IL161620A0 - Quinazoline derivatives as antitumor agents - Google Patents
Quinazoline derivatives as antitumor agentsInfo
- Publication number
- IL161620A0 IL161620A0 IL16162002A IL16162002A IL161620A0 IL 161620 A0 IL161620 A0 IL 161620A0 IL 16162002 A IL16162002 A IL 16162002A IL 16162002 A IL16162002 A IL 16162002A IL 161620 A0 IL161620 A0 IL 161620A0
- Authority
- IL
- Israel
- Prior art keywords
- antitumor agents
- quinazoline derivatives
- quinazoline
- derivatives
- antitumor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0126433.2A GB0126433D0 (en) | 2001-11-03 | 2001-11-03 | Compounds |
PCT/GB2002/004932 WO2003040109A2 (en) | 2001-11-03 | 2002-10-31 | Quinazoline derivatives as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL161620A0 true IL161620A0 (en) | 2004-09-27 |
Family
ID=9925096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16162002A IL161620A0 (en) | 2001-11-03 | 2002-10-31 | Quinazoline derivatives as antitumor agents |
Country Status (25)
Country | Link |
---|---|
US (2) | US20050054662A1 (ja) |
EP (1) | EP1444211B1 (ja) |
JP (1) | JP2005511603A (ja) |
KR (1) | KR20050042058A (ja) |
CN (1) | CN1764651A (ja) |
AR (1) | AR037193A1 (ja) |
AT (1) | ATE421507T1 (ja) |
BR (1) | BR0213843A (ja) |
CA (1) | CA2465100A1 (ja) |
CO (1) | CO5580775A2 (ja) |
DE (1) | DE60230995D1 (ja) |
ES (1) | ES2319880T3 (ja) |
GB (1) | GB0126433D0 (ja) |
HK (1) | HK1065801A1 (ja) |
HU (1) | HUP0401994A2 (ja) |
IL (1) | IL161620A0 (ja) |
IS (1) | IS7241A (ja) |
MX (1) | MXPA04004220A (ja) |
NO (1) | NO20042288L (ja) |
NZ (1) | NZ532523A (ja) |
PL (1) | PL369833A1 (ja) |
RU (1) | RU2004116908A (ja) |
TW (1) | TW200302221A (ja) |
WO (1) | WO2003040109A2 (ja) |
ZA (2) | ZA200403203B (ja) |
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DE60211317T2 (de) * | 2001-03-23 | 2007-04-12 | Bayer Corp. | Rho-kinase inhibitoren |
DK1370552T3 (da) * | 2001-03-23 | 2007-05-07 | Bayer Pharmaceuticals Corp | Rho-kinase-inhibitorer |
RU2004116911A (ru) * | 2001-11-03 | 2005-11-10 | Астразенека Аб (Se) | Производные хиназолина в качестве противоопухолевых средств |
MXPA04007459A (es) * | 2002-02-01 | 2005-09-08 | Astrazeneca Ab | Compuestos de quinazolina. |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
EP2277867B1 (en) | 2002-07-15 | 2012-12-05 | Symphony Evolution, Inc. | Compounds, pharmaceutical compositions thereof and their use in treating cancer |
GB0309009D0 (en) * | 2003-04-22 | 2003-05-28 | Astrazeneca Ab | Quinazoline derivatives |
GB0309850D0 (en) * | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
SI1667991T1 (sl) * | 2003-09-16 | 2008-10-31 | Astrazeneca Ab | Kinazolinski derivati kot inhibitorji tirozin kinaze |
WO2005026151A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
WO2005026156A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives |
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JP2007505871A (ja) * | 2003-09-16 | 2007-03-15 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
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US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
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CN110357858B (zh) * | 2018-04-09 | 2022-02-18 | 威尚(上海)生物医药有限公司 | 具有穿过血脑屏障能力的5取代二氟哌啶化合物 |
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TWI811358B (zh) | 2018-05-08 | 2023-08-11 | 大陸商迪哲(江蘇)醫藥股份有限公司 | ErbB受體抑制劑 |
CN109336828B (zh) * | 2018-11-30 | 2022-04-26 | 雅安职业技术学院 | 一种喹唑啉衍生物及其制备方法和应用 |
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UA73993C2 (uk) * | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
US20020082270A1 (en) * | 2000-08-26 | 2002-06-27 | Frank Himmelsbach | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
US6562319B2 (en) * | 2001-03-12 | 2003-05-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy |
EP1396488A1 (en) * | 2001-05-23 | 2004-03-10 | Mitsubishi Pharma Corporation | Fused heterocyclic compound and medicinal use thereof |
WO2003031406A2 (en) * | 2001-10-12 | 2003-04-17 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
RU2004116911A (ru) * | 2001-11-03 | 2005-11-10 | Астразенека Аб (Se) | Производные хиназолина в качестве противоопухолевых средств |
TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
