IL58759A - Process for purifying proteins,pure and homogeneous interferon species obtained thereby and pharmaceutical compositions containing them - Google Patents

Process for purifying proteins,pure and homogeneous interferon species obtained thereby and pharmaceutical compositions containing them

Info

Publication number
IL58759A
IL58759A IL58759A IL5875979A IL58759A IL 58759 A IL58759 A IL 58759A IL 58759 A IL58759 A IL 58759A IL 5875979 A IL5875979 A IL 5875979A IL 58759 A IL58759 A IL 58759A
Authority
IL
Israel
Prior art keywords
pure
pharmaceutical compositions
compositions containing
purifying proteins
species obtained
Prior art date
Application number
IL58759A
Other languages
English (en)
Other versions
IL58759A0 (en
Original Assignee
Sparamedica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sparamedica Ag filed Critical Sparamedica Ag
Publication of IL58759A0 publication Critical patent/IL58759A0/xx
Publication of IL58759A publication Critical patent/IL58759A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/811Interferon
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/828Cancer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/829Blood
    • Y10S530/83Plasma; serum
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/14Lymphokine; related peptides
    • Y10S930/142Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL58759A 1978-11-24 1979-11-21 Process for purifying proteins,pure and homogeneous interferon species obtained thereby and pharmaceutical compositions containing them IL58759A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96325778A 1978-11-24 1978-11-24
US6237479A 1979-07-31 1979-07-31
US7771079A 1979-09-21 1979-09-21

Publications (2)

Publication Number Publication Date
IL58759A0 IL58759A0 (en) 1980-02-29
IL58759A true IL58759A (en) 1983-02-23

Family

ID=27370266

Family Applications (1)

