MXPA05004503A - Nuevos profarmacos de monofosfato de citarabina. - Google Patents

Info

Publication number

MXPA05004503A

MXPA05004503A MXPA05004503A MXPA05004503A MXPA05004503A MX PA05004503 A MXPA05004503 A MX PA05004503A MX PA05004503 A MXPA05004503 A MX PA05004503A MX PA05004503 A MXPA05004503 A MX PA05004503A MX PA05004503 A MXPA05004503 A MX PA05004503A

Authority

MX

Mexico

Prior art keywords

compound

cytarabine

formula iii

prodrugs

formula

Prior art date

2002-10-31

Links

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• Global Dossier
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• 239000000651 prodrug Substances 0.000 title claims abstract description 127
• 229940002612 prodrug Drugs 0.000 title claims abstract description 127
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• -1 cytarabine monophosphate Chemical class 0.000 title claims description 88
• 150000001875 compounds Chemical class 0.000 claims abstract description 146
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims abstract description 76
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims abstract description 27
• 150000003839 salts Chemical class 0.000 claims abstract description 24
• 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 15
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 12
• 239000011574 phosphorus Substances 0.000 claims abstract description 12
• 239000001301 oxygen Substances 0.000 claims abstract description 10
• 229910052760 oxygen Inorganic materials 0.000 claims abstract description 10
• 238000000034 method Methods 0.000 claims description 70
• 210000004185 liver Anatomy 0.000 claims description 58
• 239000003795 chemical substances by application Substances 0.000 claims description 43
• 238000011282 treatment Methods 0.000 claims description 28
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• 241001465754 Metazoa Species 0.000 claims description 26
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