IL63422A - 5-phenyl-and 5-naphthyl derivatives of oxazolidine-2,4-dione and pharmaceutical compositions containing them - Google Patents

5-phenyl-and 5-naphthyl derivatives of oxazolidine-2,4-dione and pharmaceutical compositions containing them

Info

Publication number
IL63422A
IL63422A IL63422A IL6342281A IL63422A IL 63422 A IL63422 A IL 63422A IL 63422 A IL63422 A IL 63422A IL 6342281 A IL6342281 A IL 6342281A IL 63422 A IL63422 A IL 63422A
Authority
IL
Israel
Prior art keywords
oxazolidine
dione
phenyl
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL63422A
Other languages
English (en)
Other versions
IL63422A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL63422A0 publication Critical patent/IL63422A0/xx
Publication of IL63422A publication Critical patent/IL63422A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/008Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with tri- or tetrahalomethyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/546Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60Three or more oxygen or sulfur atoms
    • C07D239/62Barbituric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL63422A 1980-07-28 1981-07-27 5-phenyl-and 5-naphthyl derivatives of oxazolidine-2,4-dione and pharmaceutical compositions containing them IL63422A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17320680A 1980-07-28 1980-07-28
US06/222,202 US4367234A (en) 1980-07-28 1981-01-02 Hypoglycemic 5-substituted oxazolidine-2,4-diones

Publications (2)

Publication Number Publication Date
IL63422A0 IL63422A0 (en) 1981-10-30
IL63422A true IL63422A (en) 1984-11-30

Family

ID=26868872

Family Applications (1)

Application Number Title Priority Date Filing Date
IL63422A IL63422A (en) 1980-07-28 1981-07-27 5-phenyl-and 5-naphthyl derivatives of oxazolidine-2,4-dione and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US4367234A (xx)
KR (3) KR850000381B1 (xx)
AR (3) AR228061A1 (xx)
AT (1) AT376424B (xx)
AU (1) AU526905B2 (xx)
CA (1) CA1155855A (xx)
CH (1) CH653025A5 (xx)
DD (1) DD202149A5 (xx)
DE (1) DE3129309A1 (xx)
DK (1) DK151882C (xx)
ES (3) ES8306367A1 (xx)
FI (1) FI77457C (xx)
FR (1) FR2487348B1 (xx)
GB (3) GB2083810B (xx)
GR (1) GR74590B (xx)
HU (1) HU185682B (xx)
IE (1) IE51427B1 (xx)
IL (1) IL63422A (xx)
IT (1) IT1138110B (xx)
LU (1) LU83512A1 (xx)
NL (1) NL8103536A (xx)
NO (1) NO812558L (xx)
NZ (1) NZ197853A (xx)
PH (1) PH17421A (xx)
PT (1) PT73437B (xx)
SE (1) SE460849B (xx)
YU (3) YU185281A (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
GR78120B (xx) * 1982-03-01 1984-09-26 Pfizer
US4430337A (en) 1982-06-23 1984-02-07 Pfizer Inc. Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
JPS59186916A (ja) * 1983-04-06 1984-10-23 Aiji Noda 膵石症治療剤
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US4946942A (en) * 1988-03-11 1990-08-07 Bioresearch, Inc. Urethane-protected amino acid-N-carboxyanhydrides
US5442124A (en) * 1989-06-30 1995-08-15 Firmenich Sa Process for the preparation of novel aromatic compounds
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
US5036079A (en) * 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
AU646871B2 (en) * 1990-06-07 1994-03-10 Astrazeneca Uk Limited Therapeutic heterocyclic compounds
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
KR930701420A (ko) * 1990-08-23 1993-06-11 알렌 제이. 스피겔 혈당저하제로서의 하이드록시우레아 유도체
TW222626B (xx) 1991-07-22 1994-04-21 Pfizer
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
US5401761A (en) * 1993-12-09 1995-03-28 Pfizer, Inc. Thiazolidinedione hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5985884A (en) * 1996-07-01 1999-11-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) * 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
BR9913157A (pt) * 1998-08-21 2001-05-15 Viropharma Inc Processos para tratar ou previnir infecção causada por pelo menos um vìrus das flaviviridae e doenças associadas com a referida infecção e infecção causada por pelo menos um vìrus do gênero hepacivìrus da flaviviridade e doenças associadas com a referida infecção, composição farmacêutica para tratar ou previnir infecções virais, e, composto
AU6331199A (en) * 1998-09-30 2000-04-17 Roche Diagnostics Gmbh Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders
US6399640B1 (en) 1999-06-18 2002-06-04 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
DE60032898T2 (de) 1999-06-18 2007-10-25 Merck & Co., Inc. Arylthiazolidindion- und aryloxazolidinderivate
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
JP5417860B2 (ja) * 2008-08-26 2014-02-19 住友化学株式会社 α−ヒドロキシエステル類の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE729852C (de) * 1939-07-06 1943-01-04 Carl Nachtigall Verfahren zur Herstellung von 2, 4-Dioxooxazolidinen
US2338220A (en) * 1942-01-31 1944-01-04 Mallinckrodt Chemical Works Process of making oxazolidinediones
US2721197A (en) * 1953-01-05 1955-10-18 Bristol Lab Inc Bicyclic lactams
US2961377A (en) * 1957-08-05 1960-11-22 Us Vitamin Pharm Corp Oral anti-diabetic compositions and methods
FR1284516A (fr) * 1957-11-20 1962-02-16 France Etat Produits utilisables notamment comme agents susceptibles d'agir sur la croissance des plantes et leur procédé de fabrication
GB1227428A (xx) * 1968-04-08 1971-04-07
US3699229A (en) * 1970-12-18 1972-10-17 Abbott Lab 2-oxo-5-phenyl-4-oxazolidinone as an anti-depressant agent
AT322266B (de) * 1972-11-06 1975-05-12 Rath Karl Friedrich Vorrichtung zum einsetzen von pflanzen
FR2207706B1 (xx) * 1972-11-24 1975-11-28 Orsymonde
DE2813873A1 (de) * 1978-03-31 1979-10-11 Basf Ag Verfahren zur herstellung von oxazolidin-2,4-dionen
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones

Also Published As

Publication number Publication date
GB8317145D0 (en) 1983-07-27
FR2487348B1 (fr) 1986-05-02
ES514666A0 (es) 1983-05-01
HU185682B (en) 1985-03-28
YU88183A (en) 1983-12-31
GB2128987A (en) 1984-05-10
FI77457B (fi) 1988-11-30
FI77457C (fi) 1989-03-10
YU88283A (en) 1983-12-31
GB2083810B (en) 1984-03-14
GB2132609B (en) 1985-01-03
IE51427B1 (en) 1986-12-24
KR850003290A (ko) 1985-06-13
SE460849B (sv) 1989-11-27
GR74590B (xx) 1984-06-29
PT73437B (en) 1983-09-01
DK334681A (da) 1982-03-05
GB2132609A (en) 1984-07-11
IE811695L (en) 1982-01-28
CH653025A5 (fr) 1985-12-13
LU83512A1 (fr) 1982-02-17
GB2128987B (en) 1984-09-26
PH17421A (en) 1984-08-08
PT73437A (en) 1981-08-01
KR850000382B1 (ko) 1985-03-23
AR228061A1 (es) 1983-01-14
AR231721A1 (es) 1985-02-28
DD202149A5 (de) 1983-08-31
FR2487348A1 (fr) 1982-01-29
ATA328681A (de) 1984-04-15
AU526905B2 (en) 1983-02-03
ES514665A0 (es) 1983-05-01
KR850000381B1 (ko) 1985-03-23
AR230834A1 (es) 1984-07-31
ES504322A0 (es) 1983-05-16
DK151882B (da) 1988-01-11
KR850000387B1 (ko) 1985-03-25
CA1155855A (en) 1983-10-25
GB8317144D0 (en) 1983-07-27
ES8306132A1 (es) 1983-05-01
NL8103536A (nl) 1982-02-16
NO812558L (no) 1982-01-29
KR850003291A (ko) 1985-06-13
IL63422A0 (en) 1981-10-30
YU185281A (en) 1983-12-31
SE8104542L (sv) 1982-01-29
KR830006247A (ko) 1983-09-20
ES8306133A1 (es) 1983-05-01
FI812340L (fi) 1982-01-29
IT8123175A0 (it) 1981-07-27
GB2083810A (en) 1982-03-31
AT376424B (de) 1984-11-26
DK151882C (da) 1988-06-06
NZ197853A (en) 1986-09-10
US4367234A (en) 1983-01-04
DE3129309A1 (de) 1982-03-18
DE3129309C2 (xx) 1987-06-19
IT1138110B (it) 1986-09-17
ES8306367A1 (es) 1983-05-16

