IL164802A0 - Stable adenoviral vectors and methods for propagation thereof - Google Patents
Stable adenoviral vectors and methods for propagation thereofInfo
- Publication number
- IL164802A0 IL164802A0 IL16480203A IL16480203A IL164802A0 IL 164802 A0 IL164802 A0 IL 164802A0 IL 16480203 A IL16480203 A IL 16480203A IL 16480203 A IL16480203 A IL 16480203A IL 164802 A0 IL164802 A0 IL 164802A0
- Authority
- IL
- Israel
- Prior art keywords
- methods
- propagation
- complementing cell
- pix
- adenoviral vectors
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000013598 vector Substances 0.000 title abstract 3
- 241000701161 unidentified adenovirus Species 0.000 abstract 3
- 238000004806 packaging method and process Methods 0.000 abstract 2
- 101150029662 E1 gene Proteins 0.000 abstract 1
- 101710114676 E1B 55 kDa protein Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Lubricants (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL0200281 | 2002-04-25 | ||
| NL0200656 | 2002-10-15 | ||
| EP02102631 | 2002-11-25 | ||
| PCT/EP2003/050126 WO2004001032A2 (en) | 2002-04-25 | 2003-04-24 | Stable adenoviral vectors and methods for propagation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL164802A0 true IL164802A0 (en) | 2005-12-18 |
Family
ID=34068720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16480203A IL164802A0 (en) | 2002-04-25 | 2003-04-24 | Stable adenoviral vectors and methods for propagation thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7285265B2 (enExample) |
| EP (1) | EP1497440B1 (enExample) |
| JP (1) | JP4495588B2 (enExample) |
| KR (1) | KR101006594B1 (enExample) |
| CN (1) | CN100374574C (enExample) |
| AT (1) | ATE405663T1 (enExample) |
| AU (1) | AU2003271738C1 (enExample) |
| CA (1) | CA2478508C (enExample) |
| DE (1) | DE60323080D1 (enExample) |
| DK (1) | DK1497440T3 (enExample) |
| ES (1) | ES2310247T3 (enExample) |
| IL (1) | IL164802A0 (enExample) |
| NO (1) | NO334299B1 (enExample) |
| NZ (1) | NZ534865A (enExample) |
| PL (1) | PL208588B1 (enExample) |
| SI (1) | SI1497440T1 (enExample) |
| WO (1) | WO2004001032A2 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1445322B2 (en) | 1995-06-15 | 2012-06-06 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US6913922B1 (en) * | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| ES2335657T3 (es) * | 2002-04-25 | 2010-03-31 | Crucell Holland B.V. | Medios y metodos para la produccion de vectores de adenovirus. |
| CN1655827B (zh) | 2002-05-27 | 2010-06-23 | 佩尔·松内·霍尔姆 | 腺病毒和编码其的核酸的新应用 |
| EP1539937A4 (en) * | 2002-08-22 | 2006-07-26 | Merck & Co Inc | METHOD FOR THE REPRODUCTION OF ADENOVIRUS AND PRODUCT VIRUS THEREWITH |
| CA2527369A1 (en) * | 2003-07-18 | 2005-02-03 | Onyx Pharmaceuticals, Inc. | Subgroup b adenoviral vectors for treating disease |
| WO2005051430A1 (de) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
| ES2329607T3 (es) | 2004-02-23 | 2009-11-27 | Crucell Holland B.V. | Metodos de purificacion de virus. |
| NZ555907A (en) | 2004-11-16 | 2009-12-24 | Aeras Global Tb Vaccine Found | Multivalent vaccines comprising recombinant viral vectors |
| EP1830864A2 (de) * | 2004-12-31 | 2007-09-12 | Per Sonne Holm | E1 -minus adenoviren und deren verwendung |
| AU2006203736B2 (en) * | 2004-12-31 | 2012-03-29 | Per Sonne Holm | Method for reversing multiple resistance in animal cells |
| DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| KR20080052512A (ko) * | 2005-05-23 | 2008-06-11 | 박신, 인크. | 아데노바이러스-무함유 재조합 아데노바이러스 벡터의 급속생산 |
| EP1998804B1 (en) * | 2006-03-27 | 2014-04-16 | Crucell Holland B.V. | Compositions comprising a recombinant adenovirus and an adjuvant |
| BRPI0720219A2 (pt) | 2006-12-08 | 2013-12-24 | Univ Iowa State Res Found Inc | Genes de planta envolvidos em absorção e metabolismo de nitrato |
| CA2742474C (en) | 2008-11-03 | 2016-05-31 | Crucell Holland B.V. | Method for the production of adenoviral vectors |
| PT2358757T (pt) | 2008-11-18 | 2018-12-04 | Beth Israel Deaconess Medical Ct Inc | Vacinas antivirais com imunogenicidade celular melhorada |
| NZ598000A (en) | 2009-08-07 | 2013-10-25 | Transgene Sa | Composition for treating hbv infection |
| US8771709B2 (en) | 2010-09-20 | 2014-07-08 | Crucell Holland B.V. | Therapeutic vaccination against active Tuberculosis |
| MX354752B (es) | 2010-09-27 | 2018-03-20 | Janssen Vaccines & Prevention Bv | Regimen de vacunacion de sensibilizacion y refuerzo heterologo contra malaria. |
| CN103370411B (zh) | 2010-12-14 | 2016-05-04 | 美国卫生和人类服务部 | 腺病毒血清型26和血清型35线状病毒疫苗 |
| MY170927A (en) | 2011-11-28 | 2019-09-19 | Janssen Vaccines & Prevention Bv | Influenza virus vaccines and uses thereof |
| CA2864956C (en) | 2012-03-12 | 2021-11-09 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
| AP2014007993A0 (en) | 2012-03-22 | 2014-10-31 | Crucell Holland Bv | Vaccine against RSV |
| ES2663688T3 (es) * | 2012-07-04 | 2018-04-16 | Sirion Biotech Gmbh | Medios y métodos para aumentar la producción de adenovirus |
| CN105051198A (zh) * | 2012-11-16 | 2015-11-11 | 貝丝以色列女执事医疗中心 | 重组腺病毒及其用途 |
| SG11201508567XA (en) | 2013-04-25 | 2015-11-27 | Crucell Holland Bv | Stabilized soluble prefusion rsv f polypeptides |
| JP2017527564A (ja) | 2014-09-03 | 2017-09-21 | バヴァリアン ノルディック エー／エス | 免疫応答の増進を目的とする方法及び組成物 |
| CN107454848B (zh) | 2014-09-03 | 2021-06-22 | 巴法里安诺迪克有限公司 | 用于诱导针对丝状病毒感染的保护性免疫的方法和组合物 |
| CA2961024A1 (en) | 2014-09-26 | 2016-03-31 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for inducing protective immunity against human immunodeficiency virus infection |
| TWI710635B (zh) * | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
| CN107466324B (zh) | 2015-04-14 | 2022-01-14 | 扬森疫苗与预防公司 | 具有双向启动子的表达两种转基因的重组腺病毒 |
| WO2016187613A1 (en) | 2015-05-21 | 2016-11-24 | Janssen Vaccines & Prevention B.V | Methods and compositions for inducing protective immunity against filovirus infection and/or disease |
| US10457708B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| EA039065B1 (ru) | 2015-07-07 | 2021-11-29 | Янссен Вэксинс Энд Превеншн Б.В. | Вакцина против rsv |
| CA3008542C (en) | 2015-12-15 | 2020-06-02 | Janssen Vaccines & Prevention B.V. | Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof |
| EP3808374A1 (en) | 2016-04-05 | 2021-04-21 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion rsv f proteins for use in the prophylaxis of rsv infection |
| CN109069612A (zh) | 2016-04-05 | 2018-12-21 | 扬森疫苗与预防公司 | 针对rsv的疫苗 |
| BR112018072865A2 (pt) | 2016-05-12 | 2019-04-30 | Janssen Vaccines & Prevention B.V. | promotor bidirecional potente e equilibrado |
| PE20190110A1 (es) | 2016-05-30 | 2019-01-15 | Janssen Vaccines And Prevention B V | Proteinas f de prefusion del vrs estabilizadas |
