IL72409A - Aroyl-benzofuran and-benzothiophene acetic and propionic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them - Google Patents

Aroyl-benzofuran and-benzothiophene acetic and propionic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL72409A
IL72409A IL72409A IL7240984A IL72409A IL 72409 A IL72409 A IL 72409A IL 72409 A IL72409 A IL 72409A IL 7240984 A IL7240984 A IL 7240984A IL 72409 A IL72409 A IL 72409A
Authority
IL
Israel
Prior art keywords
aroyl
benzofuran
derivatives
preparation
pharmaceutical compositions
Prior art date
Application number
IL72409A
Other languages
English (en)
Other versions
IL72409A0 (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IL72409A0 publication Critical patent/IL72409A0/xx
Publication of IL72409A publication Critical patent/IL72409A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL72409A 1983-07-14 1984-07-13 Aroyl-benzofuran and-benzothiophene acetic and propionic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them IL72409A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51354583A 1983-07-14 1983-07-14

Publications (2)

Publication Number Publication Date
IL72409A0 IL72409A0 (en) 1984-11-30
IL72409A true IL72409A (en) 1988-05-31

Family

ID=24043724

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72409A IL72409A (en) 1983-07-14 1984-07-13 Aroyl-benzofuran and-benzothiophene acetic and propionic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0132130B1 (da)
JP (1) JPS6038376A (da)
KR (1) KR880002533B1 (da)
AR (1) AR240815A1 (da)
AT (1) ATE50769T1 (da)
AU (1) AU567953B2 (da)
CA (1) CA1241008A (da)
CS (1) CS252476B2 (da)
DE (1) DE3481512D1 (da)
DK (1) DK347484A (da)
ES (2) ES8604554A1 (da)
FI (1) FI842738A (da)
GR (1) GR79949B (da)
HU (1) HU200450B (da)
IL (1) IL72409A (da)
NO (1) NO842878L (da)
NZ (1) NZ208894A (da)
PH (1) PH20790A (da)
PL (4) PL145622B1 (da)
PT (1) PT78905B (da)
SU (2) SU1409130A3 (da)
ZA (1) ZA845445B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0226670B1 (en) * 1985-12-04 1991-04-10 Imperial Chemical Industries Plc Process for hydroxyaraldehydes
GB8825505D0 (en) 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
WO1996003396A1 (en) * 1994-07-27 1996-02-08 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
GB9814801D0 (en) * 1998-07-09 1998-09-09 Univ Strathclyde Integrin dependent cell adhesion inhibitors
DE60227576D1 (de) 2002-12-10 2008-08-21 Ranbaxy Lab Ltd 3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS
TW202345792A (zh) * 2022-04-28 2023-12-01 日商第一三共股份有限公司 苯并噻吩化合物
CN115403544B (zh) * 2022-09-16 2024-05-31 台州永健医药科技有限公司 一种丹酚酸c的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077733B1 (da) * 1970-02-10 1973-03-16 Roussel Uclaf
DE2909754A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
US4237144A (en) * 1979-06-21 1980-12-02 Merck & Co., Inc. 2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans
DE2931672A1 (de) * 1979-08-04 1981-02-26 Basf Ag Substituierte 2,3-dihydrobenzofurylmethylester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen
JPS5951275A (ja) * 1982-05-31 1984-03-24 Sumitomo Chem Co Ltd 新規な複素環化合物
DE3460315D1 (en) * 1983-02-19 1986-08-28 Beecham Group Plc Benzofuran and benzothiophene-carboxylic-acid derivatives

