IL296683B2 - Preparations for the treatment of congenital adrenal hyperplasia - Google Patents

Preparations for the treatment of congenital adrenal hyperplasia

Info

Publication number
IL296683B2
IL296683B2 IL296683A IL29668322A IL296683B2 IL 296683 B2 IL296683 B2 IL 296683B2 IL 296683 A IL296683 A IL 296683A IL 29668322 A IL29668322 A IL 29668322A IL 296683 B2 IL296683 B2 IL 296683B2
Authority
IL
Israel
Prior art keywords
receptor antagonist
glucocorticoid
crf1 receptor
used according
methylphenyl
Prior art date
Application number
IL296683A
Other languages
English (en)
Hebrew (he)
Other versions
IL296683B1 (en
IL296683A (en
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52450623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL296683(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of IL296683A publication Critical patent/IL296683A/en
Publication of IL296683B1 publication Critical patent/IL296683B1/en
Publication of IL296683B2 publication Critical patent/IL296683B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL296683A 2014-01-21 2015-01-21 Preparations for the treatment of congenital adrenal hyperplasia IL296683B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461929941P 2014-01-21 2014-01-21
US201461981033P 2014-04-17 2014-04-17
US201462069155P 2014-10-27 2014-10-27
PCT/US2015/012315 WO2015112642A1 (en) 2014-01-21 2015-01-21 Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia

Publications (3)

Publication Number Publication Date
IL296683A IL296683A (en) 2022-11-01
IL296683B1 IL296683B1 (en) 2023-08-01
IL296683B2 true IL296683B2 (en) 2023-12-01

Family

ID=52450623

Family Applications (5)

Application Number Title Priority Date Filing Date
IL296683A IL296683B2 (en) 2014-01-21 2015-01-21 Preparations for the treatment of congenital adrenal hyperplasia
IL317035A IL317035A (en) 2014-01-21 2015-01-21 Preparations for the treatment of congenital adrenal hyperplasia
IL304134A IL304134B2 (en) 2014-01-21 2015-01-21 Preparations for the treatment of congenital adrenal hyperplasia
IL246783A IL246783B (en) 2014-01-21 2016-07-14 Preparations for the treatment of congenital adrenal hyperplasia
IL286782A IL286782A (en) 2014-01-21 2021-09-29 Compositions for treating congenital adrenal hyperplasia

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL317035A IL317035A (en) 2014-01-21 2015-01-21 Preparations for the treatment of congenital adrenal hyperplasia
IL304134A IL304134B2 (en) 2014-01-21 2015-01-21 Preparations for the treatment of congenital adrenal hyperplasia
IL246783A IL246783B (en) 2014-01-21 2016-07-14 Preparations for the treatment of congenital adrenal hyperplasia
IL286782A IL286782A (en) 2014-01-21 2021-09-29 Compositions for treating congenital adrenal hyperplasia

Country Status (24)

Country Link
US (5) US20170020877A1 (enExample)
EP (2) EP3096756B1 (enExample)
JP (5) JP6585625B2 (enExample)
KR (2) KR20210064407A (enExample)
CN (2) CN111228274A (enExample)
AU (4) AU2015209452C1 (enExample)
BR (1) BR112016016975B1 (enExample)
CA (2) CA3155599A1 (enExample)
DK (1) DK3096756T3 (enExample)
ES (1) ES2984706T3 (enExample)
FI (1) FI3096756T3 (enExample)
HR (1) HRP20241046T1 (enExample)
HU (1) HUE068315T2 (enExample)
IL (5) IL296683B2 (enExample)
LT (1) LT3096756T (enExample)
MX (3) MX389004B (enExample)
NZ (1) NZ722122A (enExample)
PL (1) PL3096756T3 (enExample)
PT (1) PT3096756T (enExample)
RS (1) RS65839B1 (enExample)
RU (1) RU2718918C2 (enExample)
SI (1) SI3096756T1 (enExample)
SM (1) SMT202400361T1 (enExample)
WO (1) WO2015112642A1 (enExample)

