IL164324A0 - Quinolinone derivatives - Google Patents
Quinolinone derivativesInfo
- Publication number
- IL164324A0 IL164324A0 IL16432403A IL16432403A IL164324A0 IL 164324 A0 IL164324 A0 IL 164324A0 IL 16432403 A IL16432403 A IL 16432403A IL 16432403 A IL16432403 A IL 16432403A IL 164324 A0 IL164324 A0 IL 164324A0
- Authority
- IL
- Israel
- Prior art keywords
- quinolinone derivatives
- quinolinone
- derivatives
- Prior art date
Links
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/116,117 US20030028018A1 (en) | 2000-09-11 | 2002-04-05 | Quinolinone derivatives |
PCT/US2003/010463 WO2003087095A1 (en) | 2002-04-05 | 2003-04-04 | Quinolinone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
IL164324A0 true IL164324A0 (en) | 2005-12-18 |
Family
ID=29248193
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16432403A IL164324A0 (en) | 2002-04-05 | 2003-04-04 | Quinolinone derivatives |
IL164324A IL164324A (en) | 2002-04-05 | 2004-09-28 | Medicaments comprising quinolinone derivatives in combination with anti-cancer drugs |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL164324A IL164324A (en) | 2002-04-05 | 2004-09-28 | Medicaments comprising quinolinone derivatives in combination with anti-cancer drugs |
Country Status (25)
Country | Link |
---|---|
US (3) | US20030028018A1 (de) |
EP (1) | EP1497287B1 (de) |
JP (1) | JP2005527587A (de) |
KR (1) | KR101035894B1 (de) |
CN (1) | CN1659165A (de) |
AP (1) | AP2070A (de) |
AT (1) | ATE489092T1 (de) |
AU (1) | AU2003226275B2 (de) |
BR (1) | BR0308996A (de) |
CA (1) | CA2481055C (de) |
DE (1) | DE60335096D1 (de) |
EA (1) | EA010393B1 (de) |
EC (1) | ECSP045411A (de) |
ES (1) | ES2357289T3 (de) |
HK (1) | HK1067966A1 (de) |
HR (1) | HRP20041031B1 (de) |
IL (2) | IL164324A0 (de) |
MA (1) | MA28122A1 (de) |
MX (1) | MXPA04009739A (de) |
NO (1) | NO331021B1 (de) |
NZ (1) | NZ536068A (de) |
PL (1) | PL209412B1 (de) |
PT (1) | PT1497287E (de) |
SG (1) | SG143985A1 (de) |
WO (1) | WO2003087095A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2334641T3 (es) | 2000-09-01 | 2010-03-15 | Novartis Vaccines And Diagnostics, Inc. | Derivados aza heterociclicos y su uso terapeutico. |
BRPI0113757B1 (pt) * | 2000-09-11 | 2017-05-23 | Chiron Corp | derivados de quinolinona como inibibores de tirosina quinase |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
US7642278B2 (en) * | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
AU2002361577A1 (en) * | 2001-10-30 | 2003-05-12 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
EP2573079A3 (de) * | 2002-08-23 | 2015-03-11 | Novartis AG | Benzimidazolchinolinonderivate und ihre Verwendung |
US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
AU2003275282A1 (en) * | 2002-09-30 | 2004-04-23 | Bristol-Myers Squibb Company | Novel tyrosine kinase inhibitors |
KR20050075005A (ko) * | 2002-11-13 | 2005-07-19 | 카이론 코포레이션 | 암을 치료하는 방법 및 관련 방법 |
EP1648455A4 (de) * | 2003-07-23 | 2009-03-04 | Exelixis Inc | Anaplastische lymphom-kinase-modulatoren und anwendungsverfahren |
CA2544186A1 (en) * | 2003-11-07 | 2005-05-26 | Chiron Corporation | Inhibition of fgfr3 and treatment of multiple myeloma with benzimidazole quinolinones |
