BR112016016975B1 - Usos de um antagonista do receptor crf1 para o tratamento de hiperplasia adrenal congênita e para reduzir níveis de 17-ohp e acth em um paciente - Google Patents

Usos de um antagonista do receptor crf1 para o tratamento de hiperplasia adrenal congênita e para reduzir níveis de 17-ohp e acth em um paciente Download PDF

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Publication number
BR112016016975B1
BR112016016975B1 BR112016016975-1A BR112016016975A BR112016016975B1 BR 112016016975 B1 BR112016016975 B1 BR 112016016975B1 BR 112016016975 A BR112016016975 A BR 112016016975A BR 112016016975 B1 BR112016016975 B1 BR 112016016975B1
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BR
Brazil
Prior art keywords
acth
patient
receptor antagonist
crf1 receptor
crf1
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BR112016016975-1A
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English (en)
Portuguese (pt)
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BR112016016975A2 (pt
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Dimitri E. Grigoriadis
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Neurocrine Biosciences Inc
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Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of BR112016016975A2 publication Critical patent/BR112016016975A2/pt
Publication of BR112016016975B1 publication Critical patent/BR112016016975B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112016016975-1A 2014-01-21 2015-01-21 Usos de um antagonista do receptor crf1 para o tratamento de hiperplasia adrenal congênita e para reduzir níveis de 17-ohp e acth em um paciente BR112016016975B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461929941P 2014-01-21 2014-01-21
US61/929,941 2014-01-21
US201461981033P 2014-04-17 2014-04-17
US61/981,033 2014-04-17
US201462069155P 2014-10-27 2014-10-27
US62/069,155 2014-10-27
PCT/US2015/012315 WO2015112642A1 (en) 2014-01-21 2015-01-21 Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia

Publications (2)

Publication Number Publication Date
BR112016016975A2 BR112016016975A2 (pt) 2017-08-08
BR112016016975B1 true BR112016016975B1 (pt) 2022-12-27

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BR112016016975-1A BR112016016975B1 (pt) 2014-01-21 2015-01-21 Usos de um antagonista do receptor crf1 para o tratamento de hiperplasia adrenal congênita e para reduzir níveis de 17-ohp e acth em um paciente

Country Status (24)

