IL199694A - Annotated, converted, and used amino acid pyrrolidine compounds - Google Patents
Annotated, converted, and used amino acid pyrrolidine compoundsInfo
- Publication number
- IL199694A IL199694A IL199694A IL19969409A IL199694A IL 199694 A IL199694 A IL 199694A IL 199694 A IL199694 A IL 199694A IL 19969409 A IL19969409 A IL 19969409A IL 199694 A IL199694 A IL 199694A
- Authority
- IL
- Israel
- Prior art keywords
- group
- amino
- dihydro
- fluoro
- azabicyclo
- Prior art date
Links
- SBMSLRMNBSMKQC-UHFFFAOYSA-N pyrrolidin-1-amine Chemical class NN1CCCC1 SBMSLRMNBSMKQC-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 54
- -1 hydroxyimino group Chemical group 0.000 claims 40
- 150000003839 salts Chemical class 0.000 claims 40
- 125000001424 substituent group Chemical group 0.000 claims 31
- 125000004122 cyclic group Chemical group 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000002496 methyl group Chemical class [H]C([H])([H])* 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 239000004480 active ingredient Substances 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 5
- 239000000470 constituent Substances 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- CFLBIADORGSMCX-UHFFFAOYSA-N 2h-1,4-benzoxazine-6-carboxylic acid Chemical compound O1CC=NC2=CC(C(=O)O)=CC=C21 CFLBIADORGSMCX-UHFFFAOYSA-N 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000003784 fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- WLHBSWKOCXUEOJ-WBFSPCPRSA-N (2S)-6-(6-amino-8-azatricyclo[4.3.0.01,3]nonan-8-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@@H](C)CO3)=O)=C2C3=C1N1CC2(N)CCC3CC32C1 WLHBSWKOCXUEOJ-WBFSPCPRSA-N 0.000 claims 1
- WAIRJAJXTVRNSV-UUADDVKTSA-N (2S)-6-[(3aS,6aR)-6a-amino-3a-fluoro-3,4,5,6-tetrahydro-1H-cyclopenta[c]pyrrol-2-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@@H](C)CO3)=O)=C2C3=C1N1C[C@@]2(F)CCC[C@@]2(N)C1 WAIRJAJXTVRNSV-UUADDVKTSA-N 0.000 claims 1
- BHKIAANYWYSRKN-MKXJDEKUSA-N (2S)-6-[(3aS,7aS)-3a-amino-1,3,4,6,7,7a-hexahydropyrano[3,4-c]pyrrol-2-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@@H](C)CO3)=O)=C2C3=C1N1C[C@]2(N)COCC[C@H]2C1 BHKIAANYWYSRKN-MKXJDEKUSA-N 0.000 claims 1
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims 1
- XNIVKSPSCYJKBL-UHFFFAOYSA-N 2h-1,2-benzoxazine-6-carboxylic acid Chemical compound O1NC=CC2=CC(C(=O)O)=CC=C21 XNIVKSPSCYJKBL-UHFFFAOYSA-N 0.000 claims 1
- KCJYFXPQKJHWNN-LPSWCQNKSA-N 7-[(1r,5s,7r)-5-amino-7-methyl-3-azabicyclo[3.2.0]heptan-3-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@]3(N)C[C@@H](C)[C@@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F KCJYFXPQKJHWNN-LPSWCQNKSA-N 0.000 claims 1
- XSTQYURAQBOBGQ-LPSWCQNKSA-N 7-[(1r,5s,7s)-5-amino-7-(fluoromethyl)-3-azabicyclo[3.2.0]heptan-3-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@]3(N)C[C@H](CF)[C@@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F XSTQYURAQBOBGQ-LPSWCQNKSA-N 0.000 claims 1
- KCJYFXPQKJHWNN-BBBOKTADSA-N 7-[(1r,5s,7s)-5-amino-7-methyl-3-azabicyclo[3.2.0]heptan-3-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@]3(N)C[C@H](C)[C@@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F KCJYFXPQKJHWNN-BBBOKTADSA-N 0.000 claims 1
