * | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
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| DE102009037551A1 (de) | 2009-08-17 | 2011-02-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Cyclosporinderivate |
| US8623814B2 (en) * | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
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| WO2012145427A1 (en) | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
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| SG11201601274QA (en) | 2013-08-26 | 2016-03-30 | Enanta Pharm Inc | Cyclosporin analogues for preventing or treating hepatitis c |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| PH12016501545B1 (en) | 2014-03-14 | 2023-12-06 | Immutep Sas | Antibody molecules to lag-3 and uses thereof |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| CA2964367C (en) | 2014-10-14 | 2024-01-30 | Novartis Ag | Antibody molecules to pd-l1 and uses thereof |
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| JP2019500893A (ja) | 2015-11-03 | 2019-01-17 | ヤンセン バイオテツク，インコーポレーテツド | Ｐｄ−１及びｔｉｍ−３に特異的に結合する抗体及びそれらの使用 |
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| MA49457A (fr) | 2017-06-22 | 2020-04-29 | Novartis Ag | Molécules d'anticorps se liant à cd73 et leurs utilisations |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| WO2019232244A2 (en) | 2018-05-31 | 2019-12-05 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| WO2020014652A1 (en) * | 2018-07-13 | 2020-01-16 | New York University | Peptoid-peptide macrocycles, pharmaceutical compositions and methods of using the same |
| CN114502590A (zh) | 2019-09-18 | 2022-05-13 | 诺华股份有限公司 | Entpd2抗体、组合疗法、以及使用这些抗体和组合疗法的方法 |
| CN114208781B (zh) * | 2022-01-20 | 2022-12-20 | 河南农业大学 | 一种抑制草地贪夜蛾龄期的方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210581A (en) * | 1975-11-04 | 1980-07-01 | Sandoz Ltd. | Organic compounds |
| CH614931A5 (he) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| IE54936B1 (en) * | 1980-02-14 | 1990-03-28 | Sandoz Ltd | A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| GB8407618D0 (en) * | 1984-03-23 | 1984-05-02 | Sandoz Ltd | Organic compounds |
| CH667274A5 (de) * | 1984-03-23 | 1988-09-30 | Sandoz Ag | Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
-
1988
- 1988-06-14 EP EP88810403A patent/EP0296122B1/en not_active Expired - Lifetime
- 1988-06-14 AT AT88810403T patent/ATE95193T1/de not_active IP Right Cessation
- 1988-06-14 DE DE88810403T patent/DE3884470T2/de not_active Expired - Lifetime
- 1988-06-14 ES ES88810403T patent/ES2059558T3/es not_active Expired - Lifetime
- 1988-06-15 MY MYPI88000662A patent/MY103582A/en unknown
- 1988-06-15 IE IE180788A patent/IE62482B1/en not_active IP Right Cessation
- 1988-06-15 CA CA000569523A patent/CA1338728C/en not_active Expired - Fee Related
- 1988-06-15 NZ NZ225041A patent/NZ225041A/en unknown
- 1988-06-15 DK DK198803265A patent/DK173873B1/da not_active IP Right Cessation
- 1988-06-15 IL IL8675188A patent/IL86751A/he not_active IP Right Cessation
- 1988-06-15 AU AU17679/88A patent/AU614086B2/en not_active Expired
- 1988-06-16 PT PT87745A patent/PT87745B/pt not_active IP Right Cessation
- 1988-06-16 JP JP63149227A patent/JPH0832724B2/ja not_active Expired - Lifetime
- 1988-06-16 KR KR1019880007330A patent/KR970010927B1/ko not_active Expired - Fee Related
-
1991
- 1991-12-27 SK SK4117-91A patent/SK411791A3/sk unknown
- 1991-12-27 CZ CS914117A patent/CZ411791A3/cs unknown
-
1994
- 1994-11-10 US US08/337,346 patent/US5525590A/en not_active Expired - Lifetime
-
1995
- 1995-06-22 HU HU95P/P00332P patent/HU211678A9/hu unknown
- 1995-08-16 JP JP7208783A patent/JP2772372B2/ja not_active Expired - Lifetime
-
1996
- 1996-08-08 HK HK152796A patent/HK152796A/en not_active IP Right Cessation
-
1997
- 1997-03-25 SA SA97170746A patent/SA97170746A/ar unknown
- 1997-05-16 CY CY193997A patent/CY1939A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK173873B1 (da) | 2002-01-21 |
| NZ225041A (en) | 1991-03-26 |
| PT87745A (pt) | 1988-07-01 |
| SK411791A3 (en) | 1995-07-11 |
| DK326588A (da) | 1988-12-18 |
| IE881807L (en) | 1988-12-17 |
| HU211678A9 (en) | 1995-12-28 |
| ES2059558T3 (es) | 1994-11-16 |
| AU1767988A (en) | 1988-12-22 |
| EP0296122A3 (en) | 1990-06-20 |
| CY1939A (en) | 1997-05-16 |
| MY103582A (en) | 1993-08-28 |
| EP0296122A2 (en) | 1988-12-21 |
| IL86751A0 (en) | 1988-11-30 |
| SA97170746A (ar) | 2005-12-03 |
| JPH0832724B2 (ja) | 1996-03-29 |
| CA1338728C (en) | 1996-11-19 |
| JP2772372B2 (ja) | 1998-07-02 |
| KR970010927B1 (ko) | 1997-07-02 |
| US5525590A (en) | 1996-06-11 |
| DE3884470D1 (de) | 1993-11-04 |
| HK152796A (en) | 1996-08-16 |
| DK326588D0 (da) | 1988-06-15 |
| EP0296122B1 (en) | 1993-09-29 |
| KR890000519A (ko) | 1989-03-15 |
| ATE95193T1 (de) | 1993-10-15 |
| CZ411791A3 (en) | 1993-02-17 |
| JPS6445396A (en) | 1989-02-17 |
| IE62482B1 (en) | 1995-02-08 |
| JPH0848696A (ja) | 1996-02-20 |
| DE3884470T2 (de) | 1994-03-10 |
| AU614086B2 (en) | 1991-08-22 |
| PT87745B (pt) | 1992-10-30 |
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