IL166358A0 - Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids - Google Patents
Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroidsInfo
- Publication number
- IL166358A0 IL166358A0 IL16635805A IL16635805A IL166358A0 IL 166358 A0 IL166358 A0 IL 166358A0 IL 16635805 A IL16635805 A IL 16635805A IL 16635805 A IL16635805 A IL 16635805A IL 166358 A0 IL166358 A0 IL 166358A0
- Authority
- IL
- Israel
- Prior art keywords
- alpha
- hydroxysteroids
- substituted
- production
- microbiological method
- Prior art date
Links
- 238000013048 microbiological method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
- C12P33/10—Hydroxylating at 11 position at 11 alpha-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
- C12P33/16—Acting at 17 position
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10233723A DE10233723A1 (de) | 2002-07-24 | 2002-07-24 | Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene |
| US40295302P | 2002-08-14 | 2002-08-14 | |
| PCT/EP2003/008111 WO2004011663A2 (de) | 2002-07-24 | 2003-07-24 | Mikrobiologische verfahren zur herstellung von 7alpha-substituierten 11alpha-hydroxysteroiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166358A0 true IL166358A0 (en) | 2006-01-16 |
Family
ID=31189296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16635805A IL166358A0 (en) | 2002-07-24 | 2005-01-18 | Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1523568A2 (de) |
| JP (1) | JP4417838B2 (de) |
| KR (1) | KR101041328B1 (de) |
| CN (1) | CN100339486C (de) |
| BR (1) | BR0313210A (de) |
| CA (1) | CA2492079C (de) |
| CO (1) | CO5690563A2 (de) |
| CR (1) | CR7672A (de) |
| EA (2) | EA010572B1 (de) |
| EC (1) | ECSP055630A (de) |
| HR (1) | HRP20050172A2 (de) |
| IL (1) | IL166358A0 (de) |
| MX (1) | MXPA05001024A (de) |
| NO (1) | NO20050980L (de) |
| NZ (2) | NZ537871A (de) |
| PH (1) | PH12005500143B1 (de) |
| PL (1) | PL373808A1 (de) |
| RS (1) | RS51855B (de) |
| WO (1) | WO2004011663A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007049672A1 (ja) * | 2005-10-27 | 2007-05-03 | Taiho Pharmaceutical Co., Ltd. | ステロイド化合物の製造法 |
| RU2377309C1 (ru) * | 2008-04-22 | 2009-12-27 | Валентина Александровна Андрюшина | МИКРОБИОЛОГИЧЕСКИЙ СПОСОБ ПОЛУЧЕНИЯ 7α-ГИДРОКСИАНДРОСТЕНОВ |
| CN103834712B (zh) * | 2012-11-26 | 2016-03-30 | 复旦大学 | 去氧孕烯中间体纳米脂质体生物转化的优化方法 |
| CN103214543B (zh) * | 2012-12-25 | 2015-09-02 | 中国人民解放军海军医学研究所 | 新山楂酸衍生物、其制备方法及其在抗肿瘤药物中的应用 |
| CN104862323B (zh) * | 2015-06-02 | 2018-01-16 | 中国农业科学院生物技术研究所 | 修饰苯二酚类化合物的羟化酶基因 |
| PL246071B1 (pl) * | 2022-08-26 | 2024-11-25 | Wrocław University Of Environmental And Life Sciences | Sposób wytwarzania 11α-hydroksy-19-nortestosteronu |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE496261A (de) | 1949-06-11 | |||
| US2658023A (en) * | 1953-04-21 | 1953-11-03 | Pfizer & Co C | Oxygenation of steroids |
| US2985563A (en) | 1958-11-13 | 1961-05-23 | Schering Corp | 11alpha-hydroxylation of steroids by glomerella |
| US3004047A (en) | 1959-03-13 | 1961-10-10 | Olin Mathieson | 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof |
| US3341557A (en) * | 1961-06-05 | 1967-09-12 | Upjohn Co | 7-methyltestosterones |
| US3203869A (en) | 1962-10-11 | 1965-08-31 | Syntex Corp | 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section |
| US5342834A (en) | 1989-04-07 | 1994-08-30 | The Population Council, Inc. | Method for androgen supplementation |
| EP1167381A3 (de) | 1995-12-11 | 2004-09-29 | G.D. Searle & Co. | Verfahren zur Herstellung von 7-alpha-carboxyl 9,11-epoxy-steroiden und darin brauchbare Zwischenprodukte |
| ES2175175T3 (es) | 1995-12-12 | 2002-11-16 | Akzo Nobel Nv | Un metodo microbiano para la 11alfa-hidroxilacion de esteroides. |
