JP5832716B2 - ラキニモドナトリウムの結晶，及びその製造方法 - Google Patents

ラキニモドナトリウムの結晶，及びその製造方法 Download PDF

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Publication number
JP5832716B2
JP5832716B2 JP2008536806A JP2008536806A JP5832716B2 JP 5832716 B2 JP5832716 B2 JP 5832716B2 JP 2008536806 A JP2008536806 A JP 2008536806A JP 2008536806 A JP2008536806 A JP 2008536806A JP 5832716 B2 JP5832716 B2 JP 5832716B2
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mixture
laquinimod sodium
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laquinimod
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JP2008536806A
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Japanese (ja)
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JP2009512708A5 (cg-RX-API-DMAC10.html
JP2009512708A (ja
Inventor
フレンケル、アントン
グレビチ、エドゥアルド
ラクセル、アビタル
Original Assignee
テバ ファーマシューティカル インダストリーズ リミティド
テバ ファーマシューティカル インダストリーズ リミティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2008536806A 2005-10-19 2006-10-18 ラキニモドナトリウムの結晶，及びその製造方法 Expired - Fee Related JP5832716B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72865705P 2005-10-19 2005-10-19
US60/728,657 2005-10-19
PCT/US2006/040925 WO2007047863A2 (en) 2005-10-19 2006-10-18 Crystals of laquinimod sodium, and process for the manufacture thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2012277069A Division JP2013100299A (ja) 2005-10-19 2012-12-19 ラキニモドナトリウムの結晶、及びその製造方法
JP2015152209A Division JP2016020353A (ja) 2005-10-19 2015-07-31 ラキニモドナトリウムの結晶，及びその製造方法

Publications (3)

Publication Number Publication Date
JP2009512708A JP2009512708A (ja) 2009-03-26
JP2009512708A5 JP2009512708A5 (cg-RX-API-DMAC10.html) 2012-03-08
JP5832716B2 true JP5832716B2 (ja) 2015-12-16

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JP2008536806A Expired - Fee Related JP5832716B2 (ja) 2005-10-19 2006-10-18 ラキニモドナトリウムの結晶，及びその製造方法
JP2012277069A Withdrawn JP2013100299A (ja) 2005-10-19 2012-12-19 ラキニモドナトリウムの結晶、及びその製造方法
JP2015152209A Pending JP2016020353A (ja) 2005-10-19 2015-07-31 ラキニモドナトリウムの結晶，及びその製造方法

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JP2015152209A Pending JP2016020353A (ja) 2005-10-19 2015-07-31 ラキニモドナトリウムの結晶，及びその製造方法

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US (4) US7884208B2 (cg-RX-API-DMAC10.html)
EP (2) EP1937642B1 (cg-RX-API-DMAC10.html)
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KR (1) KR101440982B1 (cg-RX-API-DMAC10.html)
CN (3) CN101291911B (cg-RX-API-DMAC10.html)
AR (1) AR056708A1 (cg-RX-API-DMAC10.html)
AU (1) AU2006304672B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0617477A2 (cg-RX-API-DMAC10.html)
CA (1) CA2625287C (cg-RX-API-DMAC10.html)
DK (1) DK1937642T3 (cg-RX-API-DMAC10.html)
ES (1) ES2523762T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20141160T1 (cg-RX-API-DMAC10.html)
IL (1) IL190137A (cg-RX-API-DMAC10.html)
NZ (2) NZ567088A (cg-RX-API-DMAC10.html)
PL (1) PL1937642T3 (cg-RX-API-DMAC10.html)
PT (1) PT1937642E (cg-RX-API-DMAC10.html)
RS (1) RS53666B1 (cg-RX-API-DMAC10.html)
RU (1) RU2415841C2 (cg-RX-API-DMAC10.html)
SG (1) SG10201508623RA (cg-RX-API-DMAC10.html)
SI (1) SI1937642T1 (cg-RX-API-DMAC10.html)
UA (1) UA92761C2 (cg-RX-API-DMAC10.html)
WO (1) WO2007047863A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200803527B (cg-RX-API-DMAC10.html)

Cited By (1)

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JP2016020353A (ja) * 2005-10-19 2016-02-04 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドナトリウムの結晶，及びその製造方法

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