Application Number Title Priority Date Filing Date
IL58759A IL58759A (en) 1978-11-24 1979-11-21 Process for purifying proteins,pure and homogeneous interferon species obtained thereby and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (1) US4289690A (ja)
JP (1) JPH07224098A (ja)
KR (1) KR830002616B1 (ja)
AR (1) AR222359A1 (ja)
AU (2) AU535936B2 (ja)
BE (1) BE880201A (ja)
CA (1) CA1129409A (ja)
CH (3) CH658459A5 (ja)
DE (1) DE2947134A1 (ja)
DK (1) DK161048C (ja)
DO (1) DOP1979002953A (ja)
ES (1) ES8100502A1 (ja)
FI (1) FI69476C (ja)
FR (1) FR2442054A1 (ja)
GB (1) GB2037296B (ja)
GR (1) GR72828B (ja)
HK (1) HK26684A (ja)
IE (1) IE48882B1 (ja)
IL (1) IL58759A (ja)
IN (1) IN150740B (ja)
IT (1) IT1127253B (ja)
KE (1) KE3347A (ja)
LU (2) LU81918A1 (ja)
MC (1) MC1300A1 (ja)
MY (1) MY8500222A (ja)
NL (1) NL193085C (ja)
NO (1) NO151157C (ja)
NZ (1) NZ192201A (ja)
PH (1) PH20763A (ja)
PT (1) PT70495A (ja)
RO (1) RO79132B (ja)
SE (1) SE454276B (ja)
SG (1) SG71183G (ja)
YU (1) YU286179A (ja)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410697B1 (en) * 1979-04-20 2002-06-25 Schering Corporation Process for purifying human leukocyte interferon
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US6835557B1 (en) 1980-01-08 2004-12-28 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides
DE3177213D1 (de) 1980-04-03 1990-10-18 Biogen Inc Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
US6610830B1 (en) 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
CH657141A5 (de) * 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
IT1139487B (it) * 1980-09-25 1986-09-24 Genentech Inc Produzione microbica di interferone di fibroblasti umani
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
US4810645A (en) * 1981-08-14 1989-03-07 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
US4801685A (en) * 1981-08-14 1989-01-31 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
US4672108A (en) * 1981-12-07 1987-06-09 Hoffmann-La Roche Inc. Crystalline human leukocyte interferon
DE3262575D1 (en) * 1981-12-23 1985-04-18 Schering Corp Stabilised interferon formulations and their preparation
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
ZA83768B (en) * 1982-03-01 1983-10-26 Hoffmann La Roche Homogeneous human immune interferon and process therefor
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4432895A (en) * 1982-11-24 1984-02-21 Hoffmann-La Roche Inc. Monomeric interferons
US4820515A (en) * 1982-12-13 1989-04-11 Texas A&M University System Method of using interferon in low dosage to regulate appetite and efficiency of food utilization
JPS59137417A (ja) * 1983-01-28 1984-08-07 Morinaga Milk Ind Co Ltd 人尿由来コロニ−形成刺激因子及びカリクレインの製造法
IL67896A (en) * 1983-02-13 1987-03-31 Yeda Res & Dev Two biologically active human gama interferon subtypes,purification thereof and pharmaceutical compositions containing them
US4599306A (en) * 1983-04-15 1986-07-08 Amgen Monoclonal antibodies which specifically bind to human immune interferon
US4723000A (en) * 1983-07-05 1988-02-02 Biospectrum, Inc. Human interferon gamma and interleukin-2
US4710377A (en) * 1983-08-19 1987-12-01 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of Eimeria spp.
US4675383A (en) * 1983-11-15 1987-06-23 The Salk Institute For Biological Studies Purification of T-cell growth factor
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
US4499014A (en) * 1984-02-07 1985-02-12 Interferon Sciences, Inc. Method for purifying gamma-interferon
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
IL71555A (en) * 1984-04-15 1992-06-21 State Of Israel Israel Inst Fo Bovine interferon
US6133433A (en) * 1984-07-27 2000-10-17 City Of Hope Method for detection and prevention of human cytomegalovirus infection
US6242567B1 (en) 1984-07-27 2001-06-05 City Of Hope Method for detection and prevention of human cytomegalovirus infection
UA29377C2 (uk) * 1984-09-19 2000-11-15 Новартіс Аг Спосіб отримання білка з активністю колонієстимулювального фактора гранулоцитів та макрофагів(gm-csf) приматів
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
US5322837A (en) * 1985-01-11 1994-06-21 Genetics Institute, Inc. Homogeneous erythropoietin compositions and methods of using same
US5792450A (en) * 1985-02-05 1998-08-11 Chiron Corporation Purified human CSF-1
US5532341A (en) * 1985-03-28 1996-07-02 Sloan-Kettering Institute For Cancer Research Human pluripotent hematopoietic colony stimulating factor
IL79176A (en) * 1985-06-20 1992-06-21 Kirin Amgen Inc Process for the recovery of erythropoietin from a fluid
US4667016A (en) * 1985-06-20 1987-05-19 Kirin-Amgen, Inc. Erythropoietin purification
NZ212523A (en) * 1985-06-24 1989-01-06 Univ Massey Mobile phase for purification of proteins by high performance liquid chromatography
GB8522336D0 (en) * 1985-09-09 1985-10-16 Biogen Nv Composition for treatment of allergies
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US5427780A (en) * 1985-10-30 1995-06-27 Biogen, Inc. Composition comprising Mullerian inhibiting substance-like polypeptides
US4770781A (en) * 1986-03-03 1988-09-13 Merck & Co., Inc. Purification of human interleukin-1 species
US5030559A (en) * 1986-04-01 1991-07-09 Board Of Regents, The University Of Texas System Methods and compositions for the identification of metastatic human tumors
US4935372A (en) * 1986-05-20 1990-06-19 Dana Farber Cancer Institute Art nucleotide segments, vectors, cell lines methods of preparation and use
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
US4894440A (en) * 1986-09-17 1990-01-16 Massachusetts Institute Of Technology Method of isolating megakaryocyte stimulatory factor
IL84170A0 (en) * 1986-10-17 1988-03-31 Interferon Sciences Inc Method for detecting interferon
US4851220A (en) * 1986-11-26 1989-07-25 Schering Corporation Stable oleaginous gel
