ECSP055630A - PROCEDIMIENTOS MICROBIOLÓGICOS PARA PREPARAR 11a-HIDROXIESTEROIDES 7a-SUSTITUIDOS - Google Patents
PROCEDIMIENTOS MICROBIOLÓGICOS PARA PREPARAR 11a-HIDROXIESTEROIDES 7a-SUSTITUIDOSInfo
- Publication number
- ECSP055630A ECSP055630A EC2005005630A ECSP055630A ECSP055630A EC SP055630 A ECSP055630 A EC SP055630A EC 2005005630 A EC2005005630 A EC 2005005630A EC SP055630 A ECSP055630 A EC SP055630A EC SP055630 A ECSP055630 A EC SP055630A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydroxysteroids
- prepare
- replaced
- microbiological procedures
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
- C12P33/10—Hydroxylating at 11 position at 11 alpha-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
- C12P33/16—Acting at 17 position
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describe una novedosa síntesis para preparar productos precursores destinados a la producción de compuestos de la fórmula general (8,10,12). Durante dicha síntesis se producen los compuestos de la fórmula general (4,B) en una reacción microbiológica. Los significados de los radicales R7, R10, R11, R13, R17 y R17'y del grupo U-V-W-X-Y-Z se indican en las reivindicaciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10233723A DE10233723A1 (de) | 2002-07-24 | 2002-07-24 | Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene |
US40295302P | 2002-08-14 | 2002-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP055630A true ECSP055630A (es) | 2005-04-18 |
Family
ID=31189296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2005005630A ECSP055630A (es) | 2002-07-24 | 2005-02-24 | PROCEDIMIENTOS MICROBIOLÓGICOS PARA PREPARAR 11a-HIDROXIESTEROIDES 7a-SUSTITUIDOS |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1523568A2 (es) |
JP (1) | JP4417838B2 (es) |
KR (1) | KR101041328B1 (es) |
CN (1) | CN100339486C (es) |
BR (1) | BR0313210A (es) |
CA (1) | CA2492079C (es) |
CO (1) | CO5690563A2 (es) |
CR (1) | CR7672A (es) |
EA (2) | EA008147B1 (es) |
EC (1) | ECSP055630A (es) |
HK (1) | HK1081999A1 (es) |
HR (1) | HRP20050172A2 (es) |
IL (1) | IL166358A0 (es) |
MX (1) | MXPA05001024A (es) |
NO (1) | NO20050980L (es) |
NZ (2) | NZ537871A (es) |
PH (1) | PH12005500143B1 (es) |
PL (1) | PL373808A1 (es) |
RS (1) | RS51855B (es) |
WO (1) | WO2004011663A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200804405A (en) * | 2005-10-27 | 2008-01-16 | Taiho Pharmaceutical Co Ltd | Process for production of steroid compound |
CN103834712B (zh) * | 2012-11-26 | 2016-03-30 | 复旦大学 | 去氧孕烯中间体纳米脂质体生物转化的优化方法 |
CN103214543B (zh) * | 2012-12-25 | 2015-09-02 | 中国人民解放军海军医学研究所 | 新山楂酸衍生物、其制备方法及其在抗肿瘤药物中的应用 |
CN104862323B (zh) * | 2015-06-02 | 2018-01-16 | 中国农业科学院生物技术研究所 | 修饰苯二酚类化合物的羟化酶基因 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL75841C (es) | 1949-06-11 | |||
US2658023A (en) * | 1953-04-21 | 1953-11-03 | Pfizer & Co C | Oxygenation of steroids |
US2985563A (en) * | 1958-11-13 | 1961-05-23 | Schering Corp | 11alpha-hydroxylation of steroids by glomerella |
US3004047A (en) * | 1959-03-13 | 1961-10-10 | Olin Mathieson | 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof |
US3341557A (en) * | 1961-06-05 | 1967-09-12 | Upjohn Co | 7-methyltestosterones |
US3203869A (en) * | 1962-10-11 | 1965-08-31 | Syntex Corp | 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section |
US5342834A (en) | 1989-04-07 | 1994-08-30 | The Population Council, Inc. | Method for androgen supplementation |
EP1167381A3 (en) * | 1995-12-11 | 2004-09-29 | G.D. Searle & Co. | Process for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and Intermediates useful therein |
ATE215606T1 (de) * | 1995-12-12 | 2002-04-15 | Akzo Nobel Nv | Mikrobielle 11alpha-hydroxylierung von steroiden |
