IL58765A - Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta - Google Patents

Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta

Info

Publication number
IL58765A
IL58765A IL58765A IL5876579A IL58765A IL 58765 A IL58765 A IL 58765A IL 58765 A IL58765 A IL 58765A IL 5876579 A IL5876579 A IL 5876579A IL 58765 A IL58765 A IL 58765A
Authority
IL
Israel
Prior art keywords
production
interferon
messenger rna
essentially pure
human fibroblast
Prior art date
Application number
IL58765A
Other languages
English (en)
Other versions
IL58765A0 (en
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11051449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL58765(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL58765A priority Critical patent/IL58765A/xx
Publication of IL58765A0 publication Critical patent/IL58765A0/xx
Priority to SE8007998A priority patent/SE461223C/sv
Priority to GB8037067A priority patent/GB2063882B/en
Priority to US06/208,925 priority patent/US5468607A/en
Priority to CH8627/80A priority patent/CH664967A5/de
Priority to JP55164482A priority patent/JP2555279B2/ja
Priority to IT26172/80A priority patent/IT1194820B/it
Priority to FR8024833A priority patent/FR2475901A1/fr
Priority to DE19803043981 priority patent/DE3043981A1/de
Priority to CH788880A priority patent/CH685299A5/de
Priority to DE3051086A priority patent/DE3051086C2/de
Priority to CH3224/93A priority patent/CH684892A5/de
Priority to US06/425,933 priority patent/US5468609A/en
Priority to US06/425,935 priority patent/US5468608A/en
Priority to US06/425,934 priority patent/US5541312A/en
Priority to SE8603145A priority patent/SE469660B/sv
Publication of IL58765A publication Critical patent/IL58765A/xx
Priority to JP62157455A priority patent/JP2548201B2/ja
Priority to JP1094314A priority patent/JPH02211879A/ja
Priority to US07/449,447 priority patent/US5554513A/en
Priority to US07/657,258 priority patent/US5554514A/en
Priority to US07/883,633 priority patent/US5510472A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
IL58765A 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta IL58765A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IL58765A IL58765A (en) 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
SE8007998A SE461223C (sv) 1979-11-21 1980-11-14 mRNA och cDNA för humant fibroblastinterferon, förfarande för deras framställning samt användning därav
GB8037067A GB2063882B (en) 1979-11-21 1980-11-19 Production of interferon by genetic
US06/208,925 US5468607A (en) 1979-11-21 1980-11-20 Production of interferon
CH3224/93A CH684892A5 (de) 1979-11-21 1980-11-21 DNA, welche für ein Polypeptid mit der Aktivität von menschlichem Interferon und beta 2 kodiert und Verfahren zu dessen Herstellung.
JP55164482A JP2555279B2 (ja) 1979-11-21 1980-11-21 インタ−フエロンに転換可能なｍＲＮＡ及びその製造方法
CH788880A CH685299A5 (de) 1979-11-21 1980-11-21 Menschliches Fibroblasteninterferon beta 2, Verfahren zur Herstellung von menschlichem Fibroblasteninterferon beta 1 und beta 2 und deren Verwendung.
DE3051086A DE3051086C2 (it) 1979-11-21 1980-11-21
IT26172/80A IT1194820B (it) 1979-11-21 1980-11-21 Procedimento per la produzione di interferone
FR8024833A FR2475901A1 (fr) 1979-11-21 1980-11-21 Procede de production d'interferon
DE19803043981 DE3043981A1 (de) 1979-11-21 1980-11-21 Verfahren zur gewinnung von fuer interferon in menschlichen zellen kodierender dna, verfahren zur anreicherung von interferon boten-rna (mrna) oder einer induzierbaren mrna eines anderen proteins oder polypeptids, vektoren, verfahren zur abtrennung von mrna eines induzierbaren proteins von anderen mrna's, mrna von menschlichem interferon, in einen vektor einbaubare und fuer ein polypeptid mit interferon-aktivitaet kodierende dna, sowie menschliches interferon (beta)-1 und(beta)-2 in hochgereinigter form
CH8627/80A CH664967A5 (de) 1979-11-21 1980-11-21 Im wesentlichen reine mrna's des menschlichen fibroblasten-interferons.
US06/425,933 US5468609A (en) 1979-11-21 1982-09-28 Production of interferon
US06/425,935 US5468608A (en) 1979-11-21 1982-09-28 Production of interferon
US06/425,934 US5541312A (en) 1979-11-21 1982-09-28 Production of interferon
SE8603145A SE469660B (sv) 1979-11-21 1986-07-17 Humant fibroblastinterferon-beta, framstaellning och anvaendning daerav
JP62157455A JP2548201B2 (ja) 1979-11-21 1987-06-24 ヒトインタ−フェロンの製造方法及び高純度ヒトインタ−フェロン
JP1094314A JPH02211879A (ja) 1979-11-21 1989-04-13 ヒトインターフエロンβ２のｃＤＮＡ及びその製造法
US07/449,447 US5554513A (en) 1979-11-21 1989-12-12 Production of recombinant human interferon-beta2
US07/657,258 US5554514A (en) 1979-11-21 1991-02-19 Production of recombinant human interferon beta2.sbsb.B
US07/883,633 US5510472A (en) 1979-11-21 1992-05-15 Production of recombinant human interferon-beta2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL58765A IL58765A (en) 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta

Publications (2)

Publication Number Publication Date
IL58765A0 IL58765A0 (en) 1980-02-29
IL58765A true IL58765A (en) 1986-09-30

Family

ID=11051449

Family Applications (1)

Application Number Title Priority Date Filing Date
IL58765A IL58765A (en) 1979-11-21 1979-11-21 Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta

Country Status (9)