- KYNUKPKZEVIAJF-HQHBXOCSSA-N 7-[(1r,5s,7s)-5-amino-7-methyl-3-azabicyclo[3.2.0]heptan-3-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound C([C@]1(N)C[C@@H]([C@@H]1C1)C)N1C(C=1C)=C(F)C=C(C(C(C(O)=O)=C2)=O)C=1N2[C@@H]1C[C@@H]1F KYNUKPKZEVIAJF-HQHBXOCSSA-N 0.000 claims 1
- WVQCEAZCTMLFRB-FLBYAOOYSA-N 7-[(3as,6ar)-3a-amino-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@]3(N)CCC[C@@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F WVQCEAZCTMLFRB-FLBYAOOYSA-N 0.000 claims 1
- SBQHYQGBJUGSFW-FLBYAOOYSA-N 7-[(3as,6ar)-3a-amino-1,3,6,6a-tetrahydrocyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@]3(N)C=CC[C@@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F SBQHYQGBJUGSFW-FLBYAOOYSA-N 0.000 claims 1
- CFUWIXCXMQPSFT-MJEGUIRGSA-N 7-[(3as,6ar)-3a-amino-1,3,6,6a-tetrahydrocyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC1=C(N2C[C@]3(N)C=CC[C@@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F CFUWIXCXMQPSFT-MJEGUIRGSA-N 0.000 claims 1
- BAINYSCLQGIBAF-UTQQSMSJSA-N 7-[(3as,6ar)-6a-amino-3a-chloro-3,4,5,6-tetrahydro-1h-cyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC1=C(N2C[C@@]3(Cl)CCC[C@@]3(N)C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F BAINYSCLQGIBAF-UTQQSMSJSA-N 0.000 claims 1
- QQQJLSWMKXOGDF-BHINWFLXSA-N 7-[(3as,6ar)-6a-amino-3a-fluoro-3,4,5,6-tetrahydro-1h-cyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@@]3(F)CCC[C@@]3(N)C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F QQQJLSWMKXOGDF-BHINWFLXSA-N 0.000 claims 1
- JMXNWTLVUUGTDR-UTQQSMSJSA-N 7-[(3as,6ar)-6a-amino-3a-fluoro-3,4,5,6-tetrahydro-1h-cyclopenta[c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC1=C(N2C[C@@]3(F)CCC[C@@]3(N)C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F JMXNWTLVUUGTDR-UTQQSMSJSA-N 0.000 claims 1
- WHEZKSQLSUTGQP-BGVPSLIESA-N 7-[(3as,6ar)-6a-amino-3a-fluoro-3,4,5,6-tetrahydro-1h-cyclopenta[c]pyrrol-2-yl]-8-chloro-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid Chemical compound C([C@@]1(F)CCC[C@]1(C1)N)N1C(C=1Cl)=C(F)C=C(C(C(C(O)=O)=C2)=O)C=1N2[C@@H]1C[C@@H]1F WHEZKSQLSUTGQP-BGVPSLIESA-N 0.000 claims 1
- ZYLCRHXILNBOFC-UTQQSMSJSA-N 7-[(3as,6ar)-6a-amino-3a-fluoro-3,4,5,6-tetrahydro-1h-cyclopenta[c]pyrrol-2-yl]-8-cyano-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid Chemical compound C([C@@]1(F)CCC[C@]1(C1)N)N1C(C=1C#N)=C(F)C=C(C(C(C(O)=O)=C2)=O)C=1N2[C@@H]1C[C@@H]1F ZYLCRHXILNBOFC-UTQQSMSJSA-N 0.000 claims 1
- QEESVFWVTXIORT-GWXMJYEKSA-N 7-[(3as,7as)-3a-amino-1,3,4,6,7,7a-hexahydropyrano[3,4-c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@]3(N)COCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F QEESVFWVTXIORT-GWXMJYEKSA-N 0.000 claims 1
- CNAIVPGMJYSOAK-QHIFUMFDSA-N 7-[(3as,7as)-3a-amino-1,3,4,6,7,7a-hexahydropyrano[3,4-c]pyrrol-2-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC1=C(N2C[C@]3(N)COCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F CNAIVPGMJYSOAK-QHIFUMFDSA-N 0.000 claims 1