Similar Documents

Publication Publication Date Title
IL63422A (en) 5-phenyl-and 5-naphthyl derivatives of oxazolidine-2,4-dione and pharmaceutical compositions containing them
IL61936A (en) Derivatives of cba2 and pharmaceutical compositions containing them
PH17460A (en) Hydantoin derivatives and pharmaceutical compositions containing the same
IL62694A0 (en) Aminothiadiazole derivatives,their preparation and pharmaceutical compositions containing them
PH17079A (en) Derivatives of 4-amino-6,7-dimethoxy-2-piperazinoquinoline and compositions thereof
IL57450A0 (en) Aminothiazole derivatives and pharmaceutical compositions containing them
IL63428A0 (en) Thiazoline derivatives,their preparation and pharmaceutical compositions containing them
PT75827A (en) Process for the preparation of heterocyclic derivatives of phenlthiadiazinone oxadiazinone and triadiazinone and pharmaceutical compositions therewith
IL58730A (en) Spiro-polycyclic imidazolidinedione derivatives and pharmaceutical compositions containing them
IL63423A0 (en) 9-amino-1-hydroxyoctahydrobenzo(c)quinoline derivatives and pharmaceutical compositions containing them
PH15937A (en) Thiazolidine derivatives and their pharmaceutical compositions
IL56821A0 (en) Heterocycylcarbonyl derivatives of ure and pharmaceutical composition containing them
IL58676A (en) Histamine h2-antagonist pyrimid-4-one derivatives,their preparation and pharmaceutical compositions containing same
IL62229A0 (en) Heterocyclic derivatives,their preparation and pharmaceutical compositions containing them
IL56304A0 (en) Thiazolidine-2,4-dione derivatives, their preparation and pharmaceutical compositions containing them
PH18532A (en) Novel carbostyril derivatives and pharmaceutical compositions containing the same
IL66954A0 (en) Oxazolidinedione derivatives and pharmaceutical compositions containing them
NZ185267A (en) Derivatives of 1-amino-2hydroxy-3-heterocycloxy-propanes, and pharmaceutical compositions containing them
IL62240A0 (en) Novel quinoline derivatives,pharmaceutical compositions containing such compounds,and methods for the preparation of these compounds
IL65876A (en) Heterocyclic amidoxime derivatives,their preparation and pharmaceutical compositions containing them
IL57436A0 (en) Hydantoin derivatives and pharmaceutical compositions containing them
IL62400A0 (en) Thiazole derivatives,their preparation and pharmaceutical compositions containing them
DE3163536D1 (en) Pharmaceutical compositions containing two beta-lactam derivatives
GB2074561B (en) Benzoxazolone derivatives processes for preparation thereof and compositions containing them
NZ197416A (en) Penicillin derivatives and pharmaceutical compositions