JP2007284413A5 - - Google Patents
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- Publication number
- JP2007284413A5 JP2007284413A5 JP2006137245A JP2006137245A JP2007284413A5 JP 2007284413 A5 JP2007284413 A5 JP 2007284413A5 JP 2006137245 A JP2006137245 A JP 2006137245A JP 2006137245 A JP2006137245 A JP 2006137245A JP 2007284413 A5 JP2007284413 A5 JP 2007284413A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- salt
- hydrate
- methyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003839 salts Chemical class 0.000 claims 78
- 125000004432 carbon atom Chemical group C* 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 12
- 125000003277 amino group Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 9
- 150000004677 hydrates Chemical class 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- CFLBIADORGSMCX-UHFFFAOYSA-N 2h-1,4-benzoxazine-6-carboxylic acid Chemical compound O1CC=NC2=CC(C(=O)O)=CC=C21 CFLBIADORGSMCX-UHFFFAOYSA-N 0.000 claims 6
- 125000002496 methyl group Chemical class [H]C([H])([H])* 0.000 claims 6
- -1 acetoxymethyl group Chemical group 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- YWUAHDPNNPUBTP-HBADBFBRSA-N (2S)-6-(8-amino-8-methyl-6-azaspiro[3.4]octan-5-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1C1NCC(C)(N)C11CCC1 YWUAHDPNNPUBTP-HBADBFBRSA-N 0.000 claims 2
- HTGRVUWRSYLDBW-IHBJSSOOSA-N (3s)-10-(7-amino-7-methyl-5-azaspiro[2.4]heptane-5-yl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N(CC1(N)C)CC21CC2 HTGRVUWRSYLDBW-IHBJSSOOSA-N 0.000 claims 2
- GBLYBAYNQGZGCK-YBSGFIMXSA-N 7-(7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N(CC1(N)C)CC21CC2 GBLYBAYNQGZGCK-YBSGFIMXSA-N 0.000 claims 2
- YKMUCKLHRGEQEO-VOXKTVDUSA-N 7-(7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N(CC1(N)C)CC21CC2 YKMUCKLHRGEQEO-VOXKTVDUSA-N 0.000 claims 2
- PLPWJWDZNYOUKM-FWWONPLMSA-N 7-(8-amino-8-methyl-6-azaspiro[3.4]octan-5-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1C1NCC(C)(N)C11CCC1 PLPWJWDZNYOUKM-FWWONPLMSA-N 0.000 claims 2
- RKVRKWMLNLHWTF-CBOMSQLVSA-N 7-(8-amino-8-methyl-6-azaspiro[3.4]octan-5-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1C1NCC(C)(N)C11CCC1 RKVRKWMLNLHWTF-CBOMSQLVSA-N 0.000 claims 2
- QOZKNNVMNORWGX-AUEQRSLFSA-N 7-[(3s)-3-amino-3-(fluoromethyl)-4-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound C1[C@@](CF)(N)C(C)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN([C@H]3[C@H](C3)F)C2=C1C QOZKNNVMNORWGX-AUEQRSLFSA-N 0.000 claims 2
- NSXOMJYCOAJJDQ-HXUWFJFHSA-N 7-[(7s)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-1-cyclopropyl-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC1=C(N2C[C@@](C)(N)C3(CC3)C2)C=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 NSXOMJYCOAJJDQ-HXUWFJFHSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000000470 constituent Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- HUTIYPUNTGRRAS-NMLQZSKVSA-N (2S)-6-(3-amino-3,4-dimethylpyrrolidin-1-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid Chemical compound C1C(N)(C)C(C)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3[C@@H](C)COC1=C32 HUTIYPUNTGRRAS-NMLQZSKVSA-N 0.000 claims 1
- ILNJBIQQAIIMEY-UHFFFAOYSA-N 4-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CN=C21 ILNJBIQQAIIMEY-UHFFFAOYSA-N 0.000 claims 1
- VGWYCJBGGIYCDL-NOUAYQIGSA-N 7-(3-amino-3,4-dimethylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(C)C(C)(N)C1 VGWYCJBGGIYCDL-NOUAYQIGSA-N 0.000 claims 1
