IL60201A - 3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL60201A
IL60201A IL60201A IL6020180A IL60201A IL 60201 A IL60201 A IL 60201A IL 60201 A IL60201 A IL 60201A IL 6020180 A IL6020180 A IL 6020180A IL 60201 A IL60201 A IL 60201A
Authority
IL
Israel
Prior art keywords
phenyl
amino
substituted
preparation
pharmaceutical compositions
Prior art date
Application number
IL60201A
Other languages
English (en)
Other versions
IL60201A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL60201(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL60201A0 publication Critical patent/IL60201A0/xx
Publication of IL60201A publication Critical patent/IL60201A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL60201A 1979-06-01 1980-05-30 3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them IL60201A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (2)

Publication Number Publication Date
IL60201A0 IL60201A0 (en) 1980-07-31
IL60201A true IL60201A (en) 1984-05-31

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
IL60201A IL60201A (en) 1979-06-01 1980-05-30 3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (2) US4486354A (index.php)
EP (2) EP0059987B1 (index.php)
JP (2) JPS5625169A (index.php)
AR (1) AR227521A1 (index.php)
AT (1) AT370097B (index.php)
AU (2) AU530999B2 (index.php)
BG (1) BG60427B2 (index.php)
CA (1) CA1112643A (index.php)
CS (1) CS234018B2 (index.php)
CZ (1) CZ384891A3 (index.php)
DD (1) DD151309A5 (index.php)
DK (1) DK153787C (index.php)
ES (1) ES8104993A1 (index.php)
FI (1) FI67844C (index.php)
GE (1) GEP19960470B (index.php)
GR (1) GR68380B (index.php)
HU (1) HU182086B (index.php)
IE (1) IE49823B1 (index.php)
IL (1) IL60201A (index.php)
IT (1) IT1147087B (index.php)
MX (1) MX9202962A (index.php)
MY (1) MY8500062A (index.php)
NL (1) NL950007I2 (index.php)
NZ (1) NZ193890A (index.php)
PL (1) PL124029B1 (index.php)
SU (1) SU1055331A3 (index.php)
UA (1) UA5576A1 (index.php)
YU (1) YU145680A (index.php)
ZA (1) ZA803250B (index.php)
ZW (1) ZW12980A1 (index.php)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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EP0086502B1 (en) * 1979-08-16 1987-03-25 The Wellcome Foundation Limited Substituted aromatic triazines
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
SK282072B6 (sk) * 1991-01-30 2001-10-08 The Wellcome Foundation Limited Tableta s obsahom lamotrigínu dispergovateľná vo vode a spôsob jej prípravy
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
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MY109330A (en) * 1992-06-12 1997-01-31 The Wellcome Foundation Ltd Therapeutic triazine compounds and use.
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
US5866597A (en) * 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
RU2145602C1 (ru) * 1994-12-30 2000-02-20 Де Вэллкам Фаундейшн Лимитед Способы получения ламотриджина, промежуточные соединения и способ получения фармацевтической композиции
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6202491B1 (en) 1997-07-22 2001-03-20 Skf Condition Monitoring, Inc. Digital vibration coupling stud
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CZ20011949A3 (cs) * 1998-12-14 2001-09-12 Torrent Pharmacauticals Ltd Zlepšený způsob výroby 3,5-diamino-6-(2,3-dichlorfenyl)-1,2,4-triazinu
US20020055177A1 (en) * 1999-03-10 2002-05-09 Glaxo Wellcome Inc. Compound and its use
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US7939102B2 (en) * 2002-06-07 2011-05-10 Torrent Pharmaceuticals Ltd. Controlled release formulation of lamotrigine
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US7521553B2 (en) * 2003-03-17 2009-04-21 Hetero Drugs Limited Crystalline forms of lamotrigine
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WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
JP5646126B2 (ja) 2003-12-11 2014-12-24 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法
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US20050233010A1 (en) * 2004-04-19 2005-10-20 Satow Philip M Lithium combinations, and uses related thereto
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US8378096B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
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US7825151B2 (en) * 2005-09-23 2010-11-02 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
PL1931335T3 (pl) * 2005-09-23 2010-07-30 Janssen Pharmaceutica Nv Modulatory heksahydrocyklooktylopirazolokannabinoidowe
AU2006295121B2 (en) * 2005-09-23 2011-10-27 Janssen Pharmaceutica, N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
US7526911B2 (en) * 2006-02-03 2009-05-05 Rolls-Royce Corporation Gas turbine engine fuel system with fuel metering valve
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WO2007112402A1 (en) * 2006-03-27 2007-10-04 Janssen Pharmaceutica N.V. Tetrahydro-1h-1,2,6-triaza-azulene cannabinoid modulators
US20070254911A1 (en) * 2006-03-27 2007-11-01 Mingde Xia Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators
WO2007122638A2 (en) * 2006-04-26 2007-11-01 Ratnamani Bio-Chemicals & Pharmaceuticals Pvt. Ltd. An improved process for preparation of lamotrigine intermediates
WO2007138075A1 (en) * 2006-05-31 2007-12-06 Calaire Chimie Sas Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride
GB0613836D0 (en) * 2006-07-13 2006-08-23 Univ Greenwich New medical use of triazine derivatives
US20120142919A1 (en) 2006-08-02 2012-06-07 Medichem, S.A. Method for synthesizing lamotrigine
EP2054396A1 (en) * 2006-08-14 2009-05-06 Lonza Ag A process for the preparation of lamotrigine
WO2008090117A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
US7943653B2 (en) * 2007-08-13 2011-05-17 Janssen Pharmaceutica N.V. Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators
US20090076010A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched lamotrigine
WO2009061513A1 (en) * 2007-11-09 2009-05-14 Thar Pharmaceuticals Crystalline forms of lamotrigine
GB0800741D0 (en) 2008-01-16 2008-02-20 Univ Greenwich Cyclic triazo and diazo sodium channel blockers
US20100190752A1 (en) * 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
MX2011012044A (es) 2009-05-13 2011-12-14 Nektar Therapeutics Compuestos de triazina aromatica sustituida que contienen oligomeros.
US20100297195A1 (en) 2009-05-20 2010-11-25 Ranbaxy Laboratories Limited Controlled release lamotrigine formulations
GB2471713A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
GB2471729A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
US20110052686A1 (en) 2009-09-03 2011-03-03 Ranbaxy Laboratories Limited Modified release lamotrigine tablets
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
WO2013183985A1 (en) 2012-06-05 2013-12-12 Erasmus University Medical Center Rotterdam Method of treating cognitive impairment and compounds for use therein
US10189859B2 (en) 2013-12-21 2019-01-29 Nektar Therapeutics Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine
WO2016198878A1 (en) 2015-06-12 2016-12-15 University Of Greenwich Triazine derivatives as interferon-gamma inhibitors
MX388586B (es) 2016-12-16 2025-03-20 Idorsia Pharmaceuticals Ltd Combinacion farmaceutica que comprende un bloqueador del canal de calcio de tipo t.
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物
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Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (index.php) * 1964-05-05
DE1802364C3 (de) * 1967-10-12 1975-03-20 Shell Internationale Research Maatschappij B.V., Den Haag (Niederlande) Arzneimittel mit thymeretischer Wirkung
GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
EP0086502B1 (en) * 1979-08-16 1987-03-25 The Wellcome Foundation Limited Substituted aromatic triazines

Also Published As

Publication number Publication date
EP0059987A1 (en) 1982-09-15
SU1055331A3 (ru) 1983-11-15
JPS6133163A (ja) 1986-02-17
AU566870B2 (en) 1987-11-05
ES491998A0 (es) 1981-05-16
EP0021121B1 (en) 1983-05-11
GR68380B (index.php) 1981-12-28
DK233880A (da) 1980-12-02
ES8104993A1 (es) 1981-05-16
EP0059987B1 (en) 1985-08-14
AU530999B2 (en) 1983-08-04
EP0021121A1 (en) 1981-01-07
IT1147087B (it) 1986-11-19
NL950007I1 (nl) 1995-06-16
IL60201A0 (en) 1980-07-31
AR227521A1 (es) 1982-11-15
HU182086B (en) 1983-12-28
DK153787B (da) 1988-09-05
AU5890680A (en) 1980-12-04
YU145680A (en) 1983-02-28
DD151309A5 (de) 1981-10-14
DK153787C (da) 1989-01-16
PL224633A1 (index.php) 1981-02-13
ZA803250B (en) 1982-01-27
IT8048848A0 (it) 1980-05-30
JPH0144706B2 (index.php) 1989-09-29
NZ193890A (en) 1984-07-06
IE801126L (en) 1980-12-01
UA5576A1 (uk) 1994-12-28
MY8500062A (en) 1985-12-31
JPS5625169A (en) 1981-03-10
BG60427B2 (bg) 1995-03-31
AT370097B (de) 1983-02-25
MX9202962A (es) 1992-07-01
US4602017A (en) 1986-07-22
US4486354A (en) 1984-12-04
CZ384891A3 (en) 1993-10-13
CS234018B2 (en) 1985-03-14
ATA289680A (de) 1982-07-15
JPH0144179B2 (index.php) 1989-09-26
GEP19960470B (en) 1996-08-29
FI67844B (fi) 1985-02-28
IE49823B1 (en) 1985-12-25
FI67844C (fi) 1985-06-10
FI801758A7 (fi) 1980-12-02
ZW12980A1 (en) 1982-01-06
NL950007I2 (nl) 1997-02-03
PL124029B1 (en) 1982-12-31
CA1112643A (en) 1981-11-17

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