US20050171171A1 (en) * | 2003-11-13 | 2005-08-04 | Ambit Biosciences Corporation | Amide derivatives as FLT-3 modulators |
WO2005082340A2 (en) * | 2004-02-20 | 2005-09-09 | Chiron Corporation | Modulation of inflammatory and metastatic processes |
RU2007101544A (ru) * | 2004-06-17 | 2008-08-10 | Уайт (Us) | Антагонисты рецепторов высвобождающего гонадотропин гормона |
BRPI0512239A (pt) * | 2004-06-17 | 2008-02-19 | Wyeth Corp | processos para preparação de antagonistas de receptores de hormÈnios liberadores de gonatropina |
CA2587853A1 (en) * | 2004-11-23 | 2006-06-01 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
AU2006208012B2 (en) | 2005-01-27 | 2011-08-04 | Novartis Vaccines And Diagnostics Inc. | Treatment of metastasized tumors |
US7582634B2 (en) * | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7538113B2 (en) * | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7534796B2 (en) * | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
US20060189619A1 (en) * | 2005-02-24 | 2006-08-24 | Wyeth | 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds |
ES2440799T3 (es) | 2005-05-13 | 2014-01-30 | Novartis Ag | Métodos para tratar cáncer resistente a los fármacos |
WO2006125130A1 (en) * | 2005-05-17 | 2006-11-23 | Novartis Ag | Methods for synthesizing heterocyclic compounds |
US7531542B2 (en) * | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
CN101218228A (zh) * | 2005-05-23 | 2008-07-09 | 诺瓦提斯公司 | 4-氨基-5-氟-3-[6-(4-甲基哌嗪-1-基)-1h-苯并咪唑-2-基]-1h-喹啉-2-酮乳酸盐的结晶和其它形式 |
US7582636B2 (en) * | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
PT1957074E (pt) | 2005-11-29 | 2014-06-25 | Novartis Ag | Formulações de quinolinonas |
JP2009523410A (ja) | 2005-12-08 | 2009-06-25 | ノバルティス アクチエンゲゼルシャフト | 遺伝子転写に対するfgfr3の阻害剤の効果 |
CN100488960C (zh) * | 2006-03-09 | 2009-05-20 | 中国药科大学 | 2-位取代的喹诺酮类化合物及其在制药中的应用 |
US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
US8258154B2 (en) * | 2006-07-07 | 2012-09-04 | Kalypsys Inc. | Bicyclic heteroaryl inhibitors of PDE4 |
WO2011127192A2 (en) | 2010-04-06 | 2011-10-13 | Brigham Young University | Antimetastatic compounds |
JP2013536241A (ja) * | 2010-08-24 | 2013-09-19 | ブリガム・ヤング・ユニバーシティ | 抗転移化合物 |
WO2013063003A1 (en) | 2011-10-28 | 2013-05-02 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
US20140378422A1 (en) | 2012-01-31 | 2014-12-25 | Novartis Ag | Combination of a RTK inhibitor with an anti-estrogen and use thereof for the treatment of cancer |
CN104427986A (zh) | 2012-07-11 | 2015-03-18 | 诺华股份有限公司 | 治疗胃肠道基质瘤的方法 |
WO2014058785A1 (en) | 2012-10-10 | 2014-04-17 | Novartis Ag | Combination therapy |
CN107935988A (zh) | 2013-10-14 | 2018-04-20 | 卫材R&D管理有限公司 | 选择性取代的喹啉化合物 |
TWI702218B (zh) | 2013-10-14 | 2020-08-21 | 日商衛材R&D企管股份有限公司 | 選擇性經取代之喹啉化合物 |
JP6936007B2 (ja) | 2014-06-17 | 2021-09-15 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Chk1阻害剤とatr阻害剤との組み合わせを使用してがんを処置する方法 |
EP2977374A1 (de) * | 2014-07-21 | 2016-01-27 | Université de Strasbourg | Moleküle mit zwei Emissionseigenschaften |
AU2016331955B2 (en) | 2015-09-30 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
CN108003150A (zh) * | 2016-10-31 | 2018-05-08 | 河南工业大学 | 4-杂芳基喹啉酮衍生物的制备方法及其应用 |
KR20200020888A (ko) * | 2017-06-27 | 2020-02-26 | 얀센 파마슈티카 엔.브이. | 신규 퀴놀리논 화합물 |
KR20200090828A (ko) | 2017-11-24 | 2020-07-29 | 얀센 파마슈티카 엔.브이. | 피라졸로피리디논 화합물 |
BR112020010012A2 (pt) | 2017-11-24 | 2020-10-13 | Janssen Pharmaceutica Nv | compostos de pirazolopiridinona |
CN108516973A (zh) * | 2018-03-30 | 2018-09-11 | 广西师范大学 | 3-苯并噻唑-1-(3-二甲氨基)丙基喹啉-4-酮衍生物及其制备方法和应用 |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US102369A (en) * | 1870-04-26 | Improvement in pumps | ||
US509717A (en) * | 1893-11-28 | beach | ||
US152904A (en) * | 1874-07-14 | Improvement in rotary pumps | ||
US158224A (en) * | 1874-12-29 | Improvement in eye-cups | ||
US162252A (en) * | 1875-04-20 | Improvement in safety-catches for elevators | ||
US63A (en) * | 1836-10-20 | Kravxiig | ||
US37650A (en) * | 1863-02-10 | Improvement in apparatus for obtaining profiles of submarine beds | ||
US290153A (en) * | 1883-12-11 | Beer-scale | ||
US129025A (en) * | 1872-07-16 | Improvement in strainer-pipes | ||
US162251A (en) * | 1875-04-20 | Improvement in interfering-pads for horses | ||
US508800A (en) * | 1893-11-14 | Trustees | ||
US8A (en) * | 1836-08-10 | T Blanchard | Machine for cutting scores around ships' tackle blocks and dead eyes | |
US155114A (en) * | 1874-09-15 | Improvement in methods of laying and forming cast-iron pipes | ||
US7A (en) * | 1836-08-10 | Thomas blanchard | ||
US128993A (en) * | 1872-07-16 | Improvement in furnaces for reducing iron ores | ||
US27379A (en) * | 1860-03-06 | Improvement in seeding-machines | ||
US207883A (en) * | 1878-09-10 | Improvement in drafting-pencils | ||
US36256A (en) * | 1862-08-19 | Improvement in sewing-m ach ines | ||
US6A (en) * | 1836-08-10 | Thomas blanghard | ||
US232861A (en) * | 1880-10-05 | Machine for dressing millstones | ||
US747771A (en) * | 1903-04-16 | 1903-12-22 | Rudolf Richter | Machine for harvesting potatoes or similar root crops. |
US797376A (en) * | 1905-05-19 | 1905-08-15 | John P Schneider Sr | Vise. |
US1086705A (en) * | 1913-06-04 | 1914-02-10 | Frank O Havener | Cigar-moistener. |
US2363459A (en) * | 1944-02-19 | 1944-11-21 | Draper Corp | Picker stick checking mechanism |
US3663606A (en) * | 1966-06-21 | 1972-05-16 | Mitsui Toatsu Chemicals | Organic imino-compounds |
US4659657A (en) * | 1982-12-24 | 1987-04-21 | Bayer Aktiengesellschaft | Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases |
DE3634066A1 (de) * | 1986-10-07 | 1988-04-21 | Boehringer Mannheim Gmbh | Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
DE3932953A1 (de) * | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5151360A (en) * | 1990-12-31 | 1992-09-29 | Biomembrane Institute | Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation |
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
USRE37650E1 (en) * | 1991-05-10 | 2002-04-09 | Aventis Pharmacetical Products, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
US5856115A (en) * | 1991-05-24 | 1999-01-05 | Fred Hutchinson Cancer Research Center | Assay for identification therapeutic agents |
CA2131528C (en) * | 1992-03-05 | 2004-07-13 | Philip E. Thorpe | Methods and compositions for targeting the vasculature of solid tumors |
US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
JP3441246B2 (ja) * | 1995-06-07 | 2003-08-25 | 富士写真フイルム株式会社 | 光重合性組成物 |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
US5942385A (en) * | 1996-03-21 | 1999-08-24 | Sugen, Inc. | Method for molecular diagnosis of tumor angiogenesis and metastasis |
JP4373497B2 (ja) * | 1996-06-19 | 2009-11-25 | ローン−プーラン・ロレ・リミテツド | 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用 |
US6111110A (en) * | 1996-10-30 | 2000-08-29 | Eli Lilly And Company | Synthesis of benzo[f]quinolinones |
DE19756235A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
US6174912B1 (en) * | 1998-08-21 | 2001-01-16 | Dupont Pharmaceuticals Company | Nitrogen substituted imidazo[4,5-C]pyrazoles as corticotropin releasing hormone antagonists |
US20030087854A1 (en) * | 2001-09-10 | 2003-05-08 | Isis Pharmaceuticals Inc. | Antisense modulation of fibroblast growth factor receptor 3 expression |
DK1183033T3 (da) * | 1999-05-21 | 2006-06-06 | Bristol Myers Squibb Co | Pyrrolotriazininhibitorer af kinaser |
KR100298572B1 (ko) * | 1999-08-19 | 2001-09-22 | 박찬구 | 카바아닐라이드로부터 4-니트로디페닐아민과 4-니트로소디페닐아민의 제조방법 |
EP1226119B1 (de) * | 1999-10-19 | 2005-03-16 | MERCK & CO. INC. | Tyrosin kinase inhibitoren |
CA2387351C (en) * | 1999-10-19 | 2009-09-08 | Merck & Co., Inc. | Indole derivatives as tyrosine kinase inhibitors |
US6420382B2 (en) * | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6313138B1 (en) * | 2000-02-25 | 2001-11-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
ES2334641T3 (es) * | 2000-09-01 | 2010-03-15 | Novartis Vaccines And Diagnostics, Inc. | Derivados aza heterociclicos y su uso terapeutico. |
US7179912B2 (en) * | 2000-09-01 | 2007-02-20 | Icos Corporation | Materials and methods to potentiate cancer treatment |
BRPI0113757B1 (pt) * | 2000-09-11 | 2017-05-23 | Chiron Corp | derivados de quinolinona como inibibores de tirosina quinase |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
US20030159702A1 (en) * | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
EP2573079A3 (de) * | 2002-08-23 | 2015-03-11 | Novartis AG | Benzimidazolchinolinonderivate und ihre Verwendung |
US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
KR20050075005A (ko) * | 2002-11-13 | 2005-07-19 | 카이론 코포레이션 | 암을 치료하는 방법 및 관련 방법 |
US6774327B1 (en) * | 2003-09-24 | 2004-08-10 | Agilent Technologies, Inc. | Hermetic seals for electronic components |
CA2544186A1 (en) * | 2003-11-07 | 2005-05-26 | Chiron Corporation | Inhibition of fgfr3 and treatment of multiple myeloma with benzimidazole quinolinones |
WO2006122950A1 (en) * | 2005-05-18 | 2006-11-23 | M & G Polimeri Italia S.P.A. | Polyester composition |
-
2002
- 2002-04-05 US US10/116,117 patent/US20030028018A1/en not_active Abandoned
-
2003
- 2003-04-04 AU AU2003226275A patent/AU2003226275B2/en not_active Expired
- 2003-04-04 MX MXPA04009739A patent/MXPA04009739A/es active IP Right Grant
- 2003-04-04 PT PT03746614T patent/PT1497287E/pt unknown
- 2003-04-04 BR BR0308996-7A patent/BR0308996A/pt not_active Application Discontinuation
