IL61207A0 - Cytostatically active pharmaceutical compositions comprising isocyanuric acid derivatives, certain such novel derivatives and their preparation - Google Patents
Cytostatically active pharmaceutical compositions comprising isocyanuric acid derivatives, certain such novel derivatives and their preparationInfo
- Publication number
- IL61207A0 IL61207A0 IL61207A IL6120780A IL61207A0 IL 61207 A0 IL61207 A0 IL 61207A0 IL 61207 A IL61207 A IL 61207A IL 6120780 A IL6120780 A IL 6120780A IL 61207 A0 IL61207 A0 IL 61207A0
- Authority
- IL
- Israel
- Prior art keywords
- derivatives
- preparation
- certain
- pharmaceutical compositions
- active pharmaceutical
- Prior art date
Links
- 150000007973 cyanuric acids Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C07D251/32—Cyanuric acid; Isocyanuric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C07D251/34—Cyanuric or isocyanuric esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0655279A AT371816B (de) | 1979-10-08 | 1979-10-08 | Verfahren zur herstellung von neuen isocyanurs[urederivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL61207A0 true IL61207A0 (en) | 1980-12-31 |
Family
ID=3587457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL61207A IL61207A0 (en) | 1979-10-08 | 1980-10-06 | Cytostatically active pharmaceutical compositions comprising isocyanuric acid derivatives, certain such novel derivatives and their preparation |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4393060A (sv) |
| JP (1) | JPS5661374A (sv) |
| AT (1) | AT371816B (sv) |
| AU (1) | AU551079B2 (sv) |
| BE (1) | BE885555A (sv) |
| CA (1) | CA1159064A (sv) |
| CH (1) | CH648554A5 (sv) |
| DD (1) | DD153370A5 (sv) |
| DE (1) | DE3037094A1 (sv) |
| DK (1) | DK395380A (sv) |
| ES (1) | ES495697A0 (sv) |
| FI (1) | FI803108A (sv) |
| FR (1) | FR2484418B1 (sv) |
| GB (1) | GB2060633B (sv) |
| HU (1) | HU182210B (sv) |
| IE (1) | IE51098B1 (sv) |
| IL (1) | IL61207A0 (sv) |
| IT (1) | IT1151093B (sv) |
| LU (1) | LU82824A1 (sv) |
| MX (1) | MX7169E (sv) |
| NL (1) | NL8005187A (sv) |
| NO (1) | NO802977L (sv) |
| NZ (1) | NZ195195A (sv) |
| PL (2) | PL231791A1 (sv) |
| SE (1) | SE8006716L (sv) |
| SU (1) | SU976849A3 (sv) |
| ZA (1) | ZA806161B (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT372382B (de) * | 1980-08-14 | 1983-09-26 | Henkel Kgaa | Verfahren zur herstellung von neuen oxiranylisocyanursaeureverbindungen |
| DE3330640A1 (de) * | 1983-08-25 | 1985-03-14 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur addition von saeuren an glycidylverbindungen |
| JPS62187463A (ja) * | 1986-02-13 | 1987-08-15 | Nissan Chem Ind Ltd | トリグリシジルイソシアヌレ−トの固化方法 |
| FR2608154B1 (fr) * | 1986-12-11 | 1989-06-02 | Charbonnages Ste Chimique | Dichlorhydrine de l'acide cyanurique, ses derives trisubstitues et leur procede de preparation |
| FR2608153B1 (fr) * | 1986-12-11 | 1989-06-02 | Charbonnages Ste Chimique | Di-bishydroxypropyle de l'acide cyanurique, ses derives trisubstitues et leur procede de fabrication |
| JP2952707B2 (ja) * | 1990-10-29 | 1999-09-27 | 共同薬品株式会社 | イソシアヌル酸誘導体、その製造法および用途 |
| US5324720A (en) * | 1992-03-20 | 1994-06-28 | Merck & Co., Inc. | Methods of achieving antitumor activity using 16-membered-macrolide-type compounds |
| KR20020025091A (ko) * | 1999-06-30 | 2002-04-03 | 무네유키 가코우 | 벤즈 이미다졸 화합물 및 그것을 함유하는 의약 |
| JP2012025688A (ja) * | 2010-07-22 | 2012-02-09 | National Institute Of Advanced Industrial Science & Technology | エポキシ化合物の製造方法 |
| JP6555930B2 (ja) * | 2015-05-21 | 2019-08-07 | 株式会社カネカ | イソシアヌレート化合物の製造方法 |
| JP6513012B2 (ja) * | 2015-09-11 | 2019-05-15 | 四国化成工業株式会社 | ジグリシジルイソシアヌレート化合物、樹脂組成物およびその利用 |
| US10450475B2 (en) * | 2015-11-17 | 2019-10-22 | Ennis Paint, Inc. | Traffic marking compositions containing polyfunctional amines |