Country Link
US (5) US20170020877A1 (enExample)
EP (2) EP4450070A1 (enExample)
JP (5) JP6585625B2 (enExample)
KR (2) KR20210064407A (enExample)
CN (2) CN106102740A (enExample)
AU (4) AU2015209452C1 (enExample)
BR (1) BR112016016975B1 (enExample)
CA (2) CA3155599A1 (enExample)
DK (1) DK3096756T3 (enExample)
ES (1) ES2984706T3 (enExample)
FI (1) FI3096756T3 (enExample)
HR (1) HRP20241046T1 (enExample)
HU (1) HUE068315T2 (enExample)
IL (5) IL296683B2 (enExample)
LT (1) LT3096756T (enExample)
MX (3) MX389004B (enExample)
NZ (1) NZ722122A (enExample)
PL (1) PL3096756T3 (enExample)
PT (1) PT3096756T (enExample)
RS (1) RS65839B1 (enExample)
RU (1) RU2718918C2 (enExample)
SI (1) SI3096756T1 (enExample)
SM (1) SMT202400361T1 (enExample)
WO (1) WO2015112642A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL296683B2 (en) * 2014-01-21 2023-12-01 Neurocrine Biosciences Inc Preparations for the treatment of congenital adrenal hyperplasia
WO2015127288A1 (en) 2014-02-20 2015-08-27 Alder Biopharmaceuticals, Inc. Anti-acth antibodies and use thereof
KR102571296B1 (ko) 2016-09-07 2023-08-28 더 리전트 오브 더 유니버시티 오브 캘리포니아 P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제
WO2019036503A1 (en) * 2017-08-14 2019-02-21 Spruce Biosciences, Inc. CORTICOTROPIN RELEASE FACTOR RECEPTOR ANTAGONISTS
CN112423747A (zh) * 2018-04-27 2021-02-26 云杉生物科学公司 用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法
CN120284862A (zh) * 2018-12-07 2025-07-11 纽罗克里生物科学有限公司 用于治疗先天性肾上腺皮质增生症的crf1受体拮抗剂、其药物制剂和固体形式
JP7532328B2 (ja) * 2018-12-07 2024-08-13 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト、その医薬製剤および固体形態
WO2021016208A1 (en) 2019-07-19 2021-01-28 Spruce Biosciences, Inc. Methods of treating congenital adrenal hyperplasia
US12383536B2 (en) 2019-09-27 2025-08-12 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods of use
JP2023531164A (ja) * 2020-06-10 2023-07-21 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト
CN116322544B (zh) 2020-08-12 2024-08-02 云杉生物科学公司 用于治疗多囊卵巢综合征的方法和组合物
MD20210019A2 (ro) 2021-04-12 2022-10-31 Максим МАСЮТИН Metodă de tratament a hiperplaziei suprarenale congenitale, cauzate de deficit de 21-hidroxilază cu debut tardiv prin regimul de glucocorticoizi adaptat individual
US11708372B2 (en) 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4949582B1 (enExample) 1969-01-20 1974-12-27
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
FR2692893B1 (fr) 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
US6664261B2 (en) 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
TW477787B (en) 1996-08-27 2002-03-01 Pfizer Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
EP0927171B1 (en) 1996-09-16 2002-02-20 Du Pont Pharmaceuticals Company Pyrazinones and triazinones and their derivatives thereof
FR2754258B1 (fr) 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
PT977737E (pt) 1997-04-22 2004-02-27 Janssen Pharmaceutica Nv Quino- e quinazolinas antagonistas de crf
WO1999010350A1 (en) 1997-08-22 1999-03-04 Du Pont Pharmaceuticals Company NITROGEN SUBSTITUTED IMIDAZO[4,5-c]PYRAZOLES AS CORTICOTROPIN RELEASING HORMONE ANTAGONISTS
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
CA2369553A1 (en) 1999-04-02 2000-10-12 Raymond F. Horvath N-benzimidazolylmethyl and n-indolylmethyl-benzamides and their use as crf modulators
FR2796380B3 (fr) 1999-07-15 2001-08-17 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
FR2802530B1 (fr) 1999-12-17 2002-02-22 Sanofi Synthelabo Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
US7276526B2 (en) 2001-07-13 2007-10-02 Bristol-Myers Squibb Pharma Company Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
WO2005079807A1 (en) 2004-02-13 2005-09-01 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists
US20060078623A1 (en) 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
EP1802621B1 (en) 2004-10-19 2009-05-06 SmithKline Beecham (Cork) Limited Crf receptor antagonists and methods relating thereto
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
KR20070120963A (ko) 2005-03-21 2007-12-26 일라이 릴리 앤드 캄파니 이미다조피리다진 화합물
US7557103B2 (en) 2005-04-05 2009-07-07 Eli Lilly And Company Imidazopyridazine compounds
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
JPWO2006126718A1 (ja) 2005-05-27 2008-12-25 田辺三菱製薬株式会社 ピラゾロピリミジン誘導体
EP2361619A1 (en) 2005-11-10 2011-08-31 TopoTarget UK Limited Histone deacetylase (hdac) inhibitors (pxd-101) alone for the treatment of hematological cancer