GB0309009D0 (en) * | 2003-04-22 | 2003-05-28 | Astrazeneca Ab | Quinazoline derivatives |
GB0309850D0 (en) * | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
MXPA06001079A (es) * | 2003-07-29 | 2006-04-11 | Astrazeneca Ab | Derivados de piperidil quinazolina como inhibidores de cinasa de tirosina. |
GB0317665D0 (en) * | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
WO2005026151A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
SI1667991T1 (sl) * | 2003-09-16 | 2008-10-31 | Astrazeneca Ab | Kinazolinski derivati kot inhibitorji tirozin kinaze |
JP2007505871A (ja) * | 2003-09-16 | 2007-03-15 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
DE602004004811T2 (de) * | 2003-09-19 | 2007-11-22 | Astrazeneca Ab | Chinazolinderivate |
GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
US20070043010A1 (en) * | 2003-09-25 | 2007-02-22 | Astrazeneca Uk Limited | Quinazoline derivatives |
GB0326459D0 (en) * | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
ES2315834T3 (es) * | 2004-02-03 | 2009-04-01 | Astrazeneca Ab | Derivados de quinazolina. |
CN1993349A (zh) * | 2004-06-04 | 2007-07-04 | 阿斯利康(瑞典)有限公司 | 作为erbb受体酪氨酸激酶的喹唑啉衍生物 |
-
2001
- 2001-11-03 GB GBGB0126433.2A patent/GB0126433D0/en not_active Ceased
-
2002
- 2002-10-31 BR BR0213843-3A patent/BR0213843A/pt not_active IP Right Cessation
- 2002-10-31 US US10/494,388 patent/US20050054662A1/en not_active Abandoned
- 2002-10-31 EP EP02774961A patent/EP1444211B1/en not_active Expired - Lifetime
- 2002-10-31 MX MXPA04004220A patent/MXPA04004220A/es unknown
- 2002-10-31 RU RU2004116908/04A patent/RU2004116908A/ru not_active Application Discontinuation
- 2002-10-31 AT AT02774961T patent/ATE421507T1/de not_active IP Right Cessation
- 2002-10-31 JP JP2003542155A patent/JP2005511603A/ja not_active Ceased
- 2002-10-31 ES ES02774961T patent/ES2319880T3/es not_active Expired - Lifetime
- 2002-10-31 KR KR1020047006735A patent/KR20050042058A/ko not_active Application Discontinuation
- 2002-10-31 CN CNA028262824A patent/CN1764651A/zh active Pending
- 2002-10-31 WO PCT/GB2002/004932 patent/WO2003040109A2/en active Application Filing
- 2002-10-31 NZ NZ532523A patent/NZ532523A/en unknown
- 2002-10-31 DE DE60230995T patent/DE60230995D1/de not_active Expired - Lifetime
- 2002-10-31 HU HU0401994A patent/HUP0401994A2/hu unknown
- 2002-10-31 IL IL16162002A patent/IL161620A0/xx unknown
- 2002-10-31 PL PL02369833A patent/PL369833A1/xx not_active Application Discontinuation
- 2002-10-31 CA CA002465100A patent/CA2465100A1/en not_active Abandoned
- 2002-11-01 AR ARP020104182A patent/AR037193A1/es not_active Application Discontinuation
- 2002-11-01 TW TW091132368A patent/TW200302221A/zh unknown
-
2004
- 2004-04-28 ZA ZA200403203A patent/ZA200403203B/en unknown
- 2004-04-28 ZA ZA200403200A patent/ZA200403200B/en unknown
- 2004-04-30 IS IS7241A patent/IS7241A/is unknown
- 2004-06-02 CO CO04051630A patent/CO5580775A2/es not_active Application Discontinuation
- 2004-06-03 NO NO20042288A patent/NO20042288L/no not_active Application Discontinuation
- 2004-11-08 HK HK04108771.4A patent/HK1065801A1/xx not_active IP Right Cessation
-
2006
- 2006-05-31 US US11/443,395 patent/US20070088044A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HUP0401994A2 (hu) | 2005-01-28 |
JP2005511603A (ja) | 2005-04-28 |
MXPA04004220A (es) | 2004-09-10 |
ZA200403203B (en) | 2005-07-28 |
AR037193A1 (es) | 2004-10-27 |
CA2465100A1 (en) | 2003-05-15 |
US20050054662A1 (en) | 2005-03-10 |
CN1764651A (zh) | 2006-04-26 |
PL369833A1 (en) | 2005-05-02 |
CO5580775A2 (es) | 2005-11-30 |
NZ532523A (en) | 2007-02-23 |
WO2003040109A2 (en) | 2003-05-15 |
ES2319880T3 (es) | 2009-05-14 |
HK1065801A1 (en) | 2005-03-04 |
TW200302221A (en) | 2003-08-01 |
EP1444211B1 (en) | 2009-01-21 |
IS7241A (is) | 2004-04-30 |
NO20042288L (no) | 2004-06-03 |
BR0213843A (pt) | 2004-08-31 |
US20070088044A1 (en) | 2007-04-19 |
ZA200403200B (en) | 2005-07-28 |
WO2003040109A3 (en) | 2003-06-26 |
DE60230995D1 (de) | 2009-03-12 |
EP1444211A2 (en) | 2004-08-11 |
KR20050042058A (ko) | 2005-05-04 |
ATE421507T1 (de) | 2009-02-15 |
RU2004116908A (ru) | 2005-11-10 |
GB0126433D0 (en) | 2002-01-02 |
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