| CN108203502B (zh) * | 2018-01-13 | 2020-04-21 | 宏峰行化工(深圳)有限公司 | 一种水溶性交联剂及其在水性树脂中的应用 |
| WO2022172823A1 (ja) * | 2021-02-15 | 2022-08-18 | 株式会社Adeka | 電解めっき液用添加剤、電解めっき液、電解めっき方法及び金属層の製造方法 |
| JP7408591B2 (ja) * | 2021-03-22 | 2024-01-05 | 四国化成工業株式会社 | カルボキシル基を有するイソシアヌレート化合物および該化合物を用いたエポキシ樹脂組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD51773A (sv) * | ||||
| US3132142A (en) * | 1961-04-24 | 1964-05-05 | Spencer Chem Co | Isocyanurate compounds |
| US3910908A (en) * | 1965-05-17 | 1975-10-07 | Celanese Coatings Co | Triglycidyl isocyanurate preparation |
| CH1840069A4 (sv) * | 1969-12-10 | 1972-06-15 | ||
| US3920689A (en) * | 1969-12-10 | 1975-11-18 | Ciba Geigy Ag | N-heterocyclic perfluoroalkylmonocarboxylic acid esters, processes for their manufacture and their use |
| US3793321A (en) * | 1970-07-02 | 1974-02-19 | Ciba Geigy Ag | Process for the manufacture of triglycidylisocyanurate |
| US3779949A (en) * | 1971-11-01 | 1973-12-18 | Ciba Geigy Ag | New adducts, containing epoxide groups, from polyepoxide compounds and binuclear n-heterocyclic compounds |
| CH581628A5 (sv) * | 1973-02-02 | 1976-11-15 | Ciba Geigy Ag | |
| JPS5328917B2 (sv) * | 1974-07-22 | 1978-08-17 | ||
| JPS5114515A (ja) * | 1974-07-25 | 1976-02-05 | Kubota Ltd | Nainenkikan |
| JPS53144955A (en) * | 1977-05-23 | 1978-12-16 | Mitsubishi Rayon Co Ltd | Reinforced polyethylene terephthalate composition and its production |
| NL174157C (nl) * | 1977-07-05 | Teijin Ltd | Hardbare polyester en gevormde al dan niet geharde producten vervaardigd onder toepassing van deze hardbare polyester. | |
| US4292151A (en) * | 1978-03-01 | 1981-09-29 | Teijin Limited | Process for preparing a cured copolyetherester elastomeric composition |
| DE2907349C2 (de) * | 1979-02-24 | 1982-09-16 | Henkel KGaA, 4000 Düsseldorf | Arzneimittel mit cytostatischer Wirksamkeit |
| AT372382B (de) * | 1980-08-14 | 1983-09-26 | Henkel Kgaa | Verfahren zur herstellung von neuen oxiranylisocyanursaeureverbindungen |
-
1979
- 1979-10-08 AT AT0655279A patent/AT371816B/de not_active IP Right Cessation
-
1980
- 1980-09-17 NL NL8005187A patent/NL8005187A/nl not_active Application Discontinuation
- 1980-09-18 DK DK395380A patent/DK395380A/da not_active Application Discontinuation
- 1980-09-25 SE SE8006716A patent/SE8006716L/sv not_active Application Discontinuation
- 1980-09-30 FI FI803108A patent/FI803108A/fi not_active Application Discontinuation
- 1980-10-01 DE DE19803037094 patent/DE3037094A1/de not_active Withdrawn
- 1980-10-03 SU SU802990883A patent/SU976849A3/ru active
- 1980-10-06 LU LU82824A patent/LU82824A1/de unknown
- 1980-10-06 DD DD80224376A patent/DD153370A5/de unknown
- 1980-10-06 CA CA000361580A patent/CA1159064A/en not_active Expired
- 1980-10-06 IL IL61207A patent/IL61207A0/xx unknown
- 1980-10-06 GB GB8032108A patent/GB2060633B/en not_active Expired
- 1980-10-06 ZA ZA00806161A patent/ZA806161B/xx unknown
- 1980-10-07 BE BE0/202350A patent/BE885555A/fr not_active IP Right Cessation
- 1980-10-07 PL PL23179180A patent/PL231791A1/xx unknown
- 1980-10-07 PL PL1980227131A patent/PL125862B1/pl unknown
- 1980-10-07 IE IE2081/80A patent/IE51098B1/en unknown
- 1980-10-07 HU HU802442A patent/HU182210B/hu unknown
- 1980-10-07 FR FR8021417A patent/FR2484418B1/fr not_active Expired
- 1980-10-07 ES ES495697A patent/ES495697A0/es active Granted
- 1980-10-07 US US06/194,908 patent/US4393060A/en not_active Expired - Lifetime
- 1980-10-07 NO NO802977A patent/NO802977L/no unknown
- 1980-10-07 IT IT25159/80A patent/IT1151093B/it active
- 1980-10-07 CH CH7487/80A patent/CH648554A5/de not_active IP Right Cessation
- 1980-10-08 AU AU63063/80A patent/AU551079B2/en not_active Ceased
- 1980-10-08 NZ NZ195195A patent/NZ195195A/en unknown
- 1980-10-08 JP JP14183580A patent/JPS5661374A/ja active Pending
- 1980-10-08 MX MX809081U patent/MX7169E/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4393060A (en) | 1983-07-12 |