US4894330A (en) * 1986-12-23 1990-01-16 Cetus Corporation Purification of recombinant beta-interferon incorporating RP-HPLC
US5190751A (en) * 1987-01-20 1993-03-02 Schering Corporation Treatment of certain leukemias with a combination of gamma interferon and alpha interferon
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US5034513A (en) * 1987-05-27 1991-07-23 The United States Of America As Represented By The Secretary Of Agriculture Avian interleukin-2
US4871538A (en) * 1987-07-13 1989-10-03 Schering Corporation Insoluble copper-alpha interferon complex
ATE86633T1 (de) * 1987-10-21 1993-03-15 Akzo Nv Snrnp-a-antigen und fragmente davon.
US5559212A (en) * 1988-04-06 1996-09-24 Alfacell Corporation Frog embryo and egg-derived tumor cell anti-proliferation protein
US5179198A (en) * 1988-07-11 1993-01-12 Hidechika Okada Glycoprotein and gene coding therefor
US5256410A (en) * 1988-12-01 1993-10-26 Schering Corporation Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon
US5661126A (en) * 1989-01-19 1997-08-26 The General Hospital Corporation Use of mullerian inhibiting substance for treating certain tumors and for modulating class I major histocompatibility antigen expression
AU5104390A (en) * 1989-02-08 1990-09-05 Uab Research Foundation Antiproliferation factor
DK0393438T3 (da) 1989-04-21 2005-05-30 Amgen Inc TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor
US7264944B1 (en) 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US6221675B1 (en) 1989-04-21 2001-04-24 Amgen, Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US5849881A (en) * 1989-05-05 1998-12-15 Baylor College Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms
IL94183A (en) 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US6100054A (en) * 1989-05-05 2000-08-08 Baylor College Of Medicine Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms
US5766939A (en) * 1989-05-05 1998-06-16 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US5216128A (en) * 1989-06-01 1993-06-01 Yeda Research And Development Co., Ltd. IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc A method of producing a recombinant human necrotic factor absorber
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
GB9013016D0 (en) * 1990-06-11 1990-08-01 Mars Uk Ltd Compounds
JP3230091B2 (ja) * 1990-06-25 2001-11-19 ウェルファイド株式会社 ヒト血清アルブミンの着色抑制方法
ATE158184T1 (de) * 1990-07-02 1997-10-15 Nat Jewish Ct Immun & Respirat Herstellung und verwendung von transfer-faktor
AU650893B2 (en) * 1990-07-10 1994-07-07 Boehringer Ingelheim International Gmbh O-glycosylated alpha-2 interferon
JP3015969B2 (ja) * 1990-11-30 2000-03-06 ダイナボット株式会社 扁平上皮癌関連抗原蛋白質及び該蛋白質をコードするdna
DE4113949A1 (de) * 1991-04-29 1992-11-05 Behringwerke Ag Schizosaccharomyces spezifische polypeptide
US5676942A (en) * 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof
ATE179330T1 (de) * 1992-02-10 1999-05-15 Interferon Sciences Inc Verbesserte alpha-interferon-zusammensetzung und verfahren zu ihrer herstellung aus leukocyten des menschlichen peripheren blute
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5434249A (en) * 1992-05-27 1995-07-18 Viragen Inc. Method for modulating specific activity of inteferon alpha
WO1994000154A1 (en) * 1992-06-24 1994-01-06 Merck & Co., Inc. DNA ENCODING PRECURSOR INTERLEUKIN 1β CONVERTING ENZYME
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
CA2150378C (en) * 1992-11-30 2007-10-30 Joel Moss Mammalian muscle nad:arginine adp-ribosyltransferase
FR2701263B1 (fr) * 1993-02-09 1995-04-21 Elie Stefas Procédé d'obtention d'une composition aqueuse protéinique, composition correspondante, glycoprotéine contenue et son utilisation pour la stabilisation de l'albumine et la détection ou le dosage d'anticorps.
US5550114A (en) 1993-04-02 1996-08-27 Thomas Jefferson University Epidermal growth factor inhibitor
CA2160127A1 (en) * 1993-04-07 1994-10-13 David C. Fritzinger Dna encoding cobra c3, cvf1, and cvf2
US5714344A (en) * 1993-04-07 1998-02-03 Georgetown University Protease-derivatized CVF
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
ES2370937T3 (es) 1993-09-13 2011-12-23 Protein Sciences Corporation Un método para producir vacunas antigripales polivalentes a base de hemaglutinina.
DE69423361T2 (de) * 1993-10-05 2000-12-07 Miller Brewing Co., Milwaukee Geklonte pullulanase
US6020465A (en) * 1993-10-22 2000-02-01 University Of Connecticut Recombinant avian type i interferon
US5885567A (en) * 1993-10-22 1999-03-23 University Of Connecticut Treatment of infection in fowl by oral administration of avian interferon proteins
US5681931A (en) * 1995-03-15 1997-10-28 Becton, Dickinson And Company Human restrictin
US5883224A (en) * 1996-04-19 1999-03-16 Cytokine Sciences, Inc. Characterization of transfer factors and methods of use
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
US5922320A (en) 1996-06-14 1999-07-13 Georgetown University Recombinant proCVF
TW555765B (en) * 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
AU5696198A (en) 1996-12-06 1998-06-29 Amgen, Inc. Combination therapy using a tnf binding protein for treating tnf-mediated diseases
FR2774988B1 (fr) * 1998-02-16 2000-05-05 Commissariat Energie Atomique Procede de purification de la prpres a partir d'un echantillon biologique et ses applications
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6433144B1 (en) * 1999-01-12 2002-08-13 Viragen, Inc. Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
JP4896745B2 (ja) * 2004-02-02 2012-03-14 アンブレツクス・インコーポレイテツド 修飾されたヒトインターフェロンポリペプチドおよびこれらの使用
US8921518B2 (en) 2005-12-23 2014-12-30 Novo Nordisk A/S Purification of proteins using preparative reverse phase chromatography (RPC)
US8580935B2 (en) * 2007-02-26 2013-11-12 Alltech Associates, Inc. Ultra-fast chromatography
RU2452491C1 (ru) * 2010-11-10 2012-06-10 Александр Иванович Сотниченко Детоксикант пищеварительного тракта позвоночных