| GB9525194D0 (en) | 1995-12-12 | 1996-02-07 | Zeneca Ltd | Pharmaceutical composition |
| US20020012694A1 (en) * | 1997-09-17 | 2002-01-31 | Alfred J. Moo-Young | Transdermal administration of ment |
| US6767902B2 (en) | 1997-09-17 | 2004-07-27 | The Population Council, Inc. | Androgen as a male contraceptive and non-contraceptive androgen replacement |
| US5952319A (en) | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
| KR20020086905A (ko) | 2000-02-15 | 2002-11-20 | 쉐링 악티엔게젤샤프트 | 노르에티스테론을 포함하는 남성 피임약 제형 |
| DE10104327A1 (de) * | 2001-01-24 | 2002-07-25 | Schering Ag | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
| PL374317A1 (en) * | 2002-07-25 | 2005-10-03 | Schering Aktiengesellschaft | Composition containing an androgenous 11beta-halogen steroid and a progestational hormone, and male contraceptive based on said composition |
-
2003
- 2003-07-24 HR HR20050172A patent/HRP20050172A2/hr not_active Application Discontinuation
- 2003-07-24 EP EP03740474A patent/EP1523568A2/de not_active Withdrawn
- 2003-07-24 BR BR0313210-2A patent/BR0313210A/pt not_active IP Right Cessation
- 2003-07-24 EA EA200601030A patent/EA010572B1/ru not_active IP Right Cessation
- 2003-07-24 WO PCT/EP2003/008111 patent/WO2004011663A2/de not_active Ceased
- 2003-07-24 NZ NZ537871A patent/NZ537871A/en not_active IP Right Cessation
- 2003-07-24 MX MXPA05001024A patent/MXPA05001024A/es active IP Right Grant
- 2003-07-24 JP JP2004523777A patent/JP4417838B2/ja not_active Expired - Fee Related
- 2003-07-24 KR KR1020057001140A patent/KR101041328B1/ko not_active Expired - Fee Related
- 2003-07-24 PL PL03373808A patent/PL373808A1/xx not_active Application Discontinuation
- 2003-07-24 RS YU20050045A patent/RS51855B/sr unknown
- 2003-07-24 NZ NZ549529A patent/NZ549529A/en not_active IP Right Cessation
- 2003-07-24 EA EA200500224A patent/EA008147B1/ru not_active IP Right Cessation
- 2003-07-24 CA CA2492079A patent/CA2492079C/en not_active Expired - Fee Related
- 2003-07-24 CN CNB038176963A patent/CN100339486C/zh not_active Expired - Fee Related
-
2005
- 2005-01-18 IL IL16635805A patent/IL166358A0/xx not_active IP Right Cessation
- 2005-01-21 PH PH12005500143A patent/PH12005500143B1/en unknown
- 2005-02-03 CR CR7672A patent/CR7672A/es not_active Application Discontinuation
- 2005-02-21 CO CO05015699A patent/CO5690563A2/es not_active Application Discontinuation
- 2005-02-23 NO NO20050980A patent/NO20050980L/no not_active Application Discontinuation
- 2005-02-24 EC EC2005005630A patent/ECSP055630A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20050980L (no) | 2005-02-23 |
| HRP20050172A2 (en) | 2005-04-30 |
| EA010572B1 (ru) | 2008-10-30 |
| EA200601030A1 (ru) | 2006-10-27 |
| PH12005500143B1 (en) | 2011-03-25 |
| CN100339486C (zh) | 2007-09-26 |
| MX260952B (de) | 2008-10-01 |
| MXPA05001024A (es) | 2005-05-16 |
| NZ537871A (en) | 2006-10-27 |
| CR7672A (es) | 2006-05-29 |
| AU2003281677A1 (en) | 2004-02-16 |
| KR101041328B1 (ko) | 2011-06-14 |
| NZ549529A (en) | 2008-04-30 |
| WO2004011663A2 (de) | 2004-02-05 |
| HK1081999A1 (zh) | 2006-05-26 |
| CO5690563A2 (es) | 2006-10-31 |
| CA2492079C (en) | 2012-01-10 |
| CN1671858A (zh) | 2005-09-21 |
| RS51855B (sr) | 2012-02-29 |
| ECSP055630A (es) | 2005-04-18 |
| CA2492079A1 (en) | 2004-02-05 |
| EA008147B1 (ru) | 2007-04-27 |
| WO2004011663A9 (de) | 2004-05-06 |
| KR20050026507A (ko) | 2005-03-15 |
| JP4417838B2 (ja) | 2010-02-17 |
| WO2004011663A3 (de) | 2004-07-15 |
| JP2006503813A (ja) | 2006-02-02 |
| PL373808A1 (en) | 2005-09-19 |
| EA200500224A1 (ru) | 2005-08-25 |
| EP1523568A2 (de) | 2005-04-20 |
| RS20050045A (sr) | 2007-06-04 |
| BR0313210A (pt) | 2005-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |