IL167984A - Compositions comprising cyclic phosphate diester compounds of 1,3-propane-1-aryl diols and the use of said compounds for the preparation of prodrugs - Google Patents

Compositions comprising cyclic phosphate diester compounds of 1,3-propane-1-aryl diols and the use of said compounds for the preparation of prodrugs

Info

Publication number
IL167984A
IL167984A IL167984A IL16798405A IL167984A IL 167984 A IL167984 A IL 167984A IL 167984 A IL167984 A IL 167984A IL 16798405 A IL16798405 A IL 16798405A IL 167984 A IL167984 A IL 167984A
Authority
IL
Israel
Prior art keywords
formula
group
trans
alkyl
amino
Prior art date
Application number
IL167984A
Other languages
English (en)
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of IL167984A publication Critical patent/IL167984A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL167984A 2002-10-31 2005-04-12 Compositions comprising cyclic phosphate diester compounds of 1,3-propane-1-aryl diols and the use of said compounds for the preparation of prodrugs IL167984A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42321102P 2002-10-31 2002-10-31
US42325902P 2002-10-31 2002-10-31
PCT/US2003/034709 WO2004041834A2 (en) 2002-10-31 2003-10-31 Novel cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs

Publications (1)

Publication Number Publication Date
IL167984A true IL167984A (en) 2011-09-27

Family

ID=32314479

Family Applications (2)

Application Number Title Priority Date Filing Date
IL167984A IL167984A (en) 2002-10-31 2005-04-12 Compositions comprising cyclic phosphate diester compounds of 1,3-propane-1-aryl diols and the use of said compounds for the preparation of prodrugs
IL167990A IL167990A (en) 2002-10-31 2005-04-12 Cytarabine monophosphate analog, pharmaceutical compositions comprising it and use thereof in the manufacture of medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL167990A IL167990A (en) 2002-10-31 2005-04-12 Cytarabine monophosphate analog, pharmaceutical compositions comprising it and use thereof in the manufacture of medicaments

Country Status (13)

Country Link
US (4) US7151092B2 (enExample)
EP (2) EP1556393B1 (enExample)
JP (2) JP5046219B2 (enExample)
KR (2) KR101115210B1 (enExample)
AT (1) ATE442375T1 (enExample)
AU (2) AU2003287389B2 (enExample)
BR (2) BR0315795A (enExample)
CA (2) CA2503729C (enExample)
DE (1) DE60329211D1 (enExample)
IL (2) IL167984A (enExample)
MX (2) MXPA05004504A (enExample)
PL (2) PL376474A1 (enExample)
WO (2) WO2004041834A2 (enExample)

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JP5631414B2 (ja) * 2010-01-15 2014-11-26 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ホスホ置換アルコキシアミン化合物
WO2011113174A1 (zh) * 2010-03-15 2011-09-22 Gao Feng 阿糖胞苷衍生物及其在抗癌抗肿瘤中的用途
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JP7149183B2 (ja) 2015-12-03 2022-10-06 バイオサイト リミテッド 癌治療のためのシタラビンコンジュゲート
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US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof
CN109956985A (zh) 2017-12-22 2019-07-02 浙江柏拉阿图医药科技有限公司 肝递送阿糖胞苷前体药物核苷环磷酸酯化合物及应用
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Also Published As

Publication number Publication date
AU2003287389A1 (en) 2004-06-07
CA2503729A1 (en) 2004-05-21
CA2503730A1 (en) 2004-05-21
US20040092476A1 (en) 2004-05-13
US20070037774A1 (en) 2007-02-15
US7553826B2 (en) 2009-06-30
WO2004041834A3 (en) 2004-07-01
CA2503729C (en) 2012-09-18
AU2003287389B2 (en) 2010-08-12
EP1556398A1 (en) 2005-07-27
EP1556393B1 (en) 2013-12-25
JP2006504791A (ja) 2006-02-09
JP5046219B2 (ja) 2012-10-10
PL376327A1 (en) 2005-12-27
MXPA05004503A (es) 2005-08-16
ATE442375T1 (de) 2009-09-15
US7498320B2 (en) 2009-03-03
AU2003286816A1 (en) 2004-06-07
EP1556398B1 (en) 2009-09-09
KR101115210B1 (ko) 2012-04-12
KR20050072776A (ko) 2005-07-12
KR101026294B1 (ko) 2011-03-31
PL376474A1 (en) 2005-12-27
PL212929B1 (pl) 2012-12-31
US7151092B2 (en) 2006-12-19
KR20050083879A (ko) 2005-08-26
JP2006507308A (ja) 2006-03-02
DE60329211D1 (de) 2009-10-22
WO2004041837A1 (en) 2004-05-21
BR0315806A (pt) 2005-09-13
US20070021388A1 (en) 2007-01-25
AU2003286816B2 (en) 2010-08-19
MXPA05004504A (es) 2005-08-16
CA2503730C (en) 2011-10-18
EP1556393A2 (en) 2005-07-27
IL167990A (en) 2010-12-30
US20040192651A1 (en) 2004-09-30
JP4689274B2 (ja) 2011-05-25
BR0315795A (pt) 2005-09-13
US7148349B2 (en) 2006-12-12
WO2004041834A2 (en) 2004-05-21

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