IL262126A - Macrocycle inhibitors of pd-1/pd-l1 and cd80/pd-l1 interactions - Google Patents
Macrocycle inhibitors of pd-1/pd-l1 and cd80/pd-l1 interactionsInfo
- Publication number
- IL262126A IL262126A IL262126A IL26212618A IL262126A IL 262126 A IL262126 A IL 262126A IL 262126 A IL262126 A IL 262126A IL 26212618 A IL26212618 A IL 26212618A IL 262126 A IL262126 A IL 262126A
- Authority
- IL
- Israel
- Prior art keywords
- protein
- interactions
- macrocyclic inhibitors
- macrocyclic
- inhibitors
- Prior art date
Links
- 102000008096 B7-H1 Antigen Human genes 0.000 title 1
- 108010074708 B7-H1 Antigen Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000006916 protein interaction Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662318417P | 2016-04-05 | 2016-04-05 | |
| US15/475,227 US10358463B2 (en) | 2016-04-05 | 2017-03-31 | Immunomodulators |
| PCT/US2017/025677 WO2017176608A1 (en) | 2016-04-05 | 2017-04-03 | Macrocyclic inhibitors of the pd-1/pd-l1 and cd80/pd-l1 protein/protein interactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL262126A true IL262126A (en) | 2018-11-29 |
Family
ID=59960204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL262126A IL262126A (en) | 2016-04-05 | 2018-10-04 | Macrocycle inhibitors of pd-1/pd-l1 and cd80/pd-l1 interactions |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10358463B2 (OSRAM) |
| EP (1) | EP3440097B1 (OSRAM) |
| JP (1) | JP7122255B2 (OSRAM) |
| KR (1) | KR102548798B1 (OSRAM) |
| CN (1) | CN109311943A (OSRAM) |
| AR (1) | AR108186A1 (OSRAM) |
| AU (1) | AU2017246216A1 (OSRAM) |
| BR (1) | BR112018070377A2 (OSRAM) |
| CA (1) | CA3020300A1 (OSRAM) |
| EA (1) | EA201892243A1 (OSRAM) |
| ES (1) | ES2998042T3 (OSRAM) |
| IL (1) | IL262126A (OSRAM) |
| MA (1) | MA43774A (OSRAM) |
| MX (1) | MX2018012039A (OSRAM) |
| SG (1) | SG11201808678QA (OSRAM) |
| TW (1) | TW201738260A (OSRAM) |
| UY (1) | UY37194A (OSRAM) |
| WO (1) | WO2017176608A1 (OSRAM) |
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| US9944678B2 (en) * | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| SMT202100238T1 (it) | 2016-05-19 | 2021-05-07 | Bristol Myers Squibb Co | Immunomodulatori per l'indagine per immagini mediante pet |
| EP4234691A3 (en) | 2016-10-14 | 2023-10-18 | Precision Biosciences, Inc. | Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome |
| ES2910832T3 (es) * | 2016-11-07 | 2022-05-13 | Bristol Myers Squibb Co | Inmunomoduladores |
| EP3567049A4 (en) | 2016-12-28 | 2020-08-26 | Green Cross Lab Cell Corporation | CHEMERICAL ANTIGENIC RECEPTOR AND NATURAL KILLER CELLS EXPRESSING THE SAME |
| JP7206222B2 (ja) * | 2017-06-23 | 2023-01-17 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐｄ－１のアンタゴニストとして作用する免疫調節剤 |
| WO2019070643A1 (en) | 2017-10-03 | 2019-04-11 | Bristol-Myers Squibb Company | IMMUNOMODULATORS |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| US12116417B2 (en) | 2017-11-14 | 2024-10-15 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
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| JP7400180B2 (ja) * | 2018-02-02 | 2023-12-19 | ユーストラリス ファーマシューティカルズ リミテッド （トレーディング アズ プレススラ ニューロ） | 非経口製剤及びその使用 |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
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-
2017
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- 2017-04-03 KR KR1020187031601A patent/KR102548798B1/ko active Active
- 2017-04-03 CA CA3020300A patent/CA3020300A1/en not_active Abandoned
- 2017-04-03 MX MX2018012039A patent/MX2018012039A/es unknown
- 2017-04-03 BR BR112018070377A patent/BR112018070377A2/pt not_active Application Discontinuation
- 2017-04-03 JP JP2018552242A patent/JP7122255B2/ja active Active
- 2017-04-03 MA MA043774A patent/MA43774A/fr unknown
- 2017-04-03 WO PCT/US2017/025677 patent/WO2017176608A1/en not_active Ceased
- 2017-04-03 EP EP17718218.5A patent/EP3440097B1/en active Active
- 2017-04-03 CN CN201780033784.XA patent/CN109311943A/zh active Pending
- 2017-04-03 EA EA201892243A patent/EA201892243A1/ru unknown
- 2017-04-03 ES ES17718218T patent/ES2998042T3/es active Active
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- 2017-04-03 SG SG11201808678QA patent/SG11201808678QA/en unknown
- 2017-04-05 AR ARP170100881A patent/AR108186A1/es unknown
- 2017-04-05 TW TW106111442A patent/TW201738260A/zh unknown
- 2017-04-05 UY UY0001037194A patent/UY37194A/es unknown
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| Publication number | Publication date |
|---|---|
| EA201892243A1 (ru) | 2019-03-29 |
| AU2017246216A1 (en) | 2018-11-22 |
| JP7122255B2 (ja) | 2022-08-19 |
| TW201738260A (zh) | 2017-11-01 |
| WO2017176608A1 (en) | 2017-10-12 |
| MA43774A (fr) | 2018-11-28 |
| CN109311943A (zh) | 2019-02-05 |
| ES2998042T3 (en) | 2025-02-18 |
| BR112018070377A2 (pt) | 2019-02-05 |
| MX2018012039A (es) | 2019-01-14 |
| JP2019513734A (ja) | 2019-05-30 |
| UY37194A (es) | 2017-10-31 |
| KR20180132775A (ko) | 2018-12-12 |
| US10358463B2 (en) | 2019-07-23 |
| KR102548798B1 (ko) | 2023-06-27 |
| CA3020300A1 (en) | 2017-10-12 |
| SG11201808678QA (en) | 2018-11-29 |
| US20170283463A1 (en) | 2017-10-05 |
| AR108186A1 (es) | 2018-07-25 |
| EP3440097A1 (en) | 2019-02-13 |
| EP3440097B1 (en) | 2024-10-23 |
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