Also Published As

Publication number Publication date
PL146523B1 (en) 1989-02-28
CS545984A2 (en) 1987-01-15
CA1241008A (en) 1988-08-23
EP0132130B1 (en) 1990-03-07
PH20790A (en) 1987-04-14
SU1614762A3 (ru) 1990-12-15
ATE50769T1 (de) 1990-03-15
AU3059384A (en) 1985-01-17
CS252476B2 (en) 1987-09-17
PL145622B1 (en) 1988-10-31
DK347484D0 (da) 1984-07-13
ES544539A0 (es) 1986-06-16
DK347484A (da) 1985-01-15
PL255163A1 (en) 1986-07-15
EP0132130A3 (en) 1986-12-10
SU1409130A3 (ru) 1988-07-07
EP0132130A2 (en) 1985-01-23
JPS6038376A (ja) 1985-02-27
GR79949B (da) 1984-10-31
FI842738A0 (fi) 1984-07-09
ZA845445B (en) 1986-02-26
DE3481512D1 (de) 1990-04-12
AR240815A1 (es) 1991-02-28
FI842738A (fi) 1985-01-15
HU200450B (en) 1990-06-28
ES534324A0 (es) 1986-02-16
ES8604554A1 (es) 1986-02-16
KR880002533B1 (ko) 1988-11-28
PT78905A (en) 1984-08-01
PL255162A1 (en) 1986-07-15
ES8607960A1 (es) 1986-06-16
AU567953B2 (en) 1987-12-10
PT78905B (en) 1986-07-22
PL146833B1 (en) 1989-03-31
PL255164A1 (en) 1986-07-15
AR240815A2 (es) 1991-02-28
HUT36108A (en) 1985-08-28
KR850001202A (ko) 1985-03-16
IL72409A0 (en) 1984-11-30
NZ208894A (en) 1987-01-23
PL248729A1 (en) 1986-06-17
NO842878L (no) 1985-01-15

Similar Documents

Publication Publication Date Title
IL103746A0 (en) Acetic acid derivatives,their preparation and pharmaceutical compositions containing them
IL104446A0 (en) Acetic acid derivatives,their preparation and pharmaceutical compositions containing them
IL78569A (en) Substituted carboxamido-benz-heterocyclyl-methyl-benzoic acids,process for their preparation and pharmaceutical compositions comprising them
DE3272373D1 (en) Long-chain alpha, omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
IL74882A0 (en) Naphthyridine-,quinoline-and benzoxazine-carboxylic acids and derivatives thereof,their manufacture and pharmaceutical compositions containing them
NZ208959A (en) Insulin derivatives and pharmaceutical compositions
NZ218192A (en) Heterocyclic oxophthalazinyl acetic acids and pharmaceutical compositions
IL107956A0 (en) Carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
GB2198134B (en) Substituted a-amino acids, their preparation and pharmaceutical compositions containing them
NZ214982A (en) Alpha-(2-oxo-2,4,5,6,7,7a- hexahydrothieno-(3,2c)-5-pyridyl) -phenyl acetic acid derivatives and pharmaceutical compositions
IL68498A (en) Xanthene-and xanthone-3-carboxylic acids and(5-tetrazolyl)derivatives thereof,their preparation and pharmaceutical compositions containing them
IL70207A (en) Derivatives of azatricyclodecane carboxylic and azatricyclodecene carboxylic acids,process for their preparation and pharmaceutical compositions containing them
IL105375A0 (en) Acetic acid derivatives,their preparation and pharmaceutical compositions containing them
IL72471A0 (en) Pharmaceutical compositions containing phenylquinoline-carboxylic acids and derivatives thereof,certain such novel compounds and their preparation
GB2156818B (en) Substituted a-amino acids, their preparation and pharmaceutical compositions containing them
HUT46645A (en) Process for producing alpha-halogen-dicarboxylic acids and their derivatives and pharmaceutical compositions comprising the same
IL69543A (en) Derivatives of omega-amino acids,their preparation and pharmaceutical compositions containing them
IL81179A (en) N-phenylbutenyl substituted azaheterocyclic carboxylic acids,their preparation and pharmaceutical compositions comprising them
IL72409A (en) Aroyl-benzofuran and-benzothiophene acetic and propionic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL64732A0 (en) Carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
IL77849A0 (en) Aryldihydropyridinedicarboxylic acid ester derivatives,their preparation and pharmaceutical compositions containing them
IL72157A (en) 6-alpha-hydroxyethyl-2-substituted-2-penem-3-carboxylic acid derivatives and pharmaceutical compositions comprising them
NZ216598A (en) 1,8-bridged-4-quinolone-3-carboxylic acids and derivatives thereof; pharmaceutical and animal feedstuff compositions
IL79181A0 (en) 3-(substituted)propenylaminothiazolylcephalosporanic acids and esters thereof,their preparation and pharmaceutical compositions containing them
IL87876A0 (en) Catechol carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them