Country Link
US (4) US5468607A (it)
JP (3) JP2555279B2 (it)
CH (2) CH684892A5 (it)
DE (2) DE3051086C2 (it)
FR (1) FR2475901A1 (it)
GB (1) GB2063882B (it)
IL (1) IL58765A (it)
IT (1) IT1194820B (it)
SE (2) SE461223C (it)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56131598A (en) * 1980-03-19 1981-10-15 Japan Found Cancer Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
ES8302096A1 (es) 1980-04-03 1982-12-16 Biogen Nv Un metodo de producir un polipeptido que muestra una actividad immunologica obiologica de interferon de fibroblasto hu- mano.
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
NZ198445A (en) * 1980-09-25 1984-05-31 Genentech Inc Production of human fibroblast interferon by recombinant dna technology
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
US5582824A (en) * 1981-10-19 1996-12-10 Genentech, Inc. Recombinant DES-CYS-TYR-CYS human immune interferon
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
EP0569687B1 (en) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
US5122459A (en) * 1984-12-31 1992-06-16 Immunex Corporation Gene encoding biologically active human interleukin 1
WO1986006407A1 (en) * 1985-04-23 1986-11-06 Medical Biology Institute IDENTIFICATION OF AN IgE-BINDING PROTEIN BY MOLECULAR CLONING
DE3683186D1 (de) 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
EP0645452A1 (en) * 1985-10-14 1995-03-29 Yeda Research And Development Co. Ltd. Human interferon-beta 2A and interfeon-beta 2B, vectors containing genes coding for said interferons, cell lines producing same and use of said interferons as pharmaceuticals
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US6284237B1 (en) 1986-07-08 2001-09-04 Steven C. Clark Methods of treatment using IL-6
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
EP0585957A1 (en) * 1986-08-06 1994-03-09 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor
US4939093A (en) * 1987-02-02 1990-07-03 Cetus Corporation Human IL-2 like polypeptides, DNA sequences and recombinant DNA molecules therefore and methods for the production and use thereof
US4961969A (en) * 1987-05-11 1990-10-09 Cetus Corporation Process for recovering microbially produced interferon-β
IL88375A (en) * 1988-11-14 1995-07-31 Yeda Res & Dev Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
KR20100120246A (ko) * 2001-11-14 2010-11-12 센토코 오르토 바이오테크 인코포레이티드 항 ｉｌ-6 항체, 조성물, 방법 및 용도
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
WO2005074650A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human four helical bundle polypeptides and their uses
PE20061324A1 (es) 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
NZ597767A (en) 2007-05-21 2013-06-28 Bristol Myers Squibb Co Antibodies to IL-6 and use thereof
AU2008254578B2 (en) * 2007-05-21 2013-06-06 Alderbio Holdings Llc Novel rabbit antibody humanization methods and humanized rabbit antibodies
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US7906117B2 (en) * 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
JP5702150B2 (ja) 2008-02-08 2015-04-15 アンブルックス, インコーポレイテッドAmbrx, Inc. 修飾されているレプチンポリペプチドおよびそれらの使用
US8777182B2 (en) 2008-05-20 2014-07-15 Grinon Industries Fluid transfer assembly and methods of fluid transfer
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9452227B2 (en) * 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
EP2504030A4 (en) 2009-11-24 2013-06-26 Alderbio Holdings Llc IL-6 ANTAGONISTS FOR INCREASING ALBUMIN AND / OR REDUCING CRP
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
DK2643018T3 (da) 2010-11-23 2021-01-18 Vitaeris Inc Anti-il-6-antistoffer til behandling af oral mucositis

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US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
FR2321298A1 (fr) * 1975-08-01 1977-03-18 Anvar Procede de preparation de produits a activite interferon
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
JPS5663996A (en) * 1979-10-30 1981-05-30 Japan Found Cancer Novel recombinant having gene complementary to human interferon messenger rna
US5326859A (en) * 1979-10-30 1994-07-05 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
JPS5655731A (en) * 1979-10-11 1981-05-16 Ogura Clutch Co Ltd Clutch/brake device
NL7907791A (nl) * 1979-10-23 1981-04-27 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
ES8302096A1 (es) * 1980-04-03 1982-12-16 Biogen Nv Un metodo de producir un polipeptido que muestra una actividad immunologica obiologica de interferon de fibroblasto hu- mano.
DK171301B1 (da) * 1980-06-06 1996-08-26 Biogen Inc Plasmid-vektorer, fremgangsmåde til fremstilling deraf samt fremgangsmåde til fremstilling af polypeptid

Also Published As

Publication number Publication date
CH684892A5 (de) 1995-01-31
JPH02211879A (ja) 1990-08-23
SE8007998L (sv) 1981-05-22
US5468608A (en) 1995-11-21
SE461223B (sv) 1990-01-22
JPS5685296A (en) 1981-07-11
GB2063882B (en) 1984-05-31
CH664967A5 (de) 1988-04-15
SE469660B (sv) 1993-08-16
JP2555279B2 (ja) 1996-11-20
JP2548201B2 (ja) 1996-10-30
US5468607A (en) 1995-11-21
DE3051086C2 (it) 1992-11-05
GB2063882A (en) 1981-06-10
FR2475901A1 (fr) 1981-08-21
US5541312A (en) 1996-07-30
SE8603145D0 (sv) 1986-07-17
US5468609A (en) 1995-11-21
SE8603145L (sv) 1986-07-17
FR2475901B1 (it) 1985-02-15
DE3043981A1 (de) 1981-10-01
DE3043981C2 (it) 1989-11-30
SE461223C (sv) 1997-01-16
IL58765A0 (en) 1980-02-29
IT1194820B (it) 1988-09-28
JPS63164896A (ja) 1988-07-08
IT8026172A0 (it) 1980-11-21

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