- SFIDFWAXWOVMGQ-JAJHKKPQSA-N 7-(3-amino-3,4-dimethylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound C1C(N)(C)C(C)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN([C@H]3[C@H](C3)F)C2=C1C SFIDFWAXWOVMGQ-JAJHKKPQSA-N 0.000 claims 1
- PCPRBCGRPPZXCS-YBSGFIMXSA-N 7-(3-amino-3-methyl-4-methylidenepyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(=C)C(C)(N)C1 PCPRBCGRPPZXCS-YBSGFIMXSA-N 0.000 claims 1
- NJHRGBPBRHRCDO-VOXKTVDUSA-N 7-(3-amino-3-methyl-4-methylidenepyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N1CC(=C)C(C)(N)C1 NJHRGBPBRHRCDO-VOXKTVDUSA-N 0.000 claims 1
- UGEMFQNCXIIVHA-LTGUMBBBSA-N 7-(3-amino-3-methyl-4-propan-2-ylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(C(C)C)C(C)(N)C1 UGEMFQNCXIIVHA-LTGUMBBBSA-N 0.000 claims 1
- BIAIDRDOOIAWRT-ZTHJGWAOSA-N 7-(3-amino-3-methyl-4-propan-2-ylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound C1C(N)(C)C(C(C)C)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN([C@H]3[C@H](C3)F)C2=C1C BIAIDRDOOIAWRT-ZTHJGWAOSA-N 0.000 claims 1
- AUHGSHNXTSCISZ-LTGUMBBBSA-N 7-(3-amino-4-cyclopropyl-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N(CC1(N)C)CC1C1CC1 AUHGSHNXTSCISZ-LTGUMBBBSA-N 0.000 claims 1
- BRVSPESRZHSPDJ-ZTHJGWAOSA-N 7-(3-amino-4-cyclopropyl-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N(CC1(N)C)CC1C1CC1 BRVSPESRZHSPDJ-ZTHJGWAOSA-N 0.000 claims 1
- VWCDNLRDSNJPQN-BRHKBIEPSA-N 7-(3-amino-4-ethenyl-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(C=C)C(C)(N)C1 VWCDNLRDSNJPQN-BRHKBIEPSA-N 0.000 claims 1
- KWTXJAUDKCHIAE-VLQUHDJJSA-N 7-(3-amino-4-ethenyl-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N1CC(C=C)C(C)(N)C1 KWTXJAUDKCHIAE-VLQUHDJJSA-N 0.000 claims 1
- OWAFVOXDNWVCDD-BRHKBIEPSA-N 7-(3-amino-4-ethyl-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound C1C(N)(C)C(CC)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN([C@H]3[C@H](C3)F)C2=C1OC OWAFVOXDNWVCDD-BRHKBIEPSA-N 0.000 claims 1
- YMKFHUKWXQWENQ-VLQUHDJJSA-N 7-(3-amino-4-ethyl-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound C1C(N)(C)C(CC)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN([C@H]3[C@H](C3)F)C2=C1C YMKFHUKWXQWENQ-VLQUHDJJSA-N 0.000 claims 1
- WDVYTUBBWMMGEV-UGFQYKEISA-N 7-(3-amino-4-methoxy-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound C1C(N)(C)C(OC)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN([C@H]3[C@H](C3)F)C2=C1OC WDVYTUBBWMMGEV-UGFQYKEISA-N 0.000 claims 1
- WCPBTBMOLDDPPY-IBZQHJOJSA-N 7-(3-amino-4-methoxy-3-methylpyrrolidin-1-yl)-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound C1C(N)(C)C(OC)CN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN([C@H]3[C@H](C3)F)C2=C1C WCPBTBMOLDDPPY-IBZQHJOJSA-N 0.000 claims 1
- PCPRBCGRPPZXCS-HKMRUAMVSA-N 7-[(3r)-3-amino-3-methyl-4-methylidenepyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(=C)[C@@](C)(N)C1 PCPRBCGRPPZXCS-HKMRUAMVSA-N 0.000 claims 1
- FRJLPJDTFSRFJY-HJGCUJGDSA-N 7-[(3r)-3-amino-4-fluoro-3-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(F)[C@](C)(N)C1 FRJLPJDTFSRFJY-HJGCUJGDSA-N 0.000 claims 1
- VEALOSXLGYRTNI-GRFMVPHRSA-N 7-[(3r)-3-amino-4-fluoro-3-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N1CC(F)[C@](C)(N)C1 VEALOSXLGYRTNI-GRFMVPHRSA-N 0.000 claims 1
- NOWQPYWQINBEEP-QJYIIUMHSA-N 7-[(3s)-3-amino-3-(fluoromethyl)-4-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(C)[C@@](N)(CF)C1 NOWQPYWQINBEEP-QJYIIUMHSA-N 0.000 claims 1
- INSOQJWOOCDVRR-WVDJIFEKSA-N 7-[(3s,4s)-3-amino-4-(fluoromethyl)-3-methylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1C[C@H](CF)[C@](C)(N)C1 INSOQJWOOCDVRR-WVDJIFEKSA-N 0.000 claims 1