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3699222A (en) * 1958-03-11 1972-10-17 Nat Res Dev Production of viral interfering substances
US3144390A (en) * 1960-06-28 1964-08-11 Nat Res Dev Process for the purification of interferon
GB980227A (en) * 1962-08-16 1965-01-13 Glaxo Lab Ltd Purification and/or concentration of material containing interferon
GB1026726A (en) * 1962-11-23 1966-04-20 Ici Ltd New assay technique
GB1055895A (en) * 1963-12-10 1967-01-18 Glaxo Lab Ltd Interferon purification
US3256152A (en) * 1965-06-14 1966-06-14 Merck & Co Inc Concentration and purification of interferons, viral inhibiting substances (vis), viral inhibiting factors (vif), or viral inhibitory material
US3548053A (en) * 1965-09-07 1970-12-15 Horner Frank W Ltd Interferon production
DE1617401A1 (de) * 1966-05-02 1972-02-17 Centre Nat Rech Scient Verfahren zur Herstellung von Interferon-Praeparaten
US3652538A (en) * 1969-08-08 1972-03-28 Pfizer Formulation process for polynucleotide homopolymers
DE2041735A1 (de) * 1970-08-22 1972-02-24 Merck Patent Gmbh Thio-pyrimidin-derivate
US3773924A (en) * 1970-12-24 1973-11-20 M Ho Interferon production
BE790953A (fr) * 1971-11-05 1973-05-03 Beecham Group Ltd Matiere biologiquement active
US3800035A (en) * 1971-12-07 1974-03-26 Smithkline Corp Production of interferon from human leukocytes in the absence of serum
US3948886A (en) * 1972-03-13 1976-04-06 Icn Pharmaceuticals, Inc. 6-Substituted purine 3',5'-cyclic nucleotides
US3819482A (en) * 1972-05-08 1974-06-25 J Semancik Method of preparing high yields of double-stranded ribonucleic acid
US3970749A (en) * 1973-04-03 1976-07-20 Baugh Clarence L Interferon production
US4061538A (en) * 1973-04-04 1977-12-06 Sandoz Ltd. Enzymatically oxidizing interferon
FR2244543B1 (ja) * 1973-07-27 1977-07-01 Inst Nl Sante Rech Medica
US3910824A (en) * 1973-10-18 1975-10-07 Searle & Co Interferon assay
US4024222A (en) * 1973-10-30 1977-05-17 The Johns Hopkins University Nucleic acid complexes
NL7404590A (nl) * 1974-04-03 1975-10-07 Stichting Rega V Z W Werkwijze voor het reactiveren van interferon.
NL7404589A (nl) * 1974-04-03 1975-10-07 Stichting Rega V Z W Werkwijze voor het stabiliseren van interferon.
US3975344A (en) * 1974-10-02 1976-08-17 G. D. Searle & Co. Interferon purification
JPS5322156B2 (ja) * 1975-01-07 1978-07-06
US4144126A (en) * 1975-05-21 1979-03-13 Beecham Group Limited Cell culture method
US4100150A (en) * 1975-11-04 1978-07-11 G. D. Searle & Co. Stabilization of interferon against mechanical stress using thioctic acid
NL7605805A (nl) * 1976-05-28 1977-11-30 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
US4038139A (en) * 1976-07-16 1977-07-26 G. D. Searle & Co., Limited Cell culture medium
FR2389380B1 (ja) * 1977-05-02 1980-02-29 Anvar
JPH031320A (ja) * 1989-05-29 1991-01-08 Hitachi Maxell Ltd 磁性紛末とこれを用いた磁気記録媒体