US20090281120A1 (en) 2005-12-12 2009-11-12 Ono Pharmaceutical Co., Ltd Bicyclic heterocyclic compound
JPWO2007069671A1 (ja) 2005-12-15 2009-05-21 小野薬品工業株式会社 二環式複素環化合物
EP1982178B1 (en) 2006-02-07 2013-07-24 Phenoquest AG Methods for the treatment of affective disorders
EP1834641A1 (en) 2006-03-16 2007-09-19 Sanofi-Aventis Use of CRF1 receptor antagonists for preparing a drug for treating metabolic syndrome and/or obesity and/or dyslipoproteinemia
AU2007253684A1 (en) 2006-05-22 2007-11-29 Vanda Pharmaceuticals, Inc. Treatment for depressive disorders
ATE481405T1 (de) * 2006-09-20 2010-10-15 Lilly Co Eli Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors
CA2662000C (en) 2006-09-20 2013-01-08 Eli Lilly And Company Thiophene pyrazolopyrimidine compounds
EP2088861A4 (en) 2006-10-25 2010-07-07 Takeda Pharmaceutical Benzimidazole compounds
WO2008083070A1 (en) 2006-12-29 2008-07-10 Neurogen Corporation Crf1 receptor ligands comprising fused bicyclic heteroaryl moieties
EP2125753A1 (en) 2006-12-29 2009-12-02 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds having crf antagonistic activity
TW200902019A (en) 2007-04-26 2009-01-16 Ono Pharmaceutical Co Dicyclic heterocyclic compound
WO2009008552A1 (en) 2007-07-11 2009-01-15 Taisho Pharmaceutical Co., Ltd. 8-aryl-4-alkylpyrrolo[2,3,4-de]quinolin-5(4h)-one and 8-aryl-4-alkyl-4,5-dihydropyrrolo[2,3,4-de]quinolin-5-ol derivatives
WO2009144632A1 (en) 2008-05-30 2009-12-03 Pfizer Limited Novel compounds
US7932256B2 (en) 2008-07-31 2011-04-26 Bristol-Myers Squibb Company (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile: a pyrazinone modulator of corticotropin-releasing factor receptor activity
WO2010014687A1 (en) 2008-07-31 2010-02-04 Bristol-Myers Squibb Company Substituted carbamate derivatives as modulators of corticotropin-releasing factor receptor activity
US7994203B2 (en) 2008-08-06 2011-08-09 Novartis Ag Organic compounds
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
EP2352449B1 (en) 2008-11-03 2018-02-21 Synthes GmbH Adjustable rod assembly
US8551996B2 (en) 2009-02-20 2013-10-08 Emory University Compounds, compositions, methods of synthesis, and methods of treatment
HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof
JPWO2011043387A1 (ja) 2009-10-08 2013-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロオキサゾール化合物
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
EP2836216B1 (en) 2012-04-13 2022-06-08 Epizyme, Inc. Combination therapy for treating cancer
US20150278438A1 (en) * 2012-04-23 2015-10-01 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Genetic predictors of response to treatment with crhr1 antagonists
JP2015516979A (ja) 2012-04-23 2015-06-18 ホルスボールマッシュマイヤー ニューロケミー ゲーエムベーハーＨｏｌｓｂｏｅｒｍａｓｃｈｍｅｙｅｒ Ｎｅｕｒｏｃｈｅｍｉｅ Ｇｍｂｈ Ｃｒｈ過剰活性を有する患者の治療に用いるためのｃｒｈｒ１アンタゴニスト
IL296683B2 (en) 2014-01-21 2023-12-01 Neurocrine Biosciences Inc Preparations for the treatment of congenital adrenal hyperplasia
WO2016065177A1 (en) 2014-10-22 2016-04-28 The Trustees Of The University Of Pennsylvania Method of treating depression and other stress related disorders
WO2016127133A1 (en) 2015-02-06 2016-08-11 Neurocrine Biosciences, Inc. [9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
EP3277836B1 (en) 2015-04-02 2019-02-27 HMNC Value GmbH Method of treatment using genetic predictors of a response to treatment with ssr-125543
WO2018012066A1 (ja) * 2016-07-14 2018-01-18 株式会社コナミデジタルエンタテインメント ゲームシステム、端末装置及びプログラム
EP3548035A4 (en) 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
WO2018219804A1 (en) 2017-06-02 2018-12-06 Bayer Pharma Aktiengesellschaft Self-microemulsifying drug delivery systems
EP3630763A4 (en) 2017-08-14 2021-03-10 Spruce Biosciences, Inc. CORTICOTROPIN RELEASE FACTOR RECEPTOR ANTAGONISTS
WO2019036503A1 (en) 2017-08-14 2019-02-21 Spruce Biosciences, Inc. CORTICOTROPIN RELEASE FACTOR RECEPTOR ANTAGONISTS
CN112423747A (zh) 2018-04-27 2021-02-26 云杉生物科学公司 用于治疗睾丸肾上腺残余瘤和卵巢肾上腺残余瘤的方法
CN120284862A (zh) 2018-12-07 2025-07-11 纽罗克里生物科学有限公司 用于治疗先天性肾上腺皮质增生症的crf1受体拮抗剂、其药物制剂和固体形式
WO2021016208A1 (en) 2019-07-19 2021-01-28 Spruce Biosciences, Inc. Methods of treating congenital adrenal hyperplasia
US12383536B2 (en) 2019-09-27 2025-08-12 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods of use
TW202134241A (zh) 2019-12-04 2021-09-16 美商紐羅克里生物科學有限公司 Ｃｒｆ受體拮抗劑及使用方法
JP2023531164A (ja) 2020-06-10 2023-07-21 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト
EP4203964A1 (en) 2020-08-26 2023-07-05 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods of use