| JP6595132B2 (ja) | 2016-06-16 | 2019-10-23 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Ｈｉｖワクチン製剤 |
| EP3472327B1 (en) | 2016-06-20 | 2020-08-19 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| EP3484506A1 (en) | 2016-07-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
| US10925955B2 (en) | 2016-07-15 | 2021-02-23 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against a Marburg virus infection |
| WO2018011768A1 (en) | 2016-07-15 | 2018-01-18 | Janssen Vaccines And Prevention B.V. | Methods and compositions for inducing protective immunity against a marburg virus infection |
| WO2018075559A1 (en) | 2016-10-17 | 2018-04-26 | Beth Israel Deaconess Medical Center, Inc. | Signature-based human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same |
| CN110268061B (zh) | 2017-02-09 | 2024-07-16 | 扬森疫苗与预防公司 | 用于表达异源基因的有效的短启动子 |
| US11173204B2 (en) | 2017-04-06 | 2021-11-16 | Janssen Vaccines & Prevention B.V. | MVA-BN and Ad26.ZEBOV or Ad26.filo prime-boost regimen |
| CA3062591A1 (en) | 2017-05-08 | 2018-11-15 | Gritstone Oncology, Inc. | Alphavirus neoantigen vectors |
| WO2018210871A1 (en) | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| CA3061278A1 (en) | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| EP3638302B1 (en) | 2017-06-15 | 2024-03-13 | Janssen Vaccines & Prevention B.V. | Poxvirus vectors encoding hiv antigens, and methods of use thereof |
| BR112020001052A2 (pt) | 2017-07-28 | 2020-09-08 | Janssen Vaccines & Prevention B.V. | métodos e composições para imunizações heterólogas com reprna |
| BR112020004143A2 (pt) | 2017-09-15 | 2020-09-01 | Janssen Vaccines & Prevention B.V. | método para a indução segura de imunidade contra vírus sincicial respiratório (rsv) |
| EP3713599A1 (en) | 2017-11-20 | 2020-09-30 | Janssen Pharmaceuticals, Inc. | Method of providing safe administration of adenoviral vectors encoding a zika virus antigen |
| WO2019118480A1 (en) | 2017-12-11 | 2019-06-20 | Beth Israel Deaconess Medical Center, Inc. | Recombinant adenoviruses and uses thereof |
| MX2020006471A (es) | 2017-12-19 | 2020-09-22 | Janssen Sciences Ireland Unlimited Co | Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv). |
| JP7653013B2 (ja) | 2018-01-04 | 2025-03-28 | アイコニック セラピューティクス リミテッド ライアビリティ カンパニー | 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法 |
| EP3810277A1 (en) | 2018-07-20 | 2021-04-28 | Janssen Vaccines & Prevention B.V. | Recombinant adenoviral vector expressing zika antigen with improved productivity |
| PH12021550974A1 (en) | 2018-11-13 | 2022-05-02 | Janssen Vaccines & Prevention Bv | Stablized pre-fusion rsv f proteins |
| JP2022532723A (ja) | 2019-05-15 | 2022-07-19 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 季節性インフルエンザワクチン及びアデノウイルス系呼吸器合胞体ウイルスワクチンの共投与 |
| AU2020275910A1 (en) | 2019-05-15 | 2021-11-04 | Janssen Vaccines & Prevention B.V. | Prophylactic treatment of respiratory syncytial virus infection with an adenovirus based vaccine |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| CN110714027A (zh) * | 2019-10-28 | 2020-01-21 | 嘉铭(固安)生物科技有限公司 | 一种表达质粒、用于包装二代腺病毒的细胞株及其应用 |
| PH12023550030A1 (en) | 2020-07-08 | 2024-03-11 | Janssen Sciences Ireland Unlimited Co | Rna replicon vaccines against hbv |
| CA3187258A1 (en) | 2020-08-06 | 2022-02-10 | Karin Jooss | Multiepitope vaccine cassettes |