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Publication number Priority date Publication date Assignee Title
JP6585625B2 (ja) 2014-01-21 2019-10-02 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 先天性副腎皮質過形成の処置のためのcrf1レセプターアンタゴニスト
CA2940242A1 (en) 2014-02-20 2015-08-27 Alder Biopharmaceuticals, Inc. Anti-acth antibodies and use thereof
CN109906222B (zh) 2016-09-07 2023-08-01 加利福尼亚大学董事会 减少p-tau并且改善认知的变构促肾上腺皮质激素释放因子受体1(crfr1)拮抗剂
EP3628005A4 (en) * 2017-08-14 2021-01-20 Spruce Biosciences, Inc. Corticotropin releasing factor receptor antagonists
CN112423747A (zh) * 2018-04-27 2021-02-26 云杉生物科学公司 用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法
JP7532328B2 (ja) * 2018-12-07 2024-08-13 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 先天性副腎過形成を処置するためのcrf1受容体アンタゴニスト、その医薬製剤および固体形態
TW202446384A (zh) * 2018-12-07 2024-12-01 美商紐羅克里生物科學有限公司 用於治療先天性腎上腺增生之crf1受體拮抗劑、醫藥配方及其固體形式
AU2020318970A1 (en) 2019-07-19 2022-03-03 Spruce Biosciences, Inc. Methods of treating congenital adrenal hyperplasia
CN114502162B (zh) * 2019-09-27 2025-03-28 纽罗克里生物科学有限公司 Crf受体拮抗剂及使用方法
JP2023531164A (ja) * 2020-06-10 2023-07-21 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 先天性副腎過形成を処置するためのcrf1受容体アンタゴニスト
CN118948857A (zh) * 2020-08-12 2024-11-15 云杉生物科学公司 用于治疗多囊卵巢综合征的方法和组合物
MD20210019A2 (ro) 2021-04-12 2022-10-31 Максим МАСЮТИН Metodă de tratament a hiperplaziei suprarenale congenitale, cauzate de deficit de 21-hidroxilază cu debut tardiv prin regimul de glucocorticoizi adaptat individual
US11708372B2 (en) 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

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Also Published As

Publication number Publication date
RU2016133972A (ru) 2018-03-05
US11730739B2 (en) 2023-08-22
JP2022010260A (ja) 2022-01-14
IL296683B1 (en) 2023-08-01
CA2936974A1 (en) 2015-07-30
JP2024098001A (ja) 2024-07-19
US20170020877A1 (en) 2017-01-26
FI3096756T3 (fi) 2024-08-14
AU2022263460B2 (en) 2024-10-17
WO2015112642A1 (en) 2015-07-30
KR20160106176A (ko) 2016-09-09
JP7104743B2 (ja) 2022-07-21
MX2022000080A (es) 2022-02-03
JP2017503030A (ja) 2017-01-26
AU2015209452A1 (en) 2016-08-04
BR112016016975B1 (pt) 2022-12-27
IL286782A (en) 2021-10-31
MX2016009499A (es) 2017-02-27
IL246783A0 (en) 2016-08-31
IL296683A (en) 2022-11-01
SMT202400361T1 (it) 2024-11-15
AU2022263460A1 (en) 2022-12-08
JP6585625B2 (ja) 2019-10-02
KR20210064407A (ko) 2021-06-02
MX389004B (es) 2025-03-20
KR102258522B1 (ko) 2021-05-31
US20190231781A1 (en) 2019-08-01
IL304134A (en) 2023-09-01
CN106102740A (zh) 2016-11-09
JP2020138978A (ja) 2020-09-03
SI3096756T1 (sl) 2024-09-30
AU2024219813A1 (en) 2024-10-10
HRP20241046T1 (hr) 2024-11-08
US20210361659A1 (en) 2021-11-25
PT3096756T (pt) 2024-08-26
AU2015209452B2 (en) 2020-05-07
MX2021012539A (es) 2021-11-12
RU2718918C2 (ru) 2020-04-15
JP2019081814A (ja) 2019-05-30
HUE068315T2 (hu) 2024-12-28
AU2020207774A1 (en) 2020-08-06
LT3096756T (lt) 2024-08-26
US20240058342A1 (en) 2024-02-22
IL317035A (en) 2025-01-01
BR112016016975A2 (pt) 2017-08-08
CN111228274A (zh) 2020-06-05
US10905690B2 (en) 2021-02-02
EP4450070A1 (en) 2024-10-23
NZ722122A (en) 2020-06-26
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