- FTWHHUYLFIMQDQ-BBIWSOJXSA-N 7-[(3as,7as)-3a-amino-1,3,4,6,7,7a-hexahydropyrano[3,4-c]pyrrol-2-yl]-8-chloro-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid Chemical compound C([C@]1([C@H](C2)CCOC1)N)N2C(C=1Cl)=C(F)C=C(C(C(C(O)=O)=C2)=O)C=1N2[C@@H]1C[C@@H]1F FTWHHUYLFIMQDQ-BBIWSOJXSA-N 0.000 claims 1
- HFZZDLMWVVGKCM-GLEFEWGCSA-N 7-[(3as,7as)-3a-amino-1,3,4,6,7,7a-hexahydropyrano[3,4-c]pyrrol-2-yl]-8-cyano-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid Chemical compound C([C@]1([C@H](C2)CCOC1)N)N2C(C=1C#N)=C(F)C=C(C(C(C(O)=O)=C2)=O)C=1N2[C@@H]1C[C@@H]1F HFZZDLMWVVGKCM-GLEFEWGCSA-N 0.000 claims 1
- WNUTUOYLSLQFOM-YWCVGHFTSA-N 7-[6-amino-8-azatricyclo[4.3.0.01,3]nonan-8-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropan-1-yl]-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Chemical compound COC1=C(N2CC3(N)CCC4CC43C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F WNUTUOYLSLQFOM-YWCVGHFTSA-N 0.000 claims 1
- FKEUHHIDEBBCDV-PBUGSSMTSA-N C1C2(N)CCC3CC23CN1C(C=1C#N)=C(F)C=C(C(C(C(O)=O)=C2)=O)C=1N2[C@@H]1C[C@@H]1F Chemical compound C1C2(N)CCC3CC23CN1C(C=1C#N)=C(F)C=C(C(C(C(O)=O)=C2)=O)C=1N2[C@@H]1C[C@@H]1F FKEUHHIDEBBCDV-PBUGSSMTSA-N 0.000 claims 1
- BNNFXUCYZQQRCR-UUHZNHMGSA-N CC1=C(N2CC3(N)CCC4CC43C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F Chemical compound CC1=C(N2CC3(N)CCC4CC43C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F BNNFXUCYZQQRCR-UUHZNHMGSA-N 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000676 alkoxyimino group Chemical group 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 150000003248 quinolines Chemical group 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
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- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
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| JP2007000667 | 2007-01-05 | ||
| JP2007074991 | 2007-03-22 | ||
| PCT/JP2007/075434 WO2008082009A2 (en) | 2007-01-05 | 2007-12-28 | Fused substituted aminopyrrolidine derivative |
Publications (2)
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| IL199694A0 IL199694A0 (en) | 2010-04-15 |
| IL199694A true IL199694A (en) | 2013-08-29 |
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| EP (2) | EP2540715A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW201210595A (en) | 2010-08-06 | 2012-03-16 | Daiichi Sankyo Co Ltd | A crystal of antibacterial compound |
| WO2014152317A2 (en) * | 2013-03-15 | 2014-09-25 | Melinta Therapeutics, Inc. | Methods of treating gonorrhea infections using quinolone antibiotics |
| SI3413892T1 (sl) | 2016-02-12 | 2022-06-30 | Cytokinetics, Incorporated | Tetrahidroizokinolinski derivati |
| TW202128645A (zh) * | 2019-10-23 | 2021-08-01 | 太景生物科技股份有限公司 | 喹諾酮羧酸衍生物 |
| KR20240141704A (ko) * | 2021-07-22 | 2024-09-27 | 더 텍사스 에이 & 엠 유니버시티 시스템 | 활성화된 페레이트 용액 및 이의 방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS61282382A (ja) | 1985-06-06 | 1986-12-12 | Dainippon Pharmaceut Co Ltd | フエニル置換１，８−ナフチリジン誘導体、そのエステルおよびその塩 |
| EP0242789A3 (en) | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