- JHTKCSMHUWIJNV-PRWKNARSSA-N 7-[(3s,4s)-3-amino-4-(fluoromethyl)-3-methylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(C)=C1N1C[C@H](CF)[C@](C)(N)C1 JHTKCSMHUWIJNV-PRWKNARSSA-N 0.000 claims 1
- IGVAACMFOKOWKD-WDLYVUMTSA-N 7-[(3s,4s)-3-amino-4-(fluoromethyl)-3-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1C[C@H](CF)[C@](C)(N)C1 IGVAACMFOKOWKD-WDLYVUMTSA-N 0.000 claims 1
- KNCUDPQGGARYHI-GEGASQFASA-N 7-[(3s,4s)-3-amino-4-(fluoromethyl)-3-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N1C[C@H](CF)[C@](C)(N)C1 KNCUDPQGGARYHI-GEGASQFASA-N 0.000 claims 1
- YSWHICYPNNAHJB-HXUWFJFHSA-N 7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-1-cyclopropyl-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@@](C)(N)C3(CC3)C2)C=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 YSWHICYPNNAHJB-HXUWFJFHSA-N 0.000 claims 1
- RTXAWTVGPFVLHI-XBHMSOGKSA-N 7-[(7s)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@@](C)(N)C3(CC3)C2)C=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F RTXAWTVGPFVLHI-XBHMSOGKSA-N 0.000 claims 1
- WSLUBDLHZSZYJA-YYFZDKIDSA-N 7-[(7s)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound CC1=C(N2C[C@@](C)(N)C3(CC3)C2)C=CC(C(C(C(O)=O)=C2)=O)=C1N2[C@@H]1C[C@@H]1F WSLUBDLHZSZYJA-YYFZDKIDSA-N 0.000 claims 1
- IGVAACMFOKOWKD-NOUAYQIGSA-N 7-[3-amino-4-(fluoromethyl)-3-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N1CC(CF)C(C)(N)C1 IGVAACMFOKOWKD-NOUAYQIGSA-N 0.000 claims 1
- KNCUDPQGGARYHI-AMOONWSFSA-N 7-[3-amino-4-(fluoromethyl)-3-methylpyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N1CC(CF)C(C)(N)C1 KNCUDPQGGARYHI-AMOONWSFSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000003784 fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 125000001072 heteroaryl group Chemical class 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003248 quinolines Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006137245A JP5063032B2 (ja) | 2005-05-19 | 2006-05-17 | トリ−、テトラ−置換−３−アミノピロリジン誘導体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005146386 | 2005-05-19 | ||
| JP2005146386 | 2005-05-19 | ||
| JP2005344514 | 2005-11-29 | ||
| JP2005344514 | 2005-11-29 | ||
| JP2006080629 | 2006-03-23 | ||
| JP2006080629 | 2006-03-23 | ||
| JP2006137245A JP5063032B2 (ja) | 2005-05-19 | 2006-05-17 | トリ−、テトラ−置換−３−アミノピロリジン誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012153741A Division JP5475841B2 (ja) | 2005-05-19 | 2012-07-09 | トリ−、テトラ−置換−３−アミノピロリジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007284413A JP2007284413A (ja) | 2007-11-01 |
| JP2007284413A5 true JP2007284413A5 (enExample) | 2009-06-04 |
| JP5063032B2 JP5063032B2 (ja) | 2012-10-31 |
Family
ID=38756521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006137245A Expired - Fee Related JP5063032B2 (ja) | 2005-05-19 | 2006-05-17 | トリ−、テトラ−置換−３−アミノピロリジン誘導体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5063032B2 (enExample) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
| JPS63275567A (ja) * | 1987-05-07 | 1988-11-14 | Dainippon Pharmaceut Co Ltd | 新規キノリン誘導体、そのエステルおよびその塩 |
| MY105136A (en) * | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
| JP2807277B2 (ja) * | 1988-08-31 | 1998-10-08 | 第一製薬株式会社 | スピロ化合物 |
| JP2991381B2 (ja) * | 1990-07-16 | 1999-12-20 | 大日本製薬株式会社 | 新規キノリンカルボン酸誘導体、そのエステルおよびその塩 |
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2006
- 2006-05-17 JP JP2006137245A patent/JP5063032B2/ja not_active Expired - Fee Related
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