| WO2023198815A1 (en) | 2022-04-14 | 2023-10-19 | Janssen Vaccines & Prevention B.V. | Sequential administration of adenoviruses |
| CN117821405B (zh) * | 2023-11-24 | 2024-11-26 | 广州医科大学 | 基因嵌合型人腺病毒及其构建方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| EP1445322B2 (en) | 1995-06-15 | 2012-06-06 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US5922315A (en) | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
| IL132673A0 (en) | 1997-05-08 | 2001-03-19 | Genetic Therapy Inc | Gene transfer with adenoviruses having modified fiber proteins |
| US6670188B1 (en) | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| JP4683727B2 (ja) | 1999-03-04 | 2011-05-18 | クルーセル ホランド ベスローテン フェンノートシャップ | 線維芽細胞様またはマクロファージ様細胞の形質導入のための手段と方法 |
| EP1816204B1 (en) | 1999-05-17 | 2010-10-20 | Crucell Holland B.V. | Recombinant Adenovirus of the Ad26 serotype |
| US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6365394B1 (en) * | 1999-09-29 | 2002-04-02 | The Trustees Of The University Of Pennsylvania | Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus |
| EP1103610A1 (en) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
| DE10045687B4 (de) * | 2000-09-15 | 2006-07-06 | MICROMUN Privates Institut für Mikrobiologische Forschung GmbH Biotechnikum Greifswald | Expressionskassetten und Adenovirusvektoren |
| WO2002024730A2 (en) | 2000-09-20 | 2002-03-28 | Crucell Holland B.V. | Transduction of dendritic cells using adenoviral vectors |
| EP1348030B1 (en) | 2001-01-04 | 2009-11-25 | Wadell, Göran | Viral vector for gene therapy |
| ES2335657T3 (es) | 2002-04-25 | 2010-03-31 | Crucell Holland B.V. | Medios y metodos para la produccion de vectores de adenovirus. |
-
2003
- 2003-04-24 WO PCT/EP2003/050126 patent/WO2004001032A2/en not_active Ceased
- 2003-04-24 CN CNB038092085A patent/CN100374574C/zh not_active Expired - Fee Related
- 2003-04-24 DE DE60323080T patent/DE60323080D1/de not_active Expired - Lifetime
- 2003-04-24 SI SI200331429T patent/SI1497440T1/sl unknown
- 2003-04-24 AT AT03753569T patent/ATE405663T1/de active
- 2003-04-24 IL IL16480203A patent/IL164802A0/xx active IP Right Grant
- 2003-04-24 AU AU2003271738A patent/AU2003271738C1/en not_active Ceased
- 2003-04-24 JP JP2004514868A patent/JP4495588B2/ja not_active Expired - Lifetime
- 2003-04-24 KR KR1020047016964A patent/KR101006594B1/ko not_active Expired - Fee Related
- 2003-04-24 PL PL373337A patent/PL208588B1/pl unknown
- 2003-04-24 EP EP03753569A patent/EP1497440B1/en not_active Expired - Lifetime
- 2003-04-24 DK DK03753569T patent/DK1497440T3/da active
- 2003-04-24 CA CA2478508A patent/CA2478508C/en not_active Expired - Fee Related
- 2003-04-24 US US10/512,602 patent/US7285265B2/en not_active Expired - Lifetime
- 2003-04-24 ES ES03753569T patent/ES2310247T3/es not_active Expired - Lifetime
- 2003-04-24 NZ NZ534865A patent/NZ534865A/en not_active IP Right Cessation
-
2004
- 2004-11-24 NO NO20045131A patent/NO334299B1/no not_active IP Right Cessation
-
2007
- 2007-09-05 US US11/899,572 patent/US8052967B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR101006594B1 (ko) | 2011-01-07 |
| DK1497440T3 (da) | 2008-12-01 |
| US8052967B2 (en) | 2011-11-08 |
| WO2004001032A2 (en) | 2003-12-31 |
| US20080206837A1 (en) | 2008-08-28 |
| ES2310247T3 (es) | 2009-01-01 |
| WO2004001032A3 (en) | 2004-04-01 |
| PL373337A1 (en) | 2005-08-22 |
| CA2478508A1 (en) | 2003-12-31 |