- 2003-04-04 AT AT03746614T patent/ATE489092T1/de active
- 2003-04-04 KR KR1020047015851A patent/KR101035894B1/ko not_active IP Right Cessation
- 2003-04-04 EA EA200401318A patent/EA010393B1/ru not_active IP Right Cessation
- 2003-04-04 EP EP03746614A patent/EP1497287B1/de not_active Expired - Lifetime
- 2003-04-04 AP APAP/P/2004/003166A patent/AP2070A/en active
- 2003-04-04 CA CA2481055A patent/CA2481055C/en not_active Expired - Lifetime
- 2003-04-04 NZ NZ536068A patent/NZ536068A/en not_active IP Right Cessation
- 2003-04-04 ES ES03746614T patent/ES2357289T3/es not_active Expired - Lifetime
- 2003-04-04 IL IL16432403A patent/IL164324A0/xx unknown
- 2003-04-04 CN CN038129094A patent/CN1659165A/zh active Pending
- 2003-04-04 JP JP2003584051A patent/JP2005527587A/ja active Pending
- 2003-04-04 WO PCT/US2003/010463 patent/WO2003087095A1/en active Application Filing
- 2003-04-04 DE DE60335096T patent/DE60335096D1/de not_active Expired - Lifetime
- 2003-04-04 PL PL372871A patent/PL209412B1/pl unknown
- 2003-04-04 SG SG200606999-1A patent/SG143985A1/en unknown
-
2004
- 2004-09-28 IL IL164324A patent/IL164324A/en not_active IP Right Cessation
- 2004-10-04 MA MA27887A patent/MA28122A1/fr unknown
- 2004-11-03 HR HRP20041031AA patent/HRP20041031B1/hr not_active IP Right Cessation
- 2004-11-03 NO NO20044776A patent/NO331021B1/no not_active IP Right Cessation
- 2004-11-05 EC EC2004005411A patent/ECSP045411A/es unknown
-
2005
- 2005-02-22 HK HK05101490.8A patent/HK1067966A1/xx not_active IP Right Cessation
-
2007
- 2007-10-02 US US11/866,296 patent/US20080070906A1/en not_active Abandoned
-
2010
- 2010-01-04 US US12/651,612 patent/US20100184754A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL164324A0 (en) | Quinolinone derivatives | |
AP1850A (en) | Spiroindolineplperidine derivatives | |
EG24050A (en) | Heterocylocarboxamide derivatives | |
IL175947A0 (en) | Novel quinoline derivatives | |
HK1077068A1 (en) | Azolidinone-vinyl fused-benzene derivatives | |
IL166121A0 (en) | Indole-3-sulphur derivatives | |
EP1522540A4 (de) | Azaarenderivate | |
PL376475A1 (en) | N-substituted-2-oxodihydropyridine derivatives | |
ZA200500471B (en) | N-biarylmethyl aminocycloalkanecarboxamide derivatives | |
HK1080836A1 (en) | Isoquinoline derivatives | |
PL376997A1 (pl) | Pochodne tetrahydrochinoliny | |
PL377318A1 (pl) | Pochodne tetrahydrochinoliny | |
HK1071364A1 (en) | Quinoline derivatives | |
AU2003222659A8 (en) | 23-o-substituted 5-o-mycaminosyltylonide derivatives | |
PL371216A1 (en) | Isoquinoline derivatives | |
AU2003274551A1 (en) | Quinoline derivatives | |
AU2003252333A1 (en) | Novel tetrahydroquinoline derivatives | |
EP1531854A4 (de) | O-derivatisierte nocathiacin-derivate | |
GB0213488D0 (en) | 2-Naphthamide derivatives | |
AU2003243397A8 (en) | Homo-camptothecin derivatives | |
HK1077577A1 (en) | Tetrahydroquinoline derivatives | |
GB0221143D0 (en) | Dihydropyridinone derivatives | |
GB0210512D0 (en) | Tetrahydro-napthalene derivatives | |
AU2003285777A8 (en) | 3-substituted-4-pyrimidone derivatives | |
HK1081943A1 (en) | N-hydroxyformamidine derivative |