IL61408A - Enzyme derivatives comprising binary complexes between streptokinase and plasminogen,their preparation and pharmaceutical compositions containing them - Google Patents

Enzyme derivatives comprising binary complexes between streptokinase and plasminogen,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL61408A
IL61408A IL61408A IL6140880A IL61408A IL 61408 A IL61408 A IL 61408A IL 61408 A IL61408 A IL 61408A IL 6140880 A IL6140880 A IL 6140880A IL 61408 A IL61408 A IL 61408A
Authority
IL
Israel
Prior art keywords
streptokinase
plasminogen
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL61408A
Other languages
English (en)
Other versions
IL61408A0 (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IL61408A0 publication Critical patent/IL61408A0/xx
Publication of IL61408A publication Critical patent/IL61408A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL61408A 1979-11-05 1980-11-04 Enzyme derivatives comprising binary complexes between streptokinase and plasminogen,their preparation and pharmaceutical compositions containing them IL61408A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7938279 1979-11-05

Publications (2)

Publication Number Publication Date
IL61408A0 IL61408A0 (en) 1980-12-31
IL61408A true IL61408A (en) 1983-10-31

Family

ID=10508982

Family Applications (1)

Application Number Title Priority Date Filing Date
IL61408A IL61408A (en) 1979-11-05 1980-11-04 Enzyme derivatives comprising binary complexes between streptokinase and plasminogen,their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
US (1) US4808405A (2)
EP (1) EP0028489B1 (2)
JP (1) JPS5678590A (2)
AR (1) AR224786A1 (2)
CA (1) CA1174621A (2)
CS (2) CS391991A3 (2)
DE (1) DE3065190D1 (2)
DK (1) DK158994C (2)
ES (1) ES8204467A1 (2)
GR (1) GR72121B (2)
HK (1) HK65886A (2)
HU (1) HU185223B (2)
IE (1) IE50174B1 (2)
IL (1) IL61408A (2)
NL (1) NL930029I2 (2)
NO (1) NO163867C (2)
NZ (1) NZ195469A (2)
ZA (1) ZA806641B (2)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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DE3361610D1 (en) * 1982-04-07 1986-02-06 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
EP0125269A1 (en) * 1982-11-11 1984-11-21 Beecham Group Plc Pharmaceutically active compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
GB8430253D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US5231006A (en) * 1986-10-16 1993-07-27 Behringwerke Aktiengesellschaft Method for the determination of plasminogen
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
JPH0296536A (ja) * 1988-09-29 1990-04-09 Green Cross Corp:The プラスミノゲン乾燥製剤
EP0467987A4 (en) * 1989-05-01 1992-07-08 The University Of Notre Dame Du Lac Methods and materials for expression of human plasminogen in a eukaryotic cell system
EP0397366A1 (en) * 1989-05-09 1990-11-14 The Board Of Regents Of The University Of Oklahoma Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same
EP0472657B1 (en) * 1989-05-17 1996-03-13 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
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US5087572A (en) * 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
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US5520912A (en) * 1993-07-02 1996-05-28 Immuno Aktiengesellschaft Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
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US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
JP5236293B2 (ja) 2005-01-13 2013-07-17 ブリストル−マイヤーズ スクイブ カンパニー Ｘｉａ因子阻害剤としての置換ビアリール化合物
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US7714002B2 (en) 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
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US8222453B2 (en) 2006-06-08 2012-07-17 Bristol-Myers Squibb Company Benzamide factor VIIa inhibitors useful as anticoagulants
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
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TW201319068A (zh) 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
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US9079929B2 (en) 2011-10-14 2015-07-14 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
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ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
ES2665153T3 (es) 2013-10-09 2018-04-24 Pfizer Inc. Antagonistas del receptor EP3 de prostaglandina
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Family Cites Families (4)

* Cited by examiner, † Cited by third party
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US4178368A (en) * 1971-09-30 1979-12-11 Behringwerke Aktiengesellschaft Method for the treatment of thromboembolism
JPS5325775A (en) * 1976-08-24 1978-03-09 Miller Fluid Power Corp Module type fluid flow control element
US4082612A (en) * 1976-09-24 1978-04-04 Michael Reese Research Foundation Plasminogen activator complex
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions

Also Published As

Publication number Publication date
CA1174621A (en) 1984-09-18
EP0028489B1 (en) 1983-10-05
DK158994B (da) 1990-08-13
ZA806641B (en) 1981-10-28
NO163867C (no) 1990-08-01
JPH0316114B2 (2) 1991-03-04
NO803304L (no) 1981-05-06
GR72121B (2) 1983-09-16
NZ195469A (en) 1984-05-31
JPS5678590A (en) 1981-06-27
IE50174B1 (en) 1986-02-19
AR224786A1 (es) 1982-01-15
AU6401180A (en) 1981-05-14
HU185223B (en) 1984-12-28
AU534017B2 (en) 1983-12-22
HK65886A (en) 1986-09-12
IL61408A0 (en) 1980-12-31
US4808405A (en) 1989-02-28
DK468880A (da) 1981-05-06
CS391191A3 (en) 1992-08-12
NL930029I2 (nl) 1993-12-01
ES496586A0 (es) 1982-05-01
NL930029I1 (nl) 1993-06-01
NO163867B (no) 1990-04-23
DE3065190D1 (en) 1983-11-10
DK158994C (da) 1991-01-07
IE802277L (en) 1981-05-05
ES8204467A1 (es) 1982-05-01
CS391991A3 (en) 1992-06-17
EP0028489A1 (en) 1981-05-13

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