| JPH0676400B2 (ja) * | 1987-08-25 | 1994-09-28 | 大日本製薬株式会社 | 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| MY105136A (en) | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
| JP2844079B2 (ja) | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
| JP2807277B2 (ja) | 1988-08-31 | 1998-10-08 | 第一製薬株式会社 | スピロ化合物 |
| JPH0278659A (ja) * | 1988-09-12 | 1990-03-19 | Shionogi & Co Ltd | アザビシクロアルカン類化合物 |
| WO1994014794A1 (fr) | 1992-12-28 | 1994-07-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Derive d'acide 8-methoxyquinolonecarboxylique |
| JPH06345261A (ja) | 1993-04-16 | 1994-12-20 | Daihen Corp | 自動搬送装置の搬送用ハンド |
| EP0812838B1 (en) * | 1994-02-04 | 2002-05-02 | Dainippon Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivative substituted by bicyclic amino group, ester thereof, salt thereof, and bicyclic amine as intermediate therefor |
| DE4435479A1 (de) | 1994-10-04 | 1996-04-11 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| KR100389773B1 (ko) * | 1995-02-02 | 2003-10-23 | 다이이찌 세이야꾸 가부시기가이샤 | 헤테로사이클릭화합물 |
| CA2222322A1 (en) * | 1995-06-06 | 1996-12-12 | Abbott Laboratories | Quinolizinone type compounds |
| JP4132155B2 (ja) * | 1996-10-25 | 2008-08-13 | 第一三共株式会社 | 三環性アミン誘導体 |
| ATE297912T1 (de) * | 1998-11-24 | 2005-07-15 | Daiichi Seiyaku Co | Cycloalkylsubstituierte aminomethylpyrrolidin- derivate |
| WO2002042312A1 (en) * | 2000-11-24 | 2002-05-30 | Meiji Seika Kaisha, Ltd. | Novel carbapenem derivatives |
| WO2005049602A1 (en) * | 2003-11-18 | 2005-06-02 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
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2007
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- 2007-12-28 KR KR1020097013835A patent/KR101419085B1/ko not_active Expired - Fee Related
- 2007-12-28 EP EP12186361A patent/EP2540715A1/en not_active Withdrawn
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- 2007-12-28 AU AU2007339692A patent/AU2007339692B2/en not_active Ceased
- 2007-12-28 BR BRPI0720771-9A2A patent/BRPI0720771A2/pt not_active IP Right Cessation
- 2007-12-28 EP EP07860629.0A patent/EP2097400B1/en not_active Not-in-force
- 2007-12-28 SI SI200731318T patent/SI2097400T1/sl unknown
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- 2007-12-28 ES ES07860629T patent/ES2428344T3/es active Active
- 2007-12-28 PT PT78606290T patent/PT2097400E/pt unknown
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- 2007-12-28 MY MYPI20092809A patent/MY162052A/en unknown
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- 2007-12-28 JP JP2009527641A patent/JP5197606B2/ja not_active Expired - Fee Related
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2008
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2009
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- 2009-08-04 NO NO20092804A patent/NO20092804L/no not_active Application Discontinuation
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2013
- 2013-09-30 CY CY20131100845T patent/CY1114444T1/el unknown
- 2013-11-19 US US14/084,485 patent/US20140142096A1/en not_active Abandoned
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