Also Published As

Publication number Publication date
SE454276B (sv) 1988-04-18
FI69476B (fi) 1985-10-31
PT70495A (en) 1979-12-01
JPH07224098A (ja) 1995-08-22
IN150740B (ja) 1982-12-04
AU535936B2 (en) 1984-04-12
NO793819L (no) 1980-05-28
KR830000910A (ko) 1983-04-28
CH654843A5 (de) 1986-03-14
BE880201A (fr) 1980-05-22
IL58759A0 (en) 1980-02-29
IT7927524A0 (it) 1979-11-23
NZ192201A (en) 1985-07-31
US4289690A (en) 1981-09-15
AU1586683A (en) 1983-12-08
IE792247L (en) 1980-05-24
GB2037296B (en) 1983-07-27
LU81918A1 (de) 1981-06-04
CA1129409A (en) 1982-08-10
SE7909721L (sv) 1980-06-16
DK496779A (da) 1980-05-25
FI793649A (fi) 1980-05-25
FI69476C (fi) 1986-02-10
NO151157C (no) 1985-02-20
FR2442054A1 (fr) 1980-06-20
FR2442054B1 (ja) 1983-09-09
DE2947134A1 (de) 1980-06-12
AU561672B2 (en) 1987-05-14
RO79132A (ro) 1982-07-06
AR222359A1 (es) 1981-05-15
MC1300A1 (fr) 1980-10-03
CH658459A5 (de) 1986-11-14
PH20763A (en) 1987-04-10
YU286179A (en) 1983-10-31
SG71183G (en) 1984-08-03
GB2037296A (en) 1980-07-09
NL193085B (nl) 1998-06-02
GR72828B (ja) 1983-12-06
NL193085C (nl) 1998-10-05
ES486263A0 (es) 1980-11-01
ES8100502A1 (es) 1980-11-01
NO151157B (no) 1984-11-12
MY8500222A (en) 1985-12-31
IT1127253B (it) 1986-05-21
DE2947134C2 (ja) 1988-04-21
DOP1979002953A (es) 1992-11-10
AU5313679A (en) 1980-05-29
IE48882B1 (en) 1985-06-12
NL7908516A (nl) 1980-05-28
DK161048B (da) 1991-05-27
KR830002616B1 (ko) 1983-12-06
RO79132B (ro) 1983-05-30
HK26684A (en) 1984-03-30
KE3347A (en) 1983-12-16
LU88314I2 (fr) 1994-05-04
CH653347A5 (de) 1985-12-31
DK161048C (da) 1991-11-04