| AU2003271738A1 (en) | 2004-01-06 |
| US7285265B2 (en) | 2007-10-23 |
| US20050163753A1 (en) | 2005-07-28 |
| PL208588B1 (pl) | 2011-05-31 |
| NO20045131L (no) | 2005-01-21 |
| ATE405663T1 (de) | 2008-09-15 |
| NO334299B1 (no) | 2014-02-03 |
| EP1497440A2 (en) | 2005-01-19 |
| CA2478508C (en) | 2013-07-02 |
| NZ534865A (en) | 2008-07-31 |
| CN100374574C (zh) | 2008-03-12 |
| JP2005523730A (ja) | 2005-08-11 |
| AU2003271738C1 (en) | 2008-04-17 |
| AU2003271738B2 (en) | 2007-10-11 |
| HK1069185A1 (en) | 2005-05-13 |
| DE60323080D1 (de) | 2008-10-02 |
| EP1497440B1 (en) | 2008-08-20 |
| CN1650021A (zh) | 2005-08-03 |
| SI1497440T1 (sl) | 2009-02-28 |
| KR20040106365A (ko) | 2004-12-17 |
| JP4495588B2 (ja) | 2010-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL164802A0 (en) | Stable adenoviral vectors and methods for propagation thereof | |
| IL164803A (en) | Means and methods for the production of adenovirus vectors | |
| ES2151310T3 (es) | Nuevas lineas celulares de complementacion para vectores adenovirales defectivos. | |
| CA2391591A1 (en) | Permanent amniocyte cell line, the production thereof and its use for producing gene transfer vectors | |
| Imler et al. | Novel complementation cell lines derived from human lung carcinoma A549 cells support the growth of E1-deleted adenovirus vectors. | |
| ATE382694T1 (de) | Vektoren und methoden zum gentransfer in zellen | |
| IL137730A0 (en) | Modified adenovirus containing a fiber replacement protein | |
| WO2003049525A3 (en) | Methods and materials for the production of organic products in cells of $i(candida) species | |
| EP1369487A3 (en) | Recombinant vectors derived from adenovirus for use in gene therapy | |
| ATE516343T1 (de) | Zellinien zur produktion von replikationsdefektem adenovirus | |
| WO2004099422A3 (en) | Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes | |
| AU4624197A (en) | Packaging cell lines for use in facilitating the development of high-capacity adenoviral vectors | |
| WO2004018627A3 (en) | Methods for propagating adenovirus and virus produced thereby | |
| CA2538025A1 (en) | Packaging cells for recombinant adenovirus | |
| JP2007507216A5 (enExample) | ||
| PL1760153T3 (pl) | Hybrydowy wektor adenowirusowy/alfawirusowy do skutecznego podawania i ekspresji genów terapeutycznych w komórkach nowotworowych | |
| WO2006060089A3 (en) | Novel methods for producing adenoviral vector preparations with reduced replication-competent adenovirus contamination and novel adenoviral vectors and preparations | |
| WO2004015086A3 (en) | Enhancement of adenoviral oncolytic activity in prostate cells by modification of the e1a gene product | |
| IL116216A0 (en) | Encapsidation cell lines and expression vectors for the transcomplementation of defective retroviral vector | |
| FI3997106T3 (fi) | Onkolyyttisiä ei-ihmisadenoviruksia ja niiden käyttöjä | |
| TW200607859A (en) | Oncolytic adenoviral vectors encoding GM-CSF | |
| Tochikura et al. | Glutathione S-transferase in yeast: Induction of mRNA, cDNA cloning and expression in | |
| WO2004011489A3 (fr) | Adenovirus modifies pour changer leur tropisme, de preference pour le ciblage des lymphocytes b ou des cellules ovariennes | |
| WO2005067506A3 (en) | Method for monitoring and generating high capacity gutless adenoviral vector |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |