IL173602A0 - Heteroarylaminosulfonylphenyl derivatives and pharmaceutical compositions containing the same - Google Patents
Heteroarylaminosulfonylphenyl derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL173602A0 IL173602A0 IL173602A IL17360206A IL173602A0 IL 173602 A0 IL173602 A0 IL 173602A0 IL 173602 A IL173602 A IL 173602A IL 17360206 A IL17360206 A IL 17360206A IL 173602 A0 IL173602 A0 IL 173602A0
- Authority
- IL
- Israel
- Prior art keywords
- heteroarylaminosulfonylphenyl
- derivatives
- same
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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Applications Claiming Priority (3)
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| US49365903P | 2003-08-08 | 2003-08-08 | |
| US58471704P | 2004-07-01 | 2004-07-01 | |
| PCT/US2004/025827 WO2005013914A2 (en) | 2003-08-08 | 2004-08-09 | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
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| IL173602A0 true IL173602A0 (en) | 2006-07-05 |
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| IL173602A IL173602A0 (en) | 2003-08-08 | 2006-02-08 | Heteroarylaminosulfonylphenyl derivatives and pharmaceutical compositions containing the same |
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Families Citing this family (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100860581B1 (ko) | 2002-05-18 | 2008-09-26 | 엘지전자 주식회사 | 멀티캐스트 데이터 전송 방법 |
| KR20030097559A (ko) | 2002-06-22 | 2003-12-31 | 엘지전자 주식회사 | 무선이동통신 시스템의 멀티미디어 서비스 방법 |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| EP1673357A2 (en) * | 2003-08-08 | 2006-06-28 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| KR100595646B1 (ko) | 2004-01-09 | 2006-07-03 | 엘지전자 주식회사 | Mbms서비스를 제공하는 무선통신 시스템 |
| WO2005100305A1 (en) * | 2004-04-13 | 2005-10-27 | Warner-Lambert Company Llc | Androgen modulators |
| JP2007533726A (ja) | 2004-04-22 | 2007-11-22 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲンモジュレーター |
| MXPA06015169A (es) | 2004-07-08 | 2007-08-21 | Warner Lambert Co | Moduladores de androgenos. |
| US7671077B2 (en) * | 2004-07-19 | 2010-03-02 | Leu-Fen Hou Lin | Neuroprotective small organic molecules, compositions and uses related thereto |
| WO2006038680A1 (ja) * | 2004-10-01 | 2006-04-13 | Banyu Pharmaceutical Co.,Ltd | 2-アリールカルボキサミド-含窒素複素環化合物 |
| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| ES2382068T3 (es) | 2004-12-28 | 2012-06-05 | Kinex Pharmaceuticals, Llc | Composiciones y métodos para tratar trastornos de proliferación celular |
| EP1857444A4 (en) * | 2005-03-10 | 2009-04-29 | Kyoto Pharma Ind | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICAL USE THEREOF |
| WO2006095822A1 (ja) * | 2005-03-11 | 2006-09-14 | Ono Pharmaceutical Co., Ltd. | スルホンアミド化合物およびその医薬 |
| US20090264533A1 (en) * | 2005-03-30 | 2009-10-22 | Richard Neubig | Methods and Compositions for Modulating RHO-Mediated Gene Transcription |
| JP2008534630A (ja) * | 2005-04-08 | 2008-08-28 | ニューロメッド ファーマシューティカルズ リミテッド | 疼痛の軽減のためのn型カルシウムチャネルブロッカーを含む組み合わせ治療の方法 |
| MX2007014180A (es) * | 2005-05-10 | 2008-01-14 | Vertex Pharma | Derivados biciclicos como moduladores de canales de iones. |
| CA2608599A1 (en) * | 2005-05-16 | 2006-11-23 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
| MX2007015726A (es) * | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| CA2620179C (en) * | 2005-08-16 | 2013-10-29 | Icagen, Inc. | Inhibitors of voltage-gated sodium channels |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| EP1934191B1 (en) * | 2005-10-12 | 2012-03-28 | Vertex Pharmaceuticals, Inc. | Biphenyl derivatives as modulators of voltage gated ion channels |
| CN101331115A (zh) * | 2005-10-21 | 2008-12-24 | 沃泰克斯药物股份有限公司 | 调控离子通道的衍生物 |
| AU2006311954A1 (en) * | 2005-11-02 | 2007-05-18 | Icagen, Inc. | Inhibitors of ion channels |
| EP2316829A1 (en) | 2005-12-21 | 2011-05-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| EP2004596A2 (en) * | 2006-04-11 | 2008-12-24 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| JP5564251B2 (ja) | 2006-06-29 | 2014-07-30 | キネックス ファーマシューティカルズ, エルエルシー | キナーゼカスケードを調節するためのビアリール組成物および方法 |
| DK2054397T3 (en) | 2006-08-16 | 2016-01-18 | J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone | SMALL MOLECULAR INHIBITORS OF KYNURENIN-3-MONOOXYGENASE |
| EP2054056A4 (en) | 2006-08-16 | 2010-08-25 | J David Gladstone Inst A Testa | SMALL MOLECULAR INHIBITORS OF KYNURENINE-3-MONOOXYGENASE |
| CA2668859A1 (en) * | 2006-11-07 | 2008-05-15 | Proteologics Ltd. | Pyrimidine derivatives as posh and posh-ap inhibitors |
| US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
| US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
| TWI457336B (zh) | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
| US8729059B2 (en) * | 2007-02-09 | 2014-05-20 | Emory University | Paramyxovirus family inhibitors and methods of use thereof |
| EP1995241B1 (en) * | 2007-03-23 | 2010-03-17 | ICAgen, Inc. | Inhibitors of ion channels |
| WO2008130323A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 8-piperazine-tetrahydronaphtalene derivatives for the treatment of pain |
| WO2008130319A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain |
| WO2008130322A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 5-heterocyclyl-chromane derivatives for the treatment of pain |
| WO2008130321A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain |
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
| MX2009012678A (es) * | 2007-05-25 | 2012-09-20 | Vertex Pharma | Moduladores de canal de ion y metodos de uso. |
| US8124605B2 (en) | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| WO2009012241A1 (en) * | 2007-07-13 | 2009-01-22 | Icagen, Inc. | Sodium channel inhibitors |
| US8124610B2 (en) | 2007-07-13 | 2012-02-28 | Icagen Inc. | Sodium channel inhibitors |
| WO2009016081A2 (en) * | 2007-08-02 | 2009-02-05 | Actar Ab | Benzoind0l-2-one derivatives for use in therapy |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| AU2008310660A1 (en) | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Heteroaryl amides useful as inhibitors of voltage-gated sodium channels |
| WO2009049181A1 (en) | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Amides useful as inhibitors of voltage-gated sodium channels |
| KR20100075631A (ko) * | 2007-10-11 | 2010-07-02 | 버텍스 파마슈티칼스 인코포레이티드 | 전압개폐 나트륨 채널의 억제제로서 유용한 아릴 아미드 |
| US7994166B2 (en) * | 2007-11-13 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels for the treatment of pain |
| WO2009064752A2 (en) * | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| CN101565418B (zh) * | 2008-04-23 | 2011-09-28 | 华东理工大学 | 酰胺衍生物及其用途 |
| WO2009133641A1 (ja) * | 2008-04-30 | 2009-11-05 | シャープ株式会社 | 照明装置、及び表示装置 |
| WO2010002956A2 (en) * | 2008-07-01 | 2010-01-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| WO2010033824A1 (en) * | 2008-09-19 | 2010-03-25 | Icagen, Inc. | Sulfonamide derivatives as inhibitors of ion channels |
| WO2010035166A1 (en) * | 2008-09-23 | 2010-04-01 | Pfizer Limited | Benzamide derivatives |
| PE20120008A1 (es) * | 2009-01-12 | 2012-01-24 | Icagen Inc | Derivados de fenoxi bencenosulfonamida |
| WO2011129936A2 (en) | 2010-04-16 | 2011-10-20 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
| JP5855095B2 (ja) | 2010-06-07 | 2016-02-09 | ノボメディックス, エルエルシーNovomedix, Llc | フラニル化合物およびその使用 |
| JP5872552B2 (ja) | 2010-07-09 | 2016-03-01 | ファイザー・リミテッドPfizer Limited | 化学化合物 |
| CA2804593C (en) | 2010-07-09 | 2015-11-24 | Pfizer Limited | Biphenyloxybenzensulphonamide derivatives useful as sodium channel inhibitors |
| ES2526675T3 (es) * | 2010-07-09 | 2015-01-14 | Pfizer Limited | N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje |
| JP2013532185A (ja) | 2010-07-12 | 2013-08-15 | ファイザー・リミテッド | 化合物 |
| CA2804351A1 (en) | 2010-07-12 | 2012-01-19 | Pfizer Limited | Chemical compounds |
| JP2013536165A (ja) | 2010-07-12 | 2013-09-19 | ファイザー・リミテッド | 痛みの処置のためのnav1.7阻害薬としてのスルホンアミド誘導体 |
| JP2013531030A (ja) | 2010-07-12 | 2013-08-01 | ファイザー・リミテッド | 電位開口型ナトリウムチャネルの阻害剤としてのn−スルホニルベンズアミド |
| JP2013532184A (ja) | 2010-07-12 | 2013-08-15 | ファイザー・リミテッド | 電位開口型ナトリウムチャネル阻害剤として有用なn−スルホニルベンズアミド誘導体 |
| WO2012095781A1 (en) | 2011-01-13 | 2012-07-19 | Pfizer Limited | Indazole derivatives as sodium channel inhibitors |
| PH12013501865A1 (en) | 2011-03-16 | 2014-01-06 | Amgen Inc | Potent and selective inhibitors of nav1.3 and nav1.7 |
| WO2013009799A1 (en) * | 2011-07-11 | 2013-01-17 | Beth Israel Deaconess Medical Center, Inc. | Vitamin d receptor agonists and uses thereof |
| WO2013063012A1 (en) | 2011-10-24 | 2013-05-02 | Emory University | Myxovirus therapeutics, compounds, and uses related thereto |
| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| US9630929B2 (en) | 2011-10-31 | 2017-04-25 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| WO2013088315A1 (en) * | 2011-12-15 | 2013-06-20 | Pfizer Limited | Sulfonamide derivatives |
| WO2013093688A1 (en) | 2011-12-19 | 2013-06-27 | Pfizer Limited | Sulfonamide derivatives and use thereof as vgsc inhibitors |
| US20150291514A1 (en) | 2012-01-04 | 2015-10-15 | Pfizer Limted | N-Aminosulfonyl Benzamides |
| SG11201408284VA (en) | 2012-05-22 | 2015-02-27 | Xenon Pharmaceuticals Inc | N-substituted benzamides and their use in the treatment of pain |
| US10071957B2 (en) | 2012-07-06 | 2018-09-11 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
| CA2883144C (en) | 2012-08-30 | 2023-01-17 | Kinex Pharmaceuticals, Llc | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl) acetamide as protein|tyrosine kinase modulators |
| TWI598325B (zh) | 2012-10-12 | 2017-09-11 | H 朗德貝克公司 | 苯甲醯胺類 |
| TW201427947A (zh) | 2012-10-12 | 2014-07-16 | Lundbeck & Co As H | 環狀胺 |
| ES2798138T3 (es) | 2012-10-15 | 2020-12-09 | Dae Woong Pharma | Bloqueadores de los canales de sodio, método de preparación de los mismos y uso de los mismos |
| RU2683788C2 (ru) * | 2013-01-31 | 2019-04-02 | Вертекс Фармасьютикалз Инкорпорейтед | Амиды хинолина и хиназолина, полезные в качестве модуляторов натриевых каналов |
| RS56015B1 (sr) | 2013-01-31 | 2017-09-29 | Vertex Pharma | Piridon amidi kao modulatori natrijumovih kanala |
| US9636418B2 (en) | 2013-03-12 | 2017-05-02 | Amgen Inc. | Potent and selective inhibitors of NAV1.7 |
| WO2014165277A2 (en) | 2013-03-12 | 2014-10-09 | Amgen Inc. | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 |
| US9550775B2 (en) | 2013-03-14 | 2017-01-24 | Genentech, Inc. | Substituted triazolopyridines and methods of use thereof |
| MX2015010775A (es) | 2013-03-15 | 2016-04-25 | Genentech Inc | Benzoxazoles sustituidos y metodos para usarlos. |
| UA119147C2 (uk) | 2013-07-19 | 2019-05-10 | Вертекс Фармасьютікалз Інкорпорейтед | Сульфонаміди як модулятори натрієвих каналів |
| US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
| CR20160296A (es) | 2013-11-27 | 2016-09-20 | Genentech Inc | Benzamidas sustituidas y métodos para usarlas |
| WO2015077905A1 (en) | 2013-11-29 | 2015-06-04 | Merck Sharp & Dohme Corp. | Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels |
| CA2931550C (en) | 2013-12-13 | 2023-09-26 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
| CN105130970B (zh) * | 2014-05-30 | 2019-06-25 | 中国人民解放军军事医学科学院毒物药物研究所 | N-磺酰基高丝氨酸内酯类衍生物、其制备方法和用途 |
| CN106715418A (zh) | 2014-07-07 | 2017-05-24 | 基因泰克公司 | 治疗化合物及其使用方法 |
| JP2018520107A (ja) | 2015-05-22 | 2018-07-26 | ジェネンテック, インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
| EP3341353A1 (en) | 2015-08-27 | 2018-07-04 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| CN108290881B (zh) | 2015-09-28 | 2021-12-07 | 健泰科生物技术公司 | 治疗性化合物和其使用方法 |
| EP3368509A4 (en) * | 2015-10-30 | 2019-05-01 | Trillium Therapeutics Inc. | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS |
| US10899732B2 (en) | 2015-11-25 | 2021-01-26 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| EP3389654B1 (en) * | 2015-12-18 | 2023-08-16 | Merck Sharp & Dohme LLC | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP3390374B1 (en) * | 2015-12-18 | 2020-08-26 | Merck Sharp & Dohme Corp. | Hydroxyalkylamine- and hydroxycycloalkylamine-substituted diamine-arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP3854782A1 (en) | 2016-03-30 | 2021-07-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| HRP20250505T1 (hr) | 2016-05-20 | 2025-06-20 | Xenon Pharmaceuticals Inc. | Spojevi benzensulfonamida i njihova uporaba za terapijska sredstva |
| AU2017347549A1 (en) * | 2016-10-17 | 2019-05-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| ES2967410T3 (es) | 2016-12-09 | 2024-04-30 | Xenon Pharmaceuticals Inc | Compuestos de bencenosulfonamida y sus usos en forma de agentes terapéuticos |
| JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック, インコーポレイテッド | ナトリウムチャネル阻害剤としての4−ピペリジン−n−(ピリミジン−4−イル)クロマン−7−スルホンアミド誘導体 |
| EP3625214B1 (en) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| EP3412652A1 (en) | 2017-06-06 | 2018-12-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibitors of rac1 and uses thereof for treating cancers |
| EP3412651A1 (en) * | 2017-06-06 | 2018-12-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibitors of rac1 and uses thereof for inducing bronchodilatation |
| JP2019099550A (ja) * | 2017-12-07 | 2019-06-24 | 学校法人兵庫医科大学 | スクロース吸収阻害剤、ChREBP阻害剤およびその利用 |
| US11529337B2 (en) | 2018-02-12 | 2022-12-20 | Vertex Pharmaceuticals Incorporated | Method of treating pain |
| AR114263A1 (es) | 2018-02-26 | 2020-08-12 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| WO2019191702A1 (en) | 2018-03-30 | 2019-10-03 | F. Hoffmann-La Roche Ag | Substituted hydro-pyrido-azines as sodium channel inhibitors |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| CN112262142B (zh) | 2018-06-13 | 2023-11-14 | 泽农医药公司 | 苯磺酰胺化合物及其作为治疗剂的用途 |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
| CA3105657A1 (en) | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting nav1.8 |
| AU2019302534B2 (en) | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| MX2021001380A (es) | 2018-08-31 | 2021-05-27 | Xenon Pharmaceuticals Inc | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos. |
| MA53488A (fr) | 2018-08-31 | 2021-12-08 | Xenon Pharmaceuticals Inc | Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques |
| JP7288051B2 (ja) | 2018-11-02 | 2023-06-06 | メルク・シャープ・アンド・ドーム・エルエルシー | Nav1.8阻害薬としての2-アミノ-N-ヘテロアリール-ニコチンアミド類 |
| CA3128500A1 (en) * | 2019-02-01 | 2020-08-06 | Marshall University Research Corporation | Transient receptor potential melastatin 8 (trpm8) antagonists and related methods |
| EP3946301A4 (en) * | 2019-04-02 | 2023-08-09 | The University of Chicago | REMODILINS FOR RESPIRATORY TRACT REMODELING AND ORGAN FIBROSIS |
| DK4299135T3 (da) | 2019-06-18 | 2025-09-08 | Pfizer | Benzisoxazol-sulfonamid-derivater |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| WO2021119157A1 (en) | 2019-12-11 | 2021-06-17 | Duke University | Small molecule inhibitors of voltage-gated sodium channel 1.7 and methods of using same |
| CN113527281B (zh) * | 2020-04-20 | 2023-12-22 | 昆山彭济凯丰生物科技有限公司 | 杂环化合物及其制备方法和应用 |
| CN115697327A (zh) * | 2020-06-17 | 2023-02-03 | 默沙东有限责任公司 | 作为nav1.8抑制剂的5-氧代-吡咯烷-3-甲酰胺 |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| KR20250180156A (ko) * | 2024-06-21 | 2025-12-31 | 중앙대학교 산학협력단 | 뇌전증의 예방 또는 치료용 조성물, 및 뇌전증 치료제 스크리닝 방법과 이의 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2430051A (en) | 1944-08-16 | 1947-11-04 | Hoffmann La Roche | Soluble sulfanilamide derivatives and process of preparing them |
| FR1537695A (fr) | 1967-02-23 | 1968-08-30 | Ferlux | Nouvelles chromones carbonamides n-phénylsulfonamidées et procédé pour leur fabrication |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5360802A (en) * | 1992-05-11 | 1994-11-01 | Merck Sharpe & Dohme Ltd. | Benzodiazepine derivatives, compositions containing them and their use in therapy |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| AU1924099A (en) * | 1997-12-18 | 1999-07-05 | Lyonnaise Industrielle Pharmaceutique (Lipha) | Piperazine derivatives useful as hypoglycemic agents |
| KR20020009383A (ko) | 1998-04-01 | 2002-02-01 | 우에노 도시오 | 축합 티오펜 유도체 및 이의 유도체를 유효 성분으로 하는약제 |
| AU7031500A (en) * | 1999-09-23 | 2001-04-24 | Astrazeneca Ab | Therapeutic quinazoline compounds |
| FI116940B (fi) * | 2001-07-20 | 2006-04-13 | Juvantia Pharma Ltd Oy | Alfa-2B-adrenoseptorivälitteisen sairauden hoitoon tai ehkäisyyn käyttökelpoiset yhdisteet |
| WO2003014064A1 (en) * | 2001-07-31 | 2003-02-20 | Bayer Healthcare Ag | Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists |
| SE0103644D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
| GB0218625D0 (en) | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| EP1673357A2 (en) * | 2003-08-08 | 2006-06-28 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| US7671077B2 (en) * | 2004-07-19 | 2010-03-02 | Leu-Fen Hou Lin | Neuroprotective small organic molecules, compositions and uses related thereto |
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2004
- 2004-08-09 EP EP04780632A patent/EP1673357A2/en not_active Withdrawn
- 2004-08-09 US US10/914,988 patent/US8202861B2/en not_active Expired - Lifetime
- 2004-08-09 TW TW093123829A patent/TW200524888A/zh unknown
- 2004-08-09 WO PCT/US2004/025827 patent/WO2005013914A2/en not_active Ceased
- 2004-08-09 KR KR1020067002746A patent/KR20060073930A/ko not_active Ceased
- 2004-08-09 PE PE2004000774A patent/PE20050358A1/es not_active Application Discontinuation
- 2004-08-09 NZ NZ579370A patent/NZ579370A/en not_active IP Right Cessation
- 2004-08-09 AR ARP040102855A patent/AR045238A1/es unknown
- 2004-08-09 AU AU2004263179A patent/AU2004263179B8/en not_active Ceased
- 2004-08-09 EP EP10185719A patent/EP2327701A1/en not_active Withdrawn
- 2004-08-09 NZ NZ545710A patent/NZ545710A/en not_active IP Right Cessation
- 2004-08-09 JP JP2006522803A patent/JP2007501804A/ja active Pending
- 2004-08-09 CA CA002539227A patent/CA2539227A1/en not_active Abandoned
- 2004-08-09 EP EP10185726A patent/EP2332912A1/en not_active Withdrawn
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2006
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- 2010-11-24 JP JP2010261862A patent/JP2011032294A/ja not_active Withdrawn
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- 2012-05-23 US US13/478,538 patent/US8309543B2/en not_active Expired - Lifetime
- 2012-10-26 US US13/661,337 patent/US20130184258A1/en not_active Abandoned
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| US8202861B2 (en) | 2012-06-19 |
| JP2011032294A (ja) | 2011-02-17 |
| EP2332912A1 (en) | 2011-06-15 |
| JP2007501804A (ja) | 2007-02-01 |
| US20050137190A1 (en) | 2005-06-23 |
| EP2327701A1 (en) | 2011-06-01 |
| WO2005013914A2 (en) | 2005-02-17 |
| NZ579370A (en) | 2011-06-30 |
| PE20050358A1 (es) | 2005-05-16 |
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| TW200524888A (en) | 2005-08-01 |
| US8309543B2 (en) | 2012-11-13 |
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| AU2004263179B2 (en) | 2011-06-30 |
| WO2005013914A8 (en) | 2006-09-28 |
| CA2539227A1 (en) | 2005-02-17 |
| US20130184258A1 (en) | 2013-07-18 |
| AU2004263179A8 (en) | 2011-07-14 |
| EP1673357A2 (en) | 2006-06-28 |
| NZ545710A (en) | 2010-02-26 |
| KR20060073930A (ko) | 2006-06-29 |
| AU2004263179A1 (en) | 2005-02-17 |
| AU2004263179B8 (en) | 2011-07-14 |
| US20120238578A1 (en) | 2012-09-20 |
| AR045238A1 (es) | 2005-10-19 |
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