IL190137A - Lacquinimod crystalline mixtures, pharmaceutical compositions containing them and ways to prepare them - Google Patents

Lacquinimod crystalline mixtures, pharmaceutical compositions containing them and ways to prepare them

Info

Publication number
IL190137A
IL190137A IL190137A IL19013708A IL190137A IL 190137 A IL190137 A IL 190137A IL 190137 A IL190137 A IL 190137A IL 19013708 A IL19013708 A IL 19013708A IL 190137 A IL190137 A IL 190137A
Authority
IL
Israel
Prior art keywords
mixtures
manufacture
pharmaceutical compositions
laquinimod sodium
sodium particles
Prior art date
Application number
IL190137A
Other languages
English (en)
Hebrew (he)
Other versions
IL190137A0 (en
Inventor
Anton Frenkel
Eduard Gurevich
Avital Laxer
Original Assignee
Teva Pharma
Anton Frenkel
Eduard Gurevich
Avital Laxer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Anton Frenkel, Eduard Gurevich, Avital Laxer filed Critical Teva Pharma
Publication of IL190137A0 publication Critical patent/IL190137A0/en
Publication of IL190137A publication Critical patent/IL190137A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
IL190137A 2005-10-19 2008-03-13 Lacquinimod crystalline mixtures, pharmaceutical compositions containing them and ways to prepare them IL190137A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72865705P 2005-10-19 2005-10-19
PCT/US2006/040925 WO2007047863A2 (en) 2005-10-19 2006-10-18 Crystals of laquinimod sodium, and process for the manufacture thereof

Publications (2)

Publication Number Publication Date
IL190137A0 IL190137A0 (en) 2008-08-07
IL190137A true IL190137A (en) 2015-06-30

Family

ID=37963287

Family Applications (1)

Application Number Title Priority Date Filing Date
IL190137A IL190137A (en) 2005-10-19 2008-03-13 Lacquinimod crystalline mixtures, pharmaceutical compositions containing them and ways to prepare them

Country Status (23)

Country Link
US (4) US7884208B2 (cg-RX-API-DMAC10.html)
EP (2) EP1937642B1 (cg-RX-API-DMAC10.html)
JP (3) JP5832716B2 (cg-RX-API-DMAC10.html)
KR (1) KR101440982B1 (cg-RX-API-DMAC10.html)
CN (3) CN101291911B (cg-RX-API-DMAC10.html)
AR (1) AR056708A1 (cg-RX-API-DMAC10.html)
AU (1) AU2006304672B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0617477A2 (cg-RX-API-DMAC10.html)
CA (1) CA2625287C (cg-RX-API-DMAC10.html)
DK (1) DK1937642T3 (cg-RX-API-DMAC10.html)
ES (1) ES2523762T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20141160T1 (cg-RX-API-DMAC10.html)
IL (1) IL190137A (cg-RX-API-DMAC10.html)
NZ (2) NZ567088A (cg-RX-API-DMAC10.html)
PL (1) PL1937642T3 (cg-RX-API-DMAC10.html)
PT (1) PT1937642E (cg-RX-API-DMAC10.html)
RS (1) RS53666B1 (cg-RX-API-DMAC10.html)
RU (1) RU2415841C2 (cg-RX-API-DMAC10.html)
SG (1) SG10201508623RA (cg-RX-API-DMAC10.html)
SI (1) SI1937642T1 (cg-RX-API-DMAC10.html)
UA (1) UA92761C2 (cg-RX-API-DMAC10.html)
WO (1) WO2007047863A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200803527B (cg-RX-API-DMAC10.html)

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WO2009082471A1 (en) * 2007-12-20 2009-07-02 Teva Pharmaceutical Industries, Ltd. Stable laquinimod preparations
US8354428B2 (en) 2008-07-01 2013-01-15 Actavis Group Ptc Ehf Solid state forms of laquinimod and its sodium salt
AU2009288108B2 (en) * 2008-09-03 2013-10-17 Teva Pharmaceutical Industries, Ltd. 2-oxo-1,2-dihydro-quinoline modulators of immune function
WO2010070449A2 (en) 2008-12-17 2010-06-24 Actavis Group Ptc Ehf Highly pure laquinimod or a pharmaceutically acceptable salt thereof
DE102009008851A1 (de) 2009-02-13 2010-08-19 Amw Gmbh Transdermales System mit Immunmodulator
DE102010048788A1 (de) 2009-02-13 2011-05-19 Amw Gmbh Transdermales System mit Immunmodulator
NZ597378A (en) 2009-06-19 2014-08-29 Teva Pharma Treatment of multiple sclerosis with laquinimod
BR112012002124A2 (pt) * 2009-07-30 2015-09-15 Teva Pharma tratamento da doença de crohn com laquinimode.
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MX2014009889A (es) * 2012-02-16 2014-11-13 Teva Pharma N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinoli ncarboxamida, preparacion y usos de los mismos.
US20130259856A1 (en) 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
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TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
CN103626701A (zh) * 2012-08-28 2014-03-12 天津药物研究院 一种制备喹啉衍生物的方法
CN103626702A (zh) * 2012-08-30 2014-03-12 天津药物研究院 一种制备喹啉酮衍生物的方法
WO2014033954A1 (ja) 2012-09-03 2014-03-06 トヨタ自動車株式会社 衝突判定装置及び衝突判定方法
EA201590788A1 (ru) 2012-11-07 2015-12-30 Тева Фармасьютикал Индастриз Лтд. Аминные соли лахинимода
JP2016514162A (ja) * 2013-03-14 2016-05-19 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドナトリウムの結晶およびその製造のための改善された方法
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TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
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JP5934202B2 (ja) 2010-07-09 2016-06-15 テバ ファーマシューティカル インダストリーズ リミティド ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用
AU2011274496B2 (en) 2010-07-09 2016-03-10 Teva Pharmaceutical Industries Ltd. Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
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Also Published As

Publication number Publication date
US7884208B2 (en) 2011-02-08
US20140171647A1 (en) 2014-06-19
RU2008119456A (ru) 2009-11-27
SI1937642T1 (sl) 2015-01-30
CN101291911A (zh) 2008-10-22
US8647646B2 (en) 2014-02-11
WO2007047863A2 (en) 2007-04-26
US20110118308A1 (en) 2011-05-19
EP1937642B1 (en) 2014-09-10
EP1937642A2 (en) 2008-07-02
CN101291911B (zh) 2014-08-13
CN103333107A (zh) 2013-10-02
AU2006304672B2 (en) 2013-01-10
NZ567088A (en) 2012-06-29
KR101440982B1 (ko) 2014-09-17
IL190137A0 (en) 2008-08-07
JP2013100299A (ja) 2013-05-23
EP1937642A4 (en) 2009-03-18
ZA200803527B (en) 2009-09-30
KR20080064978A (ko) 2008-07-10
AU2006304672A1 (en) 2007-04-26
RS53666B1 (sr) 2015-04-30
CN107176923A (zh) 2017-09-19
UA92761C2 (ru) 2010-12-10
AR056708A1 (es) 2007-10-17
BRPI0617477A2 (pt) 2011-07-26
EP2687512A1 (en) 2014-01-22
RU2415841C2 (ru) 2011-04-10
DK1937642T3 (en) 2014-12-15
JP2009512708A (ja) 2009-03-26
PT1937642E (pt) 2014-11-25
CA2625287C (en) 2016-07-26
ES2523762T3 (es) 2014-12-01
SG10201508623RA (en) 2015-11-27
JP2016020353A (ja) 2016-02-04
PL1937642T3 (pl) 2015-02-27
US8673322B2 (en) 2014-03-18
NZ592897A (en) 2012-12-21
HRP20141160T1 (hr) 2015-01-16
US20110112141A1 (en) 2011-05-12
HK1117160A1 (en) 2009-01-09
WO2007047863A3 (en) 2007-06-28
JP5832716B2 (ja) 2015-12-16
CA2625287A1 (en) 2007-04-26
US20070088050A1 (en) 2007-04-19

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