BR0315806A - Fosfato diésteres cìclicos de 1,3-propano-1-aril diós e seu uso na preparação de pró-drogas - Google Patents

Fosfato diésteres cìclicos de 1,3-propano-1-aril diós e seu uso na preparação de pró-drogas

Info

Publication number
BR0315806A
BR0315806A BR0315806-3A BR0315806A BR0315806A BR 0315806 A BR0315806 A BR 0315806A BR 0315806 A BR0315806 A BR 0315806A BR 0315806 A BR0315806 A BR 0315806A
Authority
BR
Brazil
Prior art keywords
dios
propane
aryl
cyclic diesters
prodrug preparation
Prior art date
Application number
BR0315806-3A
Other languages
English (en)
Inventor
William Craigo
Zhili Sun
Serge H Boyer
Bheemarao G Ugarkar
K Raja Reddy
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of BR0315806A publication Critical patent/BR0315806A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Abstract

"FOSFATO DIéSTERES CìCLICOS DE 1,3-PROPANO-1-ARIL DIóIS E SEU USO NA PREPARAçãO DE PRó-DROGAS". Compostos de fórmula I, sua preparação e intermediários sintéticos, e seu uso na síntese de pró-drogas. Fórmula I onde: V e L são trans entre si; V é selecionado do grupo que consiste em arila carbocíclica, arila carbocíclica substituída, heteroarila e heteroarila substituída; e L é um grupo deslocável selecionado do grupo que consiste em halogênio, alquil sulfonato, arilóxi opcionalmente substituído com 1- 2 substituintes, heteroarila contendo N e heteroarila contendo N-hidroxi-nitrogênio; e sais dos mesmos.
BR0315806-3A 2002-10-31 2003-10-31 Fosfato diésteres cìclicos de 1,3-propano-1-aril diós e seu uso na preparação de pró-drogas BR0315806A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42325902P 2002-10-31 2002-10-31
US42321102P 2002-10-31 2002-10-31
PCT/US2003/034709 WO2004041834A2 (en) 2002-10-31 2003-10-31 Novel cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs

Publications (1)

Publication Number Publication Date
BR0315806A true BR0315806A (pt) 2005-09-13

Family

ID=32314479

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0315806-3A BR0315806A (pt) 2002-10-31 2003-10-31 Fosfato diésteres cìclicos de 1,3-propano-1-aril diós e seu uso na preparação de pró-drogas
BR0315795-4A BR0315795A (pt) 2002-10-31 2003-10-31 Pró-medicamentos de monofosfato de citarabina

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0315795-4A BR0315795A (pt) 2002-10-31 2003-10-31 Pró-medicamentos de monofosfato de citarabina

Country Status (13)

Country Link
US (4) US7148349B2 (pt)
EP (2) EP1556398B1 (pt)
JP (2) JP5046219B2 (pt)
KR (2) KR101115210B1 (pt)
AT (1) ATE442375T1 (pt)
AU (2) AU2003286816B2 (pt)
BR (2) BR0315806A (pt)
CA (2) CA2503729C (pt)
DE (1) DE60329211D1 (pt)
IL (2) IL167984A (pt)
MX (2) MXPA05004504A (pt)
PL (2) PL212929B1 (pt)
WO (2) WO2004041834A2 (pt)

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Also Published As

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AU2003286816B2 (en) 2010-08-19
KR20050072776A (ko) 2005-07-12
US20070021388A1 (en) 2007-01-25
KR101026294B1 (ko) 2011-03-31
PL212929B1 (pl) 2012-12-31
JP4689274B2 (ja) 2011-05-25
US20040192651A1 (en) 2004-09-30
US7148349B2 (en) 2006-12-12
US7553826B2 (en) 2009-06-30
MXPA05004503A (es) 2005-08-16
IL167990A (en) 2010-12-30
DE60329211D1 (de) 2009-10-22
EP1556393A2 (en) 2005-07-27
CA2503730A1 (en) 2004-05-21
AU2003287389B2 (en) 2010-08-12
BR0315795A (pt) 2005-09-13
CA2503730C (en) 2011-10-18
CA2503729C (en) 2012-09-18
JP2006507308A (ja) 2006-03-02
JP5046219B2 (ja) 2012-10-10
US7498320B2 (en) 2009-03-03
EP1556398B1 (en) 2009-09-09
AU2003287389A1 (en) 2004-06-07
WO2004041834A3 (en) 2004-07-01
US20040092476A1 (en) 2004-05-13
US20070037774A1 (en) 2007-02-15
MXPA05004504A (es) 2005-08-16
AU2003286816A1 (en) 2004-06-07
WO2004041834A2 (en) 2004-05-21
ATE442375T1 (de) 2009-09-15
IL167984A (en) 2011-09-27
KR101115210B1 (ko) 2012-04-12
KR20050083879A (ko) 2005-08-26
EP1556398A1 (en) 2005-07-27
US7151092B2 (en) 2006-12-19
EP1556393B1 (en) 2013-12-25
PL376474A1 (en) 2005-12-27
PL376327A1 (en) 2005-12-27
CA2503729A1 (en) 2004-05-21
JP2006504791A (ja) 2006-02-09
WO2004041837A1 (en) 2004-05-21

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