GB9525194D0 (en) | 1995-12-12 | 1996-02-07 | Zeneca Ltd | Pharmaceutical composition |
US20020012694A1 (en) * | 1997-09-17 | 2002-01-31 | Alfred J. Moo-Young | Transdermal administration of ment |
US6767902B2 (en) | 1997-09-17 | 2004-07-27 | The Population Council, Inc. | Androgen as a male contraceptive and non-contraceptive androgen replacement |
US5952319A (en) | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
EP1267885B8 (en) | 2000-02-15 | 2007-06-20 | Bayer Schering Pharma Aktiengesellschaft | Male contraceptive formulation comprising norethisterone and testosterone undecanoate |
DE10104327A1 (de) * | 2001-01-24 | 2002-07-25 | Schering Ag | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
JP2006502997A (ja) * | 2002-07-25 | 2006-01-26 | シエーリング アクチエンゲゼルシャフト | アンドロゲン11β‐ハロゲンステロイドおよびゲスタゲンを含有する組成物ならびにこの組成物に基づく男性用避妊薬 |
-
2003
- 2003-07-24 BR BR0313210-2A patent/BR0313210A/pt not_active IP Right Cessation
- 2003-07-24 WO PCT/EP2003/008111 patent/WO2004011663A2/de active Application Filing
- 2003-07-24 EA EA200500224A patent/EA008147B1/ru not_active IP Right Cessation
- 2003-07-24 JP JP2004523777A patent/JP4417838B2/ja not_active Expired - Fee Related
- 2003-07-24 CA CA2492079A patent/CA2492079C/en not_active Expired - Fee Related
- 2003-07-24 CN CNB038176963A patent/CN100339486C/zh not_active Expired - Fee Related
- 2003-07-24 RS YU20050045A patent/RS51855B/sr unknown
- 2003-07-24 EA EA200601030A patent/EA010572B1/ru not_active IP Right Cessation
- 2003-07-24 NZ NZ537871A patent/NZ537871A/en not_active IP Right Cessation
- 2003-07-24 KR KR1020057001140A patent/KR101041328B1/ko not_active IP Right Cessation
- 2003-07-24 MX MXPA05001024A patent/MXPA05001024A/es active IP Right Grant
- 2003-07-24 EP EP03740474A patent/EP1523568A2/de not_active Withdrawn
- 2003-07-24 PL PL03373808A patent/PL373808A1/xx not_active Application Discontinuation
- 2003-07-24 NZ NZ549529A patent/NZ549529A/en not_active IP Right Cessation
-
2005
- 2005-01-18 IL IL16635805A patent/IL166358A0/xx not_active IP Right Cessation
- 2005-01-21 PH PH12005500143A patent/PH12005500143B1/en unknown
- 2005-02-03 CR CR7672A patent/CR7672A/es not_active Application Discontinuation
- 2005-02-21 CO CO05015699A patent/CO5690563A2/es not_active Application Discontinuation
- 2005-02-22 HR HR20050172A patent/HRP20050172A2/hr not_active Application Discontinuation
- 2005-02-23 NO NO20050980A patent/NO20050980L/no not_active Application Discontinuation
- 2005-02-24 EC EC2005005630A patent/ECSP055630A/es unknown
-
2006
- 2006-02-17 HK HK06102071A patent/HK1081999A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EA200500224A1 (ru) | 2005-08-25 |
MX260952B (es) | 2008-10-01 |
JP4417838B2 (ja) | 2010-02-17 |
EA200601030A1 (ru) | 2006-10-27 |
KR20050026507A (ko) | 2005-03-15 |
JP2006503813A (ja) | 2006-02-02 |
CO5690563A2 (es) | 2006-10-31 |
NZ537871A (en) | 2006-10-27 |
CA2492079A1 (en) | 2004-02-05 |
WO2004011663A3 (de) | 2004-07-15 |
CN100339486C (zh) | 2007-09-26 |
KR101041328B1 (ko) | 2011-06-14 |
EA010572B1 (ru) | 2008-10-30 |
PH12005500143B1 (en) | 2011-03-25 |
HRP20050172A2 (en) | 2005-04-30 |
PL373808A1 (en) | 2005-09-19 |
CA2492079C (en) | 2012-01-10 |
AU2003281677A1 (en) | 2004-02-16 |
RS20050045A (en) | 2007-06-04 |
IL166358A0 (en) | 2006-01-16 |
HK1081999A1 (en) | 2006-05-26 |
CR7672A (es) | 2006-05-29 |
EA008147B1 (ru) | 2007-04-27 |
MXPA05001024A (es) | 2005-05-16 |
CN1671858A (zh) | 2005-09-21 |
EP1523568A2 (de) | 2005-04-20 |
RS51855B (sr) | 2012-02-29 |
NZ549529A (en) | 2008-04-30 |
NO20050980L (no) | 2005-02-23 |
WO2004011663A9 (de) | 2004-05-06 |
BR0313210A (pt) | 2005-06-28 |
WO2004011663A2 (de) | 2004-02-05 |
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