Similar Documents

Publication Publication Date Title
IL58759A (en) Process for purifying proteins,pure and homogeneous interferon species obtained thereby and pharmaceutical compositions containing them
DE3166619D1 (en) 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridine-3-carboxylic acids, process for their preparation and pharmaceutical compositions containing them
DE3263633D1 (en) Imidazodiazepines, process for their preparation and pharmaceutical compositions containing them
DE3064173D1 (en) Novel 20-0-acylmaytansinoids, process for their preparation and pharmaceutical compositions containing them
PH18036A (en) Polypeptides,their pharmaceutical compositions and process for their preparation
DE3461090D1 (en) 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
MY8500590A (en) Pyrimidones, process for their preparation and pharmaceutical compositions containing them
DE3061586D1 (en) Pancreozymin-cholezystokinin active peptides, process for their preparation and pharmaceutical compositions containing them
EP0007470A3 (en) Cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
IL57532A (en) Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines,process for their preparation and pharmaceutical compositions containing them
DE2960954D1 (en) 1-aryloxy-3-nitratoalkylamino-2-propanols, process for their preparation and pharmaceutical compositions
EP0145121A3 (en) Pyrazoloquinolines, process for their preparation, and pharmaceutical compositions containing them
IL65247A0 (en) Amido-amino acids,process for their preparation and pharmaceutical compositions containing them
ZA791276B (en) N-oxacyclic-alkylpiperidyl-diazacompounds,process for their manufacture and pharmaceutical compositions containing them
EP0003144A3 (en) 4-pyridone-3-carboxylic acid derivatives, pharmaceutical compositions containing them, processes for their preparation, their application and intermediates in their preparation
DE3070278D1 (en) Peptides, processes for their preparation and pharmaceutical compositions containing them
GB2038802B (en) Aryltrifluoroethanols process for their preparation and pharmaceutical compositions containing them
DE2961285D1 (en) Frenolicin b, process for preparation thereof and pharmaceutical compositions containing it
GB2138817B (en) 4-pheny-tetrahydro-furano-pyridines, process for their preparation, and pharmaceutical compositions containing them
DE2960503D1 (en) Novel androstadienes, processes for their preparation and pharmaceutical compositions containing them
IL60907A0 (en) Substituted quinoline-alkanecarboxylic acids,process for their preparation and pharmaceutical compositions containing them
IL61902A (en) Kijanimicin,process for its preparation and pharmaceutical compositions containing it
GB2083828B (en) Process for preparing modified protein compositions
IL61099A (en) 9-deoxy-6,9alpha-imino-delta6,8-pgi analogues,process for their preparation and pharmaceutical compositions containing them
DE3160797D1 (en) 11-alpha-amino androstanes, pharmaceutical compositions containing them and processes for their preparation