| MX7169E (es) | 1987-12-14 |
| AU6306380A (en) | 1981-04-16 |
| DD153370A5 (de) | 1982-01-06 |
| CH648554A5 (de) | 1985-03-29 |
| GB2060633A (en) | 1981-05-07 |
| DK395380A (da) | 1981-04-09 |
| PL231791A1 (sv) | 1982-02-01 |
| SE8006716L (sv) | 1981-04-09 |
| NL8005187A (nl) | 1981-04-10 |
| PL125862B1 (en) | 1983-06-30 |
| FI803108A (fi) | 1981-04-09 |
| SU976849A3 (ru) | 1982-11-23 |
| CA1159064A (en) | 1983-12-20 |
| PL227131A1 (sv) | 1981-10-30 |
| AU551079B2 (en) | 1986-04-17 |
| AT371816B (de) | 1983-08-10 |
| GB2060633B (en) | 1984-03-21 |
| IT1151093B (it) | 1986-12-17 |
| HU182210B (en) | 1983-12-28 |
| IE51098B1 (en) | 1986-10-01 |
| ZA806161B (en) | 1981-09-30 |
| ES8201576A1 (es) | 1981-12-16 |
| FR2484418B1 (fr) | 1985-09-06 |
| JPS5661374A (en) | 1981-05-26 |
| LU82824A1 (de) | 1981-06-04 |
| BE885555A (fr) | 1981-04-07 |
| ATA655279A (de) | 1982-12-15 |
| FR2484418A1 (fr) | 1981-12-18 |
| IE802081L (en) | 1981-04-08 |
| NO802977L (no) | 1981-04-09 |
| DE3037094A1 (de) | 1981-04-16 |
| NZ195195A (en) | 1984-02-03 |
| IT8025159A0 (it) | 1980-10-07 |
| ES495697A0 (es) | 1981-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL62018A0 (en) | Agmatine derivatives,their preparation and pharmaceutical compositions containing them | |
| IL60129A0 (en) | Phenylsulphonamide derivatives,their preparation and pharmaceutical compositions containing them | |
| IL61013A0 (en) | Tetraline derivatives,their preparation and pharmaceutical compositions containing them | |
| DE3068678D1 (en) | 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them | |
| IL59425A (en) | Pharmaceutical compositions comprising n-substituted aziridine-2-carboxylic acid derivatives,certain such compounds and their preparation | |
| DE3062216D1 (en) | Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them | |
| IL61207A0 (en) | Cytostatically active pharmaceutical compositions comprising isocyanuric acid derivatives, certain such novel derivatives and their preparation | |
| IL61481A0 (en) | Piperidylbenzimidazolinone derivatives,their preparation and pharmaceutical compositions containing them | |
| IL52466A (en) | 7(2-acyl-2-hydroxyiminoacetamido)-3-tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| IL56421A (en) | 4-pyridone-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| DE2966364D1 (en) | Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them | |
| DE3068074D1 (en) | Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them | |
| DE3070184D1 (en) | Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them | |
| DE3067790D1 (en) | Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them | |
| IL60058A0 (en) | Hydroxyamino-eburnane derivatives,their preparation and pharmaceutical compositions containing them | |
| IL60359A (en) | Dialkylaminoalkoxyiminocycloalkane derivatives,their preparation and pharmaceutical compositions containing them | |
| DE3067784D1 (en) | 2-hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them | |
| IL52638A (en) | Clivanic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| IL60927A (en) | Amino-propanoloxytetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them | |
| IL56461A (en) | 1-naphthyl-acetic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| IL60548A0 (en) | Ergol-8-ene and ergolin derivatives,their preparation and pharmaceutical compositions containing them | |
| IL57735A (en) | 7beta-aminothiazolyl-acetamido-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| IL60554A (en) | Benzoic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| IL59252A (en) | 4-amino-2-piperidinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them | |
| IL60513A (en) | Dihydronicotinic acid derivatives,their preparation and pharmaceutical compositions containing them |