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IL296683B2 (en) 2023-12-01
US11730739B2 (en) 2023-08-22
SMT202400361T1 (it) 2024-11-15
FI3096756T3 (fi) 2024-08-14
PL3096756T3 (pl) 2024-10-28
US11311544B2 (en) 2022-04-26
RU2016133972A3 (enExample) 2018-09-26
IL246783A0 (en) 2016-08-31
IL296683B1 (en) 2023-08-01
WO2015112642A1 (en) 2015-07-30
US20170020877A1 (en) 2017-01-26
KR20210064407A (ko) 2021-06-02
MX389004B (es) 2025-03-20
AU2015209452C1 (en) 2020-11-05
JP7104743B2 (ja) 2022-07-21
RU2020112197A (ru) 2020-05-21
US20210137926A1 (en) 2021-05-13
AU2015209452A1 (en) 2016-08-04
IL286782A (en) 2021-10-31
CN106102740A (zh) 2016-11-09
JP2020138978A (ja) 2020-09-03
AU2015209452B2 (en) 2020-05-07
AU2022263460A1 (en) 2022-12-08
IL246783B (en) 2021-10-31
BR112016016975A2 (pt) 2017-08-08
US20210361659A1 (en) 2021-11-25
EP3096756B1 (en) 2024-06-12
CA3155599A1 (en) 2015-07-30
PT3096756T (pt) 2024-08-26
CA2936974A1 (en) 2015-07-30
EP3096756A1 (en) 2016-11-30
MX2021012539A (es) 2021-11-12
RU2718918C2 (ru) 2020-04-15
AU2020207774A1 (en) 2020-08-06
MX2022000080A (es) 2022-02-03
ES2984706T3 (es) 2024-10-30
JP2022010260A (ja) 2022-01-14
NZ722122A (en) 2020-06-26
AU2020207774B2 (en) 2022-08-04
DK3096756T3 (da) 2024-08-05
SI3096756T1 (sl) 2024-09-30
RS65839B1 (sr) 2024-09-30
US20240058342A1 (en) 2024-02-22
CN111228274A (zh) 2020-06-05
IL304134A (en) 2023-09-01
AU2024219813A1 (en) 2024-10-10
IL304134B1 (en) 2024-12-01
LT3096756T (lt) 2024-08-26
KR20160106176A (ko) 2016-09-09
JP2019081814A (ja) 2019-05-30
RU2016133972A (ru) 2018-03-05
US10905690B2 (en) 2021-02-02
US20190231781A1 (en) 2019-08-01
AU2022263460B2 (en) 2024-10-17
JP2017503030A (ja) 2017-01-26
JP6936825B2 (ja) 2021-09-22
JP2024098001A (ja) 2024-07-19
IL304134B2 (en) 2025-04-01
HUE068315T2 (hu) 2024-12-28
EP4450070A1 (en) 2024-10-23
HRP20241046T1 (hr) 2024-11-08
IL296683A (en) 2022-11-01
MX2016009499A (es) 2017-02-27
KR102258522B1 (ko) 2021-05-31
JP6585625B2 (ja) 2019-10-02
IL317035A (en) 2025-01-01

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